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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzydamine
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Accession:CHEBI:94563 term browser browse the term
Definition:A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties.
Synonyms:exact_synonym: 3-[(1-benzyl-1H-indazol-3-yl)oxy]-N,N-dimethylpropan-1-aminie
 related_synonym: 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-indazole;   Formula=C19H23N3O;   InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3;   InChIKey=CNBGNNVCVSKAQZ-UHFFFAOYSA-N;   N,N-dimethyl-3-[[1-(phenylmethyl)-3-indazolyl]oxy]-1-propanamine;   SMILES=CN(C)CCCOC1=NN(C2=CC=CC=C21)CC3=CC=CC=C3;   bencidamina;   benzidamine;   benzindamine;   benzydamide;   benzydaminum
 xref: CAS:642-72-8;   Drug_Central:3881;   KEGG:D07516;   LINCS:LSM-5423
 xref_mesh: MESH:D001591
 xref: PMID:22267708;   PMID:23209922;   PMID:23439942;   PMID:23752801;   PMID:24263969;   PMID:24350416;   PMID:25343054;   PMID:25371873;   PMID:25431805;   PMID:25471468;   PMID:25715374;   PMID:25729498;   PMID:25760531;   PMID:26006195;   PMID:26149601;   PMID:26993406;   PMID:27108819;   PMID:27523475;   PMID:27644912;   PMID:27776399;   PMID:27987094;   PMID:28054999;   PMID:28127472;   PMID:28137602;   PMID:28145791;   PMID:28195065;   PMID:28247977;   PMID:28258069;   PMID:28352949;   PMID:28429885;   PMID:28442642;   Reaxys:896536;   Wikipedia:Benzydamine
 cyclic_relationship: is_conjugate_base_of CHEBI:134500


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benzydamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases oxidation
multiple interactions		 ISO FMO1 protein results in increased oxidation of Benzydamine
Benzydamine inhibits the reaction [FMO1 protein results in increased chemical synthesis of clozapine N-oxide]		 CTD PMID:18809730 PMID:21435388 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647 		JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases oxidation
multiple interactions		 ISO FMO2 protein results in increased oxidation of Benzydamine
[FMO2 protein results in increased oxidation of Benzydamine] which results in increased chemical synthesis of benzydamine N-oxide		 CTD PMID:26062974 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions
affects metabolic processing
increases metabolic processing
increases oxidation		 ISO Benzydamine inhibits the reaction [FMO3 protein results in increased chemical synthesis of clozapine N-oxide]
FMO3 gene polymorphism affects the metabolism of Benzydamine
FMO3 protein results in increased metabolism of Benzydamine
FMO3 protein results in increased oxidation of Benzydamine		 CTD PMID:17142560 PMID:18809730 PMID:21435388 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Benzydamine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        pharmacological role 19098
          analgesic 14787
            benzydamine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            inorganic hydride 18176
                              pnictogen hydride 18166
                                nitrogen hydride 18079
                                  azane 17886
                                    ammonia 17885
                                      organic amino compound 17885
                                        tertiary amino compound 10158
                                          benzydamine 4
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