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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulindac
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Accession:CHEBI:9352 term browser browse the term
Definition:A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   Clinoril;   Formula=C20H17FO3S;   InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=MLKXDPUZXIRXEP-MFOYZWKCSA-N;   SMILES=CC1=C(CC(O)=O)c2cc(F)ccc2C\\1=C/c1ccc(cc1)S(C)=O;   Sulindacum;   cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid;   cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid;   sulindaco
 xref: CAS:38194-50-2;   DrugBank:DB00605;   Drug_Central:2534;   HMDB:HMDB0014743;   KEGG:C01531;   KEGG:D00120
 xref_mesh: MESH:D013467
 xref: PDBeChem:SUZ;   PMID:11569947;   PMID:11927004;   PMID:12406542;   PMID:15020200;   PMID:15123337;   PMID:19884509;   PMID:23689354;   PMID:23804703;   Patent:DE2039426;   Patent:US3654349;   Reaxys:2951842;   Wikipedia:Sulindac


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sulindac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions 		ISO Sulindac results in increased expression of ABCC1 protein
Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC1 protein] 		CTD PMID:11820781 NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC3 protein] CTD PMID:11820781 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494 		JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 increases expression EXP Sulindac results in increased expression of ABCD3 mRNA CTD PMID:24136188 NCBI chr 2:212,536,791...212,590,379
Ensembl chr 2:212,536,791...212,590,504 		JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase increases expression EXP Sulindac results in increased expression of ABHD16A mRNA CTD PMID:24136188 NCBI chr20:3,723,756...3,738,617
Ensembl chr20:3,723,757...3,738,736 		JBrowse link
G Abi1 abl-interactor 1 decreases expression EXP Sulindac results in decreased expression of ABI1 mRNA CTD PMID:24136188 NCBI chr17:90,006,917...90,088,002
Ensembl chr17:90,006,925...90,087,827 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO Sulindac results in increased expression of ACACA mRNA CTD PMID:32535746 NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888 		JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACAD9 mRNA CTD PMID:20371263 NCBI chr 2:120,871,329...120,894,306
Ensembl chr 2:120,871,227...120,894,709 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO
EXP 		Sulindac results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:33,925,458...33,971,596 		JBrowse link
G Acly ATP citrate lyase increases expression ISO Sulindac results in increased expression of ACLY mRNA CTD PMID:32535746 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631 		JBrowse link
G Acp2 acid phosphatase 2, lysosomal increases expression ISO Sulindac results in increased expression of ACP2 mRNA CTD PMID:11906190 NCBI chr 3:97,630,654...97,642,601
Ensembl chr 3:97,631,326...97,642,565 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ACSL1 mRNA CTD PMID:20371263 NCBI chr16:52,487,870...52,554,110
Ensembl chr16:52,487,870...52,554,023 		JBrowse link
G Actr10 actin related protein 10 decreases expression EXP Sulindac results in decreased expression of ACTR10 mRNA CTD PMID:24136188 NCBI chr 6:95,182,082...95,208,325
Ensembl chr 6:95,182,111...95,209,021 		JBrowse link
G Acy1 aminoacylase 1 increases expression EXP Sulindac results in increased expression of ACY1 mRNA CTD PMID:24136188 NCBI chr 8:115,951,068...115,956,471
Ensembl chr 8:115,951,068...115,956,405 		JBrowse link
G Add1 adducin 1 increases expression EXP Sulindac results in increased expression of ADD1 mRNA CTD PMID:24136188 NCBI chr14:80,333,242...80,401,641
Ensembl chr14:80,333,244...80,391,732 		JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADHFE1 mRNA CTD PMID:20371263 NCBI chr 5:14,488,784...14,515,405
Ensembl chr 5:14,488,788...14,515,835 		JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ADIPOR2 mRNA CTD PMID:20371263 NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666 		JBrowse link
G Adss2 adenylosuccinate synthase 2 increases expression EXP Sulindac results in increased expression of ADSS2 mRNA CTD PMID:24136188 NCBI chr13:92,301,302...92,331,638
Ensembl chr13:92,301,302...92,331,638 		JBrowse link
G Agfg2 ArfGAP with FG repeats 2 increases expression EXP Sulindac results in increased expression of CCZ1B mRNA CTD PMID:24136188 NCBI chr12:24,649,008...24,692,069
Ensembl chr12:24,649,038...24,685,197 		JBrowse link
G Ahr aryl hydrocarbon receptor increases localization
multiple interactions 		ISO
EXP 		Sulindac results in increased localization of AHR protein
Sulindac binds to and results in increased activity of AHR protein 		CTD PMID:16531450 PMID:17985343 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Aif1l allograft inflammatory factor 1-like decreases expression ISO Sulindac results in decreased expression of AIF1L mRNA CTD PMID:11906190 NCBI chr 3:35,627,239...35,651,793
Ensembl chr 3:35,627,239...35,651,793 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO Sulindac affects the localization of AIFM1 protein CTD PMID:15946692 PMID:17136320 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Aifm2 AIF family member 2 increases expression ISO Sulindac results in increased expression of AIFM2 mRNA CTD PMID:11906190 NCBI chr20:30,195,781...30,222,014
Ensembl chr20:30,193,829...30,220,957 		JBrowse link
G Akap1 A-kinase anchoring protein 1 increases expression EXP Sulindac results in increased expression of AKAP1 mRNA CTD PMID:24136188 NCBI chr10:74,118,232...74,151,366
Ensembl chr10:74,119,124...74,138,190 		JBrowse link
G Akap9 A-kinase anchoring protein 9 decreases expression EXP Sulindac results in decreased expression of AKAP9 mRNA CTD PMID:24136188 NCBI chr 4:31,011,475...31,147,338
Ensembl chr 4:31,011,475...31,147,338 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO Sulindac analog binds to and results in decreased activity of AKR1B1 protein; Sulindac binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO Sulindac analog binds to and results in decreased activity of AKR1B10 protein; Sulindac binds to and results in decreased activity of AKR1B10 protein CTD PMID:25532697 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Sulindac results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Sulindac results in decreased activity of AKR1C2 protein CTD PMID:19010312 NCBI chr17:70,669,684...70,717,935
Ensembl chr17:70,669,710...70,685,686 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Sulindac results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation 		ISO
EXP 		[AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen; AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]
Sulindac analog results in decreased phosphorylation of AKT1 protein
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of AKT1 mRNA 		CTD PMID:18924134 PMID:20371263 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt1s1 AKT1 substrate 1 decreases expression EXP Sulindac results in decreased expression of AKT1S1 mRNA CTD PMID:24136188 NCBI chr 1:104,469,823...104,476,168
Ensembl chr 1:104,469,803...104,476,167 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 decreases expression
increases expression 		ISO
EXP 		Sulindac results in decreased expression of AKT2 mRNA
Sulindac results in increased expression of AKT2 mRNA 		CTD PMID:11906190 PMID:24136188 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Alb albumin multiple interactions EXP [Sulindac co-treated with REN2] results in increased expression of ALB protein CTD PMID:12586211 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1A1 mRNA CTD PMID:20371263 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH1L1 mRNA CTD PMID:20371263 NCBI chr 4:124,617,182...124,663,674
Ensembl chr 4:124,617,217...124,664,704 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Sulindac results in decreased expression of ALDH3A2 mRNA CTD PMID:24136188 NCBI chr10:46,427,789...46,448,449
Ensembl chr10:46,407,993...46,448,648 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH6A1 mRNA CTD PMID:20371263 NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743 		JBrowse link
G Alg14 ALG14, UDP-N-acetylglucosaminyltransferase subunit increases expression EXP Sulindac results in increased expression of ALG14 mRNA CTD PMID:24136188 NCBI chr 2:212,053,008...212,130,136
Ensembl chr 2:212,044,969...212,130,140 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression
increases activity
multiple interactions 		ISO Sulindac results in increased expression of ALOX15 protein
Sulindac results in increased activity of ALOX15 protein
[Sulindac results in increased expression of ALOX15 protein] which results in increased chemical synthesis of 13-hydroxy-9,11-octadecadienoic acid 		CTD PMID:10904086 PMID:11406566 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO Sulindac promotes the reaction [cobaltous chloride results in decreased expression of ALPL protein]; Sulindac promotes the reaction [Deferoxamine results in decreased expression of ALPL protein] CTD PMID:21882223 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Amd1 adenosylmethionine decarboxylase 1 multiple interactions ISO [Sulindac co-treated with Putrescine] results in decreased activity of AMD1 protein CTD PMID:17474863 NCBI chr20:45,250,289...45,324,939
Ensembl chr20:45,250,289...45,265,982 		JBrowse link
G Amt aminomethyltransferase increases expression EXP Sulindac results in increased expression of AMT mRNA CTD PMID:24136188 NCBI chr 8:117,859,700...117,866,692
Ensembl chr 8:117,860,345...117,866,803 		JBrowse link
G Amz2 archaelysin family metallopeptidase 2 decreases expression EXP Sulindac results in decreased expression of AMZ2 mRNA CTD PMID:24136188 NCBI chr10:94,901,053...94,911,629
Ensembl chr10:94,901,129...94,911,627 		JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO Sulindac results in decreased expression of ANGPTL3 mRNA CTD PMID:32535746 NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444 		JBrowse link
G Ankrd11 ankyrin repeat domain containing 11 increases expression ISO Sulindac results in increased expression of ANKRD11 mRNA CTD PMID:11906190 NCBI chr19:67,848,836...68,007,491
Ensembl chr19:67,848,844...68,007,491 		JBrowse link
