CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | thapsigargin |
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Accession: | CHEBI:9516
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browse the term
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Definition: | An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. |
Synonyms: | related_synonym: | (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate; Formula=C34H50O12; InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1; InChIKey=IXFPJGBNCFXKPI-FSIHEZPISA-N; SMILES=[H][C@@]1(OC(=O)C(\\C)=C/C)[C@@H](OC(=O)CCCCCCC)[C@@]2([H])C(=C1C)[C@]1([H])OC(=O)[C@@](C)(O)[C@@]1(O)[C@H](C[C@]2(C)OC(C)=O)OC(=O)CCC; Tg; octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester; thapsigargine |
| alt_id: | CHEBI:363811; CHEBI:45970 |
| xref: | CAS:67526-95-8; KEGG:C09561; KNApSAcK:C00003375; LIPID_MAPS_instance:LMPR0103410001 |
| xref_mesh: | MESH:D019284 |
| xref: | PDBeChem:TG1; PMID:10477042; PMID:12410314; PMID:16874404; PMID:17825049; PMID:20357004; PMID:24598360; PMID:9014219; Reaxys:4649293; Wikipedia:Thapsigargin |
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Aacs |
acetoacetyl-CoA synthetase |
increases expression |
EXP |
Thapsigargin results in increased expression of AACS protein |
CTD |
PMID:35544339 |
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NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
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Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
EXP ISO |
Thapsigargin results in increased expression of AARS1 protein |
CTD |
PMID:24648495 PMID:35544339 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression multiple interactions |
ISO |
Thapsigargin results in decreased expression of ABCB1 mRNA; Thapsigargin results in decreased expression of ABCB1 protein 1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea inhibits the reaction [Thapsigargin results in decreased expression of ABCB1 protein] |
CTD |
PMID:34915026 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc8 |
ATP binding cassette subfamily C member 8 |
increases expression |
EXP |
Thapsigargin results in increased expression of ABCC8 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Abcf3 |
ATP binding cassette subfamily F member 3 |
increases expression |
EXP |
Thapsigargin results in increased expression of ABCF3 protein |
CTD |
PMID:35544339 |
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NCBI chr11:80,340,476...80,352,211
Ensembl chr11:80,339,977...80,352,211
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Abhd16a |
abhydrolase domain containing 16A, phospholipase |
increases expression |
EXP |
Thapsigargin results in increased expression of ABHD16A protein |
CTD |
PMID:35544339 |
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NCBI chr20:3,719,089...3,733,952
Ensembl chr20:3,719,091...3,733,927
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Abr |
ABR activator of RhoGEF and GTPase |
increases expression |
EXP |
Thapsigargin results in increased expression of ABR protein |
CTD |
PMID:35544339 |
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NCBI chr10:61,262,516...61,461,331
Ensembl chr10:61,262,516...61,461,505
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Acaca |
acetyl-CoA carboxylase alpha |
increases expression |
EXP |
Thapsigargin results in increased expression of ACACA protein |
CTD |
PMID:35544339 |
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acad11 |
acyl-CoA dehydrogenase family, member 11 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACAD11 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560
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Acad9 |
acyl-CoA dehydrogenase family, member 9 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACAD9 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
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Acadvl |
acyl-CoA dehydrogenase, very long chain |
increases expression |
ISO |
Thapsigargin results in increased expression of ACADVL mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
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Acat2 |
acetyl-CoA acetyltransferase 2 |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of ACAT2 mRNA Thapsigargin results in increased expression of ACAT2 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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Acbd3 |
acyl-CoA binding domain containing 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACBD3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380
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Ackr1 |
atypical chemokine receptor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACKR1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:85,782,396...85,784,015
Ensembl chr13:85,782,398...85,783,983
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Acly |
ATP citrate lyase |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of ACLY protein |
CTD |
PMID:24648495 PMID:35544339 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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Aco1 |
aconitase 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ACO1 protein |
CTD |
PMID:35544339 |
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NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
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Aco2 |
aconitase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACO2 protein |
CTD |
PMID:24648495 |
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NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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Acot13 |
acyl-CoA thioesterase 13 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACOT13 mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851
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Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of ACOT2 protein |
CTD |
PMID:35544339 |
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NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acot7 |
acyl-CoA thioesterase 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACOT7 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309
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Acsl5 |
acyl-CoA synthetase long-chain family member 5 |
increases expression |
EXP |
Thapsigargin results in increased expression of ACSL5 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607
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Acta2 |
actin alpha 2, smooth muscle |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of ACTA2 mRNA Thapsigargin results in decreased expression of ACTA2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Actg1 |
actin, gamma 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ACTG1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232 Ensembl chr 3:105,619,737...105,624,232
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Actn1 |
actinin, alpha 1 |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of ACTN1 mRNA Thapsigargin results in decreased expression of ACTN1 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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Actn4 |
actinin alpha 4 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ACTN4 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
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Actr1a |
actin related protein 1A |
increases expression |
EXP |
Thapsigargin results in increased expression of ACTR1A protein |
CTD |
PMID:35544339 |
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NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495
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Acvr1 |
activin A receptor type 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ACVR1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
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Adamts4 |
ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ADAMTS4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:83,670,556...83,680,045
Ensembl chr13:83,670,183...83,680,065
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Adamts9 |
ADAM metallopeptidase with thrombospondin type 1 motif, 9 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ADAMTS9 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:125,290,633...125,462,988
Ensembl chr 4:125,291,490...125,462,929
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Add3 |
adducin 3 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ADD3 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
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Adhfe1 |
alcohol dehydrogenase, iron containing, 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ADHFE1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
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Adi1 |
acireductone dioxygenase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ADI1 protein |
CTD |
PMID:24648495 |
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NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842
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Adm |
adrenomedullin |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of ADM mRNA Thapsigargin results in increased expression of ADM mRNA |
CTD |
PMID:20682585 PMID:22378314 |
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NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Adm2 |
adrenomedullin 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ADM2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331
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Adra2a |
adrenoceptor alpha 2A |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein] |
CTD |
PMID:10742289 |
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NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Afap1 |
actin filament associated protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of AFAP1 protein |
CTD |
PMID:24648495 |
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NCBI chr14:74,743,322...74,856,300
Ensembl chr14:74,743,320...74,856,263
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Afdn |
afadin, adherens junction formation factor |
increases expression |
ISO |
Thapsigargin results in increased expression of AFDN protein |
CTD |
PMID:24648495 |
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NCBI chr 1:53,905,344...54,034,216
Ensembl chr 1:53,905,373...54,034,216
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Ago3 |
argonaute RISC catalytic component 3 |
multiple interactions affects localization |
ISO |
Cycloheximide inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA] |
CTD |
PMID:29576526 |
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NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
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Ahnak |
AHNAK nucleoprotein |
increases expression |
ISO |
Thapsigargin results in increased expression of AHNAK mRNA |
CTD |
PMID:19442820 |
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NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926
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Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:15364539 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Aip |
aryl-hydrocarbon receptor-interacting protein |
decreases expression |
EXP |
Thapsigargin results in decreased expression of AIP protein |
CTD |
PMID:35544339 |
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NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122
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Ak2 |
adenylate kinase 2 |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of AK2 mRNA Thapsigargin results in decreased expression of AK2 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632
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Ak3 |
adenylate kinase 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AK3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
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Ak4 |
adenylate kinase 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AK4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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Akap17a |
A-kinase anchoring protein 17A |
increases expression |
ISO |
Thapsigargin results in increased expression of AKAP17A mRNA |
CTD |
PMID:22378314 |
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NCBI chr12:16,310,427...16,315,166
Ensembl chr12:16,310,437...16,314,479
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Akap8l |
A-kinase anchoring protein 8 like |
increases expression |
ISO |
Thapsigargin results in increased expression of AKAP8L protein |
CTD |
PMID:24648495 |
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NCBI chr 7:11,332,671...11,362,287
Ensembl chr 7:11,332,672...11,362,275
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Akirin1 |
akirin 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AKIRIN1 protein |
CTD |
PMID:24648495 |
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NCBI chr 5:135,989,378...136,004,782
Ensembl chr 5:135,989,465...136,004,762
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Akna |
AT-hook transcription factor |
increases expression |
ISO |
Thapsigargin results in increased expression of AKNA mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017
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Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation decreases phosphorylation decreases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; NRF1 protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein]; TFAM protein inhibits the reaction [Thapsigargin results in decreased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein] [Thapsigargin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein Thapsigargin results in decreased expression of AKT1 protein modified form |
CTD |
PMID:15339911 PMID:16338971 PMID:22378314 PMID:24898257 PMID:25398788 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Aktip |
AKT interacting protein |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AKTIP protein |
CTD |
PMID:24648495 |
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NCBI chr19:15,866,811...15,877,123
Ensembl chr19:15,866,928...15,886,663
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Alcam |
activated leukocyte cell adhesion molecule |
increases expression |
ISO |
Thapsigargin results in increased expression of ALCAM mRNA |
CTD |
PMID:22378314 |
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NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954
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Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ALDH18A1 protein |
CTD |
PMID:24648495 |
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NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ALDH1A1 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDH1A2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107
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Aldh1a3 |
aldehyde dehydrogenase 1 family, member A3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDH1A3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Aldh3a2 |
aldehyde dehydrogenase 3 family, member A2 |
increases expression |
EXP |
Thapsigargin results in increased expression of ALDH3A2 protein |
CTD |
PMID:35544339 |
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NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
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Aldh5a1 |
aldehyde dehydrogenase 5 family, member A1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDH5A1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
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Aldh6a1 |
aldehyde dehydrogenase 6 family, member A1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ALDH6A1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
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Aldh7a1 |
aldehyde dehydrogenase 7 family, member A1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ALDH7A1 protein |
CTD |
PMID:35544339 |
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NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193
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Aldoa |
aldolase, fructose-bisphosphate A |
increases expression |
EXP |
Thapsigargin results in increased expression of ALDOA protein |
CTD |
PMID:35544339 |
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NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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Aldoc |
aldolase, fructose-bisphosphate C |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ALDOC mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066
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Alg5 |
ALG5, dolichyl-phosphate beta-glucosyltransferase |
increases expression |
ISO |
Thapsigargin results in increased expression of ALG5 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]; 1-oleoyl-2-acetoyl-sn-glycerol inhibits the reaction [1-Butanol inhibits the reaction [Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein]]; SB 203580 inhibits the reaction [Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein]; Thapsigargin results in increased activity of and results in increased localization of ALOX5 protein; Thapsigargin results in increased phosphorylation of and results in increased activity of ALOX5 protein |
CTD |
PMID:10779545 PMID:18218859 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Alpp |
alkaline phosphatase, placental |
increases expression |
ISO |
Thapsigargin results in increased expression of ALPP mRNA |
CTD |
PMID:29453283 |
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NCBI chr 9:87,765,846...87,768,606
Ensembl chr 9:87,765,860...87,768,606
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G |
Amot |
angiomotin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AMOT mRNA |
CTD |
PMID:29453283 |
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NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272
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Amt |
aminomethyltransferase |
increases expression |
ISO |
Thapsigargin results in increased expression of AMT mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:108,981,620...108,988,127
Ensembl chr 8:108,976,472...108,988,126
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G |
Angptl2 |
angiopoietin-like 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ANGPTL2 protein |
CTD |
PMID:24648495 |
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NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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G |
Angptl3 |
angiopoietin-like 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ANGPTL3 mRNA |
CTD |
PMID:32535746 |
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NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
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G |
Ank3 |
ankyrin 3 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ANK3 protein |
CTD |
PMID:35544339 |
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NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
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G |
Ankh |
ANKH inorganic pyrophosphate transport regulator |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ANKH protein |
CTD |
PMID:35544339 |
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NCBI chr 2:78,153,027...78,280,181
Ensembl chr 2:78,153,026...78,280,187
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Ankrd10 |
ankyrin repeat domain 10 |
increases expression |
ISO |
Thapsigargin results in increased expression of ANKRD10 mRNA |
CTD |
PMID:29453283 |
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NCBI chr16:77,866,489...77,889,745
Ensembl chr16:77,864,261...77,889,745
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G |
Ankrd17 |
ankyrin repeat domain 17 |
increases expression |
ISO |
Thapsigargin results in increased expression of ANKRD17 protein |
CTD |
PMID:24648495 |
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NCBI chr14:17,723,239...17,861,841
Ensembl chr14:17,721,932...17,862,617
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G |
Antxr2 |
ANTXR cell adhesion molecule 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ANTXR2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr14:11,541,718...11,682,110
Ensembl chr14:11,541,772...11,682,094
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G |
Anxa1 |
annexin A1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ANXA1 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa4 |
annexin A4 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ANXA4 protein |
CTD |
PMID:35544339 |
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NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
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G |
Anxa5 |
annexin A5 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of ANXA5 mRNA Thapsigargin results in increased expression of ANXA5 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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G |
Ap2m1 |
adaptor related protein complex 2 subunit mu 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AP2M1 protein |
CTD |
PMID:24648495 |
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NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
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G |
Ap3b1 |
adaptor related protein complex 3 subunit beta 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of AP3B1 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:25,600,069...25,800,937
Ensembl chr 2:25,600,040...25,800,935
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G |
Apeh |
acylaminoacyl-peptide hydrolase |
increases expression |
EXP |
Thapsigargin results in increased expression of APEH protein |
CTD |
PMID:35544339 |
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NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933
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G |
Apob |
apolipoprotein B |
decreases secretion decreases expression |
ISO |
Thapsigargin results in decreased secretion of APOB protein Thapsigargin results in decreased expression of APOB mRNA |
CTD |
PMID:32535746 |
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NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G |
Apoc3 |
apolipoprotein C3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of APOC3 mRNA |
CTD |
PMID:32535746 |
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NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583
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G |
App |
amyloid beta precursor protein |
increases expression |
EXP |
Thapsigargin results in increased expression of APP protein |
CTD |
PMID:35544339 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aqr |
aquarius intron-binding spliceosomal factor |
increases expression |
ISO |
Thapsigargin results in increased expression of AQR protein |
CTD |
PMID:24648495 |
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NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
Thapsigargin results in increased degradation of and results in decreased expression of AR protein |
CTD |
PMID:30280407 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Araf |
A-Raf proto-oncogene, serine/threonine kinase |
increases expression |
EXP |
Thapsigargin results in increased expression of ARAF protein |
CTD |
PMID:35544339 |
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NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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G |
Arcn1 |
archain 1 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of ARCN1 mRNA Thapsigargin results in increased expression of ARCN1 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 8:45,057,617...45,082,224
Ensembl chr 8:45,057,619...45,082,247
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G |
Arf3 |
ARF GTPase 3 |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of ARF3 mRNA Thapsigargin results in increased expression of ARF3 protein |
CTD |
PMID:29453283 PMID:35544339 |
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NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002
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G |
Arf4 |
ARF GTPase 4 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of ARF4 mRNA Thapsigargin results in increased expression of ARF4 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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G |
Arfgap3 |
ARF GTPase activating protein 3 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of ARFGAP3 mRNA Thapsigargin results in increased expression of ARFGAP3 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208
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G |
Arfip1 |
ARF interacting protein 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ARFIP1 protein |
CTD |
PMID:35544339 |
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NCBI chr 2:169,843,804...169,924,136
Ensembl chr 2:169,843,801...169,923,142
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G |
Arg2 |
arginase 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ARG2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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G |
Arhgap17 |
Rho GTPase activating protein 17 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ARHGAP17 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854
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G |
Arhgdia |
Rho GDP dissociation inhibitor alpha |
increases expression |
EXP |
Thapsigargin results in increased expression of ARHGDIA protein |
CTD |
PMID:35544339 |
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NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
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G |
Arhgef2 |
Rho/Rac guanine nucleotide exchange factor 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARHGEF2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355
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G |
Arid4a |
AT-rich interaction domain 4A |
increases expression |
ISO |
Thapsigargin results in increased expression of ARID4A protein |
CTD |
PMID:24648495 |
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NCBI chr 6:89,522,459...89,593,868
Ensembl chr 6:89,522,442...89,593,510
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G |
Arid4b |
AT-rich interaction domain 4B |
increases expression |
ISO |
Thapsigargin results in increased expression of ARID4B protein |
CTD |
PMID:24648495 |
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NCBI chr17:51,138,419...51,262,894
Ensembl chr17:51,138,535...51,262,906
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G |
Arl1 |
ARF like GTPase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARL1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
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G |
Armcx1 |
armadillo repeat containing, X-linked 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARMCX1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299
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G |
Armcx3 |
armadillo repeat containing, X-linked 3 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of ARMCX3 mRNA Thapsigargin results in increased expression of ARMCX3 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr X:97,937,115...97,942,098
Ensembl chr X:97,936,999...97,942,098
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G |
Arpc3 |
actin related protein 2/3 complex, subunit 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of ARPC3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr12:34,172,780...34,186,651
Ensembl chr12:34,172,780...34,186,651
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G |
Arsb |
arylsulfatase B |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ARSB protein |
CTD |
PMID:35544339 |
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NCBI chr 2:25,002,210...25,162,675
Ensembl chr 2:25,002,346...25,162,671
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G |
Asb5 |
ankyrin repeat and SOCS box-containing 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ASB5 protein |
CTD |
PMID:24648495 |
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NCBI chr16:37,237,869...37,305,207
Ensembl chr16:37,235,405...37,278,109
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G |
Ascl1 |
achaete-scute family bHLH transcription factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ASCL1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:21,903,136...21,906,003
Ensembl chr 7:21,903,126...21,905,993
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G |
Asf1b |
anti-silencing function 1B histone chaperone |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ASF1B mRNA |
CTD |
PMID:22378314 |
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NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549
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G |
Asgr1 |
asialoglycoprotein receptor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ASGR1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr10:54,775,727...54,779,642
Ensembl chr10:54,776,024...54,779,631
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO |
Thapsigargin results in increased expression of ASNS mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Asph |
aspartate-beta-hydroxylase |
increases expression |
ISO |
Thapsigargin results in increased expression of ASPH protein |
CTD |
PMID:24648495 |
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NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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G |
Atad2 |
ATPase family, AAA domain containing 2 |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of ATAD2 mRNA Thapsigargin results in increased expression of ATAD2 protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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G |
Atf3 |
activating transcription factor 3 |
multiple interactions increases expression |
ISO EXP |
ATF3 mutant form promotes the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA] Thapsigargin results in increased expression of ATF3 mRNA Thapsigargin results in increased expression of ATF3 mRNA; Thapsigargin results in increased expression of ATF3 protein |
CTD |
PMID:17332266 PMID:20022965 PMID:21694771 PMID:22641616 PMID:22935518 PMID:29453283 PMID:33770205 More...
