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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:swainsonine
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Accession:CHEBI:9367 term browser browse the term
Definition:An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.
Synonyms:related_synonym: Formula=C8H15NO3;   InChI=1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1;   InChIKey=FXUAIOOAOAVCGD-WCTZXXKLSA-N;   SMILES=[H][C@]12[C@H](O)CCCN1C[C@@H](O)[C@H]2O;   tridolgosir
 xref: CAS:72741-87-8;   DrugBank:DB02034;   KEGG:C10173;   KNApSAcK:C00002075
 xref_mesh: MESH:D017026
 xref: PDBeChem:SWA;   PMID:22281718;   PMID:22544335;   PMID:22578623;   Reaxys:4175740;   Wikipedia:Swainsonine


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swainsonine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression EXP Swainsonine results in increased expression of AIFM1 protein CTD PMID:33186601 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of AKT1 protein CTD PMID:36402259 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression		 ISO
EXP		 [bafilomycin A1 co-treated with Swainsonine] results in increased expression of ATG5 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of ATG5 protein
Swainsonine results in increased expression of ATG5 mRNA; Swainsonine results in increased expression of ATG5 protein		 CTD PMID:36402259 PMID:37442287 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A multiple interactions
decreases expression
increases expression		 EXP Trehalose inhibits the reaction [Swainsonine results in decreased expression of ATP6V1A protein]
Swainsonine results in increased expression of ATP6V1A mRNA		 CTD PMID:38579922 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 EXP
ISO		 [Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein
Swainsonine results in increased expression of BECN1 protein
Swainsonine results in increased expression of BECN1 mRNA; Swainsonine results in increased expression of BECN1 protein		 CTD PMID:33186601 PMID:36402259 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 EXP [Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein; [Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein
Swainsonine results in increased cleavage of CASP3 protein		 CTD PMID:33186601 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases cleavage EXP Swainsonine results in increased cleavage of CASP8 protein CTD PMID:33186601 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions		 EXP Swainsonine results in increased cleavage of CASP9 protein
[Swainsonine co-treated with Sirolimus] results in increased cleavage of CASP9 protein		 CTD PMID:33186601 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ctsb cathepsin B decreases expression
multiple interactions
increases expression		 EXP Swainsonine results in decreased expression of CTSB protein
Trehalose inhibits the reaction [Swainsonine results in decreased expression of CTSB protein]
Swainsonine results in increased expression of CTSB mRNA		 CTD PMID:38579922 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D decreases expression
multiple interactions
increases expression		 EXP Swainsonine results in decreased expression of CTSD protein
[Swainsonine affects the glycosylation of CTSD protein] which results in decreased expression of CTSD protein modified form; Trehalose inhibits the reaction [Swainsonine results in decreased expression of CTSD protein]
Swainsonine results in increased expression of CTSD mRNA		 CTD PMID:33186601 PMID:37442287 PMID:38579922 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:36402259 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Faslg Fas ligand increases expression EXP Swainsonine results in increased expression of FASLG protein CTD PMID:33186601 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 decreases expression EXP Swainsonine results in decreased expression of GFAT1 protein CTD PMID:37442287 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 multiple interactions
increases expression		 ISO [bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 protein
Swainsonine results in increased expression of LAMP1 mRNA; Swainsonine results in increased expression of LAMP1 protein		 CTD PMID:36402259 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 increases expression
decreases expression
multiple interactions		 EXP Swainsonine results in increased expression of LAMP2 mRNA
Swainsonine results in decreased expression of LAMP2 protein
Trehalose inhibits the reaction [Swainsonine results in decreased expression of LAMP2 protein]		 CTD PMID:38579922 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Man2a1 mannosidase, alpha, class 2A, member 1 multiple interactions
decreases expression		 ISO bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2A1 mRNA] CTD PMID:36402259 NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349 		JBrowse link
G Man2b1 mannosidase, alpha, class 2B, member 1 multiple interactions
decreases expression		 ISO bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2B1 mRNA] CTD PMID:36402259 NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression
increases lipidation		 ISO
EXP		 [bafilomycin A1 co-treated with Swainsonine] results in increased expression of MAP1LC3B mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of MAP1LC3B protein
Swainsonine results in increased expression of MAP1LC3B mRNA
Swainsonine results in increased lipidation of MAP1LC3B protein
Swainsonine results in increased localization of and results in increased lipidation of MAP1LC3B protein
Swainsonine results in increased expression of MAP1LC3B protein		 CTD PMID:36402259 PMID:37442287 PMID:38579922 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of MAPK1 protein CTD PMID:36402259 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of MAPK3 protein CTD PMID:36402259 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of MTOR protein CTD PMID:36402259 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of PIK3R1 protein CTD PMID:36402259 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Swainsonine results in decreased phosphorylation of RPS6KB1 protein CTD PMID:36402259 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO
EXP		 Swainsonine results in increased expression of SQSTM1 mRNA; Swainsonine results in increased expression of SQSTM1 protein
[bafilomycin A1 co-treated with Swainsonine] results in increased expression of SQSTM1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of SQSTM1 protein
Trehalose inhibits the reaction [Swainsonine results in increased expression of SQSTM1 protein]		 CTD PMID:36402259 PMID:37442287 PMID:38579922 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tfeb transcription factor EB decreases expression
increases expression
multiple interactions		 EXP Swainsonine results in decreased expression of TFEB protein
Swainsonine results in increased expression of TFEB mRNA
Trehalose inhibits the reaction [Swainsonine results in decreased expression of TFEB protein]		 CTD PMID:33186601 PMID:38579922 NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Swainsonine results in increased expression of TRP53 protein CTD PMID:36402259 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        immunomodulator 15071
          immunological adjuvant 848
            swainsonine 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17242
                                      indolizines 79
                                        indolizidine alkaloid 38
                                          swainsonine 26
paths to the root