CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: Testosterone propionate
Accession: CHEBI:9466
browse the term
Definition: A steroid ester that has formula C22H32O3.
Synonyms: related_synonym: Formula=C22H32O3; InChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1; InChIKey=PDMMFKSKQVNJMI-BLQWBTBKSA-N; SMILES=CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C; TP; virormone
xref: CAS:57-85-2; Drug_Central:4146; HMDB:HMDB0015489; KEGG:C08158; KEGG:D00959
xref_mesh: MESH:D043343
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Acvr2b
activin A receptor type 2B
multiple interactions increases expression
EXP
Flutamide inhibits the reaction [Testosterone Propionate results in increased expression of SCGB2A2 mRNA]; prochloraz inhibits the reaction [Testosterone Propionate results in increased expression of SCGB2A2 mRNA]; vinclozolin inhibits the reaction [Testosterone Propionate results in increased expression of SCGB2A2 mRNA]
CTD
PMID:11376863 PMID:12377983
NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
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Adcyap1
adenylate cyclase activating polypeptide 1
increases expression
EXP
Testosterone Propionate results in increased expression of ADCYAP1 mRNA
CTD
PMID:19427307
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
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Adgrg2
adhesion G protein-coupled receptor G2
increases expression
ISO
Testosterone Propionate results in increased expression of ADGRG2 mRNA
CTD
PMID:15601916
NCBI chr X:34,297,402...34,422,590
Ensembl chr X:34,297,402...34,422,609
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Adprhl1
ADP-ribosylhydrolase like 1
decreases expression
ISO
Testosterone Propionate results in decreased expression of ADPRHL1 mRNA
CTD
PMID:15601916
NCBI chr16:76,283,186...76,315,075
Ensembl chr16:76,283,103...76,354,440
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Agt
angiotensinogen
increases expression
EXP
Testosterone Propionate results in increased expression of AGT mRNA
CTD
PMID:1568764
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Amotl1
angiomotin-like 1
increases expression
ISO
Testosterone Propionate results in increased expression of AMOTL1 mRNA
CTD
PMID:15601916
NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
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Ar
androgen receptor
affects binding increases expression multiple interactions
EXP ISO
Testosterone Propionate binds to AR protein Testosterone Propionate results in increased expression of AR protein Testosterone Propionate inhibits the reaction [Endosulfan results in decreased expression of AR mRNA] Testosterone Propionate inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of AR protein]
CTD
PMID:14565775 PMID:23669243 PMID:25077688 PMID:31797688 PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atp6v0d2
ATPase H+ transporting V0 subunit D2
increases expression
ISO
Testosterone Propionate results in increased expression of ATP6V0D2 mRNA
CTD
PMID:15601916
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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Bdnf
brain-derived neurotrophic factor
increases expression
EXP
Testosterone Propionate results in increased expression of BDNF mRNA
CTD
PMID:19427307
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
increases expression
ISO
Testosterone Propionate results in increased expression of CACNA1A mRNA
CTD
PMID:15601916
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Cat
catalase
decreases expression multiple interactions decreases activity
EXP
Testosterone Propionate results in decreased expression of CAT protein Diosmin inhibits the reaction [Testosterone Propionate results in decreased activity of CAT protein]; Testosterone Propionate inhibits the reaction [Vanadium results in decreased activity of CAT protein]
CTD
PMID:9430440 PMID:20521886 PMID:31797688
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Clu
clusterin
multiple interactions decreases expression
EXP
Flutamide inhibits the reaction [Testosterone Propionate results in decreased expression of CLU mRNA]; vinclozolin inhibits the reaction [Testosterone Propionate results in decreased expression of CLU mRNA]
CTD
PMID:11376863
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Cr1l
complement C3b/C4b receptor 1 like
multiple interactions
ISO
Testosterone Propionate inhibits the reaction [Endosulfan results in decreased expression of CR1L mRNA]
CTD
PMID:25242399
NCBI chr13:106,606,952...106,660,442
Ensembl chr13:106,574,858...106,660,445
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Creg2
cellular repressor of E1A-stimulated genes 2
decreases expression
ISO
Testosterone Propionate results in decreased expression of CREG2 mRNA
CTD
PMID:15601916
NCBI chr 9:41,872,000...41,945,413
Ensembl chr 9:41,902,304...41,945,095
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases expression
ISO
Testosterone Propionate results in decreased expression of CYP17A1 mRNA
CTD
PMID:15601916
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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Cyp2a3
cytochrome P450, family 2, subfamily a, polypeptide 3
affects expression
ISO
Testosterone Propionate affects the expression of CYP2A4
CTD
PMID:20943812
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
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Dhx9
DExH-box helicase 9
decreases expression
ISO
Testosterone Propionate results in decreased expression of DHX9 mRNA
CTD
PMID:15601916
NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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Dnai1
dynein, axonemal, intermediate chain 1
increases expression
ISO
Testosterone Propionate results in increased expression of DNAI1 mRNA
CTD
PMID:15601916
NCBI chr 5:56,730,179...56,800,926
Ensembl chr 5:56,730,179...56,800,925
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Epha2
Eph receptor A2
decreases expression
ISO
Testosterone Propionate results in decreased expression of EPHA2 mRNA
CTD
PMID:15601916
NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
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Esr1
estrogen receptor 1
decreases expression multiple interactions
EXP ISO