G Ankrd24 ankyrin repeat domain 24 increases expression EXP Sulindac results in increased expression of ANKRD24 mRNA CTD PMID:24136188 NCBI chr 7:8,712,720...8,731,910
Ensembl chr 7:8,712,722...8,731,910 		JBrowse link
G Ankrd28 ankyrin repeat domain 28 decreases expression EXP Sulindac results in decreased expression of ANKRD28 mRNA CTD PMID:24136188 NCBI chr16:6,924,868...7,056,593
Ensembl chr16:6,924,882...7,056,593 		JBrowse link
G Ankrd40 ankyrin repeat domain 40 increases expression EXP Sulindac results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr10:79,778,966...79,792,212
Ensembl chr10:56,415,260...56,416,345
Ensembl chr10:56,415,260...56,416,345 		JBrowse link
G Ap1ar adaptor-related protein complex 1 associated regulatory protein increases expression EXP Sulindac results in increased expression of AP1AR mRNA CTD PMID:24136188 NCBI chr 2:218,951,104...218,983,495
Ensembl chr 2:218,927,373...218,983,752 		JBrowse link
G Ap3d1 adaptor related protein complex 3 subunit delta 1 increases expression EXP Sulindac results in increased expression of AP3D1 mRNA CTD PMID:24136188 NCBI chr 7:9,620,909...9,656,350
Ensembl chr 7:9,620,968...9,656,342 		JBrowse link
G Apc APC regulator of WNT signaling pathway multiple interactions
increases expression 		EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of APC mRNA]
Sulindac results in increased expression of APC protein 		CTD PMID:11076880 PMID:12458338 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G Apob apolipoprotein B decreases secretion ISO Sulindac results in decreased secretion of APOB protein CTD PMID:32535746 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814 		JBrowse link
G Apoc3 apolipoprotein C3 decreases secretion ISO Sulindac results in decreased secretion of APOC3 protein CTD PMID:32535746 NCBI chr 8:55,428,172...55,430,352
Ensembl chr 8:55,428,024...55,458,679 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA] CTD PMID:15190207 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Sulindac results in decreased expression of AQP1 mRNA CTD PMID:24136188 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504 		JBrowse link
G Arglu1 arginine and glutamate rich 1 increases expression ISO Sulindac results in increased expression of ARGLU1 mRNA CTD PMID:11906190 NCBI chr16:87,455,097...87,479,148
Ensembl chr16:87,455,113...87,479,148 		JBrowse link
G Arid1b AT-rich interaction domain 1B decreases expression EXP Sulindac results in decreased expression of ARID1B mRNA CTD PMID:24136188 NCBI chr 1:47,973,199...48,328,793
Ensembl chr 1:47,973,997...48,328,793 		JBrowse link
G Arl1 ARF like GTPase 1 increases expression EXP Sulindac results in increased expression of ARL1 mRNA CTD PMID:24136188 NCBI chr 7:25,007,401...25,018,572
Ensembl chr 7:25,006,981...25,019,319 		JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Sulindac results in increased expression of ARRDC3 mRNA CTD PMID:11906190 NCBI chr 2:12,873,202...12,885,716
Ensembl chr 2:12,873,202...12,885,875 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Sulindac results in increased expression of ASNS mRNA CTD PMID:11906190 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Asnsd1 asparagine synthetase domain containing 1 increases expression EXP Sulindac results in increased expression of ASNSD1 mRNA CTD PMID:24136188 NCBI chr 9:55,618,799...55,631,064
Ensembl chr 9:55,618,799...55,631,064 		JBrowse link
G Ate1 arginyltransferase 1 decreases expression EXP Sulindac results in decreased expression of ATE1 mRNA CTD PMID:24136188 NCBI chr 1:194,391,843...194,514,284
Ensembl chr 1:194,391,843...194,511,348 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Sulindac results in increased expression of ATF3 mRNA CTD PMID:11906190 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Sulindac results in increased expression of ATF4 mRNA CTD PMID:11906190 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Sulindac results in increased expression of ATF6 mRNA CTD PMID:32535746 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Atg3 autophagy related 3 increases expression EXP Sulindac results in increased expression of ATG3 mRNA CTD PMID:24136188 NCBI chr11:69,130,948...69,159,280
Ensembl chr11:69,121,952...69,159,280 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 decreases expression ISO Sulindac results in decreased expression of ATP2A1 mRNA CTD PMID:11906190 NCBI chr 1:190,457,198...190,475,410
Ensembl chr 1:190,457,198...190,475,423 		JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A increases expression EXP Sulindac results in increased expression of ATP6V1A mRNA CTD PMID:24136188 NCBI chr11:70,066,800...70,120,603
Ensembl chr11:70,035,134...70,120,603 		JBrowse link
G Atp6v1e1 ATPase H+ transporting V1 subunit E1 increases expression EXP Sulindac results in increased expression of ATP6V1E1 mRNA CTD PMID:24136188 NCBI chr 4:155,694,534...155,716,660
Ensembl chr 4:155,694,534...155,716,678 		JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of AUH mRNA CTD PMID:20371263 NCBI chr17:12,481,396...12,576,748
Ensembl chr17:12,481,416...12,602,587 		JBrowse link
G Aurka aurora kinase A decreases expression ISO Sulindac results in decreased expression of AURKA mRNA CTD PMID:11906190 NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771 		JBrowse link
G Aurkaip1 aurora kinase A interacting protein 1 decreases expression EXP Sulindac results in decreased expression of AURKAIP1 mRNA CTD PMID:24136188 NCBI chr 5:171,717,349...171,719,123 JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 decreases expression EXP Sulindac results in decreased expression of B4GALT1 mRNA CTD PMID:24136188 NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:60,731,602...60,778,445 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases expression 		ISO Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]
Sulindac results in decreased expression of BAD protein 		CTD PMID:12566304 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
affects localization 		ISO SB 203580 inhibits the reaction [Sulindac affects the localization of BAK1 protein] CTD PMID:17136320 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases response to substance
affects localization
increases expression 		ISO SB 203580 inhibits the reaction [Sulindac affects the localization of BAX protein]
BAX protein results in increased susceptibility to Sulindac
Sulindac results in increased expression of BAX protein 		CTD PMID:11062132 PMID:17136320 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Sulindac results in increased expression of BBC3 mRNA CTD PMID:11906190 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcap29 B-cell receptor-associated protein 29 increases expression ISO Sulindac results in increased expression of BCAP29 mRNA CTD PMID:11906190 NCBI chr 6:53,910,209...53,950,206
Ensembl chr 6:53,910,216...53,949,963 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO
EXP 		Sulindac results in decreased expression of BCL2 protein
[Sulindac results in increased abundance of Reactive Oxygen Species] which results in increased cleavage of BCL2 protein
[Olive Oil co-treated with Sulindac] results in decreased expression of BCL2 protein 		CTD PMID:10223192 PMID:15309441 PMID:15793875 PMID:17136320 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression 		ISO [Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]; MAPK8 affects the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased phosphorylation of BCL2L1 protein]
Sulindac results in decreased expression of BCL2L1 protein 		CTD PMID:11062132 PMID:18281123 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC2 protein CTD PMID:17136320 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC3 protein CTD PMID:17136320 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression 		ISO [Sulindac co-treated with Arsenic Trioxide] results in decreased expression of BIRC5 protein; [Sulindac co-treated with Vorinostat] results in decreased expression of BIRC5 mRNA; [Sulindac co-treated with Vorinostat] results in decreased expression of BIRC5 protein; [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of BIRC5 protein; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein modified form]; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein]
Sulindac results in decreased expression of BIRC5 mRNA; Sulindac results in decreased expression of BIRC5 protein 		CTD PMID:11906190 PMID:14610217 PMID:17136320 PMID:17401459 PMID:18156316 More... NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Blmh bleomycin hydrolase increases expression EXP Sulindac results in increased expression of BLMH mRNA CTD PMID:24136188 NCBI chr10:62,270,170...62,313,349
Ensembl chr10:62,270,033...62,313,345 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP Sulindac results in increased expression of BNIP3L mRNA CTD PMID:24136188 NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282 		JBrowse link
G Borcs7 BLOC-1 related complex subunit 7 increases expression EXP Sulindac results in increased expression of BORCS7 mRNA CTD PMID:24136188 NCBI chr 1:255,505,745...255,519,579
Ensembl chr 1:255,505,745...255,518,815 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Sulindac results in decreased expression of BRCA1 mRNA CTD PMID:16273229 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Brd4 bromodomain containing 4 decreases expression ISO Sulindac results in decreased expression of BRD4 mRNA CTD PMID:11906190 NCBI chr 7:11,866,997...11,946,575
Ensembl chr 7:11,866,997...11,946,923 		JBrowse link
G Btbd1 BTB domain containing 1 increases expression EXP Sulindac results in increased expression of BTBD1 mRNA CTD PMID:24136188 NCBI chr 1:145,143,806...145,183,653
Ensembl chr 1:145,143,808...145,181,197 		JBrowse link
G Bzw1 basic leucine zipper and W2 domains 1 increases expression EXP Sulindac results in increased expression of BZW1 mRNA CTD PMID:24136188 NCBI chr 9:67,424,860...67,438,656
Ensembl chr 9:67,424,866...67,439,684 		JBrowse link
G Bzw2 basic leucine zipper and W2 domains 2 decreases expression ISO Sulindac results in decreased expression of BZW2 mRNA CTD PMID:11093808 NCBI chr 6:58,555,362...58,615,921
Ensembl chr 6:58,554,961...58,615,912 		JBrowse link
G C17h7orf25 similar to human chromosome 7 open reading frame 25 decreases expression EXP Sulindac results in decreased expression of C17H7ORF25 mRNA CTD PMID:24136188 NCBI chr17:55,238,751...55,245,399
