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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tioguanine
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Accession:CHEBI:9555 term browser browse the term
Definition:A 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine. Incorporates into DNA and inhibits synthesis. Used in the treatment of leukaemia.
Synonyms:exact_synonym: 2-amino-1,9-dihydro-6H-purine-6-thione
 related_synonym: 2-Amino 6MP;   2-Amino-1,7-dihydro-6H-purine-6-thione;   2-Amino-6-mercaptopurine;   2-Amino-6-merkaptopurin;   2-Amino-6-purinethiol;   2-Aminopurin-6-thiol;   2-Aminopurine-6(1H)-thione;   2-Aminopurine-6-thiol;   2-amino-1,9-dihydropurine-6-thione;   6-Mercapto-2-aminopurine;   6-Mercaptoguanine;   6-TG;   6-Thioguanine;   Formula=C5H5N5S;   InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11);   InChIKey=WYWHKKSPHMUBEB-UHFFFAOYSA-N;   SMILES=Nc1nc2[nH]cnc2c(=S)[nH]1;   TG;   ThG;   Thioguanine;   Tioguanin;   tioguanina;   tioguaninum
 xref: CAS:154-42-7;   DrugBank:DB00352;   Drug_Central:2632;   KEGG:C07648;   KEGG:D08603;   KNApSAcK:C00018807;   LINCS:LSM-6723
 xref_mesh: MESH:D013866
 xref: MetaCyc:CPD-5721;   PDBeChem:DX4;   PMID:21803983;   PMID:22178190;   PMID:22245861;   PMID:22261533;   PMID:22280519;   PMID:22563779;   PMID:22646133;   PMID:22822082;   PMID:22983983;   PMID:23259153;   PMID:23261807;   PMID:23377192;   PMID:23377281;   PMID:23393198;   PMID:25542975;   PMID:28166217;   Reaxys:1074099;   Wikipedia:Thioguanine


show annotations for term's descendants           Sort by:
tioguanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; Quercetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; verlukast inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine] CTD PMID:16156793 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions
decreases response to substance		 ISO 5-nitro-2-(3-phenylpropylamino)benzoic acid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; daidzein inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; Probenecid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; Quercetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 PMID:16156793 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253 		JBrowse link
G Acer2 alkaline ceramidase 2 increases expression EXP Thioguanine results in increased expression of ACER2 mRNA CTD PMID:16005536 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614 		JBrowse link
G Acp3 acid phosphatase 3 decreases expression EXP Thioguanine results in decreased expression of ACP3 mRNA CTD PMID:16005536 NCBI chr 8:104,905,570...104,956,146
Ensembl chr 8:104,905,586...104,954,236 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression EXP Thioguanine results in decreased expression of ALAS2 mRNA CTD PMID:16005536 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type decreases expression EXP Thioguanine results in decreased expression of ALOX12 mRNA CTD PMID:16005536 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases response to substance ISO BIRC2 protein results in decreased susceptibility to Thioguanine CTD PMID:10815900 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 decreases expression EXP Thioguanine results in decreased expression of BMAL1 mRNA CTD PMID:16005536 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Casp8 caspase 8 increases expression
increases response to substance		 ISO Thioguanine results in increased expression of CASP8 protein
CASP8 protein results in increased susceptibility to Thioguanine		 CTD PMID:22010212 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP Thioguanine results in increased expression of CCNE1 mRNA CTD PMID:16005536 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdc25b cell division cycle 25B decreases expression EXP Thioguanine results in decreased expression of CDC25B mRNA CTD PMID:16005536 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP Thioguanine results in decreased expression of CDKN3 mRNA CTD PMID:16005536 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945 		JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression EXP Thioguanine results in increased expression of CGREF1 mRNA CTD PMID:16005536 NCBI chr 6:25,431,846...25,443,853
Ensembl chr 6:25,431,799...25,443,852 		JBrowse link
G Col5a3 collagen type V alpha 3 chain decreases expression EXP Thioguanine results in decreased expression of COL5A3 mRNA CTD PMID:16005536 NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853 		JBrowse link
G Ctsl cathepsin L increases expression EXP Thioguanine results in increased expression of CTSL mRNA CTD PMID:16005536 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Dmd dystrophin increases splicing ISO Thioguanine results in increased splicing of DMD exon CTD PMID:23259153 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207 		JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression EXP Thioguanine results in increased expression of ENC1 mRNA CTD PMID:16005536 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713 		JBrowse link
G Espn espin increases expression EXP Thioguanine results in increased expression of ESPN mRNA CTD PMID:16005536 NCBI chr 5:162,626,560...162,660,439
Ensembl chr 5:162,626,560...162,660,256 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP Thioguanine results in increased expression of F3 mRNA CTD PMID:16005536 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fbln5 fibulin 5 decreases expression EXP Thioguanine results in decreased expression of FBLN5 mRNA CTD PMID:16005536 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Thioguanine results in increased expression of FKBP5 mRNA CTD PMID:16005536 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 decreases expression EXP Thioguanine results in decreased expression of GUCY1B2 mRNA CTD PMID:16005536 NCBI chr15:36,589,501...36,669,441
Ensembl chr15:36,598,883...36,669,441 		JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 decreases expression EXP Thioguanine results in decreased expression of HACL1 mRNA CTD PMID:16005536 NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases response to substance ISO HPRT1 gene mutant form results in decreased susceptibility to Thioguanine CTD PMID:28446605 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression EXP Thioguanine results in decreased expression of IGFBP3 mRNA CTD PMID:16005536 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 increases expression ISO Thioguanine results in increased expression of IMPDH2 mRNA CTD PMID:18222062 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359 		JBrowse link