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression increases activity decreases response to substance |
ISO EXP |
2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 mRNA]; ATF4 mutant form inhibits the reaction [Thapsigargin results in increased expression of PMAIP1 protein]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Dactinomycin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; NUPR1 mutant form promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; Thapsigargin promotes the reaction [ATF4 protein binds to PMAIP1 promoter] 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; salubrinal promotes the reaction [Thapsigargin results in increased expression of ATF4 protein] Thapsigargin results in increased expression of ATF4 mRNA; Thapsigargin results in increased expression of ATF4 protein 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; ATF4 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; Dantrolene inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein]; Dantrolene promotes the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; GSK2656157 inhibits the reaction [Thapsigargin results in increased expression of ATF4 protein] Thapsigargin results in increased activity of ATF4 protein ATF4 results in decreased susceptibility to Thapsigargin |
CTD |
PMID:16298333 PMID:17283163 PMID:20022965 PMID:20589738 PMID:22378314 PMID:23383089 PMID:23741617 PMID:24648495 PMID:24865413 PMID:27226639 PMID:27358234 PMID:27587023 PMID:28223344 PMID:28844859 PMID:29109149 PMID:32357311 PMID:32578922 More...
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf5 |
activating transcription factor 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATF5 mRNA Thapsigargin results in increased expression of ATF5 mRNA; Thapsigargin results in increased expression of ATF5 protein |
CTD |
PMID:22378314 PMID:24648495 PMID:28942281 |
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NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions increases cleavage increases expression increases activity |
ISO EXP |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein] Thapsigargin results in increased expression of ATF6 mRNA; Thapsigargin results in increased expression of ATF6 protein; Thapsigargin results in increased expression of ATF6 protein modified form 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; ATF6 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of ATF6 protein modified form]; Thapsigargin results in increased cleavage of and affects the localization of ATF6 protein Thapsigargin results in increased activity of ATF6 protein |
CTD |
PMID:17963750 PMID:18477628 PMID:20493918 PMID:22378314 PMID:23383089 PMID:23576437 PMID:23741617 PMID:24638036 PMID:26264395 PMID:27358234 PMID:27587023 PMID:28223344 PMID:30796460 PMID:32407927 More...
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atg10 |
autophagy related 10 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATG10 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:22,109,304...22,398,313
Ensembl chr 2:22,108,426...22,398,233
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G |
Atp1a1 |
ATPase Na+/K+ transporting subunit alpha 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ATP1A1 protein |
CTD |
PMID:35544339 |
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NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP1B1 mRNA |
CTD |
PMID:33770205 |
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NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
affects response to substance increases expression decreases activity multiple interactions |
ISO EXP |
ATP2A2 protein affects the susceptibility to Thapsigargin Thapsigargin results in increased expression of ATP2A2 mRNA; Thapsigargin results in increased expression of ATP2A2 protein Thapsigargin results in decreased activity of ATP2A2 protein [Thapsigargin results in decreased activity of ATP2A2 protein] which results in decreased transport of Calcium; Tetradecanoylphorbol Acetate inhibits the reaction [Thapsigargin results in increased expression of ATP2A2 mRNA]; Thapsigargin results in increased expression of and results in decreased activity of ATP2A2 protein |
CTD |
PMID:17287366 PMID:17475205 PMID:19244478 PMID:20816668 PMID:35544339 |
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NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Atp2a3 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
multiple interactions |
ISO |
[Thapsigargin co-treated with Ionomycin] promotes the reaction [STIM1 protein binds to ATP2A3 protein] |
CTD |
PMID:18439569 |
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NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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G |
Atp2b1 |
ATPase plasma membrane Ca2+ transporting 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ATP2B1 protein |
CTD |
PMID:35544339 |
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NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP5F1A mRNA |
CTD |
PMID:22378314 |
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NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atp5f1c |
ATP synthase F1 subunit gamma |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ATP5F1C protein |
CTD |
PMID:35544339 |
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NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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G |
Atp5f1e |
ATP synthase F1 subunit epsilon |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ATP5F1E protein |
CTD |
PMID:35544339 |
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NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
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G |
Atp5mc1 |
ATP synthase membrane subunit c locus 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATP5MC1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124 Ensembl chr10:81,023,925...81,027,124
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G |
Atp5mc3 |
ATP synthase membrane subunit c locus 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATP5MC3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279
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G |
Atp5mf |
ATP synthase membrane subunit f |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ATP5MF mRNA |
CTD |
PMID:22378314 |
|
NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
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G |
Atp6ap2 |
ATPase H+ transporting accessory protein 2 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ATP6AP2 protein |
CTD |
PMID:35544339 |
|
NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918
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G |
Atp6v0a1 |
ATPase H+ transporting V0 subunit a1 |
increases expression decreases expression |
ISO EXP |
Thapsigargin results in increased expression of ATP6V0A1 mRNA Thapsigargin results in decreased expression of ATP6V0A1 protein |
CTD |
PMID:29453283 PMID:35544339 |
|
NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895
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G |
Atp6v0a2 |
ATPase H+ transporting V0 subunit a2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP6V0A2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr12:31,947,220...31,979,875
Ensembl chr12:31,822,733...32,007,069
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G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
multiple interactions decreases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ATP6V0D2 mRNA] |
CTD |
PMID:19442820 |
|
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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G |
Atp8a1 |
ATPase phospholipid transporting 8A1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ATP8A1 protein |
CTD |
PMID:24648495 |
|
NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611
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G |
Atp8b1 |
ATPase phospholipid transporting 8B1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ATP8B1 protein |
CTD |
PMID:35544339 |
|
NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
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G |
Atrx |
ATRX, chromatin remodeler |
increases expression |
ISO |
Thapsigargin results in increased expression of ATRX protein |
CTD |
PMID:24648495 |
|
NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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G |
Auh |
AU RNA binding methylglutaconyl-CoA hydratase |
increases expression |
ISO |
Thapsigargin results in increased expression of AUH mRNA |
CTD |
PMID:22378314 |
|
NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896
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G |
Aurkb |
aurora kinase B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of AURKB mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Aven |
apoptosis and caspase activation inhibitor |
increases expression |
ISO |
Thapsigargin results in increased expression of AVEN mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634
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G |
B4galt5 |
beta-1,4-galactosyltransferase 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of B4GALT5 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 3:156,018,056...156,033,983
Ensembl chr 3:156,018,053...156,070,074
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G |
Bach2 |
BTB domain and CNC homolog 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of BACH2 mRNA |
CTD |
PMID:24247028 |
|
NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877
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Bad |
BCL2-associated agonist of cell death |
increases expression |
ISO |
Thapsigargin results in increased expression of BAD mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Banf1 |
barrier to autointegration nuclear assembly factor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BANF1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:202,672,170...202,674,215
Ensembl chr 1:202,671,305...202,674,188
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G |
Basp1 |
brain abundant, membrane attached signal protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BASP1 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
|
NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases activity increases expression multiple interactions |
ISO EXP |
Thapsigargin results in increased activity of BAX protein Thapsigargin results in increased expression of BAX protein [Thapsigargin co-treated with dapagliflozin] inhibits the reaction [IL1B protein results in increased expression of BAX protein]; shikonin inhibits the reaction [Thapsigargin results in increased expression of BAX protein] Thapsigargin promotes the reaction [arsenite results in increased expression of BAX protein] |
CTD |
PMID:20130848 PMID:26677073 PMID:35028790 PMID:35033536 PMID:37741535 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Baz1a |
bromodomain adjacent to zinc finger domain, 1A |
increases expression |
ISO |
Thapsigargin results in increased expression of BAZ1A protein |
CTD |
PMID:24648495 |
|
NCBI chr 6:72,389,701...72,512,516
Ensembl chr 6:72,389,703...72,512,459
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G |
Baz1b |
bromodomain adjacent to zinc finger domain, 1B |
increases expression |
ISO |
Thapsigargin results in increased expression of BAZ1B protein |
CTD |
PMID:24648495 |
|
NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of BBC3 mRNA |
CTD |
PMID:16018998 PMID:22378314 |
|
NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bcam |
basal cell adhesion molecule (Lutheran blood group) |
decreases expression |
EXP |
Thapsigargin results in decreased expression of BCAM protein |
CTD |
PMID:35544339 |
|
NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403
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G |
Bcas2 |
BCAS2, pre-mRNA processing factor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BCAS2 protein |
CTD |
PMID:24648495 |
|
NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389
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G |
Bcat1 |
branched chain amino acid transaminase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BCAT1 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
|
NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597
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G |
Bcat2 |
branched chain amino acid transaminase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of BCAT2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
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G |
Bckdk |
branched chain ketoacid dehydrogenase kinase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BCKDK mRNA Thapsigargin results in decreased expression of BCKDK protein |
CTD |
PMID:22378314 PMID:24648495 |
|
NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633
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G |
Bcl2 |
BCL2, apoptosis regulator |
increases expression multiple interactions decreases expression |
ISO EXP |
Thapsigargin results in increased expression of BCL2 mRNA shikonin inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein] 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in decreased expression of BCL2 protein] Thapsigargin promotes the reaction [arsenite results in decreased expression of BCL2 protein] |
CTD |
PMID:22378314 PMID:26677073 PMID:30841431 PMID:35028790 PMID:35033536 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression increases expression affects splicing |
EXP ISO |
6-(bromomethylene)tetrahydro-3-(1-naphthaleneyl)-2H-pyran-2-one inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; GW 4869 inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA]; PLA2G6 mutant form inhibits the reaction [Thapsigargin affects the splicing of BCL2L1 mRNA] Thapsigargin results in decreased expression of BCL2L1 protein 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in decreased expression of BCL2L1 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in decreased expression of BCL2L1 protein] BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of XBP1 protein alternative form] Thapsigargin results in increased expression of BCL2L1 protein |
CTD |
PMID:23885834 PMID:25762722 PMID:30841431 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Bclaf1 |
BCL2-associated transcription factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BCLAF1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832
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G |
Begain |
brain-enriched guanylate kinase-associated |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BEGAIN mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 6:127,943,651...127,979,876
Ensembl chr 6:127,943,651...127,979,841
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G |
Bend6 |
BEN domain containing 6 |
increases expression |
ISO |
Thapsigargin results in increased expression of BEND6 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 9:36,081,033...36,135,309
Ensembl chr 9:36,081,484...36,135,228
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G |
Best1 |
bestrophin 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BEST1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:206,629,340...206,646,085
Ensembl chr 1:206,629,500...206,646,063
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G |
Bet1 |
Bet1 golgi vesicular membrane trafficking protein |
decreases expression multiple interactions |
ISO |
Thapsigargin results in decreased expression of BET1 mRNA [Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of BET1 mRNA |
CTD |
PMID:19442820 |
|
NCBI chr 4:32,116,232...32,126,592
Ensembl chr 4:32,116,235...32,126,617
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G |
Bet1l |
Bet1 golgi vesicular membrane trafficking protein-like |
increases expression |
ISO |
Thapsigargin results in increased expression of BET1L mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040
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G |
Bex1 |
brain expressed X-linked 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BEX2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr X:99,219,014...99,220,518
Ensembl chr X:99,219,014...99,220,958
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BHLHE40 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Bid |
BH3 interacting domain death agonist |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BID mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bin1 |
bridging integrator 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of BIN1 protein |
CTD |
PMID:35544339 |
|
NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BIRC2 protein |
CTD |
PMID:16382148 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 protein] Thapsigargin results in increased expression of BIRC3 mRNA; Thapsigargin results in increased expression of BIRC3 protein |
CTD |
PMID:15339911 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G |
Blm |
BLM RecQ like helicase |
increases expression |
ISO |
Thapsigargin results in increased expression of BLM protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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G |
Blnk |
B-cell linker |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BLNK protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113
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G |
Bloc1s2 |
biogenesis of lysosomal organelles complex-1, subunit 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of BLOC1S2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:243,024,611...243,031,749
Ensembl chr 1:243,024,614...243,031,653
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G |
Bmf |
Bcl2 modifying factor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BMF mRNA |
CTD |
PMID:33770205 |
|
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bmp2k |
BMP-2 inducible kinase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BMP2K protein |
CTD |
PMID:24648495 |
|
NCBI chr14:12,481,194...12,579,411
Ensembl chr14:12,484,729...12,579,134
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G |
Bms1 |
BMS1 ribosome biogenesis factor |
increases expression |
ISO |
Thapsigargin results in increased expression of BMS1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 4:151,558,163...151,595,187
Ensembl chr 4:151,558,163...151,595,127
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G |
Bnc2 |
basonuclin zinc finger protein 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BNC2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:98,679,071...99,016,044
Ensembl chr 5:98,687,410...99,079,426
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G |
Bnip3 |
BCL2 interacting protein 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BNIP3 mRNA Thapsigargin results in decreased expression of BNIP3 protein |
CTD |
PMID:22378314 PMID:24648495 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bola3 |
bolA family member 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BOLA3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797
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G |
Bphl |
biphenyl hydrolase like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BPHL mRNA |
CTD |
PMID:22378314 |
|
NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288
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G |
Brca1 |
BRCA1, DNA repair associated |
increases expression multiple interactions affects localization |
ISO |
Thapsigargin results in increased expression of BRCA1 mRNA; Thapsigargin results in increased expression of BRCA1 protein Cycloheximide inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA] |
CTD |
PMID:16434996 PMID:29576526 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Brca2 |
BRCA2, DNA repair associated |
increases expression |
ISO |
Thapsigargin results in increased expression of BRCA2 mRNA; Thapsigargin results in increased expression of BRCA2 protein |
CTD |
PMID:16434996 |
|
NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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G |
Brinp1 |
BMP/retinoic acid inducible neural specific 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BRINP1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:82,348,501...82,550,506
Ensembl chr 5:82,348,930...82,493,150
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G |
Brix1 |
biogenesis of ribosomes BRX1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of BRIX1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 2:59,450,608...59,461,486
Ensembl chr 2:59,450,614...59,461,495
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G |
Brsk1 |
BR serine/threonine kinase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of BRSK1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 1:69,134,166...69,159,947
Ensembl chr 1:69,134,565...69,160,365
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G |
Btbd8 |
BTB domain containing 8 |
increases expression |
EXP |
Thapsigargin results in increased expression of BTBD8 protein |
CTD |
PMID:35544339 |
|
NCBI chr14:2,265,187...2,338,426
Ensembl chr14:2,266,454...2,334,393
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G |
Bub1b |
BUB1 mitotic checkpoint serine/threonine kinase B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of BUB1B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
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G |
Bysl |
bystin-like |
increases expression |
EXP |
Thapsigargin results in increased expression of BYSL protein |
CTD |
PMID:35544339 |
|
NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339
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|
G |
C12h12orf43 |
similar to human chromosome 12 open reading frame 43 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of C12H12ORF43 protein |
CTD |
PMID:35544339 |
|
NCBI chr12:41,672,089...41,677,722
Ensembl chr12:41,672,114...41,677,714
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G |
C1qbp |
complement C1q binding protein |
decreases expression |
ISO |
Thapsigargin results in decreased expression of C1QBP mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
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|
G |
C2h1orf162 |
similar to human chromosome 1 open reading frame 162 |
increases expression |
ISO |
Thapsigargin results in increased expression of C1ORF162 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 2:193,410,730...193,420,824
Ensembl chr 2:193,412,971...193,420,030
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|
G |
C3h11orf96 |
similar to human chromosome 11 open reading frame 96 |
increases expression |
ISO |
Thapsigargin results in increased expression of C11ORF96 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523
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G |
C5 |
complement C5 |
increases expression |
ISO |
Thapsigargin results in increased expression of C5 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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|
G |
C9h6orf141 |
similar to human chromosome 6 open reading frame 141 |
increases expression |
ISO |
Thapsigargin results in increased expression of C6ORF141 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 9:20,024,916...20,029,094
Ensembl chr 9:20,024,916...20,029,094
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|
G |
Cacna1a |
calcium voltage-gated channel subunit alpha1 A |
increases expression |
ISO |
Thapsigargin results in increased expression of CACNA1A mRNA |
CTD |
PMID:19442820 |
|
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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|
G |
Cacna2d1 |
calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of CACNA2D1 protein |
CTD |
PMID:24648495 PMID:35544339 |
|
NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
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|
G |
Cacna2d2 |
calcium voltage-gated channel auxiliary subunit alpha2delta 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CACNA2D2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173
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|
G |
Cacng4 |
calcium voltage-gated channel auxiliary subunit gamma 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CACNG4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126
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Cadm1 |
cell adhesion molecule 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CADM1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 8:47,847,836...48,178,703
Ensembl chr 8:47,847,325...48,182,833
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Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [Lipopolysaccharides results in increased expression of CALCA mRNA] |
CTD |
PMID:20682585 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Calcb |
calcitonin-related polypeptide, beta |
increases expression |
ISO |
Thapsigargin results in increased expression of CALCB mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:168,965,383...168,970,259
Ensembl chr 1:168,966,465...168,970,125
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Calr |
calreticulin |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of CALR mRNA; Thapsigargin results in increased expression of CALR protein |
CTD |
PMID:17353921 PMID:22378314 PMID:27587023 PMID:29453283 PMID:35544339 |
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NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
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Calu |
calumenin |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of CALU mRNA; Thapsigargin results in decreased expression of CALU protein Thapsigargin results in increased expression of CALU mRNA |
CTD |
PMID:21692457 PMID:22378314 PMID:35544339 |
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NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
multiple interactions |
EXP |
Thapsigargin inhibits the reaction [LIF protein results in increased activity of CAMK4 protein] |
CTD |
PMID:11073891 |
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NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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Canx |
calnexin |
increases expression affects localization |
ISO EXP |
Thapsigargin results in increased expression of CANX mRNA; Thapsigargin results in increased expression of CANX protein Thapsigargin affects the localization of CANX protein |
CTD |
PMID:17353921 PMID:22378314 PMID:28315715 PMID:28940366 PMID:29453283 PMID:35544339 More...