Ensembl chr17:55,236,313...55,246,284 		JBrowse link
G C18h18orf32 similar to human chromosome 18 open reading frame 32 decreases expression EXP Sulindac results in decreased expression of C18H18ORF32 mRNA CTD PMID:24136188 NCBI chr18:70,861,434...70,869,983
Ensembl chr18:70,861,435...70,869,983 		JBrowse link
G C1galt1c1 C1GALT1-specific chaperone 1 decreases expression EXP Sulindac results in decreased expression of C1GALT1C1 mRNA CTD PMID:24136188 NCBI chr  X:122,243,736...122,248,217
Ensembl chr  X:122,234,454...122,248,422 		JBrowse link
G C2h1orf52 similar to human chromosome 1 open reading frame 52 increases expression ISO Sulindac results in increased expression of C1ORF52 mRNA CTD PMID:11906190 NCBI chr 2:237,510,974...237,520,346
Ensembl chr 2:237,513,711...237,520,346 		JBrowse link
G C4b complement C4B decreases expression EXP Sulindac results in decreased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,201,961...4,216,289 		JBrowse link
G Ca9 carbonic anhydrase 9 decreases expression ISO Sulindac analog results in decreased expression of CA9 mRNA CTD PMID:18924134 NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:62,558,823...62,565,626 		JBrowse link
G Calm3 calmodulin 3 decreases expression
increases expression 		ISO
EXP 		Sulindac results in decreased expression of CALM3 mRNA
Sulindac results in increased expression of CALM3 mRNA 		CTD PMID:11906190 PMID:24136188 NCBI chr 1:86,718,761...86,725,869
Ensembl chr 1:86,717,321...86,725,960 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity 		ISO
EXP 		[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased activity of CASP3 protein]
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP3 protein
Sulindac results in increased activity of CASP3 protein
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in decreased expression of CASP3 protein] 		CTD PMID:12017300 PMID:15713900 PMID:15946692 PMID:18281123 PMID:29999212 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein CTD PMID:21171083 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression 		ISO [Sulindac co-treated with arsenic trioxide] results in increased activity of CASP9 protein
Sulindac results in increased activity of CASP9 protein
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP9 protein 		CTD PMID:15713900 PMID:18281123 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cast calpastatin decreases expression EXP Sulindac results in decreased expression of CAST mRNA CTD PMID:24136188 NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:5,707,640...5,817,180 		JBrowse link
G Cavin3 caveolae associated protein 3 increases expression ISO Sulindac results in increased expression of CAVIN3 mRNA CTD PMID:11906190 NCBI chr 1:169,238,384...169,239,973
Ensembl chr 1:169,238,384...169,239,981 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Sulindac inhibits the reaction [IL1B protein results in increased expression of CCL5 mRNA]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:16159934 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Sulindac results in decreased expression of CCNA2 protein CTD PMID:16488075 NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:121,355,363...121,361,701 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Sulindac results in decreased expression of CCNB1 mRNA CTD PMID:11906190 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CCND1 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]
[Sulindac co-treated with Plant Extracts] results in decreased expression of CCND1 protein 		CTD PMID:11504793 PMID:11593435 PMID:12351151 PMID:12584176 PMID:15020200 More... NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Sulindac results in decreased expression of CCNE1 protein CTD PMID:16488075 NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Ccnj cyclin J decreases expression ISO Sulindac results in decreased expression of CCNJ mRNA CTD PMID:11906190 NCBI chr 1:249,608,991...249,626,798
Ensembl chr 1:249,608,969...249,626,794 		JBrowse link
G Ccnq cyclin Q decreases expression EXP Sulindac results in decreased expression of CCNQ mRNA CTD PMID:24136188 NCBI chr10:64,144,560...64,145,723
Ensembl chr10:64,144,555...64,145,911 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 decreases expression EXP Sulindac results in decreased expression of CCT4 mRNA CTD PMID:24136188 NCBI chr14:101,193,057...101,205,935
Ensembl chr14:101,192,772...101,205,770 		JBrowse link
G Cdc37l1 cell division cycle 37-like 1 decreases expression EXP Sulindac results in decreased expression of CDC37L1 mRNA CTD PMID:24136188 NCBI chr 1:236,118,630...236,147,527
Ensembl chr 1:236,118,555...236,207,079 		JBrowse link
G Cdc42ep1 CDC42 effector protein 1 increases expression ISO Sulindac results in increased expression of CDC42EP1 mRNA CTD PMID:11906190 NCBI chr 7:112,275,759...112,283,665
Ensembl chr 7:112,275,792...112,283,664 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO Sulindac results in decreased expression of CDK1 mRNA CTD PMID:16273229 NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions
decreases activity 		ISO Sulindac promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein]
Sulindac results in decreased activity of CDK2 protein 		CTD PMID:14566837 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
decreases expression 		ISO
EXP 		CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CDK4 protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CDK4 mRNA 		CTD PMID:17292881 PMID:18291362 PMID:20371263 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Sulindac results in decreased expression of CDK6 protein CTD PMID:16488075 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
decreases activity
increases activity
increases expression
increases response to substance 		ISO
EXP 		[Sulindac co-treated with epigallocatechin gallate] results in increased expression of CDKN1A mRNA; CDKN1A protein promotes the reaction [Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein]; CSK protein affects the reaction [Sulindac results in increased expression of CDKN1A protein]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of APP mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of CTSB mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GBA1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of IL32 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SAA1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SHC1 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SOD2 mRNA]; Sulindac inhibits the reaction [CDKN1A protein results in increased expression of TGM2 mRNA]; Sulindac promotes the reaction [CDKN1A protein results in decreased activity of CDK2 protein]
Sulindac results in decreased activity of CDKN1A protein
Sulindac results in increased activity of CDKN1A protein
Sulindac results in increased expression of CDKN1A mRNA; Sulindac results in increased expression of CDKN1A protein
CDKN1A protein results in increased susceptibility to Sulindac
[Azoxymethane co-treated with Sulindac] results in increased expression of CDKN1A protein 		CTD PMID:11507085 PMID:12628509 PMID:14566837 PMID:15190207 PMID:15688007 More... NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN1B protein] CTD PMID:12189186 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions EXP Sulindac inhibits the reaction [Azoxymethane results in decreased expression of CDKN2A mRNA] CTD PMID:12189186 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Cep15 centrosomal protein 15 decreases expression EXP Sulindac results in decreased expression of CEP15 mRNA CTD PMID:24136188 NCBI chr15:15,247,627...15,265,560
Ensembl chr15:15,247,932...15,265,475 		JBrowse link
G Cfl2 cofilin 2 decreases expression EXP Sulindac results in decreased expression of CFL2 mRNA CTD PMID:24136188 NCBI chr 6:78,090,843...78,094,888
Ensembl chr 6:78,090,843...78,094,888 		JBrowse link
G Chchd3 coiled-coil-helix-coiled-coil-helix domain containing 3 decreases expression EXP Sulindac results in decreased expression of CHCHD3 mRNA CTD PMID:24136188 NCBI chr 4:62,327,574...62,584,085
Ensembl chr 4:62,327,576...62,584,035 		JBrowse link
G Chchd5 coiled-coil-helix-coiled-coil-helix domain containing 5 increases expression EXP Sulindac results in increased expression of CHCHD5 mRNA CTD PMID:24136188 NCBI chr 3:136,815,034...136,819,230
Ensembl chr 3:136,815,048...136,821,914 		JBrowse link
G Chd8 chromodomain helicase DNA binding protein 8 decreases expression EXP Sulindac results in decreased expression of CHD8 mRNA CTD PMID:24136188 NCBI chr15:27,379,285...27,438,959
Ensembl chr15:27,379,285...27,417,851 		JBrowse link
G Chmp2a charged multivesicular body protein 2A decreases expression EXP Sulindac results in decreased expression of CHMP2A mRNA CTD PMID:24136188 NCBI chr 1:82,731,212...82,735,088
Ensembl chr 1:82,732,231...82,738,613 		JBrowse link
G Chrac1 chromatin accessibility complex subunit 1 increases expression EXP Sulindac results in increased expression of CHRAC1 mRNA CTD PMID:24136188 NCBI chr 7:106,901,841...106,905,441 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Sulindac inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15489888 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit increases expression EXP Sulindac results in increased expression of CLPP mRNA CTD PMID:24136188 NCBI chr 9:1,917,305...1,924,706
Ensembl chr 9:1,918,682...1,924,705 		JBrowse link
G Clu clusterin affects expression ISO Sulindac affects the expression of CLU protein CTD PMID:12388792 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 increases expression EXP Sulindac results in increased expression of CMTM6 mRNA CTD PMID:24136188 NCBI chr 8:123,301,131...123,319,230
Ensembl chr 8:123,300,918...123,319,230 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 decreases expression EXP Sulindac results in decreased expression of CNGB1 mRNA CTD PMID:24136188 NCBI chr19:9,732,646...9,798,864
Ensembl chr19:9,732,646...9,797,224 		JBrowse link
G Cnnm4 cyclin and CBS domain divalent metal cation transport mediator 4 increases expression ISO Sulindac results in increased expression of CNNM4 mRNA CTD PMID:11906190 NCBI chr 9:46,207,602...46,246,817
Ensembl chr 9:46,207,551...46,246,817 		JBrowse link
