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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolnaftate
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Accession:CHEBI:9620 term browser browse the term
Definition:A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.
Synonyms:exact_synonym: O-2-naphthyl methyl(3-methylphenyl)carbamothioate
 related_synonym: 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate;   Formula=C19H17NOS;   InChI=1S/C19H17NOS/c1-14-6-5-9-17(12-14)20(2)19(22)21-18-11-10-15-7-3-4-8-16(15)13-18/h3-13H,1-2H3;   InChIKey=FUSNMLFNXJSCDI-UHFFFAOYSA-N;   Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester;   N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide;   O-2-Naphthyl m,N-dimethylthiocarbanilate;   SMILES=CN(C(=S)Oc1ccc2ccccc2c1)c1cccc(C)c1;   Separin;   Tinactin;   Tolnaphthate;   m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester;   tolnaftato;   tolnaftatum
 xref: CAS:2398-96-1;   DrugBank:DB00525;   Drug_Central:3617;   HMDB:HMDB0005005;   KEGG:D00381;   LINCS:LSM-5554
 xref_mesh: MESH:D014047
 xref: PMID:20347664;   PMID:2061794;   PMID:20635527;   PMID:21565546;   PMID:22125963;   PMID:24706116;   PMID:3509341;   PMID:4568708;   PMID:5319027;   PMID:5705341;   PMID:5745067;   PMID:5847820;   PMID:5856396;   PMID:5952516;   PMID:697362;   Patent:US2010035939;   Patent:WO2010037089;   Reaxys:2752620;   Wikipedia:Tolnaftate


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tolnaftate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gli1 GLI family zinc finger 1 multiple interactions ISO Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Tolnaftate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Il4 interleukin 4 multiple interactions
decreases secretion
decreases expression		 ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL4 protein] CTD PMID:11886533 PMID:15284827 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
decreases secretion		 ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Tolnaftate results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Tolnaftate results in decreased secretion of IL5 protein] CTD PMID:11886533 PMID:15284827 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO Tolnaftate inhibits the reaction [SHH protein results in increased expression of GLI1 mRNA] CTD PMID:20434536 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      chemical role 19473
        antioxidant 16145
          radical scavenger 6704
            2-naphthol 37
              tolnaftate 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  cyclic hydrocarbon 17231
                                    arene 17212
                                      polycyclic arene 17037
                                        ortho-fused polycyclic arene 9836
                                          ortho-fused bicyclic arene 2432
                                            naphthalene 2376
                                              naphthol 199
                                                2-naphthol 37
                                                  tolnaftate 5
paths to the root