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NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Capn1 |
calpain 1 |
increases expression multiple interactions |
EXP |
Thapsigargin results in increased expression of CAPN1 protein Thapsigargin promotes the reaction [cadmium acetate results in increased expression of CAPN1 protein] |
CTD |
PMID:28347754 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Capzb |
capping actin protein of muscle Z-line subunit beta |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CAPZB protein |
CTD |
PMID:35544339 |
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NCBI chr 5:151,435,600...151,535,409
Ensembl chr 5:151,434,871...151,535,409
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G |
Car10 |
carbonic anhydrase 10 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CA10 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:78,055,875...78,556,490
Ensembl chr10:78,054,114...78,555,834
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G |
Car5b |
carbonic anhydrase 5B |
increases expression |
ISO |
Thapsigargin results in increased expression of CA5B mRNA |
CTD |
PMID:22378314 |
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NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837
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G |
Card9 |
caspase recruitment domain family, member 9 |
increases expression |
ISO |
Thapsigargin results in increased expression of CARD9 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
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G |
Carhsp1 |
calcium regulated heat stable protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CARHSP1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019
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G |
Casp1 |
caspase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CASP1 mRNA |
CTD |
PMID:30796460 |
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NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp12 |
caspase 12 |
multiple interactions increases expression increases activity increases cleavage |
ISO EXP |
demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Resveratrol inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased cleavage of CASP12 protein] Thapsigargin results in increased cleavage of CASP12 protein alternative form 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased expression of CASP12 protein modified form]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form] |
CTD |
PMID:12198651 PMID:16338971 PMID:18477628 PMID:20493918 PMID:24224909 PMID:26264395 PMID:27638049 PMID:30841431 More...
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NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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G |
Casp2 |
caspase 2 |
multiple interactions increases activity |
ISO |
Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP2 protein] |
CTD |
PMID:16388830 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G |
Casp3 |
caspase 3 |
multiple interactions increases expression increases cleavage increases activity increases metabolic processing |
ISO EXP |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of CASP3 protein]; Bortezomib promotes the reaction [Thapsigargin results in increased activity of CASP3 protein]; Cyclosporine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP3 protein]; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] Thapsigargin results in increased cleavage of CASP3 protein 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein] 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased expression of CASP3 protein]; 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; HR protein affects the reaction [Thapsigargin results in increased activity of CASP3 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased cleavage of CASP3 protein]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form] Thapsigargin results in increased metabolism of CASP3 protein Thapsigargin results in increased expression of CASP3 protein; Thapsigargin results in increased expression of CASP3 protein alternative form |
CTD |
PMID:12198651 PMID:12871656 PMID:16338971 PMID:16357177 PMID:16382148 PMID:16388830 PMID:17559149 PMID:18178165 PMID:19028522 PMID:20022965 PMID:20130848 PMID:20493918 PMID:20886113 PMID:22800509 PMID:23576437 PMID:25341683 PMID:27638049 PMID:30841431 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP4 protein]; Thapsigargin results in increased cleavage of and results in increased activity of CASP4 protein |
CTD |
PMID:17559149 PMID:25341683 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp6 |
caspase 6 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CASP6 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO |
Doxorubicin inhibits the reaction [Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein]; Thapsigargin results in increased activity of and results in increased cleavage of CASP7 protein; ursodoxicoltaurine inhibits the reaction [Thapsigargin results in increased activity of CASP7 protein] |
CTD |
PMID:12198651 PMID:16298333 PMID:17559149 PMID:19139269 PMID:20022965 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
increases activity |
ISO |
Thapsigargin results in increased activity of CASP8 protein |
CTD |
PMID:16018998 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases cleavage increases activity |
ISO |
Diclofenac inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Melatonin inhibits the reaction [Thapsigargin results in increased activity of CASP9 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased activity of CASP9 protein] Thapsigargin results in increased cleavage of CASP9 protein 4-(3-3,4-p-menthadien-(1,8)-yl)olivetol inhibits the reaction [Thapsigargin results in increased cleavage of CASP9 protein]; O-1602 compound inhibits the reaction [Thapsigargin results in increased cleavage of CASP9 protein] |
CTD |
PMID:16018998 PMID:16388830 PMID:20130848 PMID:25341683 PMID:30841431 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Casr |
calcium-sensing receptor |
multiple interactions |
EXP |
Thapsigargin inhibits the reaction [Spermine binds to and results in increased activity of CASR protein] |
CTD |
PMID:11071898 |
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NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
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G |
Cat |
catalase |
increases expression |
EXP |
Thapsigargin results in increased expression of CAT protein |
CTD |
PMID:35544339 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Catsper2 |
cation channel, sperm associated 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CATSPER2 mRNA |
CTD |
PMID:19442820 |
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NCBI chr 3:108,368,654...108,389,380
Ensembl chr 3:108,368,668...108,388,050
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G |
Cbln2 |
cerebellin 2 precursor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CBLN2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr18:79,940,412...79,948,766
Ensembl chr18:79,942,590...79,947,855
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G |
Cbr1 |
carbonyl reductase 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of CBR1 protein |
CTD |
PMID:35544339 |
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NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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G |
Cc2d1a |
coiled-coil and C2 domain containing 1A |
increases expression |
EXP |
Thapsigargin results in increased expression of CC2D1A protein |
CTD |
PMID:35544339 |
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NCBI chr19:24,011,897...24,026,937
Ensembl chr19:24,011,938...24,026,936
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G |
Ccdc171 |
coiled-coil domain containing 171 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCDC171 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:97,919,965...98,403,853
Ensembl chr 5:97,920,002...98,282,833
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G |
Ccdc47 |
coiled-coil domain containing 47 |
increases expression |
EXP |
Thapsigargin results in increased expression of CCDC47 protein |
CTD |
PMID:35544339 |
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NCBI chr10:91,130,303...91,148,829
Ensembl chr10:91,130,303...91,148,881
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G |
Ccdc61 |
coiled-coil domain containing 61 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CCDC61 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:78,537,494...78,557,686
Ensembl chr 1:78,537,494...78,557,686
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases expression multiple interactions decreases expression |
ISO EXP |
Thapsigargin results in increased expression of CCL2 mRNA Thapsigargin inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Thapsigargin inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA] Thapsigargin results in decreased expression of CCL2 mRNA |
CTD |
PMID:8764118 PMID:18799549 PMID:18951912 PMID:20830808 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
increases expression |
EXP |
Thapsigargin results in increased expression of CCL3 mRNA; Thapsigargin results in increased expression of CCL3 protein |
CTD |
PMID:20830808 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccn1 |
cellular communication network factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCN1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNA2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNB1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnb1ip1 |
cyclin B1 interacting protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCNB1IP1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr15:24,014,905...24,031,357
Ensembl chr15:24,014,908...24,028,475
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCND1 mRNA |
CTD |
PMID:17332266 PMID:22378314 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnf |
cyclin F |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNF mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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G |
Ccng2 |
cyclin G2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCNG2 mRNA |
CTD |
PMID:17332266 |
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NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Ccnq |
cyclin Q |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CCNQ protein |
CTD |
PMID:24648495 |
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NCBI chr10:63,646,532...63,647,695
Ensembl chr10:63,646,527...63,647,961
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G |
Ccpg1 |
cell cycle progression 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CCPG1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
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G |
Cd2ap |
CD2-associated protein |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CD2AP protein |
CTD |
PMID:35544339 |
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NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
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G |
Cd44 |
CD44 molecule |
increases expression |
ISO |
Thapsigargin results in increased expression of CD44 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
increases expression |
ISO |
Thapsigargin results in increased expression of CD55 mRNA |
CTD |
PMID:24247028 |
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NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cd69 |
Cd69 molecule |
increases expression |
ISO |
Thapsigargin results in increased expression of CD69 mRNA |
CTD |
PMID:24247028 |
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NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
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G |
Cd70 |
Cd70 molecule |
increases expression |
ISO |
Thapsigargin results in increased expression of CD70 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715
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G |
Cdc20 |
cell division cycle 20 |
multiple interactions increases expression |
ISO |
[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in increased expression of CDC20 mRNA; [Thapsigargin co-treated with caffeic acid] results in increased expression of CDC20 mRNA; [Thapsigargin co-treated with Drugs, Chinese Herbal] results in increased expression of CDC20 mRNA Thapsigargin results in increased expression of CDC20 mRNA |
CTD |
PMID:19442820 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc45 |
cell division cycle 45 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDC45 mRNA |
CTD |
PMID:22378314 |
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NCBI chr11:82,185,427...82,210,630
Ensembl chr11:82,185,473...82,210,619
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G |
Cdc5l |
cell division cycle 5-like |
increases expression |
ISO |
Thapsigargin results in increased expression of CDC5L protein |
CTD |
PMID:24648495 |
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NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450
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G |
Cdc7 |
cell division cycle 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDC7 mRNA |
CTD |
PMID:22378314 |
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NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
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G |
Cdc73 |
cell division cycle 73 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CDC73 protein |
CTD |
PMID:35544339 |
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NCBI chr13:55,357,226...55,449,690
Ensembl chr13:55,357,226...55,449,656
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G |
Cdca2 |
cell division cycle associated 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDCA2 protein |
CTD |
PMID:24648495 |
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NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611
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G |
Cdca7 |
cell division cycle associated 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDCA7 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:57,322,718...57,333,353
Ensembl chr 3:57,322,708...57,333,353
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G |
Cdca7l |
cell division cycle associated 7 like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDCA7L mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:138,793,953...138,839,889
Ensembl chr 6:138,794,228...138,839,888
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G |
Cdh15 |
cadherin 15 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDH15 mRNA |
CTD |
PMID:22378314 |
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NCBI chr19:50,903,757...50,927,151
Ensembl chr19:50,903,638...50,927,105
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G |
Cdipt |
CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDIPT protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDK1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions decreases expression increases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CDK2 mRNA] Thapsigargin results in decreased expression of CDK2 mRNA |
CTD |
PMID:19442820 PMID:22378314 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk2ap2 |
cyclin-dependent kinase 2 associated protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDK2AP2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137
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G |
Cdk5rap2 |
CDK5 regulatory subunit associated protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDK5RAP2 protein |
CTD |
PMID:24648495 |
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NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782
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G |
Cdk5rap3 |
CDK5 regulatory subunit associated protein 3 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of CDK5RAP3 mRNA Thapsigargin results in increased expression of CDK5RAP3 protein |
CTD |
PMID:29453283 PMID:35544339 |
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NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590
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G |
Cdk7 |
cyclin-dependent kinase 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CDK7 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
Thapsigargin results in increased expression of CDKN1A mRNA |
CTD |
PMID:29453283 PMID:33770205 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdr2 |
cerebellar degeneration-related protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CDR2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
increases expression multiple interactions |
ISO |
Thapsigargin results in increased expression of CEBPB mRNA; Thapsigargin results in increased expression of CEBPB protein alternative form Thapsigargin promotes the reaction [CEBPB protein binds to NR1I2 promoter] |
CTD |
PMID:22378314 PMID:25616597 PMID:29453283 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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Cebpe |
CCAAT/enhancer binding protein epsilon |
increases expression |
ISO |
Thapsigargin results in increased expression of CEBPE mRNA |
CTD |
PMID:29453283 |
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NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814
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Cebpg |
CCAAT/enhancer binding protein gamma |
increases expression |
ISO |
Thapsigargin results in increased expression of CEBPG mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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Cenpa |
centromere protein A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CENPA mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675
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G |
Cenpf |
centromere protein F |
increases expression |
ISO |
Thapsigargin results in increased expression of CENPF mRNA |
CTD |
PMID:19442820 |
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NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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G |
Cenpu |
centromere protein U |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CENPU mRNA |
CTD |
PMID:22378314 |
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NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823
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Cep290 |
centrosomal protein 290 |
increases expression |
ISO |
Thapsigargin results in increased expression of CEP290 protein |
CTD |
PMID:24648495 |
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NCBI chr 7:35,310,071...35,399,388
Ensembl chr 7:35,310,199...35,399,392
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G |
Ces5a |
carboxylesterase 5A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CES5A protein |
CTD |
PMID:24648495 |
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NCBI chr19:11,469,431...11,499,007
Ensembl chr19:11,469,469...11,499,006
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G |
Cetn2 |
centrin 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CETN2 protein |
CTD |
PMID:24648495 |
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NCBI chr X:150,769,944...150,774,833
Ensembl chr X:150,769,953...150,774,919
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G |
Cfl1 |
cofilin 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CFL1 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587
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G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [5-butyl-7-chloro-6-hydroxybenzo(c)quinolizinium results in increased activity of CFTR protein mutant form]; Thapsigargin promotes the reaction [miglustat inhibits the reaction [CFTR protein mutant form inhibits the reaction [[Colforsin co-treated with Genistein] results in increased transport of Iodides]]]; Thapsigargin promotes the reaction [miglustat results in increased activity of CFTR protein mutant form] |
CTD |
PMID:18230692 |
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NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Cga |
glycoprotein hormones, alpha polypeptide |
increases expression |
ISO |
Thapsigargin results in increased expression of CGA mRNA |
CTD |
PMID:21694771 PMID:29453283 |
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NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191
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Cgn |
cingulin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CGN mRNA |
CTD |
PMID:29453283 |
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NCBI chr 2:182,308,389...182,335,747
Ensembl chr 2:182,308,714...182,334,645
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G |
Cgnl1 |
cingulin-like 1 |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of CGNL1 protein Thapsigargin results in decreased expression of CGNL1 mRNA |
CTD |
PMID:24648495 PMID:29453283 |
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NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917
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G |
Chac1 |
ChaC glutathione-specific gamma-glutamylcyclotransferase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHAC1 mRNA |
CTD |
PMID:19442820 |
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NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526
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G |
Chaf1a |
chromatin assembly factor 1 subunit A |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of CHAF1A mRNA Thapsigargin results in decreased expression of CHAF1A mRNA |
CTD |
PMID:19442820 PMID:22378314 |
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NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654
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G |
Chaf1b |
chromatin assembly factor 1 subunit B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHAF1B mRNA |
CTD |
PMID:22378314 |
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NCBI chr11:33,200,894...33,221,076
Ensembl chr11:33,200,981...33,221,070
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G |
Chchd6 |
coiled-coil-helix-coiled-coil-helix domain containing 6 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHCHD6 protein |
CTD |
PMID:24648495 |
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NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
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G |
Chchd7 |
coiled-coil-helix-coiled-coil-helix domain containing 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHCHD7 protein |
CTD |
PMID:24648495 |
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NCBI chr 5:16,957,127...16,961,682
Ensembl chr 5:16,957,188...16,961,184
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G |
Chd4 |
chromodomain helicase DNA binding protein 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of CHD4 protein |
CTD |
PMID:24648495 |
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NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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G |
Chek1 |
checkpoint kinase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHEK1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chga |
chromogranin A |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of CHGA mRNA Thapsigargin results in increased expression of CHGA protein Thapsigargin results in increased expression of CHGA mRNA |
CTD |
PMID:22378314 PMID:29453283 PMID:35544339 |
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NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
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G |
Chgb |
chromogranin B |
increases expression |
EXP |
Thapsigargin results in increased expression of CHGB protein |
CTD |
PMID:35544339 |
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NCBI chr 3:120,043,824...120,057,169
Ensembl chr 3:120,043,738...120,057,166
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G |
Chid1 |
chitinase domain containing 1 |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of CHID1 protein |
CTD |
PMID:24648495 PMID:35544339 |
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NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606
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G |
Chkb |
choline kinase beta |
increases expression |
EXP |
Thapsigargin results in increased expression of CHKB protein |
CTD |
PMID:35544339 |
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NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461
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G |
Chpf |
chondroitin polymerizing factor |