G Cnot6 CCR4-NOT transcription complex, subunit 6 decreases expression EXP Sulindac results in decreased expression of CNOT6 mRNA CTD PMID:24136188 NCBI chr10:34,479,892...34,532,166
Ensembl chr10:34,481,938...34,524,416 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Sulindac results in increased expression of COL1A2 mRNA CTD PMID:18499699 NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:33,518,420...33,553,995 		JBrowse link
G Col5a2 collagen type V alpha 2 chain increases expression ISO Sulindac results in increased expression of COL5A2 mRNA CTD PMID:18499699 NCBI chr 9:54,940,768...55,090,151
Ensembl chr 9:54,940,764...55,090,150 		JBrowse link
G Col6a2 collagen type VI alpha 2 chain increases expression ISO Sulindac results in increased expression of COL6A2 mRNA CTD PMID:18499699 NCBI chr20:12,021,182...12,048,932
Ensembl chr20:12,021,265...12,057,042 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain increases expression ISO Sulindac results in increased expression of COL6A3 mRNA CTD PMID:18499699 NCBI chr 9:98,809,171...98,887,060
Ensembl chr 9:98,809,171...98,886,990 		JBrowse link
G Commd3 COMM domain containing 3 increases expression EXP Sulindac results in increased expression of COMMD3 mRNA CTD PMID:24136188 NCBI chr17:86,235,863...86,239,610
Ensembl chr17:86,235,863...86,239,610 		JBrowse link
G Commd5 COMM domain containing 5 increases expression EXP Sulindac results in increased expression of COMMD5 mRNA CTD PMID:24136188 NCBI chr 7:110,502,492...110,503,916
Ensembl chr 7:110,479,403...110,505,897 		JBrowse link
G Cops7a COP9 signalosome subunit 7A increases expression EXP Sulindac results in increased expression of COPS7A mRNA CTD PMID:24136188 NCBI chr 4:159,452,878...159,478,878
Ensembl chr 4:159,452,897...159,460,315 		JBrowse link
G Cox15 cytochrome c oxidase assembly homolog COX15 increases expression EXP Sulindac results in increased expression of COX15 mRNA CTD PMID:24136188 NCBI chr 1:252,554,811...252,571,471
Ensembl chr 1:252,554,811...252,571,471 		JBrowse link
G Cpne1 copine 1 decreases expression ISO Sulindac results in decreased expression of CPNE1 mRNA CTD PMID:11906190 NCBI chr 3:165,047,615...165,089,994 JBrowse link
G Cpsf3 cleavage and polyadenylation specific factor 3 increases expression EXP Sulindac results in increased expression of CPSF3 mRNA CTD PMID:24136188 NCBI chr 6:46,564,855...46,592,776
Ensembl chr 6:46,564,735...46,594,136 		JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 increases expression EXP Sulindac results in increased expression of CREB3L3 mRNA CTD PMID:24136188 NCBI chr 7:9,273,320...9,281,755
Ensembl chr 7:9,273,338...9,281,778 		JBrowse link
G Crebzf CREB/ATF bZIP transcription factor increases expression EXP Sulindac results in increased expression of CREBZF mRNA CTD PMID:24136188 NCBI chr 1:153,829,544...153,836,073
Ensembl chr 1:153,829,448...153,845,122 		JBrowse link
G Cry2 cryptochrome circadian regulator 2 decreases expression EXP Sulindac results in decreased expression of CRY2 mRNA CTD PMID:24136188 NCBI chr 3:98,830,479...98,860,437
Ensembl chr 3:98,830,483...98,860,447 		JBrowse link
G Csf1 colony stimulating factor 1 decreases expression EXP Sulindac results in decreased expression of CSF1 mRNA CTD PMID:24136188 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468 		JBrowse link
G Csk C-terminal Src kinase multiple interactions ISO
EXP 		CSK protein affects the reaction [Sulindac results in increased expression of CDKN1A protein]
[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein; [Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein 		CTD PMID:18644992 NCBI chr 8:66,925,650...66,944,861
Ensembl chr 8:66,925,651...66,930,274 		JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 decreases expression
increases expression 		ISO
EXP 		Sulindac results in decreased expression of CSNK2A1 mRNA
Sulindac results in increased expression of CSNK2A1 mRNA 		CTD PMID:11906190 PMID:24136188 NCBI chr 3:161,170,295...161,217,073
Ensembl chr 3:161,170,405...161,215,698 		JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 increases expression ISO Sulindac results in increased expression of CSNK2A2 mRNA CTD PMID:11906190 NCBI chr19:9,562,340...9,602,136
Ensembl chr19:9,562,321...9,602,136 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression 		ISO
EXP 		CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CCND1 protein]; CTNNB1 protein affects the reaction [Sulindac results in decreased expression of CDK4 protein]; CTNNB1 protein affects the reaction [Sulindac results in decreased expression of MYC protein]; Sulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein]
Sulindac results in decreased expression of CTNNB1 protein
[Sulindac co-treated with Plant Extracts] results in decreased expression of CTNNB1 protein
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] 		CTD PMID:10223192 PMID:11751639 PMID:12351151 PMID:18291362 PMID:29999212 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsb cathepsin B multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of CTSB mRNA] CTD PMID:15190207 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Sulindac inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:17010317 NCBI chr14:16,007,166...16,012,077
Ensembl chr14:16,007,204...16,014,299 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
increases activity
decreases activity 		ISO
EXP 		Sulindac results in increased expression of CYP1A1 mRNA
Sulindac results in increased activity of CYP1A1 protein
Sulindac results in decreased activity of CYP1A1 protein 		CTD PMID:16531450 PMID:17985343 PMID:33814510 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression 		ISO
EXP 		Sulindac results in increased expression of CYP1A2 mRNA
Sulindac results in decreased expression of CYP1A2 mRNA 		CTD PMID:16531450 PMID:17985343 PMID:24136188 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases activity
decreases activity 		ISO
EXP 		Sulindac results in increased expression of CYP1B1 mRNA
Sulindac results in increased activity of CYP1B1 protein
Sulindac results in decreased activity of CYP1B1 protein 		CTD PMID:16531450 PMID:17985343 PMID:33814510 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2D4 mRNA CTD PMID:20371263 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP2J4 mRNA CTD PMID:20371263 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP4B1 mRNA CTD PMID:20371263 NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116 		JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of CYP8B1 mRNA CTD PMID:20371263 NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:130,442,503...130,457,689 		JBrowse link
G Dcn decorin decreases expression ISO Sulindac results in decreased expression of DCN mRNA CTD PMID:11507085 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926 		JBrowse link
G Dctn5 dynactin subunit 5 decreases expression EXP Sulindac results in decreased expression of DCTN5 mRNA CTD PMID:24136188 NCBI chr 1:186,120,415...186,137,146
Ensembl chr 1:186,119,913...186,137,146 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression 		ISO [Sulindac co-treated with epigallocatechin gallate] results in increased expression of DDIT3 mRNA
Sulindac results in increased expression of DDIT3 mRNA 		CTD PMID:12628509 PMID:24136188 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddx1 DEAD-box helicase 1 decreases expression EXP Sulindac results in decreased expression of DDX1 mRNA CTD PMID:24136188 NCBI chr 6:41,725,365...41,756,236
Ensembl chr 6:41,725,367...41,758,302 		JBrowse link
G Degs1 delta(4)-desaturase, sphingolipid 1 increases expression EXP Sulindac results in increased expression of DEGS1 mRNA CTD PMID:24136188 NCBI chr13:96,478,645...96,485,302
Ensembl chr13:96,478,646...96,485,302 		JBrowse link
G Dffb DNA fragmentation factor subunit beta affects localization ISO Sulindac affects the localization of DFFB protein CTD PMID:15946692 NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:169,804,889...169,817,225 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Sulindac results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:70,195,637...70,205,735
Ensembl chr10:70,195,637...70,205,893 		JBrowse link
G Dhx36 DEAH-box helicase 36 increases expression EXP Sulindac results in increased expression of DHX36 mRNA CTD PMID:24136188 NCBI chr 2:149,006,089...149,044,192
Ensembl chr 2:149,006,089...149,044,191 		JBrowse link
G Dip2c disco-interacting protein 2 homolog C increases expression EXP Sulindac results in increased expression of DIP2C mRNA CTD PMID:24136188 NCBI chr17:65,338,711...65,724,111
Ensembl chr17:65,338,711...65,723,344 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression EXP Sulindac results in increased expression of DLG1 mRNA CTD PMID:24136188 NCBI chr11:82,416,853...82,607,797
Ensembl chr11:82,416,853...82,607,797 		JBrowse link
G Dnajc10 DnaJ heat shock protein family (Hsp40) member C10 increases expression EXP Sulindac results in increased expression of DNAJC10 mRNA CTD PMID:24136188 NCBI chr 3:85,636,890...85,679,620
Ensembl chr 3:85,639,589...85,689,368 		JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 increases expression EXP Sulindac results in increased expression of DNAJC15 mRNA CTD PMID:24136188 NCBI chr15:59,594,314...59,658,862
Ensembl chr15:59,594,314...59,658,987 		JBrowse link
G Dpys dihydropyrimidinase increases expression ISO Sulindac results in increased expression of DPYS mRNA CTD PMID:11906190 NCBI chr 7:72,707,566...72,814,183
Ensembl chr 7:72,721,048...72,814,142 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression EXP Sulindac results in decreased expression of DYNLL1 mRNA CTD PMID:24136188 NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Sulindac results in decreased expression of E2F1 protein CTD PMID:16488075 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G Eci2 enoyl-CoA delta isomerase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ECI2 mRNA CTD PMID:20371263 NCBI chr17:30,056,274...30,092,169
Ensembl chr17:30,076,524...30,092,161 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12566304 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 decreases expression ISO Sulindac results in decreased expression of EHMT2 mRNA CTD PMID:11906190 NCBI chr20:3,924,263...3,941,238
