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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:torasemide
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Accession:CHEBI:9637 term browser browse the term
Definition:An N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure.
Synonyms:exact_synonym: 4-(3-methylanilino)-N-(propan-2-ylcarbamoyl)pyridine-3-sulfonamide
 related_synonym: 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea;   AC-4464;   AC4464;   BM 02015;   BM-02.015;   BM02.015;   BM02015;   Demadex;   Formula=C16H20N4O3S;   InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21);   InChIKey=NGBFQHCMQULJNZ-UHFFFAOYSA-N;   JDL 464;   Luprac;   N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide;   N-(isopropylcarbamoyl)-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide;   N-[(propan-2-yl)carbamoyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide;   SMILES=C=1(C(NC=2C=C(C=CC2)C)=CC=NC1)S(NC(NC(C)C)=O)(=O)=O;   Torem;   Torsemide;   Unat;   torasemida;   torasemidum
 xref: CAS:56211-40-6;   DrugBank:DB00214;   Drug_Central:2708;   HMDB:HMDB0014359;   KEGG:D00382;   LINCS:LSM-2662
 xref_mesh: MESH:C026116
 xref: PMID:21391491;   PMID:21906812;   PMID:22030290;   PMID:22364690;   PMID:22407343;   PMID:23013124;   PMID:23237447;   PMID:23792294;   PMID:23837587;   PMID:23877845;   PMID:24040049;   PMID:24243991;   PMID:24367917;   PMID:24432564;   PMID:24554915;   PMID:28891228;   PMID:29488197;   PMID:30649675;   PMID:30827731;   PMID:31124957;   PMID:31436024;   PMID:31699358;   PMID:31809955;   PMID:32098657;   PMID:32302808;   PMID:32411731;   Reaxys:498515;   Wikipedia:Torasemide


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torasemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases expression EXP Torsemide results in increased expression of AGT protein modified form CTD PMID:18154949 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects expression EXP Torsemide affects the expression of CYP11B2 protein CTD PMID:18001696 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing EXP CYP2C11 protein affects the metabolism of Torsemide CTD PMID:15890479 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions		 ISO CYP2C8 protein results in increased metabolism of Torsemide
Torsemide inhibits the reaction [Amiodarone results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Fluoxetine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Nortriptyline results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Phenelzine results in decreased activity of CYP2C8 protein]; Torsemide inhibits the reaction [Verapamil results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522
G Nppa natriuretic peptide A decreases expression EXP Torsemide results in decreased expression of NPPA protein CTD PMID:18154949 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 multiple interactions EXP Torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein] CTD PMID:7954537 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Ren renin increases expression EXP Torsemide results in increased expression of REN protein CTD PMID:7954537 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc12a2 solute carrier family 12 member 2 decreases activity
multiple interactions		 ISO Torsemide results in decreased activity of SLC12A2 protein
Torsemide inhibits the reaction [SLC12A2 protein results in increased uptake of Rubidium]		 CTD PMID:29959396 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
affects expression		 EXP Torsemide results in decreased expression of TGFB1 protein
Torsemide affects the expression of TGFB1 protein		 CTD PMID:18001696 PMID:18154949 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      application 19713
        pesticide 18090
          avicide 5560
            4-aminopyridine 43
              torasemide 9
                4'-hydroxy torasemide 0
                hydroxy torasemide 0
                torasemide carboxylic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19532
                              organochalcogen compound 19293
                                organooxygen compound 19209
                                  carbon oxoacid 18678
                                    carboxylic acid 18675
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              monocarboxylic acid amide 15750
                                                urea 6233
                                                  ureas 6231
                                                    N-sulfonylurea 148
                                                      torasemide 9
                                                        4'-hydroxy torasemide 0
                                                        hydroxy torasemide 0
                                                        torasemide carboxylic acid 0
paths to the root