increases expression |
ISO |
Thapsigargin results in increased expression of CHPF mRNA |
CTD |
PMID:22378314 |
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NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878
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G |
Chpt1 |
choline phosphotransferase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CHPT1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103
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G |
Chrm1 |
cholinergic receptor, muscarinic 1 |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium] |
CTD |
PMID:18316702 |
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NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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G |
Chrna3 |
cholinergic receptor nicotinic alpha 3 subunit |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHRNA3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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G |
Chrna5 |
cholinergic receptor nicotinic alpha 5 subunit |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHRNA5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
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G |
Chrnb4 |
cholinergic receptor nicotinic beta 4 subunit |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CHRNB4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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G |
Chst15 |
carbohydrate sulfotransferase 15 |
increases expression |
ISO |
Thapsigargin results in increased expression of CHST15 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:187,028,860...187,107,908
Ensembl chr 1:187,028,970...187,107,707
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G |
Ciapin1 |
cytokine induced apoptosis inhibitor 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of CIAPIN1 protein |
CTD |
PMID:35544339 |
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NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503
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G |
Cirbp |
cold inducible RNA binding protein |
increases expression |
ISO |
Thapsigargin results in increased expression of CIRBP mRNA |
CTD |
PMID:29453283 |
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NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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G |
Ckap5 |
cytoskeleton associated protein 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of CKAP5 protein |
CTD |
PMID:24648495 |
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NCBI chr 3:77,491,195...77,593,300
Ensembl chr 3:77,491,276...77,593,264
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G |
Ckb |
creatine kinase B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CKB mRNA; Thapsigargin results in decreased expression of CKB protein |
CTD |
PMID:21692457 PMID:22378314 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Clcc1 |
chloride channel CLIC-like 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CLCC1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:196,296,350...196,326,914
Ensembl chr 2:196,296,393...196,326,913
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G |
Clec11a |
C-type lectin domain containing 11A |
increases expression |
ISO |
Thapsigargin results in increased expression of CLEC11A mRNA |
CTD |
PMID:19442820 |
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NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633
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G |
Clip2 |
CAP-GLY domain containing linker protein 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of CLIP2 protein |
CTD |
PMID:35544339 |
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NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023
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G |
Cln8 |
CLN8, transmembrane ER and ERGIC protein |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CLN8 protein |
CTD |
PMID:24648495 |
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NCBI chr16:74,749,662...74,759,553
Ensembl chr16:74,749,662...74,759,774
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G |
Clpb |
ClpB family mitochondrial disaggregase |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CLPB protein |
CTD |
PMID:35544339 |
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NCBI chr 1:156,028,740...156,158,183
Ensembl chr 1:156,028,930...156,168,788
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G |
Clpp |
caseinolytic mitochondrial matrix peptidase proteolytic subunit |
increases expression |
ISO |
Thapsigargin results in increased expression of CLPP mRNA |
CTD |
PMID:22378314 |
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NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693
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G |
Cltb |
clathrin, light chain B |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CLTB protein |
CTD |
PMID:35544339 |
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NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169
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G |
Cltc |
clathrin heavy chain |
increases expression |
ISO |
Thapsigargin results in increased expression of CLTC protein |
CTD |
PMID:24648495 |
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NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737
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G |
Cmbl |
carboxymethylenebutenolidase homolog |
increases expression |
EXP |
Thapsigargin results in increased expression of CMBL protein |
CTD |
PMID:35544339 |
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NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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G |
Cndp2 |
carnosine dipeptidase 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of CNDP2 protein |
CTD |
PMID:35544339 |
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NCBI chr18:78,039,924...78,057,030
Ensembl chr18:78,039,932...78,056,922
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G |
Cnn3 |
calponin 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CNN3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104
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G |
Cntfr |
ciliary neurotrophic factor receptor |
increases expression |
EXP |
Thapsigargin results in increased expression of CNTFR protein |
CTD |
PMID:35544339 |
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NCBI chr 5:56,823,448...56,861,049
Ensembl chr 5:56,823,965...56,841,392
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G |
Cntnap2 |
contactin associated protein 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CNTNAP2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027
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G |
Cog1 |
component of oligomeric golgi complex 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of COG1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:98,695,481...98,708,495
Ensembl chr10:98,695,423...98,709,292
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G |
Cog3 |
component of oligomeric golgi complex 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of COG3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr15:51,020,808...51,071,288
Ensembl chr15:51,020,813...51,070,570
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G |
Cog6 |
component of oligomeric golgi complex 6 |
increases expression |
ISO |
Thapsigargin results in increased expression of COG6 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:137,062,127...137,099,176
Ensembl chr 2:137,061,346...137,099,190
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G |
Col11a1 |
collagen type XI alpha 1 chain |
increases expression |
ISO |
Thapsigargin results in increased expression of COL11A1 protein |
CTD |
PMID:24648495 |
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NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
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G |
Col5a1 |
collagen type V alpha 1 chain |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of COL5A1 mRNA Thapsigargin results in decreased expression of COL5A1 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588
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G |
Col5a2 |
collagen type V alpha 2 chain |
increases expression |
ISO |
Thapsigargin results in increased expression of COL5A2 protein |
CTD |
PMID:24648495 |
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NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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G |
Col6a3 |
collagen type VI alpha 3 chain |
multiple interactions |
ISO |
Thapsigargin promotes the reaction [COL6A3 gene mutant form results in increased susceptibility to Rotenone] |
CTD |
PMID:18435905 |
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NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
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G |
Colec12 |
collectin sub-family member 12 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COLEC12 protein |
CTD |
PMID:24648495 |
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NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
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G |
Copa |
COPI coat complex subunit alpha |
increases expression |
ISO |
Thapsigargin results in increased expression of COPA mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874
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G |
Copb2 |
COPI coat complex subunit beta 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of COPB2 protein |
CTD |
PMID:35544339 |
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NCBI chr 8:99,161,324...99,183,452
Ensembl chr 8:99,161,350...99,185,197
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G |
Copg1 |
COPI coat complex subunit gamma 1 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of COPG1 mRNA Thapsigargin results in increased expression of COPG1 protein |
CTD |
PMID:22378314 PMID:29453283 PMID:35544339 |
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NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616
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G |
Cops4 |
COP9 signalosome subunit 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COPS4 protein |
CTD |
PMID:21692457 |
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NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
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G |
Cops7a |
COP9 signalosome subunit 7A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COPS7A protein |
CTD |
PMID:24648495 |
|
NCBI chr 4:157,766,626...157,792,632
Ensembl chr 4:157,766,588...157,773,948
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G |
Coq3 |
coenzyme Q3 methyltransferase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COQ3 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
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G |
Coq8a |
coenzyme Q8A |
increases expression |
ISO |
Thapsigargin results in increased expression of COQ8A mRNA |
CTD |
PMID:22378314 |
|
NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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G |
Coro1a |
coronin 1A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CORO1A mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
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G |
Coro1b |
coronin 1B |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CORO1B protein |
CTD |
PMID:35544339 |
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NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
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G |
Cotl1 |
coactosin-like F-actin binding protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COTL1 protein |
CTD |
PMID:24648495 |
|
NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
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G |
Cox10 |
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 |
increases expression |
ISO |
Thapsigargin results in increased expression of COX10 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:48,630,993...48,742,805
Ensembl chr10:48,630,676...48,746,667
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G |
Cox11 |
cytochrome c oxidase copper chaperone COX11 |
increases expression |
ISO |
Thapsigargin results in increased expression of COX11 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322
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G |
Cox17 |
cytochrome c oxidase copper chaperone COX17 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COX17 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr11:62,400,733...62,406,507
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G |
Cox4i1 |
cytochrome c oxidase subunit 4i1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of COX4I1 protein |
CTD |
PMID:35544339 |
|
NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
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G |
Cox5b |
cytochrome c oxidase subunit 5B |
decreases expression |
EXP |
Thapsigargin results in decreased expression of COX5B protein |
CTD |
PMID:35544339 |
|
NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
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G |
Cox6b1 |
cytochrome c oxidase subunit 6B1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COX6B1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001 Ensembl chr 2:85,875,109...85,884,001 Ensembl chr 5:85,875,109...85,884,001
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G |
Cox6c |
cytochrome c oxidase subunit 6C |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of COX6C mRNA Thapsigargin results in decreased expression of COX6C protein |
CTD |
PMID:22378314 PMID:35544339 |
|
NCBI chr 7:67,129,265...67,142,001
Ensembl chr 7:67,111,024...67,141,963
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G |
Cox7b |
cytochrome c oxidase subunit 7B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of COX7B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:71,083,486...71,089,733
Ensembl chr X:71,083,456...71,089,732
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G |
Cpne1 |
copine 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CPNE1 protein |
CTD |
PMID:21692457 |
|
NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636
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G |
Cpox |
coproporphyrinogen oxidase |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CPOX protein |
CTD |
PMID:35544339 |
|
NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746
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G |
Cpsf1 |
cleavage and polyadenylation specific factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CPSF1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 7:108,319,429...108,330,018
Ensembl chr 7:108,319,434...108,329,934
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G |
Cpsf7 |
cleavage and polyadenylation specific factor 7 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CPSF7 protein |
CTD |
PMID:35544339 |
|
NCBI chr 1:207,167,690...207,191,938
Ensembl chr 1:207,167,859...207,191,905
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G |
Cpt1c |
carnitine palmitoyltransferase 1c |
increases expression |
ISO |
Thapsigargin results in increased expression of CPT1C mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:95,442,814...95,457,347
Ensembl chr 1:95,442,817...95,457,342
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G |
Cr1l |
complement C3b/C4b receptor 1 like |
increases expression |
EXP |
Thapsigargin results in increased expression of CR1L protein |
CTD |
PMID:35544339 |
|
NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
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G |
Crabp1 |
cellular retinoic acid binding protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CRABP1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:55,138,363...55,159,360
Ensembl chr 8:55,151,285...55,159,360
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G |
Crabp2 |
cellular retinoic acid binding protein 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CRABP2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:173,417,004...173,421,352
Ensembl chr 2:173,416,857...173,421,379
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G |
Crat |
carnitine O-acetyltransferase |
increases expression |
ISO |
Thapsigargin results in increased expression of CRAT mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
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G |
Creb1 |
cAMP responsive element binding protein 1 |
affects localization multiple interactions |
ISO |
Thapsigargin affects the localization of CREB1 mRNA Cycloheximide inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA]; Emetine inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA] |
CTD |
PMID:29576526 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Creb3l1 |
cAMP responsive element binding protein 3-like 1 |
increases activity multiple interactions |
ISO |
Thapsigargin results in increased activity of CREB3L1 protein [Thapsigargin results in increased activity of CREB3L1 protein] which results in increased expression of VEGFA mRNA |
CTD |
PMID:23383089 |
|
NCBI chr 3:77,952,589...77,993,513
Ensembl chr 3:77,952,540...77,993,456
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G |
Creb3l2 |
cAMP responsive element binding protein 3-like 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CREB3L2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
|
NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
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G |
Crebbp |
CREB binding protein |
increases expression |
ISO |
Thapsigargin results in increased expression of CREBBP mRNA |
CTD |
PMID:24247028 |
|
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Creg1 |
cellular repressor of E1A-stimulated genes 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CREG1 protein |
CTD |
PMID:24648495 |
|
NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
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G |
Creld1 |
cysteine-rich with EGF-like domains 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRELD1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499
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G |
Creld2 |
cysteine-rich with EGF-like domains 2 |
increases expression decreases expression |
ISO EXP |
Thapsigargin results in increased expression of CRELD2 mRNA; Thapsigargin results in increased expression of CRELD2 protein Thapsigargin results in decreased expression of CRELD2 protein |
CTD |
PMID:22378314 PMID:24648495 PMID:29453283 PMID:35544339 |
|
NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
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G |
Crk |
CRK proto-oncogene, adaptor protein |
multiple interactions |
EXP |
Thapsigargin inhibits the reaction [Sincalide results in increased phosphorylation of CRK protein] |
CTD |
PMID:16187300 |
|
NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
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G |
Crmp1 |
collapsin response mediator protein 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of CRMP1 protein |
CTD |
PMID:35544339 |
|
NCBI chr14:73,509,933...73,556,192
Ensembl chr14:73,509,933...73,556,177
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G |
Crnkl1 |
crooked neck pre-mRNA splicing factor 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CRNKL1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 3:133,338,593...133,354,329
Ensembl chr 3:133,337,039...133,354,302 Ensembl chr 6:133,337,039...133,354,302
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G |
Crtac1 |
cartilage acidic protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRTAC1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 1:241,091,679...241,233,677
Ensembl chr 1:241,078,864...241,233,421
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G |
Cry1 |
cryptochrome circadian regulator 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CRY1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
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G |
Crybb2 |
crystallin, beta B2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRYBB2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr12:43,569,747...43,579,671
Ensembl chr12:43,569,747...43,579,671
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G |
Crybg3 |
crystallin beta-gamma domain containing 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of CRYBG3 protein |
CTD |
PMID:24648495 |
|
NCBI chr11:40,749,198...40,861,753
Ensembl chr11:40,749,214...40,861,752
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G |
Cryz |
crystallin zeta |
multiple interactions decreases expression increases expression |
ISO |
Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of CRYZ mRNA] Thapsigargin results in decreased expression of CRYZ mRNA |
CTD |
PMID:19442820 PMID:22378314 |
|
NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
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G |
Cs |
citrate synthase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CS mRNA |
CTD |
PMID:28223344 |
|
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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|
G |
Csnk2a2 |
casein kinase 2 alpha 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of CSNK2A2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr19:9,556,443...9,596,080
Ensembl chr19:9,556,260...9,596,080
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G |
Cspg5 |
chondroitin sulfate proteoglycan 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CSPG5 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 8:110,220,506...110,234,766
Ensembl chr 8:110,220,653...110,234,758
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G |
Csrnp1 |
cysteine and serine rich nuclear protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CSRNP1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183
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G |
Csrp2 |
cysteine and glycine-rich protein 2 |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of CSRP2 mRNA Thapsigargin results in decreased expression of CSRP2 protein |
CTD |
PMID:22378314 PMID:35544339 |
|
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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G |
Cstb |
cystatin B |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CSTB protein |
CTD |
PMID:35544339 |
|
NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526
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G |
Cstf2 |
cleavage stimulation factor subunit 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CSTF2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
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|
G |
Ctbp1 |
C-terminal binding protein 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CTBP1 protein |
CTD |
PMID:35544339 |
|
NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
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G |
Ctbs |
chitobiase |
increases expression |
EXP |
Thapsigargin results in increased expression of CTBS protein |
CTD |
PMID:35544339 |
|
NCBI chr 2:235,340,520...235,355,091
Ensembl chr 2:235,340,547...235,355,091
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G |
Ctf1 |
cardiotrophin 1 |
multiple interactions |
ISO |
[Thapsigargin co-treated with 4-methoxycinnamate methyl ester] results in decreased expression of CTF1 mRNA; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CTF1 mRNA] |
CTD |
PMID:19442820 |
|
NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
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G |
Cth |
cystathionine gamma-lyase |
increases expression |
ISO |
Thapsigargin results in increased expression of CTH mRNA; Thapsigargin results in increased expression of CTH protein |
CTD |
PMID:29453283 |
|
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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G |
Ctnnbl1 |
catenin, beta like 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CTNNBL1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 3:146,387,940...146,548,987
Ensembl chr 3:146,387,889...146,548,987
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G |
Ctps1 |
CTP synthase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CTPS1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:134,125,022...134,154,155
Ensembl chr 5:134,125,025...134,154,180
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G |
Ctps2 |
CTP synthase 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of CTPS2 protein |
CTD |
PMID:35544339 |
|