Ensembl chr20:3,924,263...3,941,384 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression ISO Sulindac results in increased expression of EIF2AK3 mRNA CTD PMID:32535746 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression EXP Sulindac results in increased expression of EIF5B mRNA CTD PMID:24136188 NCBI chr 9:47,718,706...47,773,289
Ensembl chr 9:47,718,706...47,778,583 		JBrowse link
G Elapor2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 increases expression ISO Sulindac results in increased expression of ELAPOR2 mRNA CTD PMID:11906190 NCBI chr 4:25,565,298...25,760,684
Ensembl chr 4:25,568,122...25,760,684 		JBrowse link
G Eloc elongin C increases expression EXP Sulindac results in increased expression of ELOC mRNA CTD PMID:24136188 NCBI chr 5:7,444,769...7,461,187
Ensembl chr 5:7,445,018...7,464,128
Ensembl chr20:7,445,018...7,464,128 		JBrowse link
G Endog endonuclease G affects localization ISO Sulindac affects the localization of ENDOG protein CTD PMID:15946692 NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease decreases expression ISO Sulindac results in decreased expression of ERCC5 mRNA CTD PMID:11906190 NCBI chr 9:53,801,471...53,846,611
Ensembl chr 9:53,801,714...53,875,084 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Sulindac results in increased expression of ERN1 mRNA CTD PMID:32535746 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 decreases expression EXP Sulindac results in decreased expression of ERRFI1 mRNA CTD PMID:24136188 NCBI chr 5:166,606,841...166,620,124
Ensembl chr 5:166,606,834...166,620,432 		JBrowse link
G Ess2 ess-2 splicing factor homolog increases expression ISO Sulindac results in increased expression of ESS2 mRNA CTD PMID:11906190 NCBI chr11:96,580,185...96,596,673
Ensembl chr11:96,580,169...96,590,146 		JBrowse link
G Etfdh electron transfer flavoprotein dehydrogenase decreases expression EXP Sulindac results in decreased expression of ETFDH mRNA CTD PMID:24136188 NCBI chr 2:167,038,707...167,060,758
Ensembl chr 2:167,025,823...167,060,770 		JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor increases expression ISO Sulindac results in increased expression of ETS1 mRNA CTD PMID:11906190 NCBI chr 8:39,303,936...39,426,022
Ensembl chr 8:39,303,925...39,426,021 		JBrowse link
G Exoc3 exocyst complex component 3 decreases expression EXP Sulindac results in decreased expression of EXOC3 mRNA CTD PMID:24136188 NCBI chr 1:30,919,871...30,950,624 JBrowse link
G Exoc7 exocyst complex component 7 increases expression EXP Sulindac results in increased expression of EXOC7 mRNA CTD PMID:24136188 NCBI chr10:102,019,805...102,039,333
Ensembl chr10:102,019,806...102,039,447 		JBrowse link
G Exosc5 exosome component 5 decreases expression EXP Sulindac results in decreased expression of EXOSC5 mRNA CTD PMID:24136188 NCBI chr 1:90,295,495...90,305,047
Ensembl chr 1:90,293,797...90,305,046 		JBrowse link
G Exosc7 exosome component 7 decreases expression EXP Sulindac results in decreased expression of EXOSC7 mRNA CTD PMID:24136188 NCBI chr 8:131,650,988...131,676,399
Ensembl chr 8:131,651,050...131,696,825 		JBrowse link
G Fam219b family with sequence similarity 219, member B decreases expression EXP Sulindac results in decreased expression of FAM219B mRNA CTD PMID:24136188 NCBI chr 8:66,837,230...66,842,819
Ensembl chr 8:66,837,205...66,842,819 		JBrowse link
G Fam241b family with sequence similarity 241 member B increases expression EXP Sulindac results in increased expression of FAM241B mRNA CTD PMID:24136188 NCBI chr20:30,595,082...30,598,007
Ensembl chr20:30,595,084...30,597,844
Ensembl chr 6:30,595,084...30,597,844 		JBrowse link
G Fasn fatty acid synthase increases expression ISO Sulindac results in increased expression of FASN mRNA CTD PMID:32535746 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583 		JBrowse link
G Fbxl4 F-box and leucine-rich repeat protein 4 increases expression EXP Sulindac results in increased expression of FBXL4 mRNA CTD PMID:24136188 NCBI chr 5:40,752,513...40,826,154
Ensembl chr 5:40,752,521...40,850,826 		JBrowse link
G Fbxo42 F-box protein 42 increases expression ISO Sulindac results in increased expression of FBXO42 mRNA CTD PMID:11906190 NCBI chr 5:158,734,165...158,792,560
Ensembl chr 5:158,734,175...158,792,565 		JBrowse link
G Fbxo6 F-box protein 6 decreases expression EXP Sulindac results in decreased expression of FBXO6 mRNA CTD PMID:24136188 NCBI chr 5:163,859,909...163,865,693
Ensembl chr 5:163,859,916...163,865,574 		JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Sulindac results in increased expression of FHL2 mRNA CTD PMID:11906190 NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A decreases expression EXP Sulindac results in decreased expression of FKBP1A mRNA CTD PMID:24136188 NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:160,500,726...160,524,233 		JBrowse link
G Fli1 Fli-1 proto-oncogene, ETS transcription factor decreases expression EXP Sulindac results in decreased expression of FLI1 mRNA CTD PMID:24136188 NCBI chr 8:39,089,526...39,209,511
Ensembl chr 8:39,089,533...39,208,557 		JBrowse link
G Flnb filamin B increases expression EXP Sulindac results in increased expression of FLNB mRNA CTD PMID:24136188 NCBI chr15:19,392,212...19,525,278
Ensembl chr15:19,392,216...19,525,209 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
multiple interactions
increases metabolic processing 		ISO FMO3 gene polymorphism affects the metabolism of Sulindac
FMO3 gene polymorphism results in decreased metabolism of and results in increased susceptibility to Sulindac
FMO3 protein results in increased metabolism of Sulindac 		CTD PMID:15623613 PMID:17050781 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Sulindac results in decreased expression of FOS protein CTD PMID:15020200 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression ISO Sulindac results in increased expression of FTH1 mRNA CTD PMID:11093808 NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:216,051,998...216,055,214 		JBrowse link
G Ftl1 ferritin light chain 1 decreases expression EXP Sulindac results in decreased expression of FTL1 mRNA CTD PMID:24136188 NCBI chr 1:105,072,858...105,074,705
Ensembl chr  X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915 		JBrowse link
G Fxn frataxin increases expression EXP Sulindac results in increased expression of FXN mRNA CTD PMID:24136188 NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:231,300,150...231,323,989 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Sulindac results in increased expression of GADD45A mRNA CTD PMID:11906190 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Gal galanin and GMAP prepropeptide affects expression ISO Sulindac affects the expression of GAL protein CTD PMID:12388792 NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229 		JBrowse link
G Galk1 galactokinase 1 increases expression EXP Sulindac results in increased expression of GALK1 mRNA CTD PMID:24136188 NCBI chr10:101,742,067...101,746,244
Ensembl chr10:101,735,061...101,746,258 		JBrowse link
G Gap43 growth associated protein 43 affects expression ISO Sulindac affects the expression of GAP43 protein CTD PMID:12388792 NCBI chr11:71,882,131...71,975,799
Ensembl chr11:71,882,131...71,975,797 		JBrowse link
G Gatad1 GATA zinc finger domain containing 1 increases expression EXP Sulindac results in increased expression of GATAD1 mRNA CTD PMID:24136188 NCBI chr 4:31,462,251...31,473,827
Ensembl chr 4:31,462,309...31,503,921 		JBrowse link
G Gatad2a GATA zinc finger domain containing 2A increases expression EXP Sulindac results in increased expression of GATAD2A mRNA CTD PMID:24136188 NCBI chr16:19,463,500...19,553,497
Ensembl chr16:19,463,500...19,553,497 		JBrowse link
G Gatd3a glutamine amidotransferase class 1 domain containing 3A decreases expression ISO Sulindac results in decreased expression of GATD3 mRNA CTD PMID:11906190 NCBI chr20:10,514,459...10,522,556
Ensembl chr20:10,514,443...10,522,555 		JBrowse link
G Gba1 glucosylceramidase beta 1 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GBA1 mRNA] CTD PMID:15190207 NCBI chr 2:176,902,141...176,916,015
Ensembl chr 2:176,907,154...176,916,985 		JBrowse link
G Gcdh glutaryl-CoA dehydrogenase multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GCDH mRNA CTD PMID:20371263 NCBI chr19:40,168,038...40,174,536
Ensembl chr19:40,168,141...40,175,686 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
affects expression
increases expression 		ISO Acetylcysteine inhibits the reaction [Sulindac results in increased expression of GCLC protein]
Sulindac affects the expression of GCLC mRNA 		CTD PMID:11820781 PMID:15946948 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893 		JBrowse link
G Gcnt1 glucosaminyl (N-acetyl) transferase 1 increases expression ISO Sulindac results in increased expression of GCNT1 mRNA CTD PMID:11093808 NCBI chr 1:224,145,104...224,182,496
Ensembl chr 1:224,141,108...224,185,741 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO Sulindac results in increased expression of GDF15 mRNA; Sulindac results in increased expression of GDF15 protein CTD PMID:11906190 PMID:11984525 PMID:15180942 NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Ghitm growth hormone inducible transmembrane protein increases expression EXP Sulindac results in increased expression of GHITM mRNA CTD PMID:24136188 NCBI chr16:12,907,062...12,918,149
Ensembl chr16:12,905,806...12,918,123 		JBrowse link
G Ghr growth hormone receptor multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GHR mRNA CTD PMID:20371263 NCBI chr 2:54,269,066...54,532,595
Ensembl chr 2:54,270,206...54,532,331 		JBrowse link
G Glo1 glyoxalase 1 decreases activity ISO Sulindac results in decreased activity of GLO1 protein CTD PMID:17243824 NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191 		JBrowse link
G Gnas GNAS complex locus increases expression EXP Sulindac results in increased expression of GNAS mRNA CTD PMID:24136188 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536 		JBrowse link
G Gnl3l G protein nucleolar 3 like decreases expression EXP Sulindac results in decreased expression of GNL3L mRNA CTD PMID:24136188 NCBI chr  X:23,404,324...23,437,501
Ensembl chr  X:23,404,324...23,439,315 		JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Sulindac results in decreased expression of GNMT mRNA CTD PMID:24136188 NCBI chr 9:21,752,235...21,756,368