G Islr immunoglobulin superfamily containing leucine-rich repeat decreases expression EXP Thioguanine results in decreased expression of ISLR mRNA CTD PMID:16005536 NCBI chr 8:58,571,155...58,574,128
Ensembl chr 8:58,570,777...58,574,130 		JBrowse link
G Kif2c kinesin family member 2C decreases expression EXP Thioguanine results in decreased expression of KIF2C mRNA CTD PMID:16005536 NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637 		JBrowse link
G Lig1 DNA ligase 1 decreases expression EXP Thioguanine results in decreased expression of LIG1 mRNA CTD PMID:16005536 NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413 		JBrowse link
G Lsp1 lymphocyte-specific protein 1 decreases expression EXP Thioguanine results in decreased expression of LSP1 mRNA CTD PMID:16005536 NCBI chr 1:197,614,677...197,648,414
Ensembl chr 1:197,614,687...197,648,416 		JBrowse link
G Mocos molybdenum cofactor sulfurase multiple interactions ISO [MOCOS gene SNP results in decreased oxidation of Mercaptopurine] which results in increased chemical synthesis of Thioguanine CTD PMID:29935280 NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187 		JBrowse link
G Msh2 mutS homolog 2 increases response to substance ISO MSH2 results in increased susceptibility to Thioguanine CTD PMID:20025921 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mybl2 MYB proto-oncogene like 2 increases expression EXP Thioguanine results in increased expression of MYBL2 mRNA CTD PMID:16005536 NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708 		JBrowse link
G Nek6 NIMA-related kinase 6 increases expression EXP Thioguanine results in increased expression of NEK6 mRNA CTD PMID:16005536 NCBI chr 3:22,284,269...22,356,302
Ensembl chr 3:22,284,279...22,395,990 		JBrowse link
G Ngef neuronal guanine nucleotide exchange factor decreases expression EXP Thioguanine results in decreased expression of NGEF mRNA CTD PMID:16005536 NCBI chr 9:88,146,956...88,244,454
Ensembl chr 9:88,146,956...88,244,914 		JBrowse link
G Nid2 nidogen 2 decreases expression EXP Thioguanine results in decreased expression of NID2 mRNA CTD PMID:16005536 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843 		JBrowse link
G Npr1 natriuretic peptide receptor 1 decreases expression EXP Thioguanine results in decreased expression of NPR1 mRNA CTD PMID:16005536 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
G Ocln occludin decreases activity ISO Thioguanine results in decreased activity of OCLN protein CTD PMID:17015055 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Thioguanine results in increased expression of ORM1 mRNA CTD PMID:16005536 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pknox2 PBX/knotted 1 homeobox 2 decreases expression EXP Thioguanine results in decreased expression of PKNOX2 mRNA CTD PMID:16005536 NCBI chr 8:36,600,633...36,863,131
Ensembl chr 8:36,600,636...36,790,940 		JBrowse link
G Pkp2 plakophilin 2 increases expression EXP Thioguanine results in increased expression of PKP2 mRNA CTD PMID:16005536 NCBI chr11:84,661,783...84,727,730
Ensembl chr11:84,661,783...84,727,730 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression EXP Thioguanine results in increased expression of PNPLA2 mRNA CTD PMID:16005536 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Prph peripherin decreases expression EXP Thioguanine results in decreased expression of PRPH mRNA CTD PMID:16005536 NCBI chr 7:130,218,149...130,222,136
Ensembl chr 7:130,218,357...130,222,136 		JBrowse link
G Pth2r parathyroid hormone 2 receptor decreases expression EXP Thioguanine results in decreased expression of PTH2R mRNA CTD PMID:16005536 NCBI chr 9:66,706,050...66,810,601
Ensembl chr 9:66,706,050...66,810,036 		JBrowse link
G Rfc3 replication factor C subunit 3 decreases expression EXP Thioguanine results in decreased expression of RFC3 mRNA CTD PMID:16005536 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 increases expression EXP Thioguanine results in increased expression of SCN1B mRNA CTD PMID:16005536 NCBI chr 1:86,353,917...86,363,820
Ensembl chr 1:86,353,917...86,363,739 		JBrowse link
G Septin4 septin 4 decreases expression EXP Thioguanine results in decreased expression of SEPTIN4 mRNA CTD PMID:16005536 NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768 		JBrowse link
G Slc19a2 solute carrier family 19 member 2 decreases expression EXP Thioguanine results in decreased expression of SLC19A2 mRNA CTD PMID:16005536 NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression EXP Thioguanine results in increased expression of SLC3A2 mRNA CTD PMID:16005536 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Tp53 tumor protein p53 increases activity ISO Thioguanine results in increased activity of TP53 protein CTD PMID:22010212 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Zfp189 zinc finger protein 189 increases expression EXP Thioguanine results in increased expression of ZNF189 mRNA CTD PMID:16005536 NCBI chr 5:63,872,596...63,884,348
Ensembl chr 5:63,872,738...63,884,121 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          antimetabolite 10331
            tioguanine 51
              6-methylthioguanine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19724
                              organic cyclic compound 19514
                                organic heterocyclic compound 18893
                                  organic heteropolycyclic compound 18320
                                    organic heterobicyclic compound 17272
                                      imidazopyrimidine 7770
                                        purines 7769
                                          aminopurine 6738
                                            2-aminopurines 6304
                                              tioguanine 51
                                                6-methylthioguanine 0
paths to the root