NCBI chr X:31,645,873...31,786,733
Ensembl chr X:31,645,873...31,786,733
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G |
Ctr9 |
CTR9 homolog, Paf1/RNA polymerase II complex component |
increases expression |
ISO |
Thapsigargin results in increased expression of CTR9 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303
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G |
Ctsb |
cathepsin B |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CTSB protein |
CTD |
PMID:35544339 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Ctsl |
cathepsin L |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein] |
CTD |
PMID:25639782 |
|
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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G |
Cttn |
cortactin |
increases expression |
EXP |
Thapsigargin results in increased expression of CTTN protein |
CTD |
PMID:35544339 |
|
NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
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G |
Ctxn1 |
cortexin 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CTXN1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr12:2,610,465...2,612,076
|
|
G |
Cwc15 |
CWC15 spliceosome-associated protein |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CWC15 protein |
CTD |
PMID:35544339 |
|
NCBI chr 8:11,305,401...11,316,326
Ensembl chr 8:11,305,424...11,316,325 Ensembl chr 2:11,305,424...11,316,325
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of CXCL2 mRNA] |
CTD |
PMID:19442820 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of CXCL1 mRNA |
CTD |
PMID:8764118 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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|
G |
Cyb561d2 |
cytochrome b561 family, member D2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYB561D2 protein |
CTD |
PMID:24648495 |
|
NCBI chr 8:108,213,201...108,215,778
Ensembl chr 8:108,213,205...108,215,759
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G |
Cyb5a |
cytochrome b5 type A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYB5A mRNA |
CTD |
PMID:22378314 |
|
NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
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G |
Cyb5b |
cytochrome b5 type B |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of CYB5B mRNA Thapsigargin results in increased expression of CYB5B protein |
CTD |
PMID:22378314 PMID:35544339 |
|
NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249
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G |
Cyb5r1 |
cytochrome b5 reductase 1 |
increases expression decreases expression |
ISO EXP |
Thapsigargin results in increased expression of CYB5R1 mRNA Thapsigargin results in decreased expression of CYB5R1 protein |
CTD |
PMID:29453283 PMID:35544339 |
|
NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458
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G |
Cyba |
cytochrome b-245 alpha chain |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYBA mRNA |
CTD |
PMID:29453283 |
|
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cycs |
cytochrome c, somatic |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYCS mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyfip1 |
cytoplasmic FMR1 interacting protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYFIP1 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:106,710,924...106,799,393
Ensembl chr 1:106,711,016...106,799,386
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G |
Cygb |
cytoglobin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYGB mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442
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|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
NR1I2 protein inhibits the reaction [Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]]; Thapsigargin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA] |
CTD |
PMID:25616597 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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|
G |
Cyp4f18 |
cytochrome P450, family 4, subfamily f, polypeptide 18 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of CYP4F3 mRNA |
CTD |
PMID:19442820 |
|
NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940
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|
G |
Cyp4v3 |
cytochrome P450, family 4, subfamily v, polypeptide 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYP4V2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr16:46,917,929...46,958,735
Ensembl chr16:46,918,401...46,943,395
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|
G |
Cyp4x1 |
cytochrome P450, family 4, subfamily x, polypeptide 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of CYP4X1 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 5:128,651,681...128,683,338
Ensembl chr 5:128,651,776...128,682,779
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|
G |
Cyp51 |
cytochrome P450, family 51 |
increases expression |
EXP |
Thapsigargin results in increased expression of CYP51 protein |
CTD |
PMID:35544339 |
|
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410 Ensembl chr 6:30,036,865...30,055,410
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|
G |
Czib |
CXXC motif containing zinc binding protein |
decreases expression |
EXP |
Thapsigargin results in decreased expression of CZIB protein |
CTD |
PMID:35544339 |
|
NCBI chr 5:122,648,333...122,657,767
Ensembl chr 5:122,648,411...122,656,910
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G |
Dap |
death-associated protein |
multiple interactions increases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of DAP mRNA] Thapsigargin results in increased expression of DAP mRNA |
CTD |
PMID:19442820 PMID:22378314 |
|
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Dbi |
diazepam binding inhibitor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DBI mRNA |
CTD |
PMID:22378314 |
|
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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|
G |
Dbnl |
drebrin-like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DBNL mRNA |
CTD |
PMID:22378314 |
|
NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155
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|
G |
Dck |
deoxycytidine kinase |
decreases expression |
EXP |
Thapsigargin results in decreased expression of DCK protein |
CTD |
PMID:35544339 |
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NCBI chr14:19,305,218...19,326,247
Ensembl chr14:19,305,218...19,326,247
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Dctpp1 |
dCTP pyrophosphatase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DCTPP1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:181,877,440...181,880,833
Ensembl chr 1:181,877,437...181,880,839
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Dcx |
doublecortin |
decreases expression |
EXP |
Thapsigargin results in decreased expression of DCX protein |
CTD |
PMID:35544339 |
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NCBI chr X:107,430,767...107,573,612
Ensembl chr X:107,430,767...107,507,476
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G |
Ddah1 |
dimethylarginine dimethylaminohydrolase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DDAH1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
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Ddb1 |
damage-specific DNA binding protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DDB1 protein |
CTD |
PMID:24648495 |
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NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
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Ddc |
dopa decarboxylase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DDC mRNA |
CTD |
PMID:22378314 |
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NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Ddias |
DNA damage-induced apoptosis suppressor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DDIAS mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
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Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression increases activity decreases response to substance |
ISO EXP |
ATF6 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Doxorubicin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Quercetin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; Thapsigargin promotes the reaction [DDIT3 protein binds to LCN2 promoter]; Thapsigargin promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 protein thapsigargin promotes the reaction [glucose increases expression of Ddit3 protein in cardiac muscle cell] Thapsigargin results in increased expression of DDIT3 mRNA; Thapsigargin results in increased expression of DDIT3 protein 1-Deoxynojirimycin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; GW 506033X inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; salubrinal promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin results in increased expression of and affects the localization of DDIT3 protein Thapsigargin results in increased activity of DDIT3 protein 2-aminoethoxydiphenyl borate inhibits the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased expression of DDIT3 protein]]; Thapsigargin promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; Vaticanol B inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] DDIT3 results in decreased susceptibility to Thapsigargin |
CTD RGD |
PMID:16298333 PMID:16330322 PMID:16338971 PMID:17283163 PMID:17332266 PMID:17353921 PMID:17475668 PMID:19028522 PMID:19135031 PMID:19139269 PMID:19285962 PMID:19428936 PMID:20022965 PMID:20493918 PMID:20589738 PMID:20626587 PMID:21525004 PMID:21694771 PMID:22378314 PMID:22509299 PMID:22641616 PMID:22800509 PMID:22843330 PMID:22935518 PMID:23123503 PMID:24648495 PMID:24668805 PMID:24865413 PMID:25289770 PMID:25324550 PMID:25341683 PMID:26264395 PMID:26513129 PMID:27226639 PMID:27358234 PMID:27587023 PMID:27638049 PMID:28223344 PMID:28315715 PMID:28844859 PMID:28940366 PMID:28942281 PMID:29109149 PMID:29414781 PMID:29453283 PMID:30508555 PMID:32407927 PMID:32535746 PMID:32574669 PMID:32578922 PMID:34915026 PMID:35033536 PMID:35544339 PMID:36044268 More...
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RGD:156430337 |
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddost |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of DDOST mRNA Thapsigargin results in increased expression of DDOST protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
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G |
Ddr2 |
discoidin domain receptor tyrosine kinase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of DDR2 protein |
CTD |
PMID:24648495 |
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NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
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G |
Ddrgk1 |
DDRGK domain containing 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DDRGK1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 3:117,861,916...117,882,680
Ensembl chr 3:117,861,653...117,882,680
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G |
Ddx21 |
DExD-box helicase 21 |
increases expression |
EXP |
Thapsigargin results in increased expression of DDX21 protein |
CTD |
PMID:35544339 |
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NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543
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G |
Decr1 |
2,4-dienoyl-CoA reductase 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of DECR1 protein |
CTD |
PMID:35544339 |
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NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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G |
Dek |
DEK proto-oncogene |
decreases expression |
EXP |
Thapsigargin results in decreased expression of DEK protein |
CTD |
PMID:35544339 |
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NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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G |
Dennd4c |
DENN domain containing 4C |
increases expression |
ISO |
Thapsigargin results in increased expression of DENND4C protein |
CTD |
PMID:24648495 |
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NCBI chr 5:101,272,298...101,369,529
Ensembl chr 5:101,272,005...101,368,118
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G |
Depdc1b |
DEP domain containing 1B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DEPDC1B mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779
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G |
Deptor |
DEP domain containing MTOR-interacting protein |
increases expression |
ISO |
Thapsigargin results in increased expression of DEPTOR mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
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G |
Derl2 |
derlin 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of DERL2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:55,727,764...55,739,442
Ensembl chr10:55,727,643...55,739,518
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G |
Dglucy |
D-glutamate cyclase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DGLUCY mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:120,055,480...120,130,910
Ensembl chr 6:120,055,460...120,130,910
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G |
Dhcr24 |
24-dehydrocholesterol reductase |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of DHCR24 mRNA Thapsigargin results in increased expression of DHCR24 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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G |
Dhcr7 |
7-dehydrocholesterol reductase |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of DHCR7 mRNA Thapsigargin results in increased expression of DHCR7 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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G |
Dhrs13 |
dehydrogenase/reductase 13 |
increases expression |
ISO |
Thapsigargin results in increased expression of DHRS13 mRNA |
CTD |
PMID:29453283 |
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NCBI chr10:62,920,791...62,925,952
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G |
Dhrs3 |
dehydrogenase/reductase 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of DHRS3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
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G |
Dhx36 |
DEAH-box helicase 36 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of DHX36 protein |
CTD |
PMID:24648495 PMID:35544339 |
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NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572
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G |
Dhx9 |
DExH-box helicase 9 |
increases expression |
ISO |
Thapsigargin results in increased expression of DHX9 protein |
CTD |
PMID:24648495 |
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NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
affects response to substance increases expression affects localization |
ISO |
DIABLO protein affects the susceptibility to Thapsigargin Thapsigargin results in increased expression of DIABLO mRNA Thapsigargin affects the localization of DIABLO protein |
CTD |
PMID:15339911 PMID:16382148 PMID:22378314 |
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NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Diaph2 |
diaphanous-related formin 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of DIAP2 protein |
CTD |
PMID:24648495 |
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NCBI chr X:92,395,189...93,234,521
Ensembl chr X:92,395,251...93,229,869
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G |
Diaph3 |
diaphanous-related formin 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of DIAPH3 protein |
CTD |
PMID:24648495 |
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NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
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G |
Dkk1 |
dickkopf WNT signaling pathway inhibitor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DKK1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202
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G |
Dld |
dihydrolipoamide dehydrogenase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DLD mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
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G |
Dlg4 |
discs large MAGUK scaffold protein 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of DLG4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153
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G |
Dlgap5 |
DLG associated protein 5 |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of DLGAP5 mRNA Thapsigargin results in increased expression of DLGAP5 protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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G |
Dlk1 |
delta like non-canonical Notch ligand 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DLK1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522
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G |
Dlst |
dihydrolipoamide S-succinyltransferase |
decreases expression |
EXP |
Thapsigargin results in decreased expression of DLST protein |
CTD |
PMID:35544339 |
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NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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G |
Dlx5 |
distal-less homeobox 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DLX5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407
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G |
Dmac2l |
distal membrane arm assembly component 2 like |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DMAC2L mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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G |
Dnaja1 |
DnaJ heat shock protein family (Hsp40) member A1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DNAJA1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
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G |
Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNAJA3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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G |
Dnajb11 |
DnaJ heat shock protein family (Hsp40) member B11 |
multiple interactions increases expression decreases expression |
ISO EXP |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]; [DNAJB11 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA] Thapsigargin results in increased expression of DNAJB11 protein Thapsigargin results in increased expression of DNAJB11 mRNA; Thapsigargin results in increased expression of DNAJB11 protein |
CTD |
PMID:19442820 PMID:22378314 PMID:26085089 PMID:29453283 PMID:35544339 |
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NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of DNAJB9 mRNA |
CTD |
PMID:19135031 PMID:22378314 PMID:23123503 PMID:29453283 |
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NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnajc1 |
DnaJ heat shock protein family (Hsp40) member C1 |
affects expression |
ISO |
Thapsigargin affects the expression of DNAJC1 mRNA |
CTD |
PMID:24247028 |
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NCBI chr17:80,955,209...81,112,025
Ensembl chr17:80,955,237...81,111,988
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G |
Dnajc10 |
DnaJ heat shock protein family (Hsp40) member C10 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNAJC10 mRNA; Thapsigargin results in increased expression of DNAJC10 protein |
CTD |
PMID:17353921 PMID:29453283 |
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NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719
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G |
Dnajc3 |
DnaJ heat shock protein family (Hsp40) member C3 |
increases expression multiple interactions |
ISO |
Thapsigargin results in increased expression of DNAJC3 mRNA; Thapsigargin results in increased expression of DNAJC3 protein [DNAJC3 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin |
CTD |
PMID:19135031 PMID:26085089 PMID:29453283 |
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NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
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G |
Dnase2 |
deoxyribonuclease 2, lysosomal |
increases expression |
ISO |
Thapsigargin results in increased expression of DNASE2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr19:23,244,656...23,247,376
Ensembl chr19:23,244,664...23,247,376
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G |
Dnhd1 |
dynein heavy chain domain 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNHD1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:159,990,785...160,077,990
Ensembl chr 1:159,990,438...160,074,858
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G |
Dnm1l |
dynamin 1-like |
increases expression |
ISO |
Thapsigargin results in increased expression of DNM1L mRNA |
CTD |
PMID:28940366 |
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NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmt1 |
DNA methyltransferase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DNMT1 protein |
CTD |
PMID:24648495 |
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NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
decreases expression |
EXP |
Thapsigargin results in decreased expression of DNMT3A protein |
CTD |
PMID:35544339 |
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NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dock7 |
dedicator of cytokinesis 7 |
increases expression |
ISO |
Thapsigargin results in increased expression of DOCK7 protein |
CTD |
PMID:24648495 |
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NCBI chr 5:113,599,371...113,782,871
Ensembl chr 5:113,600,198...113,782,813
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G |
Dpf1 |
double PHD fingers 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DPF1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:84,602,212...84,615,954
Ensembl chr 1:84,602,336...84,615,950
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G |
Dph5 |
diphthamide biosynthesis 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of DPH5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433
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G |
Dpysl3 |
dihydropyrimidinase-like 3 |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of DPYSL3 mRNA Thapsigargin results in decreased expression of DPYSL3 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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G |
Dpysl4 |
dihydropyrimidinase-like 4 |
multiple interactions increases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of DPYSL4 mRNA] |
CTD |
PMID:19442820 |
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NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914
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G |
Dpysl5 |
dihydropyrimidinase-like 5 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of DPYSL5 protein |
CTD |
PMID:35544339 |
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NCBI chr 6:25,575,104...25,659,422
Ensembl chr 6:25,575,104...25,659,422
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G |
Dscc1 |
DNA replication and sister chromatid cohesion 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DSCC1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212
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G |
Dse |
dermatan sulfate epimerase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DSE protein |
CTD |
PMID:24648495 |
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NCBI chr20:26,118,194...26,196,889
Ensembl chr20:26,118,196...26,196,992
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G |
Dtl |
denticleless E3 ubiquitin protein ligase homolog |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DTL mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
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G |
Dtna |
dystrobrevin, alpha |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DTNA mRNA |
CTD |
PMID:22378314 |
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NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
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G |
Dusp1 |
dual specificity phosphatase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of DUSP1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr10:16,680,478...16,683,275
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G |
Dusp26 |
dual specificity phosphatase 26 |
increases expression |
ISO |
Thapsigargin results in increased expression of DUSP26 mRNA |
