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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tomatidine
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Accession:CHEBI:9629 term browser browse the term
Definition:A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.
Synonyms:exact_synonym: (22S,25S)-5alpha-spirosolan-3beta-ol
 related_synonym: (3beta,5alpha,22beta,25S)-spirosolan-3-ol;   5alpha-tomatidan-3beta-ol;   Formula=C27H45NO2;   InChI=1S/C27H45NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28-29H,5-15H2,1-4H3/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27-/m0/s1;   InChIKey=XYNPYHXGMWJBLV-VXPJTDKGSA-N;   SMILES=[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])C[C@]3([H])O[C@@]5(CC[C@H](C)CN5)[C@@H](C)[C@]43[H])[C@@]1(C)CC[C@H](O)C2;   Tomatidin
 xref: Beilstein:91747;   CAS:77-59-8;   KEGG:C10826;   KNApSAcK:C00002267
 xref_mesh: MESH:C003677
 xref: PMID:18544347;   PMID:21357296;   PMID:5704163;   PMID:6056488;   Patent:US2770618;   Reaxys:91747
 cyclic_relationship: is_conjugate_base_of CHEBI:166999



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tomatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase decreases activity ISO tomatidine results in decreased activity of BCHE protein CTD PMID:31152736 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK1 protein CTD PMID:23566884 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO tomatidine results in decreased phosphorylation of MAPK3 protein CTD PMID:23566884 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO tomatidine results in decreased expression of MMP2 mRNA; tomatidine results in decreased expression of MMP2 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein modified form]
CTD PMID:23566884 PMID:31545954 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO tomatidine results in decreased expression of MMP9 mRNA; tomatidine results in decreased expression of MMP9 protein
tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
CTD PMID:23566884 PMID:31545954 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Reck reversion-inducing-cysteine-rich protein with kazal motifs increases expression ISO tomatidine results in increased expression of RECK mRNA CTD PMID:23566884 NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO tomatidine results in decreased expression of RELA protein CTD PMID:23566884 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO tomatidine results in increased expression of TIMP1 mRNA CTD PMID:23566884 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19915
    role 19885
      biological role 19883
        biochemical role 19566
          metabolite 19570
            alkaloid 8011
              spirosolane 8
                tomatidane 8
                  tomatidine 8
                    tomatidine 3-O-beta-D-glucopyranoside(1+) 0
                    tomatine + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19915
    subatomic particle 19913
      composite particle 19895
        hadron 19895
          baryon 19913
            nucleon 19895
              atomic nucleus 19913
                atom 19895
                  main group element atom 19852
                    p-block element atom 19834
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19722
                              organic cyclic compound 19529
                                organic heterocyclic compound 18893
                                  organonitrogen heterocyclic compound 18176
                                    azaspiro compound 876
                                      spirosolane 8
                                        tomatidane 8
                                          tomatidine 8
                                            tomatidine 3-O-beta-D-glucopyranoside(1+) 0
                                            tomatine + 0
paths to the root