Testosterone Propionate results in decreased expression of ESR1 protein Testosterone Propionate binds to and results in increased activity of ESR1 protein
CTD
PMID:23669243 PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
Testosterone Propionate binds to and results in decreased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fshb
follicle stimulating hormone subunit beta
multiple interactions
EXP
Testosterone Propionate inhibits the reaction [Cyclosporine results in increased expression of FSHB protein]
CTD
PMID:2128298
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
decreases expression
ISO
Testosterone Propionate results in decreased expression of GABRA1 mRNA
CTD
PMID:16957604
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
decreases expression
ISO
Testosterone Propionate results in decreased expression of GABRA2 mRNA
CTD
PMID:16957604
NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944
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Gabra4
gamma-aminobutyric acid type A receptor subunit alpha 4
increases expression
ISO
Testosterone Propionate results in increased expression of GABRA4 mRNA
CTD
PMID:16957604
NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
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Gabra5
gamma-aminobutyric acid type A receptor subunit alpha 5
increases expression
ISO
Testosterone Propionate results in increased expression of GABRA5 mRNA
CTD
PMID:16957604
NCBI chr 1:108,268,728...108,381,670
Ensembl chr 1:108,268,776...108,380,917
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
decreases expression
ISO
Testosterone Propionate results in decreased expression of GABRG2 mRNA
CTD
PMID:16957604
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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Gap43
growth associated protein 43
increases expression
EXP
Testosterone Propionate results in increased expression of GAP43 mRNA
CTD
PMID:19427307
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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Ghrh
growth hormone releasing hormone
affects expression
ISO
Testosterone Propionate affects the expression of GHRH mRNA
CTD
PMID:20943812
NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889
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Gmppb
GDP-mannose pyrophosphorylase B
decreases expression
ISO
Testosterone Propionate results in decreased expression of GMPPB mRNA
CTD
PMID:15601916
NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286
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Gsr
glutathione-disulfide reductase
multiple interactions decreases activity
EXP
Diosmin inhibits the reaction [Testosterone Propionate results in decreased activity of GSR protein]
CTD
PMID:31797688
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Testosterone Propionate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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H3c1
H3 clustered histone 1
decreases expression
ISO
Testosterone Propionate results in decreased expression of H3C1 mRNA
CTD
PMID:15601916
NCBI chr17:41,368,379...41,368,902
Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856 Ensembl chr17:41,368,386...41,368,856
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Hspbap1
HSPB1 associated protein 1
decreases expression
ISO
Testosterone Propionate results in decreased expression of HSPBAP1 mRNA
CTD
PMID:15601916
NCBI chr11:64,940,089...64,994,753
Ensembl chr11:64,940,091...64,994,756
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Il1b
interleukin 1 beta
multiple interactions
ISO
Testosterone Propionate promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]
CTD
PMID:21745355
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions increases expression
ISO EXP
Testosterone Propionate inhibits the reaction [Endosulfan results in increased expression of IL6 mRNA]; Testosterone Propionate promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA] Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of IL6 protein]
CTD
PMID:21745355 PMID:22591281 PMID:31797688
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Klk1c10
kallikrein 1-related peptidase C10
multiple interactions increases expression
EXP
Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of KLK3 protein]
CTD
PMID:31797688
NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052
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Lhb
luteinizing hormone subunit beta
decreases expression multiple interactions
EXP ISO
Testosterone Propionate results in decreased expression of LHB protein Flutamide inhibits the reaction [Testosterone Propionate results in decreased expression of LHB protein] Testosterone Propionate inhibits the reaction [Endosulfan results in increased expression of LHB]
CTD
PMID:2128298 PMID:11376863 PMID:25077688
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Mir204
microRNA 204
decreases expression
EXP
Testosterone Propionate results in decreased expression of MIR204 mRNA
CTD
PMID:25797256
NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040
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Mpv17
mitochondrial inner membrane protein MPV17
increases expression
ISO
Testosterone Propionate results in increased expression of MPV17 mRNA
CTD
PMID:15601916
NCBI chr 6:25,221,668...25,236,241
Ensembl chr 6:25,222,896...25,236,244
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Mrpl54
mitochondrial ribosomal protein L54
increases expression
ISO
Testosterone Propionate results in increased expression of MRPL54 mRNA
CTD
PMID:15601916
NCBI chr 7:8,452,801...8,455,321
Ensembl chr 7:8,452,716...8,455,321
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Mycn
MYCN proto-oncogene, bHLH transcription factor
decreases expression
ISO
Testosterone Propionate results in decreased expression of MYCN mRNA
CTD
PMID:15601916
NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590
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Nphp1
nephrocystin 1
decreases expression
ISO
Testosterone Propionate results in decreased expression of NPHP1 mRNA
CTD
PMID:15601916
NCBI chr 3:114,960,650...115,016,234
Ensembl chr 3:114,960,650...115,016,234
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
IEP
