CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine
Accession: CHEBI:94402
browse the term
Definition: A diarylmethane that has formula C18H21ClN2.
Synonyms: related_synonym: Formula=C18H21ClN2; InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3; InChIKey=WFNAKBGANONZEQ-UHFFFAOYSA-N; SMILES=CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl; chlorcycline; chlorcyclizine HCl; chlorcyclizine hydrochloride; chlorocycline; perazyl
xref: CAS:82-93-9; Drug_Central:593; HMDB:HMDB0240224; LINCS:LSM-5088
xref_mesh: MESH:C084597
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Abcg1
ATP binding cassette subfamily G member 1
decreases expression
EXP
chlorcyclizine results in decreased expression of ABCG1 mRNA
CTD
PMID:21058326
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
decreases expression
EXP
chlorcyclizine results in decreased expression of ADH1 mRNA
CTD
PMID:21058326
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Ago1
argonaute RISC component 1
decreases expression
EXP
chlorcyclizine results in decreased expression of AGO1 mRNA
CTD
PMID:21058326
NCBI chr 5:138,722,111...138,757,118
Ensembl chr 5:138,722,111...138,773,546
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Akap9
A-kinase anchoring protein 9
decreases expression
EXP
chlorcyclizine results in decreased expression of AKAP9 mRNA
CTD
PMID:21058326
NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
chlorcyclizine results in increased expression of ALDH1A1 mRNA
CTD
PMID:21058326
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Asah1
N-acylsphingosine amidohydrolase 1
increases expression
ISO
chlorcyclizine results in increased expression of ASAH1 mRNA
CTD
PMID:15342952
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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Atrx
ATRX, chromatin remodeler
decreases expression
EXP
chlorcyclizine results in decreased expression of ATRX mRNA
CTD
PMID:21058326
NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330
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Bcam
basal cell adhesion molecule (Lutheran blood group)
increases expression
EXP
chlorcyclizine results in increased expression of BCAM mRNA
CTD
PMID:21058326
NCBI chr 1:79,415,016...79,429,403
Ensembl chr 1:79,415,017...79,429,403
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Bmp2
bone morphogenetic protein 2
increases expression
EXP
chlorcyclizine results in increased expression of BMP2 mRNA
CTD
PMID:21058326
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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Bmp4
bone morphogenetic protein 4
increases expression
EXP
chlorcyclizine results in increased expression of BMP4 mRNA
CTD
PMID:21058326
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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Bod1l1
biorientation of chromosomes in cell division 1-like 1
decreases expression
EXP
chlorcyclizine results in decreased expression of BOD1L1 mRNA
CTD
PMID:21058326
NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490
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Camk2g
calcium/calmodulin-dependent protein kinase II gamma
increases expression
EXP
chlorcyclizine results in increased expression of CAMK2G mRNA
CTD
PMID:21058326
NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050
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Cdh22
cadherin 22
decreases expression
EXP
chlorcyclizine results in decreased expression of CDH22 mRNA
CTD
PMID:21058326
NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588
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Cox4i2
cytochrome c oxidase subunit 4i2
increases expression
EXP
chlorcyclizine results in increased expression of COX4I2 mRNA
CTD
PMID:21058326
NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331
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Cplx1
complexin 1
increases expression
EXP
chlorcyclizine results in increased expression of CPLX1 mRNA
CTD
PMID:21058326
NCBI chr14:1,184,677...1,216,392
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Crebbp
CREB binding protein
decreases expression
EXP
chlorcyclizine results in decreased expression of CREBBP mRNA
CTD
PMID:21058326
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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Depp1
DEPP autophagy regulator 1
increases expression
ISO
chlorcyclizine results in increased expression of DEPP1 mRNA
CTD
PMID:15342952
NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542
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Dpysl3
dihydropyrimidinase-like 3
decreases expression increases expression
EXP
chlorcyclizine results in decreased expression of DPYSL3 mRNA chlorcyclizine results in increased expression of DPYSL3 mRNA
CTD
PMID:21058326
NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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Efna5
ephrin A5
increases expression
EXP
chlorcyclizine results in increased expression of EFNA5 mRNA
CTD
PMID:21058326
NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413
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Eln
elastin
increases expression
EXP
chlorcyclizine results in increased expression of ELN mRNA
CTD
PMID:21058326
NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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Fabp1
fatty acid binding protein 1