Ensembl chr 9:21,752,266...21,755,692 		JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GPX3 mRNA CTD PMID:20371263 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405 		JBrowse link
G Grb10 growth factor receptor bound protein 10 increases expression ISO Sulindac results in increased expression of GRB10 mRNA CTD PMID:11906190 NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387 		JBrowse link
G Grb2 growth factor receptor bound protein 2 increases expression EXP Sulindac results in increased expression of GRB2 mRNA CTD PMID:24136188 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 affects expression EXP Sulindac affects the expression of GRIN1 protein CTD PMID:15123337 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Sulindac affects the expression of GRIN2B protein CTD PMID:15123337 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570 		JBrowse link
G Grk6 G protein-coupled receptor kinase 6 decreases expression EXP Sulindac results in decreased expression of GRK6 mRNA CTD PMID:24136188 NCBI chr17:9,182,160...9,198,380
Ensembl chr17:9,182,160...9,197,954 		JBrowse link
G Grn granulin precursor multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of GRN mRNA] CTD PMID:15190207 NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,886,122...87,893,936 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO Sulindac results in decreased phosphorylation of GSK3B protein CTD PMID:11593435 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GSTM2 mRNA CTD PMID:20371263 NCBI chr 2:198,312,179...198,316,962 JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Sulindac results in increased expression of GSTT1 protein CTD PMID:9729437 NCBI chr20:12,856,068...12,873,020
Ensembl chr20:12,856,083...12,873,019 		JBrowse link
G Gtf2b general transcription factor IIB increases expression
decreases expression 		ISO
EXP 		Sulindac results in increased expression of GTF2B mRNA
Sulindac results in decreased expression of GTF2B mRNA 		CTD PMID:11906190 PMID:24136188 NCBI chr 2:234,427,734...234,446,043
Ensembl chr 2:234,427,637...234,446,049 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [Arsenic Trioxide co-treated with Sulindac] results in increased phosphorylation of H2AX protein CTD PMID:18636201 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G H2az1 H2A.Z variant histone 1 increases expression EXP Sulindac results in increased expression of H2AZ1 mRNA CTD PMID:24136188 NCBI chr 2:229,026,464...229,031,411
Ensembl chr 2:229,028,843...229,031,411 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP Sulindac results in decreased expression of HADHB mRNA CTD PMID:24136188 NCBI chr 6:31,873,404...31,907,557
Ensembl chr 6:31,873,404...31,907,835 		JBrowse link
G Helz2 helicase with zinc finger 2 decreases expression EXP Sulindac results in decreased expression of HELZ2 mRNA CTD PMID:24136188 NCBI chr 3:188,716,370...188,730,776
Ensembl chr 3:188,716,370...188,730,716 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Sulindac results in increased expression of HERPUD1 mRNA CTD PMID:11093808 NCBI chr19:10,604,360...10,624,168
Ensembl chr19:10,604,362...10,624,081 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression 		ISO [AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]] which affects the susceptibility to Oxygen; AKT1 protein affects the reaction [Sulindac analog results in decreased expression of HIF1A protein]
Sulindac analog results in decreased expression of HIF1A mRNA; Sulindac analog results in decreased expression of HIF1A protein 		CTD PMID:18924134 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A increases expression EXP Sulindac results in increased expression of HIGD1A mRNA CTD PMID:24136188 NCBI chr 8:130,391,658...130,400,888
Ensembl chr 8:130,391,661...130,400,888 		JBrowse link
G Hlcs holocarboxylase synthetase decreases expression ISO Sulindac results in decreased expression of HLCS mRNA CTD PMID:11906190 NCBI chr11:46,925,491...47,123,111
Ensembl chr11:46,925,491...47,105,082 		JBrowse link
G Hmgb3 high mobility group box 3 increases expression EXP Sulindac results in increased expression of HMGB3 mRNA CTD PMID:24136188 NCBI chr  X:154,341,106...154,346,087
Ensembl chr  X:154,340,935...154,346,097 		JBrowse link
G Hmmr hyaluronan-mediated motility receptor decreases expression ISO Sulindac results in decreased expression of HMMR mRNA CTD PMID:11906190 NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,635,915...25,665,390 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; pyrazolanthrone inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; SB 203580 inhibits the reaction [Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]]; Sulindac promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein]
Sulindac results in decreased expression of HMOX1 protein 		CTD PMID:18636201 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HNF4A mRNA CTD PMID:20371263 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of HSD17B4 mRNA CTD PMID:20371263 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Sulindac results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:110,076,710...110,103,665 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 increases expression EXP Sulindac results in increased expression of HSPA9 mRNA CTD PMID:24136188 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Sulindac results in decreased expression of ICAM1 protein CTD PMID:18059344 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression EXP Sulindac results in decreased expression of IFI27 mRNA CTD PMID:24136188 NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:128,355,079...128,361,781 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression EXP Sulindac results in decreased expression of IFITM3 mRNA CTD PMID:24136188 NCBI chr 1:205,540,649...205,541,758
Ensembl chr 1:205,481,168...205,547,920 		JBrowse link
G Ifnar1 interferon alpha and beta receptor subunit 1 decreases expression EXP Sulindac results in decreased expression of IFNAR1 mRNA CTD PMID:24136188 NCBI chr11:44,211,769...44,238,206
Ensembl chr11:44,211,845...44,238,205 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulindac inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA] CTD PMID:17010317 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216 		JBrowse link
G Iftap intraflagellar transport associated protein increases expression EXP Sulindac results in increased expression of IFTAP mRNA CTD PMID:24136188 NCBI chr 3:108,242,105...108,361,607
Ensembl chr 3:108,267,132...108,361,573 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO Sulindac results in decreased activity of IKBKB protein CTD PMID:19526344 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il11ra1 interleukin 11 receptor subunit alpha 1 increases expression EXP Sulindac results in increased expression of IL11RA1 mRNA CTD PMID:24136188 NCBI chr 5:61,727,650...61,737,265
Ensembl chr 5:61,727,931...61,737,264 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IL1A mRNA CTD PMID:20371263 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
increases expression 		ISO
EXP 		[Sulindac co-treated with epigallocatechin gallate] results in decreased expression of IL1B mRNA; Sulindac inhibits the reaction [IL1B protein results in increased abundance of Hyaluronic Acid]; Sulindac inhibits the reaction [IL1B protein results in increased expression of CCL5 mRNA]
Sulindac results in decreased expression of IL1B mRNA
Sulindac results in decreased expression of IL1B protein
Sulindac results in increased expression of IL1B 		CTD PMID:10328874 PMID:11318944 PMID:12628509 PMID:15123337 PMID:16159934 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il24 interleukin 24 multiple interactions
increases expression 		ISO Sulindac promotes the reaction [IL24 protein results in increased phosphorylation of MAPK8 protein]
[Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP3 protein; [Sulindac results in increased expression of IL24 protein] which results in increased expression of CASP9 protein; Sulindac results in increased expression of IL24 protein 		CTD PMID:15713900 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IL6 mRNA
Sulindac results in increased expression of IL6 		CTD PMID:20371263 PMID:24136188 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ilk integrin-linked kinase decreases activity ISO Sulindac results in decreased activity of ILK protein CTD PMID:11593435 NCBI chr 1:169,500,716...169,506,972
Ensembl chr 1:169,498,681...169,506,964 		JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E increases expression ISO Sulindac results in increased expression of INPP5E mRNA CTD PMID:11906190 NCBI chr 3:29,614,868...29,627,542
Ensembl chr 3:29,614,868...29,627,542 		JBrowse link
G Ipmk inositol polyphosphate multikinase decreases expression EXP Sulindac results in decreased expression of IPMK mRNA CTD PMID:24136188 NCBI chr20:17,216,151...17,250,826
Ensembl chr20:17,216,151...17,250,757 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of IRAK2 mRNA CTD PMID:20371263 NCBI chr 4:148,341,704...148,398,211
Ensembl chr 4:148,341,719...148,398,210 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP Sulindac results in decreased expression of IRF7 mRNA CTD PMID:24136188 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 decreases expression EXP Sulindac results in decreased expression of ISCA1 mRNA CTD PMID:24136188 NCBI chr17:4,910,816...4,923,478
Ensembl chr17:4,910,795...4,923,476 		JBrowse link
G Itga2 integrin subunit alpha 2 increases expression ISO Sulindac results in increased expression of ITGA2 mRNA CTD PMID:11906190 NCBI chr 2:48,253,412...48,354,509
Ensembl chr 2:48,253,412...48,354,509 		JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA] CTD PMID:15190207 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:90,009,900...90,067,800 		JBrowse link
G Itgb4 integrin subunit beta 4 multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of ITGB4 mRNA CTD PMID:12628509 NCBI chr10:101,705,592...101,741,933
Ensembl chr10:101,705,587...101,741,932 		JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein decreases expression EXP Sulindac results in decreased expression of JKAMP mRNA CTD PMID:24136188 NCBI chr 6:96,383,976...96,397,917
