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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dinaciclib
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Accession:CHEBI:95060 term browser browse the term
Definition:A pyrazolopyrimidine that is pyrazolo[1,5-a]pyrimidine substituted by ethyl, (2S)-2-(2-hydroxyethyl)piperidin-1-yl, and [(1-oxidopyridin-3-yl)methyl]amino groups at positions 3, 5, and 7, respectively. It is a potent pan-cyclin dependent kinase inhibitor that exhibits antineoplastic activity.
Synonyms:exact_synonym: 2-[(2S)-1-(3-ethyl-7-{[(1-oxidopyridin-3-yl)methyl]amino}pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-2-yl]ethanol
 related_synonym: (2S)-1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol;   2-[(2S)-1-[3-ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol;   Formula=C21H28N6O2;   InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1;   InChIKey=PIMQWRZWLQKKBJ-SFHVURJKSA-N;   MK-7965;   MK7965;   SCH 727965;   SCH727965;   SMILES=CCC1=C2N=C(C=C(NCC3=C[N+]([O-])=CC=C3)N2N=C1)N1CCCC[C@H]1CCO;   dinaciclibum
 xref: CAS:779353-01-4;   DrugBank:DB12021;   KEGG:D09604;   LINCS:LSM-6306
 xref_mesh: MESH:C553669
 xref: PDBeChem:1QK;   PMID:20663931;   PMID:21490307;   PMID:22315240;   PMID:23949430;   PMID:24007471;   PMID:24388167;   PMID:24393852;   PMID:24568369;   PMID:24900195;   PMID:25947565;   PMID:26018905;   PMID:27496135;   PMID:30472117;   PMID:31207099;   PMID:32269732;   PMID:32944844;   PMID:34972202;   PMID:35170591;   PMID:35884614;   PMID:36505806;   PMID:36586018;   PMID:36700399;   PMID:36979907;   PMID:37104883;   PMID:37270540;   PMID:37694833;   PMID:37703185;   PMID:37704591;   PMID:38135130;   PMID:38254859;   PMID:38438856;   PMID:38474332;   PMID:38480681;   PMID:38545471;   PMID:38685605;   PMID:38786326;   PMID:38845263;   Wikipedia:Dinaciclib


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dinaciclib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO dinaciclib binds to and results in decreased activity of AKR1C3 protein; dinaciclib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin] CTD PMID:29992508 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO dinaciclib results in decreased expression of BRCA1 mRNA; dinaciclib results in decreased expression of BRCA1 protein CTD PMID:27880910 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression ISO dinaciclib results in decreased expression of BRCA2 protein CTD PMID:27880910 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [dinaciclib results in increased susceptibility to Doxorubicin] which results in increased cleavage of CASP3 protein; dinaciclib promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein] CTD PMID:27378523 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccna1 cyclin A1 decreases expression ISO dinaciclib results in decreased expression of CCNA1 protein CTD PMID:38135130 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO dinaciclib results in decreased expression of CCND1 protein CTD PMID:38135130 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO dinaciclib results in decreased expression of CDK1 protein CTD PMID:38135130 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk12 cyclin-dependent kinase 12 decreases activity ISO dinaciclib results in decreased activity of CDK12 protein CTD PMID:27880910 NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
Ensembl chr10:83,201,211...83,280,888 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity ISO dinaciclib results in decreased activity of CDK2 protein CTD PMID:27378523 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO dinaciclib results in decreased expression of CDK4 protein CTD PMID:38135130 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO dinaciclib results in decreased expression of CDK6 protein CTD PMID:38135130 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdk9 cyclin-dependent kinase 9 decreases activity ISO dinaciclib results in decreased activity of CDK9 protein CTD PMID:27378523 PMID:27880910 NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410 		JBrowse link
G Fancd2 FA complementation group D2 decreases expression ISO dinaciclib results in decreased expression of FANCD2 protein CTD PMID:27880910 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation ISO dinaciclib affects the phosphorylation of MAPK1 protein CTD PMID:38135130 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation ISO dinaciclib affects the phosphorylation of MAPK3 protein CTD PMID:38135130 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects expression ISO dinaciclib affects the expression of MYC protein CTD PMID:38135130 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO dinaciclib results in increased cleavage of PARP1 protein
[dinaciclib results in increased susceptibility to Doxorubicin] which results in increased cleavage of PARP1 protein; dinaciclib promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]		 CTD PMID:20663931 PMID:27378523 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO dinaciclib results in decreased expression of RAD51 protein CTD PMID:27880910 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO dinaciclib results in decreased phosphorylation of RB1 protein CTD PMID:20663931 PMID:27378523 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO dinaciclib results in decreased phosphorylation of STAT3 protein CTD PMID:38135130 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        biochemical role 19582
          apoptosis inducer 13663
            dinaciclib 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        tertiary amino compound 10155
                                          dinaciclib 20
paths to the root