increases expression
ISO
chlorcyclizine results in increased expression of FABP1 mRNA
CTD
PMID:15342952
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fgf10
fibroblast growth factor 10
increases expression
EXP
chlorcyclizine results in increased expression of FGF10 mRNA
CTD
PMID:21058326
NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
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Fgfr2
fibroblast growth factor receptor 2
increases expression
EXP
chlorcyclizine results in increased expression of FGFR2 mRNA
CTD
PMID:21058326
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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Fmod
fibromodulin
increases expression
EXP
chlorcyclizine results in increased expression of FMOD mRNA
CTD
PMID:21058326
NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133
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Fndc4
fibronectin type III domain containing 4
increases expression
ISO
chlorcyclizine results in increased expression of FNDC4 mRNA
CTD
PMID:15342952
NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675
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Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
increases expression
EXP
chlorcyclizine results in increased expression of GABRB3 mRNA
CTD
PMID:21058326
NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
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Gdpd3
glycerophosphodiester phosphodiesterase domain containing 3
increases expression
ISO
chlorcyclizine results in increased expression of GDPD3 mRNA
CTD
PMID:15342952
NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063
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Ggcx
gamma-glutamyl carboxylase
increases expression
EXP
chlorcyclizine results in increased expression of GGCX mRNA
CTD
PMID:21058326
NCBI chr 4:104,469,737...104,485,631
Ensembl chr 4:104,469,765...104,487,063
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Gpnmb
glycoprotein nmb
increases expression
EXP
chlorcyclizine results in increased expression of GPNMB mRNA
CTD
PMID:21058326
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Gsk3b
glycogen synthase kinase 3 beta
decreases expression
EXP
chlorcyclizine results in decreased expression of GSK3B mRNA
CTD
PMID:21058326
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gstm2
glutathione S-transferase mu 2
increases expression
EXP
chlorcyclizine results in increased expression of GSTM2 mRNA
CTD
PMID:21058326
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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Hapln1
hyaluronan and proteoglycan link protein 1
increases expression
EXP
chlorcyclizine results in increased expression of HAPLN1 mRNA
CTD
PMID:21058326
NCBI chr 2:20,631,640...20,696,388
Ensembl chr 2:20,631,640...20,693,777
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Hist1h4b
histone cluster 1 H4 family member B
decreases expression
EXP
chlorcyclizine results in decreased expression of HIST1H4B mRNA
CTD
PMID:21058326
NCBI chr17:42,480,467...42,484,912
Ensembl chr17:42,480,313...42,485,370
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Hpn
hepsin
increases expression
ISO
chlorcyclizine results in increased expression of HPN mRNA
CTD
PMID:15342952
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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Hyou1
hypoxia up-regulated 1
increases expression
EXP
chlorcyclizine results in increased expression of HYOU1 mRNA
CTD
PMID:21058326
NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
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Ibsp
integrin-binding sialoprotein
increases expression
EXP
chlorcyclizine results in increased expression of IBSP mRNA
CTD
PMID:21058326
NCBI chr14:5,439,825...5,452,570
Ensembl chr14:5,439,829...5,452,693
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Idi1
isopentenyl-diphosphate delta isomerase 1
increases expression
EXP
chlorcyclizine results in increased expression of IDI1 mRNA
CTD
PMID:21058326
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Il6st
interleukin 6 cytokine family signal transducer
decreases expression
EXP
chlorcyclizine results in decreased expression of IL6ST mRNA
CTD
PMID:21058326
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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Ilf3
interleukin enhancer binding factor 3
decreases expression
EXP
chlorcyclizine results in decreased expression of ILF3 mRNA
CTD
PMID:21058326
NCBI chr 8:19,922,409...19,960,495
Ensembl chr 8:19,922,460...19,960,350
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Inhbe
inhibin subunit beta E
increases expression
ISO
chlorcyclizine results in increased expression of INHBE mRNA
CTD
PMID:15342952
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Insig1
insulin induced gene 1
increases expression
EXP
chlorcyclizine results in increased expression of INSIG1 mRNA
CTD
PMID:21058326
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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Khdrbs2
KH RNA binding domain containing, signal transduction associated 2
increases expression
EXP
chlorcyclizine results in increased expression of KHDRBS2 mRNA
CTD
PMID:21058326
NCBI chr 9:34,447,023...34,953,684
Ensembl chr 9:34,447,056...34,915,530
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Ldlr
