CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: tomatidine
Accession: CHEBI:9629
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Definition: A 3beta-hydroxy steroid resulting from the substitution of the 3beta-hydrogen of tomatidane by a hydroxy group.
Synonyms: exact_synonym: (22S,25S)-5alpha-spirosolan-3beta-ol
related_synonym: (3beta,5alpha,22beta,25S)-spirosolan-3-ol; 5alpha-tomatidan-3beta-ol; Formula=C27H45NO2; InChI=1S/C27H45NO2/c1-16-7-12-27(28-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(29)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28-29H,5-15H2,1-4H3/t16-,17-,18-,19-,20+,21-,22-,23-,24-,25-,26-,27-/m0/s1; InChIKey=XYNPYHXGMWJBLV-VXPJTDKGSA-N; SMILES=[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])C[C@]3([H])O[C@@]5(CC[C@H](C)CN5)[C@@H](C)[C@]43[H])[C@@]1(C)CC[C@H](O)C2; Tomatidin
xref: Beilstein:91747; CAS:77-59-8; KEGG:C10826; KNApSAcK:C00002267
xref_mesh: MESH:C003677
xref: PMID:18544347; PMID:21357296; PMID:5704163; PMID:6056488; Patent:US2770618; Reaxys:91747
cyclic_relationship: is_conjugate_base_of CHEBI:166999
G
Bche
butyrylcholinesterase
decreases activity
ISO
tomatidine results in decreased activity of BCHE protein
CTD
PMID:31152736
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
tomatidine results in decreased phosphorylation of MAPK1 protein
CTD
PMID:23566884
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
tomatidine results in decreased phosphorylation of MAPK3 protein
CTD
PMID:23566884
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mmp2
matrix metallopeptidase 2
decreases expression multiple interactions
ISO
tomatidine results in decreased expression of MMP2 mRNA; tomatidine results in decreased expression of MMP2 protein tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein modified form]
CTD
PMID:23566884 PMID:31545954
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Mmp9
matrix metallopeptidase 9
decreases expression multiple interactions
ISO
tomatidine results in decreased expression of MMP9 mRNA; tomatidine results in decreased expression of MMP9 protein tomatidine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
CTD
PMID:23566884 PMID:31545954
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Reck
reversion-inducing-cysteine-rich protein with kazal motifs
increases expression
ISO
tomatidine results in increased expression of RECK mRNA
CTD
PMID:23566884
NCBI chr 5:58,102,961...58,169,516
Ensembl chr 5:58,102,981...58,169,502
G
Rela
RELA proto-oncogene, NF-kB subunit
decreases expression
ISO
tomatidine results in decreased expression of RELA protein
CTD
PMID:23566884
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Timp1
TIMP metallopeptidase inhibitor 1
increases expression
ISO
tomatidine results in increased expression of TIMP1 mRNA
CTD
PMID:23566884
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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