Ensembl chr 6:96,366,624...96,398,432 		JBrowse link
G Josd1 Josephin domain containing 1 decreases expression EXP Sulindac results in decreased expression of JOSD1 mRNA CTD PMID:24136188 NCBI chr 7:113,110,709...113,124,632
Ensembl chr 7:113,110,717...113,124,632 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions 		ISO Sulindac results in decreased expression of JUN protein
[Sulindac co-treated with Plant Extracts] results in decreased expression of JUN protein 		CTD PMID:12351151 PMID:12584176 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Sulindac results in increased expression of JUND mRNA CTD PMID:11906190 NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,764,985...18,782,148 		JBrowse link
G Kcnh3 potassium voltage-gated channel subfamily H member 3 decreases expression EXP Sulindac results in decreased expression of KCNH3 mRNA CTD PMID:24136188 NCBI chr 7:132,244,492...132,262,725
Ensembl chr 7:132,244,880...132,262,721 		JBrowse link
G Kctd5 potassium channel tetramerization domain containing 5 increases expression EXP Sulindac results in increased expression of KCTD5 mRNA CTD PMID:24136188 NCBI chr10:13,583,781...13,609,762
Ensembl chr10:13,583,781...13,610,062 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP Sulindac results in decreased expression of KEAP1 mRNA CTD PMID:24136188 NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042 		JBrowse link
G Khsrp KH-type splicing regulatory protein increases expression EXP Sulindac results in increased expression of KHSRP mRNA CTD PMID:24136188 NCBI chr 9:1,949,557...1,959,400
Ensembl chr 9:1,949,557...1,959,497 		JBrowse link
G Kif14 kinesin family member 14 increases expression ISO Sulindac results in increased expression of KIF14 mRNA CTD PMID:11906190 NCBI chr13:50,478,646...50,542,256
Ensembl chr13:50,478,721...50,542,248 		JBrowse link
G Klf5 KLF transcription factor 5 increases expression ISO Sulindac results in increased expression of KLF5 mRNA CTD PMID:11906190 NCBI chr15:82,472,081...82,487,267
Ensembl chr15:82,472,065...82,487,262 		JBrowse link
G Kras KRAS proto-oncogene, GTPase affects response to substance ISO KRAS protein affects the susceptibility to Sulindac CTD PMID:11751493 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Lad1 ladinin 1 increases expression ISO Sulindac results in increased expression of LAD1 mRNA CTD PMID:11507085 NCBI chr13:49,801,347...49,815,709
Ensembl chr13:49,800,472...49,815,709 		JBrowse link
G Lamtor4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 decreases expression EXP Sulindac results in decreased expression of LAMTOR4 mRNA CTD PMID:24136188 NCBI chr12:22,372,269...22,376,090
Ensembl chr12:22,372,269...22,376,090 		JBrowse link
G Larp1b La ribonucleoprotein 1B decreases expression EXP Sulindac results in decreased expression of LARP1B mRNA CTD PMID:24136188 NCBI chr 2:125,860,935...125,897,189
Ensembl chr 2:125,863,997...125,897,189 		JBrowse link
G Larp4 La ribonucleoprotein 4 increases expression ISO Sulindac results in increased expression of LARP4 mRNA CTD PMID:11906190 NCBI chr 7:132,983,276...133,031,514
Ensembl chr 7:132,980,385...133,029,633 		JBrowse link
G Lbp lipopolysaccharide binding protein multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of LBP mRNA CTD PMID:20371263 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518 		JBrowse link
G Ldb1 LIM domain binding 1 increases expression ISO Sulindac results in increased expression of LDB1 mRNA CTD PMID:11906190 NCBI chr 1:254,813,161...254,838,931
Ensembl chr 1:254,826,160...254,838,998 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO Sulindac results in decreased activity of [LEF1 protein binds to CTNNB1 protein] CTD PMID:11751639 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase increases expression ISO Sulindac results in increased expression of LFNG mRNA CTD PMID:11906190 NCBI chr12:19,144,474...19,152,951
Ensembl chr12:19,124,662...19,152,918 		JBrowse link
G Lgals3 galectin 3 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3 mRNA] CTD PMID:15190207 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737 		JBrowse link
G Lgals3bp galectin 3 binding protein multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of LGALS3BP mRNA] CTD PMID:15190207 NCBI chr10:104,118,510...104,127,848
Ensembl chr10:104,118,510...104,127,848 		JBrowse link
G Lipe lipase E, hormone sensitive type decreases expression EXP Sulindac results in decreased expression of LIPE mRNA CTD PMID:24136188 NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:90,093,433...90,112,117 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor increases expression EXP Sulindac results in increased expression of LITAF mRNA CTD PMID:24136188 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930 		JBrowse link
G Lmf2 lipase maturation factor 2 decreases expression EXP Sulindac results in decreased expression of LMF2 mRNA CTD PMID:24136188 NCBI chr 7:122,297,971...122,302,423
Ensembl chr 7:122,297,973...122,302,423 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial decreases expression EXP Sulindac results in decreased expression of LONP1 mRNA CTD PMID:24136188 NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,534,584...1,547,427 		JBrowse link
G Lox lysyl oxidase decreases expression ISO Sulindac analog results in decreased expression of LOX mRNA CTD PMID:18924134 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810 		JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing decreases expression EXP Sulindac results in decreased expression of LRPPRC mRNA CTD PMID:24136188 NCBI chr 6:15,612,638...15,695,113
Ensembl chr 6:15,612,655...15,695,116 		JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated increases expression EXP Sulindac results in increased expression of LSM10 mRNA CTD PMID:24136188 NCBI chr 5:143,649,817...143,660,391
Ensembl chr 5:143,615,360...143,663,986 		JBrowse link
G Lsm12 LSM12 homolog increases expression EXP Sulindac results in increased expression of LSM12 mRNA CTD PMID:24136188 NCBI chr10:87,618,518...87,640,556
Ensembl chr10:87,618,518...87,640,556 		JBrowse link
G Lsm6 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated increases expression EXP Sulindac results in increased expression of LSM6 mRNA CTD PMID:24136188 NCBI chr19:46,002,592...46,017,152 JBrowse link
G Macroh2a1 macroH2A.1 histone decreases expression EXP Sulindac results in decreased expression of MACROH2A1 mRNA CTD PMID:24136188 NCBI chr17:8,484,340...8,547,268
Ensembl chr17:8,484,246...8,547,257 		JBrowse link
G Maoa monoamine oxidase A decreases expression EXP Sulindac results in decreased expression of MAOA mRNA CTD PMID:24136188 NCBI chr  X:8,615,239...8,681,372
Ensembl chr  X:8,615,239...8,682,631 		JBrowse link
G Maob monoamine oxidase B multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAOB mRNA CTD PMID:20371263 NCBI chr  X:8,490,405...8,594,065
Ensembl chr  X:8,490,344...8,594,375 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAP3K8 mRNA CTD PMID:20371263 NCBI chr17:58,078,175...58,098,455
Ensembl chr17:58,078,320...58,098,452 		JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 increases expression ISO Sulindac results in increased expression of MAP4K3 mRNA CTD PMID:11906190 NCBI chr 6:20,029,246...20,198,583
Ensembl chr 6:20,029,397...20,198,583 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation 		ISO
EXP 		[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK1 protein; Arsenic Trioxide promotes the reaction [Sulindac results in increased phosphorylation of MAPK1 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Sulindac promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK1 protein]
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MAPK1 mRNA 		CTD PMID:12566304 PMID:18281123 PMID:18636201 PMID:20371263 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO [Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK3 protein; Arsenic Trioxide promotes the reaction [Sulindac results in increased phosphorylation of MAPK3 protein]; Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Sulindac promotes the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK3 protein] CTD PMID:12566304 PMID:18281123 PMID:18636201 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression
increases phosphorylation 		ISO CDKN1A protein promotes the reaction [Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein]; MAPK8 affects the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; Sulindac promotes the reaction [IL24 protein results in increased phosphorylation of MAPK8 protein]; Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein; Sulindac results in increased phosphorylation of and results in increased activity of MAPK8 protein
Sulindac results in increased expression of MAPK8 mRNA
Sulindac results in increased phosphorylation of MAPK8 protein 		CTD PMID:15713900 PMID:17292881 PMID:18281123 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mark3 microtubule affinity regulating kinase 3 decreases expression EXP Sulindac results in decreased expression of MARK3 mRNA CTD PMID:24136188 NCBI chr 6:136,447,327...136,537,409
Ensembl chr 6:136,448,531...136,537,404 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 decreases expression EXP Sulindac results in decreased expression of MBD2 mRNA CTD PMID:24136188 NCBI chr18:66,449,196...66,516,112
Ensembl chr18:66,449,358...66,516,111 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression EXP Sulindac results in decreased expression of MBD3 mRNA CTD PMID:24136188 NCBI chr 7:9,961,053...9,970,845
Ensembl chr 7:9,963,797...9,970,265 		JBrowse link
G Me1 malic enzyme 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ME1 mRNA CTD PMID:20371263 NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:96,429,057...96,540,275 		JBrowse link
G Med10 mediator complex subunit 10 increases expression EXP Sulindac results in increased expression of MED10 mRNA CTD PMID:24136188 NCBI chr 1:35,298,494...35,310,163
Ensembl chr 1:35,298,495...35,304,154 		JBrowse link
G Med15 mediator complex subunit 15 increases expression ISO Sulindac results in increased expression of MED15 mRNA CTD PMID:11906190 NCBI chr11:96,784,974...96,859,635
Ensembl chr11:96,784,999...96,859,644 		JBrowse link
G Mesd mesoderm development LRP chaperone decreases expression EXP Sulindac results in decreased expression of MESD mRNA CTD PMID:24136188 NCBI chr 1:147,275,904...147,289,134