CTD |
PMID:22378314 |
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NCBI chr16:61,041,784...61,049,319
Ensembl chr16:61,041,792...61,049,051
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G |
Dusp5 |
dual specificity phosphatase 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DUSP5 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of DUSP6 mRNA Thapsigargin results in decreased expression of DUSP6 mRNA |
CTD |
PMID:22378314 PMID:24247028 |
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NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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Dut |
deoxyuridine triphosphatase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DUT mRNA Thapsigargin results in decreased expression of DUT protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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G |
Dym |
dymeclin |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DYM protein |
CTD |
PMID:24648495 |
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NCBI chr18:68,605,131...68,900,905
Ensembl chr18:68,605,185...68,900,903
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G |
Dync1h1 |
dynein cytoplasmic 1 heavy chain 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of DYNC1H1 protein |
CTD |
PMID:35544339 |
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NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883
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G |
Dync1i1 |
dynein cytoplasmic 1 intermediate chain 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DYNC1I1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
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G |
Dync2i2 |
dynein 2 intermediate chain 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of DYNC2I2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:13,306,039...13,322,121
Ensembl chr 3:13,306,039...13,322,121
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G |
Dyrk4 |
dual specificity tyrosine phosphorylation regulated kinase 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of DYRK4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 4:159,715,658...159,757,660
Ensembl chr 4:159,715,417...159,757,627
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G |
E2f1 |
E2F transcription factor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of E2F1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
E2f2 |
E2F transcription factor 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of E2F2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217
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G |
E2f7 |
E2F transcription factor 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of E2F7 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734
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G |
Ears2 |
glutamyl-tRNA synthetase 2, mitochondrial |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EARS2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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G |
Ebf1 |
EBF transcription factor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EBF1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665
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G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ECH1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Edc4 |
enhancer of mRNA decapping 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of EDC4 protein |
CTD |
PMID:24648495 |
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NCBI chr19:33,774,062...33,786,054
Ensembl chr19:33,774,055...33,787,758
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G |
Edem1 |
ER degradation enhancing alpha-mannosidase like protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of EDEM1 mRNA |
CTD |
PMID:22378314 PMID:27587023 |
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NCBI chr 4:141,797,631...141,829,717
Ensembl chr 4:141,797,701...141,829,717
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G |
Eef1a1 |
eukaryotic translation elongation factor 1 alpha 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of EEF1A1 protein |
CTD |
PMID:35544339 |
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NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
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G |
Eef1a2 |
eukaryotic translation elongation factor 1 alpha 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of EEF1A2 protein |
CTD |
PMID:35544339 |
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NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
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G |
Eef1akmt1 |
EEF1A lysine methyltransferase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EEF1AKMT1 protein |
CTD |
PMID:24648495 |
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NCBI chr15:31,694,284...31,711,367
Ensembl chr15:31,694,292...31,711,336
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G |
Eef1d |
eukaryotic translation elongation factor 1 delta |
decreases expression |
EXP |
Thapsigargin results in decreased expression of EEF1D protein |
CTD |
PMID:35544339 |
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NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799
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G |
Eef2 |
eukaryotic translation elongation factor 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of EEF2 protein |
CTD |
PMID:35544339 |
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NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
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G |
Eepd1 |
endonuclease/exonuclease/phosphatase family domain containing 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EEPD1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340
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G |
Efr3a |
EFR3 homolog A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EFR3A protein |
CTD |
PMID:24648495 |
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NCBI chr 7:97,552,677...97,633,369
Ensembl chr 7:97,552,677...97,633,369
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G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein] |
CTD |
PMID:17991733 |
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NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Egfr |
epidermal growth factor receptor |
increases expression |
ISO |
Thapsigargin results in increased expression of EGFR protein |
CTD |
PMID:24648495 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of EGR1 mRNA Thapsigargin results in decreased expression of EGR1 mRNA |
CTD |
PMID:8764118 PMID:21694771 PMID:22378314 |
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NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr2 |
early growth response 2 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of EGR2 mRNA |
CTD |
PMID:20830808 |
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NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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G |
Eif1 |
eukaryotic translation initiation factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of EIF1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327 Ensembl chr 5:85,246,764...85,427,327
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G |
Eif1a |
eukaryotic translation initiation factor 1A |
increases expression |
EXP |
Thapsigargin results in increased expression of EIF1A protein |
CTD |
PMID:35544339 |
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NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions increases expression increases phosphorylation |
ISO EXP |
Doxorubicin promotes the reaction [Thapsigargin results in increased phosphorylation of EIF2A protein] Thapsigargin results in increased expression of EIF2A mRNA Thapsigargin promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:12606582 PMID:16298333 PMID:17283163 PMID:17353921 PMID:19285962 PMID:19428936 PMID:20589738 PMID:22378314 More...
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NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
increases phosphorylation multiple interactions |
ISO |
Thapsigargin results in increased phosphorylation of EIF2AK2 protein imoxin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK2 protein] |
CTD |
PMID:24150608 |
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NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions increases acetylation increases phosphorylation increases expression increases response to substance |
ISO EXP |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide promotes the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2AK3 promotes the reaction [Thapsigargin results in increased expression of HSPA5 protein]; Thapsigargin promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] Thapsigargin results in increased acetylation of EIF2AK3 protein Thapsigargin results in increased expression of EIF2AK3 mRNA; Thapsigargin results in increased expression of EIF2AK3 protein; Thapsigargin results in increased expression of EIF2AK3 protein modified form EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin inhibits the reaction [dapagliflozin inhibits the reaction [IL1B protein results in increased expression of EIF2AK3 mRNA]] 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2AK3 protein]; [Thapsigargin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein; EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]; Thapsigargin promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]; Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein EIF2AK3 gene mutant form results in increased susceptibility to Thapsigargin |
CTD |
PMID:16324875 PMID:17283163 PMID:17963750 PMID:20022965 PMID:22378314 PMID:22509299 PMID:23576437 PMID:23741617 PMID:24150608 PMID:24224909 PMID:24648495 PMID:24865413 PMID:24898257 PMID:25341683 PMID:26264395 PMID:27358234 PMID:29653943 PMID:30796460 PMID:35028790 PMID:37741535 More...
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions decreases phosphorylation increases expression increases phosphorylation decreases response to substance |
ISO EXP |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2AK3 mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein] Thapsigargin results in decreased phosphorylation of EIF2S1 protein Thapsigargin results in increased expression of EIF2S1 mRNA 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of ATF4 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of DDIT3 protein]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of PPP1R15A mRNA]; EIF2S1 protein modified form affects the reaction [Thapsigargin results in increased expression of PPP1R15A protein]; EIF2S1 protein mutant form inhibits the reaction [Thapsigargin results in decreased expression of TIMM17A protein]; EIF2S1 protein mutant form inhibits the reaction [Thapsigargin results in increased expression of IBTK mRNA alternative form]; PTPN1 gene mutant form promotes the reaction [Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2S1 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of EIF2S1 protein]]; Thapsigargin results in increased activity of and results in increased phosphorylation of EIF2S1 protein Thapsigargin results in increased expression of EIF2S1 protein modified form EIF2S1 protein mutant form results in decreased susceptibility to Thapsigargin EIF2AK3 gene mutant form inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein]; salubrinal inhibits the reaction [Thapsigargin results in increased expression of EIF2S1 mRNA]; shikonin inhibits the reaction [Thapsigargin results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:16324875 PMID:17553788 PMID:19233273 PMID:20022965 PMID:22509299 PMID:23576437 PMID:23690448 PMID:23741617 PMID:24150608 PMID:24224909 PMID:24315374 PMID:24648495 PMID:27587023 PMID:28844859 PMID:29109149 PMID:29414781 PMID:30508555 PMID:32357311 PMID:32407927 PMID:32578922 PMID:35028790 More...
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
affects expression increases expression |
ISO |
Thapsigargin affects the expression of EIF2S2 mRNA Thapsigargin results in increased expression of EIF2S2 mRNA |
CTD |
PMID:22378314 PMID:24247028 |
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NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
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G |
Eif3a |
eukaryotic translation initiation factor 3, subunit A |
increases expression |
ISO |
Thapsigargin results in increased expression of EIF3A protein |
CTD |
PMID:24648495 |
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NCBI chr 1:259,902,767...259,932,976
Ensembl chr 1:259,902,680...259,932,976
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G |
Eif3b |
eukaryotic translation initiation factor 3, subunit B |
increases expression |
EXP |
Thapsigargin results in increased expression of EIF3B protein |
CTD |
PMID:35544339 |
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NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886
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G |
Eif3d |
eukaryotic translation initiation factor 3, subunit D |
increases expression |
EXP |
Thapsigargin results in increased expression of EIF3D protein |
CTD |
PMID:35544339 |
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NCBI chr 7:109,539,795...109,552,184
Ensembl chr 7:109,539,356...109,552,206
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G |
Eif3i |
eukaryotic translation initiation factor 3, subunit I |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of EIF3I protein Thapsigargin results in increased expression of EIF3I protein |
CTD |
PMID:21692457 PMID:35544339 |
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NCBI chr 5:141,935,135...141,942,589
Ensembl chr 5:141,935,044...141,942,676
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G |
Eif4a2 |
eukaryotic translation initiation factor 4A2 |
increases expression |
EXP |
Thapsigargin results in increased expression of EIF4A2 protein |
CTD |
PMID:35544339 |
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NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
decreases expression increases expression |
ISO EXP |
Thapsigargin results in decreased expression of EIF4E mRNA; Thapsigargin results in decreased expression of EIF4E protein Thapsigargin results in increased expression of EIF4E protein |
CTD |
PMID:24648495 PMID:35544339 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of EIF4EBP1 mRNA; Thapsigargin results in increased expression of EIF4EBP1 protein |
CTD |
PMID:29453283 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Eif4h |
eukaryotic translation initiation factor 4H |
decreases expression |
EXP |
Thapsigargin results in decreased expression of EIF4H protein |
CTD |
PMID:35544339 |
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NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
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G |
Eif5 |
eukaryotic translation initiation factor 5 |
increases expression |
EXP |
Thapsigargin results in increased expression of EIF5 protein |
CTD |
PMID:35544339 |
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NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
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G |
Eif5a |
eukaryotic translation initiation factor 5A |
affects response to substance |
ISO |
EIF5A protein affects the susceptibility to Thapsigargin |
CTD |
PMID:20376341 |
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NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656
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G |
Eif5b |
eukaryotic translation initiation factor 5B |
increases expression |
ISO |
Thapsigargin results in increased expression of EIF5B protein |
CTD |
PMID:24648495 |
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NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482
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G |
Elavl1 |
ELAV like RNA binding protein 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ELAVL1 protein |
CTD |
PMID:35544339 |
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NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
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G |
Elf1 |
E74 like ETS transcription factor 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ELF1 mRNA |
CTD |
PMID:29453283 |
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NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
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G |
Elf3 |
E74 like ETS transcription factor 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ELF3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481
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G |
Elmo2 |
engulfment and cell motility 2 |
multiple interactions |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of ELMO2 mRNA] |
CTD |
PMID:19442820 |
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NCBI chr 3:154,023,661...154,061,259
Ensembl chr 3:154,023,661...154,061,185
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G |
Elovl2 |
ELOVL fatty acid elongase 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ELOVL2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:23,544,598...23,584,855
Ensembl chr17:23,544,568...23,584,848
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G |
Emc4 |
ER membrane protein complex subunit 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EMC4 protein |
CTD |
PMID:24648495 |
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NCBI chr 3:99,169,711...99,174,730
Ensembl chr 3:99,169,711...99,174,729
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G |
Emilin2 |
elastin microfibril interfacer 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of EMILIN2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 9:111,160,708...111,220,463
Ensembl chr 9:111,160,712...111,220,352
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G |
Eml2 |
EMAP like 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of EML2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341
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G |
Enc1 |
ectodermal-neural cortex 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ENC1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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G |
Endog |
endonuclease G |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ENDOG mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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G |
Enkd1 |
enkurin domain containing 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of ENKD1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr19:33,592,074...33,596,552
Ensembl chr19:33,592,078...33,596,545
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G |
Eno1 |
enolase 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ENO1 protein |
CTD |
PMID:35544339 |
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NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 Ensembl chr 3:160,719,951...160,731,336
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G |
Eno2 |
enolase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of ENO2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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G |
Eno3 |
enolase 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of ENO3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of ENPP2 mRNA Thapsigargin results in increased expression of ENPP2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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Entpd5 |
ectonucleoside triphosphate diphosphohydrolase 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ENTPD5 protein |
CTD |
PMID:24648495 |
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NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
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Eogt |
EGF domain specific O-linked N-acetylglucosamine transferase |
increases expression |
EXP |
Thapsigargin results in increased expression of EOGT protein |
CTD |
PMID:35544339 |
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NCBI chr 4:129,718,897...129,756,558
Ensembl chr 4:129,718,901...129,756,445
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Ep400 |
E1A binding protein p400 |
increases expression |
ISO |
Thapsigargin results in increased expression of EP400 protein |
CTD |
PMID:24648495 |
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NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
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Epas1 |
endothelial PAS domain protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EPAS1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Ephx4 |
epoxide hydrolase 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of EPHX4 mRNA |
CTD |
PMID:29453283 |
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NCBI chr14:2,343,376...2,372,680
Ensembl chr14:2,340,248...2,373,022
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Eprs1 |
glutamyl-prolyl-tRNA synthetase 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of EPRS1 mRNA Thapsigargin results in increased expression of EPRS1 protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
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Eps8 |
EGFR pathway substrate 8, signaling adaptor |
decreases expression |
EXP |
Thapsigargin results in decreased expression of EPS8 protein |
CTD |
PMID:35544339 |
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NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
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G |
Erap1 |
endoplasmic reticulum aminopeptidase 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ERAP1 protein |
CTD |
PMID:35544339 |
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NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
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Ercc6l |
ERCC excision repair 6 like, spindle assembly checkpoint helicase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ERCC6L mRNA |
CTD |
PMID:22378314 |
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NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756
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Erf |
Ets2 repressor factor |
multiple interactions increases expression |
ISO |
caffeic acid promotes the reaction [Thapsigargin results in increased expression of ERF mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in increased expression of ERF mRNA] |
CTD |
PMID:19442820 |
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NCBI chr 1:80,829,935...80,838,388
Ensembl chr 1:80,829,935...80,838,388
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Erlin2 |
ER lipid raft associated 2 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of ERLIN2 protein |
CTD |
PMID:35544339 |
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NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions affects splicing increases expression increases phosphorylation |
ISO EXP |
1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; [Thapsigargin co-treated with HRAS protein] results in increased expression of ERN1 protein; Apigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]] Thapsigargin affects the splicing of ERN1 mRNA Thapsigargin results in increased expression of ERN1 protein Thapsigargin results in increased expression of ERN1 mRNA; Thapsigargin results in increased expression of ERN1 protein; Thapsigargin results in increased expression of ERN1 protein modified form 1-(1-methanesulfonylpiperidin-4-yl)-3-(4-trifluoromethoxyphenyl)urea inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; 4-phenylbutyric acid inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; [Thapsigargin affects the splicing of ERN1 mRNA] which results in increased expression of ERN1 protein alternative form; BCL2L1 protein inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; demethoxycurcumin analog inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein]; EUK-134 inhibits the reaction [Thapsigargin results in increased expression of ERN1 protein]; Luteolin inhibits the reaction [Thapsigargin results in increased expression of and results in increased phosphorylation of ERN1 protein]; Thapsigargin results in increased expression of and results in increased phosphorylation of ERN1 protein |
CTD |
PMID:17963750 PMID:19139269 PMID:20493918 PMID:22378314 PMID:23576437 PMID:23885834 PMID:24224909 PMID:24638036 PMID:24898257 PMID:26264395 PMID:27587023 PMID:29414781 PMID:30796460 PMID:32407927 PMID:32535746 PMID:35033536 More...