low density lipoprotein receptor
increases expression
EXP
chlorcyclizine results in increased expression of LDLR mRNA
CTD
PMID:21058326
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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Lgals7
galectin 7
increases expression
EXP
chlorcyclizine results in increased expression of LGALS7 mRNA
CTD
PMID:21058326
NCBI chr 1:84,148,612...84,152,016
Ensembl chr 1:84,150,252...84,152,015
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Lmna
lamin A/C
increases expression
EXP
chlorcyclizine results in increased expression of LMNA mRNA
CTD
PMID:21058326
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
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Lss
lanosterol synthase
increases expression
ISO
chlorcyclizine results in increased expression of LSS mRNA
CTD
PMID:15342952
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Mapt
microtubule-associated protein tau
increases expression
EXP
chlorcyclizine results in increased expression of MAPT mRNA
CTD
PMID:21058326
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mbp
myelin basic protein
increases expression
EXP
chlorcyclizine results in increased expression of MBP mRNA
CTD
PMID:21058326
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Msmo1
methylsterol monooxygenase 1
increases expression
EXP
chlorcyclizine results in increased expression of MSMO1 mRNA
CTD
PMID:21058326
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Msx1
msh homeobox 1
increases expression
EXP
chlorcyclizine results in increased expression of MSX1 mRNA
CTD
PMID:21058326
NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966
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Msx2
msh homeobox 2
increases expression
EXP
chlorcyclizine results in increased expression of MSX2 mRNA
CTD
PMID:21058326
NCBI chr17:11,097,214...11,102,879
Ensembl chr17:11,097,103...11,102,879
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Mvk
mevalonate kinase
increases expression
EXP
chlorcyclizine results in increased expression of MVK mRNA
CTD
PMID:21058326
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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Mybpc1
myosin binding protein C1
increases expression
EXP
chlorcyclizine results in increased expression of MYBPC1 mRNA
CTD
PMID:21058326
NCBI chr 7:22,930,350...23,015,981
Ensembl chr 7:22,930,350...23,015,957
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Ncam1
neural cell adhesion molecule 1
decreases expression
EXP
chlorcyclizine results in decreased expression of NCAM1 mRNA
CTD
PMID:21058326
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Nfix
nuclear factor I X
decreases expression increases expression
EXP
chlorcyclizine results in decreased expression of NFIX mRNA chlorcyclizine results in increased expression of NFIX mRNA
CTD
PMID:21058326
NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
ISO
chlorcyclizine results in increased expression of NR0B2 mRNA
CTD
PMID:15342952
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr2f1
nuclear receptor subfamily 2, group F, member 1
increases expression
EXP
chlorcyclizine results in increased expression of NR2F1 mRNA
CTD
PMID:21058326
NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123
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Ntrk1
neurotrophic receptor tyrosine kinase 1
increases expression
EXP
chlorcyclizine results in increased expression of NTRK1 mRNA
CTD
PMID:21058326
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
decreases expression
EXP
chlorcyclizine results in decreased expression of NUCKS1 mRNA
CTD
PMID:21058326
NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
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Nupr1
nuclear protein 1, transcriptional regulator
increases expression
ISO
chlorcyclizine results in increased expression of NUPR1 mRNA
CTD
PMID:15342952
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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Omd
osteomodulin
increases expression
EXP
chlorcyclizine results in increased expression of OMD mRNA
CTD
PMID:21058326
NCBI chr17:15,060,217...15,068,441
Ensembl chr17:15,060,217...15,068,441
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P3h1
prolyl 3-hydroxylase 1
increases expression
EXP
chlorcyclizine results in increased expression of P3H1 mRNA
CTD
PMID:21058326
NCBI chr 5:132,841,868...132,856,664
Ensembl chr 5:132,841,928...132,856,659
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
increases expression
EXP
chlorcyclizine results in increased expression of PIK3R1 mRNA
CTD
PMID:21058326
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pou3f3
POU class 3 homeobox 3
increases expression
EXP
chlorcyclizine results in increased expression of POU3F3 mRNA
CTD
PMID:21058326
NCBI chr 9:44,945,872...44,948,998
Ensembl chr 9:44,945,872...44,948,992
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Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
decreases expression
EXP
chlorcyclizine results in decreased expression of PPP1R12A mRNA
CTD
PMID:21058326
NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
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Ppp1r17
protein phosphatase 1, regulatory subunit 17
increases expression
EXP
chlorcyclizine results in increased expression of PPP1R17 mRNA
CTD
PMID:21058326
NCBI chr 4:85,213,595...85,230,607
