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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thioridazine
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Accession:CHEBI:9566 term browser browse the term
Definition:A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Synonyms:related_synonym: 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulfanyl-phenothiazine;   10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine;   2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine;   3-Methylmercapto-N-(2'-(N-methyl-2-piperidyl)ethyl)phenothiazine;   Mallorol;   Malloryl;   Meleril;   Mellaril;   Mellaril-S;   Mellerets;   Mellerette;   Melleril;   Orsanil;   Sonapax;   Thioridazin;   thioridazinum;   tioridazina
 xref: CAS:50-52-2;   DrugBank:DB00679;   HMDB:HMDB0014817
 xref_mesh: MESH:D013881
 xref: Reaxys:94457;   drugcentral:2637;   kegg.drug:D00373;   lincs.smallmolecule:LSM-1863;   pubmed:10796547;   pubmed:11686961;   pubmed:1650428;   pubmed:17764469;   pubmed:17876580;   pubmed:19747949;   pubmed:20825390;   pubmed:26956010;   pubmed:27023487;   pubmed:27068340;   pubmed:9352572;   wikipedia.en:Thioridazine
 chemrof_formula: C21H26N2S2
 chemrof_smiles: CSc1ccc2c(c1)N(CCC1CCCCN1C)c1ccccc1S2
 chemrof_inchi: InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
 chemrof_inchikey: KLBQZWRITKRQQV-UHFFFAOYSA-N


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thioridazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Thioridazine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:25,261,958...25,272,483
Ensembl chr12:25,262,036...25,272,483 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Thioridazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Thioridazine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Casp3 caspase 3 increases activity ISO Thioridazine results in increased activity of CASP3 protein CTD PMID:21035837 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thioridazine results in decreased expression of CCND1 protein CTD PMID:21035837 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdc25a cell division cycle 25A increases phosphorylation ISO Thioridazine results in increased phosphorylation of CDC25A protein CTD PMID:21035837 NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Thioridazine results in decreased expression of CDK4 protein CTD PMID:21035837 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Thioridazine results in increased expression of CDKN1A protein CTD PMID:21035837 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Thioridazine results in increased expression of CDKN2A protein CTD PMID:21035837 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449 		JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Thioridazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases activity 		ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP2C19 protein 		CTD PMID:15135088 PMID:23397584 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Thioridazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity 		ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP3A4 protein 		CTD PMID:15135088 PMID:23397584 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Thioridazine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:151,583,105...151,585,455
Ensembl chr 4:151,581,502...151,586,233 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Thioridazine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:21035837 NCBI chr16:71,495,457...71,508,845
Ensembl chr16:71,487,930...71,508,874 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Thioridazine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Thioridazine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:30,797,102...30,800,782
Ensembl chr 6:30,796,871...30,800,769 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Thioridazine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606 		JBrowse link
G Hpn hepsin increases expression ISO Thioridazine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:95,464,468...95,480,169
Ensembl chr 1:95,464,470...95,480,199 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Thioridazine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity 		ISO Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Thioridazine results in decreased activity of KCNH2 protein 		CTD PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Lss lanosterol synthase increases expression ISO Thioridazine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Thioridazine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:151,063,160...151,066,475 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Thioridazine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:190,643,866...190,645,901
Ensembl chr 1:190,643,867...190,645,901 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Thioridazine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:78,238,747...78,255,645
Ensembl chr17:78,238,747...78,255,645 		JBrowse link
G Prl prolactin increases expression ISO Thioridazine results in increased expression of PRL protein CTD PMID:4065553 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Thioridazine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Thioridazine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:157,632,887...157,698,034
Ensembl chr 4:157,632,887...157,646,186 		JBrowse link
G Tagln transgelin decreases expression ISO Thioridazine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:55,121,301...55,127,563 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Thioridazine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Thioridazine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        pharmacological role 19772
          antagonist 17418
            dopaminergic antagonist 1650
              thioridazine 35
                thioridazine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            organic molecule 20499
                              organic cyclic compound 20390
                                organic heterocyclic compound 19381
                                  organic heteropolycyclic compound 18616
                                    organic heterotricyclic compound 16085
                                      phenothiazines 367
                                        thioridazine 35
                                          thioridazine hydrochloride 0
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