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
increases expression multiple interactions |
EXP ISO |
Thapsigargin results in increased expression of ERO1A protein 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [Thapsigargin results in increased expression of ERO1A protein] |
CTD |
PMID:28315715 PMID:35964836 |
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NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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Ero1b |
endoplasmic reticulum oxidoreductase 1 beta |
increases expression |
ISO |
Thapsigargin results in increased expression of ERO1B mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:85,861,086...86,003,244
Ensembl chr17:85,929,618...86,003,398
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Erp44 |
endoplasmic reticulum protein 44 |
increases expression |
ISO |
Thapsigargin results in increased expression of ERP44 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761
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Esd |
esterase D |
increases expression |
EXP |
Thapsigargin results in increased expression of ESD protein |
CTD |
PMID:35544339 |
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NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144
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G |
Esf1 |
ESF1 nucleolar pre-rRNA processing protein homolog |
increases expression |
ISO |
Thapsigargin results in increased expression of ESF1 protein |
CTD |
PMID:24648495 |
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NCBI chr 3:127,454,744...127,507,941
Ensembl chr 3:127,454,811...127,507,817
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G |
Esrp1 |
epithelial splicing regulatory protein 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ESRP1 protein |
CTD |
PMID:35544339 |
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NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062
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G |
Esrrg |
estrogen-related receptor gamma |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ESRRG mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
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Esyt1 |
extended synaptotagmin 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ESYT1 protein |
CTD |
PMID:35544339 |
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NCBI chr 7:928,848...946,199
Ensembl chr 7:928,848...946,199
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G |
Etf1 |
eukaryotic translation termination factor 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of ETF1 protein |
CTD |
PMID:35544339 |
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NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810
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G |
Ethe1 |
ETHE1, persulfide dioxygenase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ETHE1 protein |
CTD |
PMID:24648495 |
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NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
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G |
Etv4 |
ETS variant transcription factor 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ETV4 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:86,706,749...86,721,974
Ensembl chr10:86,706,749...86,721,974
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G |
Etv5 |
ETS variant transcription factor 5 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of ETV5 mRNA |
CTD |
PMID:22378314 |
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NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215
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G |
Evi2a |
ecotropic viral integration site 2A |
increases expression |
ISO |
Thapsigargin results in increased expression of EVI2A mRNA |
CTD |
PMID:24247028 |
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NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
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G |
Exo1 |
exonuclease 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EXO1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654
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G |
Exoc4 |
exocyst complex component 4 |
increases expression |
ISO |
Thapsigargin results in increased expression of EXOC4 protein |
CTD |
PMID:24648495 |
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NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723
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G |
Exoc6 |
exocyst complex component 6 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of EXOC6 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015
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G |
Exosc2 |
exosome component 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EXOSC2 mRNA |
CTD |
PMID:24247028 |
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NCBI chr 3:14,962,930...14,973,645
Ensembl chr 3:14,962,917...14,973,575
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G |
Exosc7 |
exosome component 7 |
affects expression |
ISO |
Thapsigargin affects the expression of EXOSC7 mRNA |
CTD |
PMID:24247028 |
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NCBI chr 8:122,773,607...122,798,943
Ensembl chr 8:122,773,591...122,799,270
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G |
Ext2 |
exostosin glycosyltransferase 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EXT2 protein |
CTD |
PMID:24648495 |
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NCBI chr 3:79,665,414...79,798,077
Ensembl chr 3:79,665,415...79,798,059
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G |
Eya1 |
EYA transcriptional coactivator and phosphatase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of EYA1 protein |
CTD |
PMID:24648495 |
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NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483
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G |
F2rl1 |
F2R like trypsin receptor 1 |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of F2RL1 protein Thapsigargin results in increased expression of F2RL1 mRNA |
CTD |
PMID:24648495 PMID:29453283 |
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NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
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G |
Faah |
fatty acid amide hydrolase |
increases expression |
EXP |
Thapsigargin results in increased expression of FAAH protein |
CTD |
PMID:35544339 |
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NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
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G |
Fads1 |
fatty acid desaturase 1 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of FADS1 mRNA Thapsigargin results in increased expression of FADS1 protein |
CTD |
PMID:29453283 PMID:35544339 |
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NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
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G |
Fads2 |
fatty acid desaturase 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of FADS2 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
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G |
Fads3 |
fatty acid desaturase 3 |
increases expression |
ISO |
Thapsigargin results in increased expression of FADS3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:206,685,667...206,702,538
Ensembl chr 1:206,685,894...206,704,769
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G |
Fam107b |
family with sequence similarity 107, member B |
increases expression decreases expression |
ISO |
Thapsigargin results in increased expression of FAM107B mRNA Thapsigargin results in decreased expression of FAM107B protein |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr17:74,478,608...74,685,027
Ensembl chr17:74,478,608...74,684,989
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G |
Fam118b |
family with sequence similarity 118, member B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FAM118B protein |
CTD |
PMID:24648495 |
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NCBI chr 8:33,566,681...33,617,310
Ensembl chr 8:33,566,669...33,617,270
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Fam120a |
family with sequence similarity 120 member A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FAM120A protein |
CTD |
PMID:24648495 |
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NCBI chr17:15,684,233...15,774,964
Ensembl chr17:15,684,233...15,774,964
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G |
Fam120c |
family with sequence similarity 120 member C |
increases expression |
ISO |
Thapsigargin results in increased expression of FAM120C protein |
CTD |
PMID:24648495 |
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NCBI chr X:20,324,046...20,477,831
Ensembl chr X:20,323,381...20,477,275
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G |
Fam13b |
family with sequence similarity 13, member B |
increases expression |
ISO |
Thapsigargin results in increased expression of FAM13B mRNA |
CTD |
PMID:29453283 |
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NCBI chr18:26,040,285...26,107,112
Ensembl chr18:26,040,285...26,106,587
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G |
Fam174b |
family with sequence similarity 174, member B |
increases expression |
ISO |
Thapsigargin results in increased expression of FAM174B mRNA |
CTD |
PMID:29453283 |
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NCBI chr 1:127,515,393...127,618,591
Ensembl chr 1:127,514,041...127,596,128 Ensembl chr 1:127,514,041...127,596,128
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Fam193a |
family with sequence similarity 193, member A |
increases expression |
ISO |
Thapsigargin results in increased expression of FAM193A protein |
CTD |
PMID:24648495 |
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NCBI chr14:76,250,103...76,382,525
Ensembl chr14:76,256,161...76,382,514
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G |
Fam234a |
family with sequence similarity 234, member A |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FAM234A protein |
CTD |
PMID:24648495 |
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NCBI chr10:15,232,267...15,263,529
Ensembl chr10:15,232,278...15,263,488
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G |
Fam234b |
family with sequence similarity 234, member B |
decreases expression |
EXP |
Thapsigargin results in decreased expression of FAM234B protein |
CTD |
PMID:35544339 |
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NCBI chr 4:168,048,313...168,124,017
Ensembl chr 4:168,048,396...168,097,338
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G |
Fam24b |
family with sequence similarity 24 member B |
increases expression |
ISO |
Thapsigargin results in increased expression of FAM24B mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr 1:186,112,544...186,115,957
Ensembl chr 1:186,112,551...186,115,899
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G |
Fam3c |
FAM3 metabolism regulating signaling molecule C |
increases expression |
EXP |
Thapsigargin results in increased expression of FAM3C protein |
CTD |
PMID:35544339 |
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NCBI chr 4:50,839,929...50,887,276
Ensembl chr 4:50,838,818...50,888,078
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G |
Fam83d |
family with sequence similarity 83, member D |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FAM83D mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192
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G |
Fanci |
FA complementation group I |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FANCI mRNA |
CTD |
PMID:22378314 |
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NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
Thapsigargin results in increased expression of FAS mRNA |
CTD |
PMID:33770205 |
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NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
increases expression |
EXP |
Thapsigargin results in increased expression of FASN protein |
CTD |
PMID:35544339 |
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbn2 |
fibrillin 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of FBN2 mRNA |
CTD |
PMID:29453283 |
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NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976
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G |
Fbp1 |
fructose-bisphosphatase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FBP1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
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G |
Fbxo32 |
F-box protein 32 |
increases expression |
ISO |
Thapsigargin results in increased expression of FBXO32 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FDFT1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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G |
Fdps |
farnesyl diphosphate synthase |
increases expression |
EXP |
Thapsigargin results in increased expression of FDPS protein |
CTD |
PMID:35544339 |
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NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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G |
Fdxr |
ferredoxin reductase |
increases expression |
ISO |
Thapsigargin results in increased expression of FDXR mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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G |
Fen1 |
flap structure-specific endonuclease 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of FEN1 protein |
CTD |
PMID:35544339 |
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NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003
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G |
Fgf13 |
fibroblast growth factor 13 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FGF13 mRNA |
CTD |
PMID:19442820 |
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NCBI chr X:137,276,498...137,800,056
Ensembl chr X:137,276,511...137,800,391
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions increases expression increases secretion |
ISO EXP |
indolo(3,2-b)carbazole inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]; N-(2-(3H-indol-3-yl)ethyl)-9-isopropyl-2-(5-methyl-3-pyridyl)purin-6-amine inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA]]; Tetrachlorodibenzodioxin inhibits the reaction [Thapsigargin results in increased expression of FGF21 mRNA] Thapsigargin results in increased secretion of FGF21 protein |
CTD |
PMID:23123503 PMID:27226639 |
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NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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Fggy |
FGGY carbohydrate kinase domain containing |
increases expression |
ISO |
Thapsigargin results in increased expression of FGGY mRNA |
CTD |
PMID:22378314 |
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NCBI chr 5:110,398,866...110,786,019
Ensembl chr 5:110,398,863...110,786,017
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Fh |
fumarate hydratase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FH mRNA |
CTD |
PMID:22378314 |
|
NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
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G |
Ficd |
FIC domain protein adenylyltransferase |
increases expression |
ISO |
Thapsigargin results in increased expression of FICD mRNA |
CTD |
PMID:22378314 |
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NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
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G |
Fignl1 |
fidgetin-like 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FIGNL1 mRNA |
CTD |
PMID:22378314 |
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NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455
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G |
Filip1l |
filamin A interacting protein 1-like |
increases expression |
ISO |
Thapsigargin results in increased expression of FILIP1L protein |
CTD |
PMID:24648495 |
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NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
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G |
Fis1 |
fission, mitochondrial 1 |
increases expression |
ISO |
Thapsigargin results in increased expression of FIS1 mRNA |
CTD |
PMID:28940366 |
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NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Fjx1 |
four-jointed box kinase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FJX1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:88,774,220...88,776,321
Ensembl chr 3:88,774,220...88,776,321
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|
G |
Fkbp11 |
FKBP prolyl isomerase 11 |
increases expression |
ISO |
Thapsigargin results in increased expression of FKBP11 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
|
NCBI chr 7:129,871,870...129,877,760
Ensembl chr 7:129,871,870...129,875,303
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|
G |
Fkbp3 |
FKBP prolyl isomerase 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FKBP3 protein |
CTD |
PMID:24648495 |
|
NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011
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|
G |
Flii |
FLII, actin remodeling protein |
increases expression |
ISO |
Thapsigargin results in increased expression of FLII protein |
CTD |
PMID:24648495 |
|
NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970
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|
G |
Flot2 |
flotillin 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FLOT2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
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|
G |
Flrt2 |
fibronectin leucine rich transmembrane protein 2 |
decreases expression multiple interactions |
ISO |
Thapsigargin results in decreased expression of FLRT2 mRNA 4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of FLRT2 mRNA] |
CTD |
PMID:19442820 |
|
NCBI chr 6:114,777,547...114,872,688
Ensembl chr 6:114,777,599...114,872,785
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|
G |
Flt4 |
Fms related receptor tyrosine kinase 4 |
multiple interactions |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of FLT4 mRNA] |
CTD |
PMID:19442820 |
|
NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
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|
G |
Fmr1 |
fragile X messenger ribonucleoprotein 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of FMR1 protein |
CTD |
PMID:35544339 |
|
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
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|
G |
Fn1 |
fibronectin 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of FN1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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|
G |
Fnbp1l |
formin binding protein 1-like |
decreases expression |
EXP |
Thapsigargin results in decreased expression of FNBP1L protein |
CTD |
PMID:35544339 |
|
NCBI chr 2:210,647,241...210,748,203
Ensembl chr 2:210,647,246...210,738,455
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|
G |
Fndc3b |
fibronectin type III domain containing 3B |
increases expression |
ISO |
Thapsigargin results in increased expression of FNDC3B mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
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|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Thapsigargin results in increased expression of FOS mRNA |
CTD |
PMID:21694771 PMID:29453283 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Thapsigargin results in increased expression of FOSB mRNA |
CTD |
PMID:21694771 PMID:29453283 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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|
G |
Foxd2 |
forkhead box D2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FOXD2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 5:128,427,986...128,430,709
Ensembl chr 5:128,429,020...128,430,504
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|
G |
Foxo4 |
forkhead box O4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FOXO4 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
|
|
G |
Fubp1 |
far upstream element binding protein 1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of FUBP1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602
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|
G |
Fundc2 |
FUN14 domain containing 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FUNDC2 protein |
CTD |
PMID:24648495 |
|
NCBI chr18:128,473...138,232
Ensembl chr18:132,248...138,345
|
|
G |
Fyb1 |
FYN binding protein 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of FYB1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629
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|
G |
Fzd7 |
frizzled class receptor 7 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of FZD7 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
|
|
G |
G3bp1 |
G3BP stress granule assembly factor 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of G3BP1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr10:39,586,864...39,620,268
Ensembl chr10:39,586,864...39,620,268
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|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression |
EXP |
Thapsigargin results in increased expression of G6PD protein |
CTD |
PMID:35544339 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gabbr1 |
gamma-aminobutyric acid type B receptor subunit 1 |
affects localization |
EXP |
Thapsigargin affects the localization of GABBR1 protein |
CTD |
PMID:24668805 |
|
NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
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|
G |
Gabbr2 |
gamma-aminobutyric acid type B receptor subunit 2 |
affects localization |
EXP |
Thapsigargin affects the localization of GABBR2 protein |
CTD |
PMID:24668805 |
|
NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
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|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO |
Thapsigargin results in increased expression of GADD45A mRNA |
CTD |
PMID:17332266 PMID:29453283 PMID:33770205 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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|
G |
Gadd45b |
growth arrest and DNA-damage-inducible, beta |
increases expression |
ISO |
Thapsigargin results in increased expression of GADD45B mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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|
G |
Gadd45g |
growth arrest and DNA-damage-inducible, gamma |
increases expression |
ISO |
Thapsigargin results in increased expression of GADD45G mRNA |
CTD |
PMID:29453283 |
|
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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|
G |
Gal |