Testosterone propionate increases NQO1 protein in liver
RGD
PMID:31819135
RGD:25823186
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Testosterone Propionate binds to and results in increased activity of NR1I2 protein Testosterone Propionate binds to and results in decreased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nrn1
neuritin 1
increases expression
EXP
Testosterone Propionate results in increased expression of NRN1 mRNA
CTD
PMID:19427307
NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896
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Odc1
ornithine decarboxylase 1
multiple interactions increases expression
EXP
Flutamide inhibits the reaction [Testosterone Propionate results in increased expression of ODC1 mRNA]; prochloraz inhibits the reaction [Testosterone Propionate results in increased expression of ODC1 mRNA]
CTD
PMID:12377983 PMID:17688994
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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Osbpl3
oxysterol binding protein-like 3
decreases expression
ISO
Testosterone Propionate results in decreased expression of OSBPL3 mRNA
CTD
PMID:15601916
NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393
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Pgr
progesterone receptor
decreases expression increases expression
ISO EXP
Testosterone Propionate results in decreased expression of PGR mRNA Testosterone Propionate results in decreased expression of PGR protein Testosterone Propionate results in increased expression of PGR protein
CTD
PMID:17574608 PMID:23669243
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Plagl1
PLAG1 like zinc finger 1
decreases expression
ISO
Testosterone Propionate results in decreased expression of PLAGL1 mRNA
CTD
PMID:15601916
NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
Testosterone Propionate binds to and results in decreased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
EXP
Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of PTGS2 protein]
CTD
PMID:31797688
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Ptpn23
protein tyrosine phosphatase, non-receptor type 23
decreases expression
ISO
Testosterone Propionate results in decreased expression of PTPN23 mRNA
CTD
PMID:15601916
NCBI chr 8:110,360,804...110,383,271
Ensembl chr 8:110,360,804...110,383,271
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Recql
RecQ like helicase
decreases expression
ISO
Testosterone Propionate results in decreased expression of RECQL mRNA
CTD
PMID:15601916
NCBI chr 4:175,308,337...175,332,965
Ensembl chr 4:175,304,117...175,332,945
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Ren
renin
increases expression
EXP
Testosterone Propionate results in increased expression of REN mRNA; Testosterone Propionate results in increased expression of REN protein
CTD
PMID:1568764
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Rnase9
ribonuclease A family member 9
increases expression
EXP
Testosterone Propionate results in increased expression of RNASE9 mRNA
CTD
PMID:17005942
NCBI chr15:24,259,525...24,263,079
Ensembl chr15:24,259,525...24,263,079
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Slc12a1
solute carrier family 12 member 1
increases expression
ISO
Testosterone Propionate results in increased expression of SLC12A1 mRNA
CTD
PMID:15601916
NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
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Slc9a2
solute carrier family 9 member A2
increases expression
ISO
Testosterone Propionate results in increased expression of SLC9A2 mRNA
CTD
PMID:15601916
NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444
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Syt6
synaptotagmin 6
increases expression
ISO
Testosterone Propionate results in increased expression of SYT6 mRNA
CTD
PMID:15601916
NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956
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Thrb
thyroid hormone receptor beta
multiple interactions
ISO
Testosterone Propionate binds to and results in increased activity of THRB protein
CTD
PMID:33049310
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
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Tnf
tumor necrosis factor
multiple interactions
ISO
Testosterone Propionate promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]
CTD
PMID:21745355
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tshz2
teashirt zinc finger homeobox 2
decreases expression
ISO
Testosterone Propionate results in decreased expression of TSHZ2 mRNA
CTD
PMID:15601916
NCBI chr 3:158,405,469...158,666,915
Ensembl chr 3:158,405,423...158,850,128
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Tuba1a
tubulin, alpha 1A
increases expression
EXP
Testosterone Propionate results in increased expression of TUBA1A mRNA
CTD
PMID:19427307
NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
decreases expression
EXP
Testosterone Propionate results in decreased expression of UGT2B1 mRNA
CTD
PMID:16829708
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Ugt8
UDP glycosyltransferase 8
increases expression
ISO
Testosterone Propionate results in increased expression of UGT8A mRNA
CTD
PMID:15601916
NCBI chr 2:214,264,483...214,332,769
Ensembl chr 2:214,264,483...214,332,660
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Xdh
xanthine dehydrogenase
increases activity multiple interactions
EXP
Testosterone Propionate results in increased activity of XDH protein Diosmin inhibits the reaction [Testosterone Propionate results in increased activity of XDH protein]
CTD
PMID:31797688
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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Xrn1
5'-3' exoribonuclease 1
increases expression
EXP
Testosterone Propionate results in increased expression of XRN1 protein
CTD
PMID:25797256
NCBI chr 8:96,527,871...96,637,385
Ensembl chr 8:96,528,195...96,632,739
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Zfp276
zinc finger protein (C2H2 type) 276
decreases expression
ISO
Testosterone Propionate results in decreased expression of ZFP276 mRNA
CTD
PMID:15601916
NCBI chr19:51,291,005...51,304,240
Ensembl chr19:51,290,777...51,304,049
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