Ensembl chr 4:85,213,887...85,230,603
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Rab38
RAB38, member RAS oncogene family
increases expression
EXP
chlorcyclizine results in increased expression of RAB38 mRNA
CTD
PMID:21058326
NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
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Rnd2
Rho family GTPase 2
affects expression
EXP
chlorcyclizine affects the expression of RND2 mRNA
CTD
PMID:21058326
NCBI chr10:86,399,151...86,402,750
Ensembl chr10:86,399,148...86,402,742
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Sema6c
semaphorin 6C
increases expression
EXP
chlorcyclizine results in increased expression of SEMA6C mRNA
CTD
PMID:21058326
NCBI chr 2:182,733,635...182,750,066
Ensembl chr 2:182,737,474...182,746,856
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Serpina3n
serpin family A member 3N
increases expression
ISO
chlorcyclizine results in increased expression of SERPINA3 mRNA
CTD
PMID:15342952
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Shh
sonic hedgehog signaling molecule
decreases expression
EXP
chlorcyclizine results in decreased expression of SHH mRNA
CTD
PMID:21058326
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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Slc2a3
solute carrier family 2 member 3
decreases expression
ISO
chlorcyclizine results in decreased expression of SLC2A3 mRNA
CTD
PMID:15342952
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
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Slc6a4
solute carrier family 6 member 4
increases expression
EXP
chlorcyclizine results in increased expression of SLC6A4 mRNA
CTD
PMID:21058326
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Smarca4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
decreases expression
EXP
chlorcyclizine results in decreased expression of SMARCA4 mRNA
CTD
PMID:21058326
NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975
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Smpd3
sphingomyelin phosphodiesterase 3
increases expression
EXP
chlorcyclizine results in increased expression of SMPD3 mRNA
CTD
PMID:21058326
NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749
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Sparc
secreted protein acidic and cysteine rich
increases expression
EXP
chlorcyclizine results in increased expression of SPARC mRNA
CTD
PMID:21058326
NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
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Srpx
sushi-repeat-containing protein, X-linked
increases expression
EXP
chlorcyclizine results in increased expression of SRPX mRNA
CTD
PMID:21058326
NCBI chr X:12,676,984...12,751,296
Ensembl chr X:12,566,645...12,747,882
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Tagln
transgelin
decreases expression
ISO
chlorcyclizine results in decreased expression of TAGLN mRNA
CTD
PMID:15342952
NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668
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Tmod2
tropomodulin 2
decreases expression
EXP
chlorcyclizine results in decreased expression of TMOD2 mRNA
CTD
PMID:21058326
NCBI chr 8:76,316,736...76,366,003
Ensembl chr 8:76,325,667...76,365,720
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Tnmd
tenomodulin
increases expression
EXP
chlorcyclizine results in increased expression of TNMD mRNA
CTD
PMID:21058326
NCBI chr X:97,057,137...97,072,634
Ensembl chr X:97,057,137...97,072,634
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Tspan8
tetraspanin 8
increases expression
EXP
chlorcyclizine results in increased expression of TSPAN8 mRNA
CTD
PMID:21058326
NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356
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Tst
thiosulfate sulfurtransferase
affects expression decreases expression
EXP
chlorcyclizine affects the expression of TST mRNA chlorcyclizine results in decreased expression of TST mRNA
CTD
PMID:21058326
NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216
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Ttr
transthyretin
increases expression
EXP
chlorcyclizine results in increased expression of TTR mRNA
CTD
PMID:21058326
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Vof16
ischemia related factor vof-16
decreases expression
EXP
chlorcyclizine results in decreased expression of VOF16 mRNA
CTD
PMID:21058326
NCBI chr 8:41,953,062...41,955,169
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Wif1
Wnt inhibitory factor 1
increases expression
EXP
chlorcyclizine results in increased expression of WIF1 mRNA
CTD
PMID:21058326
NCBI chr 7:56,548,060...56,618,364
Ensembl chr 7:56,548,053...56,618,360
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Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
chlorcyclizine results in increased expression of WIPI1 mRNA
CTD
PMID:15342952
NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846
G
Wnt4
Wnt family member 4
increases expression
EXP
chlorcyclizine results in increased expression of WNT4 mRNA
CTD
PMID:21058326
NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
G
Wnt5a
Wnt family member 5A
increases expression
EXP
chlorcyclizine results in increased expression of WNT5A mRNA
CTD
PMID:21058326
NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234
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