galanin and GMAP prepropeptide |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GAL mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
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|
G |
Galk2 |
galactokinase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of GALK2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 3:113,110,057...113,243,014
Ensembl chr 3:113,110,030...113,233,306
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|
G |
Galnt7 |
polypeptide N-acetylgalactosaminyltransferase 7 |
increases expression |
EXP |
Thapsigargin results in increased expression of GALNT7 protein |
CTD |
PMID:35544339 |
|
NCBI chr16:32,578,643...32,703,189
Ensembl chr16:32,578,690...32,702,690
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|
G |
Galr2 |
galanin receptor 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of GALR2 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176
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|
G |
Ganab |
glucosidase II alpha subunit |
increases expression |
ISO |
Thapsigargin results in increased expression of GANAB mRNA Thapsigargin results in increased expression of GANAB protein |
CTD |
PMID:22378314 PMID:24648495 |
|
NCBI chr 1:205,793,910...205,813,704
Ensembl chr 1:205,793,895...205,813,695
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|
G |
Gap43 |
growth associated protein 43 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GAP43 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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|
G |
Gapdh |
glyceraldehyde-3-phosphate dehydrogenase |
increases expression |
EXP |
Thapsigargin results in increased expression of GAPDH protein |
CTD |
PMID:35544339 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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|
G |
Gars1 |
glycyl-tRNA synthetase 1 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of GARS1 mRNA; Thapsigargin results in increased expression of GARS1 protein |
CTD |
PMID:22378314 PMID:29453283 PMID:35544339 |
|
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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|
G |
Gas1 |
growth arrest-specific 1 |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of GAS1 protein Thapsigargin results in increased expression of GAS1 mRNA |
CTD |
PMID:24648495 PMID:29453283 |
|
NCBI chr17:4,482,168...4,485,153
|
|
G |
Gata2 |
GATA binding protein 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GATA2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
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|
G |
Gc |
GC, vitamin D binding protein |
increases expression |
EXP |
Thapsigargin results in increased expression of GC protein |
CTD |
PMID:35544339 |
|
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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|
G |
Gcat |
glycine C-acetyltransferase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GCAT mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 7:110,595,126...110,601,474
Ensembl chr 7:110,595,091...110,601,473
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|
G |
Gcdh |
glutaryl-CoA dehydrogenase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GCDH mRNA |
CTD |
PMID:22378314 |
|
NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681
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|
G |
Gck |
glucokinase |
increases expression |
EXP |
Thapsigargin results in increased expression of GCK protein |
CTD |
PMID:35544339 |
|
NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
|
|
G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
EXP |
Thapsigargin results in increased expression of GCLC protein |
CTD |
PMID:35544339 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G |
Gde1 |
glycerophosphodiester phosphodiesterase 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of GDE1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429
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|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
Thapsigargin results in increased expression of GDF15 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
|
|
G |
Gdi1 |
GDP dissociation inhibitor 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of GDI1 protein |
CTD |
PMID:35544339 |
|
NCBI chr X:152,087,611...152,094,274
Ensembl chr X:152,087,444...152,094,272
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|
G |
Gdi2 |
GDP dissociation inhibitor 2 |
increases expression |
EXP |
Thapsigargin results in increased expression of GDI2 protein |
CTD |
PMID:35544339 |
|
NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366
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|
G |
Gem |
GTP binding protein overexpressed in skeletal muscle |
increases expression |
ISO |
Thapsigargin results in increased expression of GEM mRNA |
CTD |
PMID:21694771 PMID:29453283 |
|
NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
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|
G |
Gemin4 |
gem (nuclear organelle) associated protein 4 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GEMIN4 mRNA |
CTD |
PMID:24247028 |
|
NCBI chr10:61,062,420...61,073,529
Ensembl chr10:61,066,425...61,073,431 Ensembl chr10:61,066,425...61,073,431
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|
G |
Gemin5 |
gem (nuclear organelle) associated protein 5 |
increases expression |
ISO |
Thapsigargin results in increased expression of GEMIN5 protein |
CTD |
PMID:24648495 |
|
NCBI chr10:42,295,729...42,342,902
Ensembl chr10:42,297,515...42,342,892
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|
G |
Get3 |
guided entry of tail-anchored proteins factor 3, ATPase |
increases expression |
EXP |
Thapsigargin results in increased expression of GET3 protein |
CTD |
PMID:35544339 |
|
NCBI chr19:23,130,109...23,138,196
Ensembl chr19:23,130,109...23,138,193
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|
G |
Gfm1 |
G elongation factor, mitochondrial 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GFM1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471
|
|
G |
Gfpt1 |
glutamine fructose-6-phosphate transaminase 1 |
increases expression |
ISO EXP |
Thapsigargin results in increased expression of GFPT1 mRNA Thapsigargin results in increased expression of GFPT1 protein |
CTD |
PMID:22378314 PMID:29453283 PMID:35544339 |
|
NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471
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|
G |
Ggct |
gamma-glutamyl cyclotransferase |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GGCT protein |
CTD |
PMID:24648495 |
|
NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277
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|
G |
Ggt7 |
gamma-glutamyltransferase 7 |
increases expression |
EXP |
Thapsigargin results in increased expression of GGT7 protein |
CTD |
PMID:35544339 |
|
NCBI chr 3:143,978,073...144,004,597
Ensembl chr 3:143,978,082...144,001,492
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|
G |
Gins2 |
GINS complex subunit 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GINS2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339
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|
G |
Gipc2 |
GIPC PDZ domain containing family, member 2 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of GIPC2 protein |
CTD |
PMID:35544339 |
|
NCBI chr 2:241,030,764...241,110,236
Ensembl chr 2:241,030,770...241,110,236
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|
G |
Gla |
galactosidase, alpha |
increases expression |
ISO |
Thapsigargin results in increased expression of GLA mRNA |
CTD |
PMID:29453283 |
|
NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664
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|
G |
Gldc |
glycine decarboxylase |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of GLDC mRNA Thapsigargin results in increased expression of GLDC mRNA |
CTD |
PMID:22378314 PMID:33770205 |
|
NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097
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|
G |
Glg1 |
golgi glycoprotein 1 |
increases expression decreases expression |
ISO EXP |
Thapsigargin results in increased expression of GLG1 protein Thapsigargin results in decreased expression of GLG1 protein |
CTD |
PMID:24648495 PMID:35544339 |
|
NCBI chr19:39,124,892...39,224,178
Ensembl chr19:39,124,641...39,224,178
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|
G |
Glo1 |
glyoxalase 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GLO1 protein |
CTD |
PMID:24648495 |
|
NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649
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|
G |
Glrx3 |
glutaredoxin 3 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GLRX3 protein |
CTD |
PMID:24648495 |
|
NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
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|
G |
Gls |
glutaminase |
increases expression decreases expression |
ISO EXP |
Thapsigargin results in increased expression of GLS mRNA Thapsigargin results in decreased expression of GLS protein |
CTD |
PMID:22378314 PMID:29453283 PMID:35544339 |
|
NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
|
|
G |
Glul |
glutamate-ammonia ligase |
decreases expression |
EXP |
Thapsigargin results in decreased expression of GLUL protein |
CTD |
PMID:35544339 |
|
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
|
|
G |
Glyr1 |
glyoxylate reductase 1 homolog |
decreases expression |
EXP |
Thapsigargin results in decreased expression of GLYR1 protein |
CTD |
PMID:35544339 |
|
NCBI chr10:10,532,036...10,567,639
Ensembl chr10:10,532,154...10,567,637
|
|
G |
Gmeb1 |
glucocorticoid modulatory element binding protein 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GMEB1 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 5:144,421,151...144,462,448
Ensembl chr 5:144,420,555...144,462,602
|
|
G |
Gmnn |
geminin, DNA replication inhibitor |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GMNN mRNA |
CTD |
PMID:22378314 |
|
NCBI chr17:40,301,771...40,310,054
Ensembl chr17:40,301,808...40,310,054
|
|
G |
Gmppa |
GDP-mannose pyrophosphorylase A |
increases expression |
ISO |
Thapsigargin results in increased expression of GMPPA mRNA |
CTD |
PMID:22378314 |
|
NCBI chr 9:76,926,724...76,934,274
Ensembl chr 9:76,926,739...76,934,269
|
|
G |
Gnai3 |
G protein subunit alpha i3 |
increases expression |
EXP |
Thapsigargin results in increased expression of GNAI3 protein |
CTD |
PMID:35544339 |
|
NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
|
|
G |
Gnao1 |
G protein subunit alpha o1 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of GNAO1 protein |
CTD |
PMID:35544339 |
|
NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493
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|
G |
Gnas |
GNAS complex locus |
increases expression |
EXP |
Thapsigargin results in increased expression of GNAS protein |
CTD |
PMID:35544339 |
|
NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
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|
G |
Gnb1 |
G protein subunit beta 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of GNB1 protein |
CTD |
PMID:35544339 |
|
NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124
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|
G |
Gng12 |
G protein subunit gamma 12 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GNG12 mRNA |
CTD |
PMID:29453283 |
|
NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
|
|
G |
Gng2 |
G protein subunit gamma 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GNG2 mRNA |
CTD |
PMID:22378314 |
|
NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183
|
|
G |
Gnl3l |
G protein nucleolar 3 like |
increases expression |
ISO |
Thapsigargin results in increased expression of GNL3L mRNA |
CTD |
PMID:22378314 |
|
NCBI chr X:19,961,277...19,994,454
Ensembl chr X:19,958,603...19,994,508
|
|
G |
Golga2 |
golgin A2 |
increases expression |
ISO |
Thapsigargin results in increased expression of GOLGA2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
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G |
Golga3 |
golgin A3 |
increases expression |
ISO |
Thapsigargin results in increased expression of GOLGA3 mRNA |
CTD |
PMID:22378314 |
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NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509 Ensembl chr 4:46,454,870...46,500,509
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G |
Golga5 |
golgin A5 |
increases expression decreases expression |
ISO EXP |
Thapsigargin results in increased expression of GOLGA5 mRNA Thapsigargin results in decreased expression of GOLGA5 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr 6:121,612,389...121,640,552
Ensembl chr 6:121,612,529...121,640,413
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G |
Golim4 |
golgi integral membrane protein 4 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of GOLIM4 protein |
CTD |
PMID:35544339 |
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NCBI chr 2:160,640,837...160,733,475
Ensembl chr 2:160,640,938...160,733,253
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G |
Gosr1 |
golgi SNAP receptor complex member 1 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GOSR1 mRNA |
CTD |
PMID:19442820 |
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NCBI chr10:61,570,499...61,607,287
Ensembl chr10:61,450,494...61,607,177 Ensembl chr10:61,450,494...61,607,177
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G |
Got2 |
glutamic-oxaloacetic transaminase 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GOT2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
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G |
Gpd1 |
glycerol-3-phosphate dehydrogenase 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of GPD1 protein |
CTD |
PMID:35544339 |
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NCBI chr 7:130,842,526...130,851,530
Ensembl chr 7:130,844,138...130,851,529
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G |
Gpd2 |
glycerol-3-phosphate dehydrogenase 2 |
increases expression decreases expression |
ISO EXP |
Thapsigargin results in increased expression of GPD2 protein Thapsigargin results in decreased expression of GPD2 protein |
CTD |
PMID:24648495 PMID:35544339 |
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NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901
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G |
Gpi |
glucose-6-phosphate isomerase |
increases expression |
EXP |
Thapsigargin results in increased expression of GPI protein |
CTD |
PMID:35544339 |
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NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
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G |
Gpr137b |
G protein-coupled receptor 137B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GPR137B mRNA |
CTD |
PMID:29453283 |
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NCBI chr17:86,003,635...86,041,841
Ensembl chr17:85,966,921...86,041,835
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G |
Gpr22 |
G protein-coupled receptor 22 |
increases expression |
ISO |
Thapsigargin results in increased expression of GPR22 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 6:48,309,619...48,317,864
Ensembl chr 6:48,310,505...48,317,486
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G |
Gprc5b |
G protein-coupled receptor, class C, group 5, member B |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GPRC5B protein |
CTD |
PMID:24648495 |
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NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932
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G |
Gps2 |
G protein pathway suppressor 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of GPS2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
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G |
Gpsm2 |
G-protein signaling modulator 2 |
decreases expression |
ISO |
Thapsigargin results in decreased expression of GPSM2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr 2:196,327,149...196,375,322
Ensembl chr 2:196,327,149...196,375,154
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G |
Gpt2 |
glutamic--pyruvic transaminase 2 |
increases expression |
ISO |
Thapsigargin results in increased expression of GPT2 mRNA |
CTD |
PMID:22378314 PMID:29453283 |
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NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610
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G |
Gpx4 |
glutathione peroxidase 4 |
increases expression |
EXP |
Thapsigargin results in increased expression of GPX4 protein |
CTD |
PMID:35544339 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G |
Gpx8 |
glutathione peroxidase 8 |
increases expression |
ISO |
Thapsigargin results in increased expression of GPX8 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 2:44,676,448...44,680,042
Ensembl chr 2:44,676,454...44,680,195
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G |
Grcc10 |
gene rich cluster, C10 gene |
increases expression |
ISO |
Thapsigargin results in increased expression of C12ORF57 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 4:157,551,276...157,552,924
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G |
Grpel1 |
GrpE-like 1, mitochondrial |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of GRPEL1 mRNA Thapsigargin results in decreased expression of GRPEL1 protein |
CTD |
PMID:22378314 PMID:35544339 |
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NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
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G |
Grpel2 |
GrpE-like 2, mitochondrial |
increases expression |
ISO |
Thapsigargin results in increased expression of GRPEL2 mRNA |
CTD |
PMID:22378314 |
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NCBI chr18:55,167,831...55,180,073
Ensembl chr18:55,168,209...55,180,180
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G |
Gsdmd |
gasdermin D |
increases expression |
ISO |
Thapsigargin results in increased expression of GSDMD mRNA |
CTD |
PMID:30796460 |
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NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G |
Gsn |
gelsolin |
increases expression |
EXP |
Thapsigargin results in increased expression of GSN protein |
CTD |
PMID:35544339 |
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NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions decreases expression |
ISO |
4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]; caffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]; Drugs, Chinese Herbal promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA] |
CTD |
PMID:19442820 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gtf2i |
general transcription factor II I |
decreases expression |
EXP |
Thapsigargin results in decreased expression of GTF2I protein |
CTD |
PMID:35544339 |
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NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243
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G |
H1f0 |
H1.0 linker histone |
decreases expression |
EXP |
Thapsigargin results in decreased expression of H1F0 protein |
CTD |
PMID:35544339 |
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NCBI chr 7:110,592,834...110,594,694
Ensembl chr 7:110,592,208...110,594,694
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G |
H1f1 |
H1.1 linker histone, cluster member |
decreases expression |
EXP |
Thapsigargin results in decreased expression of H1F1 protein |
CTD |
PMID:35544339 |
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NCBI chr17:41,366,268...41,367,011
Ensembl chr17:41,366,268...41,367,011
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G |
H1f2 |
H1.2 linker histone, cluster member |
decreases expression increases expression |
ISO |
Thapsigargin results in decreased expression of H1F2 protein Thapsigargin results in increased expression of H1-2 mRNA |
CTD |
PMID:22378314 PMID:24648495 |
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NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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G |
H1f4 |
H1.4 linker histone, cluster member |
decreases expression |
ISO EXP |
Thapsigargin results in decreased expression of H1F4 protein |
CTD |
PMID:24648495 PMID:35544339 |
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NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
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G |
H2ac18 |
H2A clustered histone 18 |
increases expression |
ISO |
Thapsigargin results in increased expression of H2AC18 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 2:183,808,398...183,808,992
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G |
H2ac20 |
H2A clustered histone 20 |
increases expression |
ISO |
Thapsigargin results in increased expression of H2AC20 mRNA |
CTD |
PMID:29453283 |
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NCBI chr 2:183,779,879...183,780,357
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G |
H2ac25 |
H2A clustered histone 25 |
increases expression |
ISO |
Thapsigargin results in increased expression of H2AC25 mRNA |
CTD |
PMID:22378314 |
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NCBI chr10:43,733,702...43,735,254
Ensembl chr10:43,733,668...43,744,874
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G |
H2ax |
H2A.X variant histone |
increases expression decreases phosphorylation |
ISO |
Thapsigargin results in increased expression of H2AX mRNA Thapsigargin results in decreased phosphorylation of H2AX protein |
CTD |
PMID:19442820 PMID:32482060 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G |
H4c14 |
H4 clustered histone 14 |
decreases expression |
EXP |
Thapsigargin results in decreased expression of H4C2 protein |
CTD |
PMID:35544339 |
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NCBI chr 2:183,831,601...183,831,996
Ensembl chr 2:183,825,994...183,832,048
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G |
Hacl1 |
2-hydroxyacyl-CoA lyase 1 |
increases expression |
EXP |
Thapsigargin results in increased expression of HACL1 protein |
CTD |
PMID:35544339 |
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NCBI chr16:6,826,881...6,863,027
Ensembl chr16:6,824,906...6,863,027
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G |
Hadh |
hydroxyacyl-CoA dehydrogenase |
decreases expression |
EXP |
Thapsigargin results in decreased expression of HADH protein |
CTD |
PMID:35544339 |
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NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
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G |
Hadha |
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
increases expression |
ISO |
Thapsigargin results in increased expression of HADHA protein |
CTD |
PMID:24648495 |
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