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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-[(2,3,4-trimethoxyphenyl)methyl]piperazine
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Accession:CHEBI:94789 term browser browse the term
Definition:An aromatic amine that has formula C14H22N2O3.
Synonyms:related_synonym: Formula=C14H22N2O3;   InChI=1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3;   InChIKey=UHWVSEOVJBQKBE-UHFFFAOYSA-N;   SMILES=COC1=C(C(=C(C=C1)CN2CCNCC2)OC)OC;   trimetazidine HCl;   trimetazidine dihydrochloride;   trimetazidine hydrochloride;   vastarel
 xref: CAS:5011-34-7;   Drug_Central:2750;   LINCS:LSM-5938
 xref_mesh: MESH:D014292


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1-[(2,3,4-trimethoxyphenyl)methyl]piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP Trimetazidine promotes the reaction [Oxygen deficiency results in decreased expression of ACADM mRNA] CTD PMID:25937560 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Trimetazidine promotes the reaction [Oxygen deficiency results in decreased expression of ACHE mRNA] CTD PMID:25937560 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Trimetazidine results in decreased phosphorylation of AKT1 protein CTD PMID:37591408 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions ISO Trimetazidine inhibits the reaction [Folic Acid results in decreased expression of ALB protein] CTD PMID:35191561 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of ATF3 protein] CTD PMID:35662665 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of ATP2A2 mRNA] CTD PMID:25937560 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Trimetazidine inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]
Trimetazidine inhibits the reaction [Folic Acid results in increased expression of BAX protein]		 CTD PMID:25937560 PMID:33704910 PMID:35191561 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]
Trimetazidine inhibits the reaction [Folic Acid results in decreased expression of BCL2 protein]		 CTD PMID:25937560 PMID:35191561 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]]; Trimetazidine inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 mRNA]; Trimetazidine inhibits the reaction [Paclitaxel results in increased activity of CASP3 protein]
Trimetazidine inhibits the reaction [Folic Acid results in increased expression of CASP3 protein]		 CTD PMID:25937560 PMID:35191561 PMID:35662665 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Trimetazidine inhibits the reaction [Doxorubicin results in decreased expression of CAT protein] CTD PMID:33704910 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Grn granulin precursor multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of GRN mRNA]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of GRN mRNA] CTD PMID:35662665 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Trimetazidine promotes the reaction [Folic Acid results in increased expression of HIF1A protein] CTD PMID:35191561 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Trimetazidine promotes the reaction [Folic Acid results in increased expression of HMOX1 protein] CTD PMID:35191561 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of IL10 protein] CTD PMID:36898573 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Trimetazidine inhibits the reaction [Folic Acid results in increased expression of IL18 protein] CTD PMID:35191561 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]
Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]		 CTD PMID:33704910 PMID:36898573 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il20 interleukin 20 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of IL20 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of IL20 protein] CTD PMID:35662665 NCBI chr13:42,380,981...42,384,625
Ensembl chr13:42,380,981...42,384,625 		JBrowse link
G Kl Klotho multiple interactions ISO Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of KL protein] CTD PMID:36898573 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Trimetazidine results in decreased expression of LDHA mRNA CTD PMID:37591408 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK1 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK1 protein] CTD PMID:35662665 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Trimetazidine inhibits the reaction [Paclitaxel results in increased phosphorylation of MAPK14 protein] CTD PMID:36898573 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK3 protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased phosphorylation of MAPK3 protein] CTD PMID:35662665 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of MMP9 protein] CTD PMID:36898573 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of MPO protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of MPO protein]
Trimetazidine inhibits the reaction [Folic Acid results in increased expression of MPO protein]		 CTD PMID:35191561 PMID:35662665 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Trimetazidine results in decreased expression of MYC protein CTD PMID:37591408 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in increased expression of MYH7 mRNA] CTD PMID:25937560 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nefl neurofilament light chain multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of NEFL protein]]; Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of NEFL protein] CTD PMID:35662665 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793 		JBrowse link
G Notch1 notch receptor 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of NOTCH1 mRNA] CTD PMID:35662665 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO Trimetazidine results in decreased expression of PDK1 mRNA CTD PMID:37591408 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression ISO Trimetazidine results in decreased expression of PDK4 mRNA CTD PMID:37591408 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Trimetazidine inhibits the reaction [Folic Acid results in increased expression of RELA protein]; Trimetazidine inhibits the reaction [Paclitaxel results in increased phosphorylation of RELA protein] CTD PMID:35191561 PMID:36898573 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of RYR2 mRNA] CTD PMID:25937560 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 multiple interactions EXP Trimetazidine promotes the reaction [Oxygen deficiency results in increased expression of SLC18A3 mRNA] CTD PMID:25937560 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases expression		 EXP
ISO		 Trimetazidine promotes the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA]
Trimetazidine results in decreased expression of SLC2A1 mRNA		 CTD PMID:25937560 PMID:37591408 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions EXP Trimetazidine inhibits the reaction [Oxygen deficiency results in decreased expression of SLC8A1 mRNA] CTD PMID:25937560 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of SLPI mRNA]]; Trimetazidine inhibits the reaction [Paclitaxel results in decreased expression of SLPI mRNA] CTD PMID:35662665 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Trimetazidine inhibits the reaction [Paclitaxel results in increased expression of TLR4 protein] CTD PMID:36898573 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of TNF protein]
Trimetazidine inhibits the reaction [Folic Acid results in increased expression of TNF protein]		 CTD PMID:33704910 PMID:35191561 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Trimetazidine results in increased expression of TP53 protein CTD PMID:37591408 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Trimetazidine inhibits the reaction [Doxorubicin results in increased expression of VEGFA protein] CTD PMID:33704910 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        NMR chemical shift reference compound 18065
          ammonia 17865
            organic amino compound 17865
              aromatic amine 15478
                1-[(2,3,4-trimethoxyphenyl)methyl]piperazine 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          1-[(2,3,4-trimethoxyphenyl)methyl]piperazine 40
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