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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:taurodeoxycholic acid
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Accession:CHEBI:9410 term browser browse the term
Definition:A bile acid taurine conjugate of deoxycholic acid.
Synonyms:exact_synonym: 2-[(3alpha,12alpha-dihydroxy-24-oxo-5beta-cholan-24-yl)amino]ethanesulfonic acid
 related_synonym: Formula=C26H45NO6S;   InChI=1S/C26H45NO6S/c1-16(4-9-24(30)27-12-13-34(31,32)33)20-7-8-21-19-6-5-17-14-18(28)10-11-25(17,2)22(19)15-23(29)26(20,21)3/h16-23,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1;   InChIKey=AWDRATDZQPNJFN-VAYUFCLWSA-N;   SMILES=[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCCS(O)(=O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2;   Taurodeoxycholate
 xref: CAS:516-50-7;   HMDB:HMDB0000896;   KEGG:C05463;   LINCS:LSM-5477;   LIPID_MAPS_instance:LMST05040013
 xref_mesh: MESH:D013657
 xref: Reaxys:3228310;   Wikipedia:Taurodeoxycholic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:36261



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taurodeoxycholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
increases abundance
increases transport
ISO
EXP
[Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Ketoconazole results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [Troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; Aconitine inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; aurantio-obtusin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; carboxyatractyloside inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; celastrol inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; cryptotanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; Cyclosporine inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; dihydrotanshinone I inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; diosbulbin B metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; diosbulbin B promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; Enzymes and Coenzymes inhibits the reaction [celastrol inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [diosbulbin B promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [saikosaponin D analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes inhibits the reaction [saikosaponin D inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes promotes the reaction [saikogenin A analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes promotes the reaction [saikogenin A inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; Enzymes and Coenzymes promotes the reaction [Troglitazone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; isobavachalcone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; kansuinin A inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; kansuinin B inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; mesaconitine inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; NADP promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; NADP promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; NADP promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; rhein promotes the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikogenin A analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikogenin A inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikogenin F inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikosaponin D analog inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; saikosaponin D inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; tanshinone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; toosendanin inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]; Troglitazone inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]
ABCB11 protein results in increased abundance of Taurodeoxycholic Acid
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased export of Taurodeoxycholic Acid
CTD PMID:14570929 PMID:20147439 PMID:35101544 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO Taurodeoxycholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] CTD PMID:16101123 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases secretion
ISO AHR gene mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in decreased secretion of Taurodeoxycholic Acid]
AHR gene mutant form results in increased secretion of Taurodeoxycholic Acid
CTD PMID:29452137 PMID:32679164 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO Taurodeoxycholic Acid results in increased activity of CASP3 protein
ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP3 protein]
CTD PMID:12773247 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO Taurodeoxycholic Acid results in increased activity of CASP9 protein
ursodoxicoltaurine inhibits the reaction [Taurodeoxycholic Acid results in increased activity of CASP9 protein]
CTD PMID:12773247 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 increases response to substance
increases activity
ISO CHRM3 protein results in increased susceptibility to Taurodeoxycholic Acid
Taurodeoxycholic Acid results in increased activity of CHRM3 protein
CTD PMID:15964566 NCBI chr17:64,696,549...65,158,622
Ensembl chr17:64,696,066...65,173,304
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation ISO CYP3A4 protein results in increased hydroxylation of Taurodeoxycholic Acid CTD PMID:36473578 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 decreases activity
decreases expression
EXP Taurodeoxycholic Acid results in decreased activity of CYP7B1 protein
Taurodeoxycholic Acid results in decreased expression of CYP7B1 mRNA
CTD PMID:12029625 NCBI chr 2:102,419,011...102,586,047
Ensembl chr 2:102,419,011...102,451,804
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Taurodeoxycholic Acid inhibits the reaction [Tunicamycin results in increased expression of GPT protein] CTD PMID:33527851 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Taurodeoxycholic Acid inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA] CTD PMID:40015660 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Taurodeoxycholic Acid inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein] CTD PMID:33527851 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Il10 interleukin 10 multiple interactions
increases abundance
ISO Taurodeoxycholic Acid promotes the reaction [irinotecan results in decreased secretion of IL10 protein]
IL10 gene mutant form results in increased abundance of Taurodeoxycholic Acid
CTD PMID:26706406 PMID:27580383 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases activity ISO Taurodeoxycholic Acid results in increased activity of MAPK14 protein CTD PMID:14762791 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases activity ISO Taurodeoxycholic Acid results in increased activity of NR1H4 protein CTD PMID:17567710 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389
JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions EXP Taurodeoxycholic Acid inhibits the reaction [Tunicamycin results in increased expression of and results in increased activity of PLA2G4A protein] CTD PMID:33527851 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
JBrowse link
G Pnlip pancreatic lipase affects folding ISO Taurodeoxycholic Acid affects the folding of PNLIP protein CTD PMID:19346257 NCBI chr 1:267,760,073...267,797,797
Ensembl chr 1:267,784,724...267,797,795
JBrowse link
G Por cytochrome p450 oxidoreductase affects abundance ISO POR gene mutant form affects the abundance of Taurodeoxycholic Acid CTD PMID:25034404 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Taurodeoxycholic Acid inhibits the reaction [Tunicamycin results in increased expression of and results in increased activity of PTGS2 protein] CTD PMID:33527851 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases uptake
multiple interactions
ISO SLC10A1 protein results in increased uptake of Taurodeoxycholic Acid
Sodium deficiency inhibits the reaction [SLC10A1 protein results in increased uptake of Taurodeoxycholic Acid]
CTD PMID:34079822 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
JBrowse link
G Slc10a2 solute carrier family 10 member 2 increases uptake
multiple interactions
ISO SLC10A2 protein results in increased uptake of Taurodeoxycholic Acid
Sodium deficiency inhibits the reaction [SLC10A2 protein results in increased uptake of Taurodeoxycholic Acid]
CTD PMID:34079822 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions EXP Taurodeoxycholic Acid inhibits the reaction [Tunicamycin results in increased activity of SMPD2 protein] CTD PMID:33527851 NCBI chr20:46,568,627...46,571,741
Ensembl chr20:46,568,629...46,571,741
JBrowse link
G Stim1 stromal interaction molecule 1 multiple interactions
affects localization
EXP STIM1 protein promotes the reaction [Taurodeoxycholic Acid results in increased abundance of Calcium]
Taurodeoxycholic Acid affects the localization of STIM1 protein
CTD PMID:18342630 NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:166,067,962...166,233,108
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        antioxidant 16464
          taurine 438
            bile acid taurine conjugate 306
              taurodeoxycholic acid 22
                7-oxotaurodeoxycholic acid 0
                Sodium taurodeoxycholate hydrate 0
                taurodeoxycholic acid-d4 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic polycyclic compound 17588
                                  steroid 15343
                                    steroid fundamental parent 15177
                                      cholane 1170
                                        cholanoid 1170
                                          cholanic acids 1155
                                            cholanic acid 1155
                                              5beta-cholanic acid 1155
                                                hydroxy-5beta-cholanic acid 1155
                                                  dihydroxy-5beta-cholanic acid 988
                                                    deoxycholic acid 478
                                                      taurodeoxycholic acid 22
                                                        7-oxotaurodeoxycholic acid 0
                                                        Sodium taurodeoxycholate hydrate 0
                                                        taurodeoxycholic acid-d4 0
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