Ensembl chr 1:147,275,396...147,289,134 		JBrowse link
G Mettl23 methyltransferase 23, arginine increases expression EXP Sulindac results in increased expression of METTL23 mRNA CTD PMID:24136188 NCBI chr10:102,546,102...102,550,782
Ensembl chr10:102,545,430...102,553,909 		JBrowse link
G Mfap3 microfibril associated protein 3 decreases expression EXP Sulindac results in decreased expression of MFAP3 mRNA CTD PMID:24136188 NCBI chr10:42,197,292...42,213,011
Ensembl chr10:42,197,275...42,210,988 		JBrowse link
G Mff mitochondrial fission factor decreases expression EXP Sulindac results in decreased expression of MFF mRNA CTD PMID:24136188 NCBI chr 9:91,455,931...91,484,171
Ensembl chr 9:91,455,871...91,484,171 		JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST2 mRNA CTD PMID:20371263 NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:137,836,140...137,866,661 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of MGST3 mRNA CTD PMID:20371263 NCBI chr13:82,059,480...82,080,418
Ensembl chr13:82,059,480...82,080,575 		JBrowse link
G Miip migration and invasion inhibitory protein increases expression ISO Sulindac results in increased expression of MIIP mRNA CTD PMID:11906190 NCBI chr 5:163,575,689...163,582,739
Ensembl chr 5:163,575,437...163,582,873 		JBrowse link
G Mllt6 MLLT6, PHD finger containing decreases expression EXP Sulindac results in decreased expression of MLLT6 mRNA CTD PMID:24136188 NCBI chr10:83,152,317...83,175,264
Ensembl chr10:83,153,698...83,175,250 		JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression EXP Sulindac results in decreased expression of MMP14 mRNA CTD PMID:24136188 NCBI chr15:31,857,824...31,867,049
Ensembl chr15:31,857,546...31,869,893 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO Sulindac results in decreased expression of MMP7 mRNA; Sulindac results in decreased expression of MMP7 protein CTD PMID:18499699 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755 		JBrowse link
G Mogs mannosyl-oligosaccharide glucosidase decreases expression EXP Sulindac results in decreased expression of MOGS mRNA CTD PMID:24136188 NCBI chr 4:117,179,335...117,182,738
Ensembl chr 4:117,179,335...117,182,744 		JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 decreases expression EXP Sulindac results in decreased expression of MRPL1 mRNA CTD PMID:24136188 NCBI chr14:13,604,498...13,663,633
Ensembl chr14:13,604,499...13,663,602 		JBrowse link
G Mrpl11 mitochondrial ribosomal protein L11 decreases expression EXP Sulindac results in decreased expression of MRPL11 mRNA CTD PMID:24136188 NCBI chr 1:211,693,807...211,696,667
Ensembl chr 1:211,693,804...211,697,177 		JBrowse link
G Mrpl13 mitochondrial ribosomal protein L13 increases expression EXP Sulindac results in increased expression of MRPL13 mRNA CTD PMID:24136188 NCBI chr 7:88,841,265...88,862,821
Ensembl chr 7:88,841,266...88,862,848 		JBrowse link
G Mrpl17 mitochondrial ribosomal protein L17 decreases expression EXP Sulindac results in decreased expression of MRPL17 mRNA CTD PMID:24136188 NCBI chr 1:169,574,010...169,575,699
Ensembl chr 1:169,574,010...169,575,818 		JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 decreases expression EXP Sulindac results in decreased expression of MRPL20 mRNA CTD PMID:24136188 NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:171,691,198...171,695,728 		JBrowse link
G Mrpl22 mitochondrial ribosomal protein L22 increases expression EXP Sulindac results in increased expression of MRPL22 mRNA CTD PMID:24136188 NCBI chr10:42,843,165...42,856,243
Ensembl chr10:42,843,222...42,856,227 		JBrowse link
G Mrpl23 mitochondrial ribosomal protein L23 decreases expression EXP Sulindac results in decreased expression of MRPL23 mRNA CTD PMID:24136188 NCBI chr 1:207,116,930...207,124,702
Ensembl chr 1:207,116,462...207,124,699 		JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 increases expression EXP Sulindac results in increased expression of MRPL32 mRNA CTD PMID:24136188 NCBI chr17:55,260,651...55,263,517
Ensembl chr17:55,260,270...55,263,517 		JBrowse link
G Mrpl37 mitochondrial ribosomal protein L37 decreases expression EXP Sulindac results in decreased expression of MRPL37 mRNA CTD PMID:24136188 NCBI chr 5:127,056,679...127,075,000
Ensembl chr 5:127,058,716...127,074,980 		JBrowse link
G Mrpl53 mitochondrial ribosomal protein L53 increases expression EXP Sulindac results in increased expression of MRPL53 mRNA CTD PMID:24136188 NCBI chr 4:117,173,043...117,173,933 JBrowse link
G Mrpl54 mitochondrial ribosomal protein L54 increases expression EXP Sulindac results in increased expression of MRPL54 mRNA CTD PMID:24136188 NCBI chr 7:9,103,525...9,106,045
Ensembl chr 7:9,103,525...9,106,045 		JBrowse link
G Mrpl58 mitochondrial ribosomal protein L58 decreases expression EXP Sulindac results in decreased expression of MRPL58 mRNA CTD PMID:24136188 NCBI chr10:101,145,342...101,151,838
Ensembl chr10:101,145,162...101,151,838 		JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression EXP Sulindac results in decreased expression of MRPS14 mRNA CTD PMID:24136188 NCBI chr13:74,962,597...74,968,344
Ensembl chr13:74,962,515...74,970,975 		JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 decreases expression EXP Sulindac results in decreased expression of MRPS24 mRNA CTD PMID:24136188 NCBI chr14:84,798,649...84,802,777 JBrowse link
G Mrps31 mitochondrial ribosomal protein S31 decreases expression EXP Sulindac results in decreased expression of MRPS31 mRNA CTD PMID:24136188 NCBI chr16:76,303,807...76,332,970
Ensembl chr16:76,301,645...76,333,065 		JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 increases expression EXP Sulindac results in increased expression of MRPS33 mRNA CTD PMID:24136188 NCBI chr 4:69,563,501...69,572,317
Ensembl chr 4:69,563,503...69,572,177 		JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 decreases expression EXP Sulindac results in decreased expression of MRPS7 mRNA CTD PMID:24136188 NCBI chr10:101,342,642...101,345,790
Ensembl chr10:101,342,421...101,346,082 		JBrowse link
G Mrps9 mitochondrial ribosomal protein S9 increases expression EXP Sulindac results in increased expression of MRPS9 mRNA CTD PMID:24136188 NCBI chr 9:52,605,678...52,664,499
Ensembl chr 9:52,605,678...52,664,499 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO Sulindac results in increased expression of MTHFD2 mRNA CTD PMID:11906190 NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350 		JBrowse link
G Mtpn myotrophin increases expression EXP Sulindac results in increased expression of MTPN mRNA CTD PMID:24136188 NCBI chr 4:65,126,390...65,153,803
Ensembl chr 4:65,115,980...65,153,924 		JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO Sulindac results in increased expression of MTTP mRNA CTD PMID:32535746 NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650 		JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Sulindac results in decreased expression of MUG1 mRNA CTD PMID:24136188 NCBI chr 4:156,748,351...156,802,132 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression 		ISO
EXP 		CTNNB1 protein affects the reaction [Sulindac results in decreased expression of MYC protein]
Sulindac results in increased expression of MYC mRNA
Sulindac inhibits the reaction [Azoxymethane results in increased expression of MYC mRNA]; Sulindac inhibits the reaction [Azoxymethane results in increased expression of MYC protein] 		CTD PMID:12189186 PMID:12414619 PMID:17292881 PMID:18291362 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Mzf1 myeloid zinc finger 1 decreases expression EXP Sulindac results in decreased expression of MZF1 mRNA CTD PMID:24136188 NCBI chr 1:82,742,709...82,755,069
Ensembl chr 1:82,742,726...82,753,820 		JBrowse link
G Naa35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit decreases expression EXP Sulindac results in decreased expression of NAA35 mRNA CTD PMID:24136188 NCBI chr17:5,039,897...5,091,916
Ensembl chr17:5,039,911...5,092,418 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase decreases expression EXP Sulindac results in decreased expression of NAMPT mRNA CTD PMID:24136188 NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:55,151,926...55,189,544 		JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 decreases expression ISO Sulindac results in decreased expression of NAP1L1 mRNA CTD PMID:11507085 NCBI chr 7:48,819,464...48,844,108
Ensembl chr 7:48,819,477...48,844,104 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases expression ISO Sulindac results in decreased expression of NAT1 mRNA CTD PMID:11828994 NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527 		JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression
decreases expression 		ISO
EXP 		Sulindac results in increased expression of NDRG1 mRNA
Sulindac results in decreased expression of NDRG1 mRNA 		CTD PMID:16273229 PMID:24136188 NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:100,573,523...100,614,913 		JBrowse link
G Ndst2 N-deacetylase and N-sulfotransferase 2 decreases expression ISO Sulindac results in decreased expression of NDST2 mRNA CTD PMID:11906190 NCBI chr15:3,612,775...3,623,061
Ensembl chr15:3,612,775...3,623,061 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 increases expression EXP Sulindac results in increased expression of NDUFA5 mRNA CTD PMID:24136188 NCBI chr 4:53,962,877...53,971,235
Ensembl chr 4:53,962,877...53,971,235 		JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 increases expression EXP Sulindac results in increased expression of NDUFV3 mRNA CTD PMID:24136188 NCBI chr20:9,613,786...9,622,941
Ensembl chr13:48,468,224...48,488,847
Ensembl chr20:48,468,224...48,488,847 		JBrowse link
G Nek7 NIMA-related kinase 7 decreases expression EXP Sulindac results in decreased expression of NEK7 mRNA CTD PMID:24136188 NCBI chr13:52,573,730...52,700,869
Ensembl chr13:52,573,730...52,700,823 		JBrowse link
G Neu1 neuraminidase 1 increases expression ISO Sulindac results in increased expression of NEU1 mRNA CTD PMID:11906190 NCBI chr20:3,902,120...3,906,383
Ensembl chr20:3,902,120...3,906,383 		JBrowse link
G Nfe2l1 NFE2 like bZIP transcription factor 1 increases expression ISO
EXP 		Sulindac results in increased expression of NFE2L1 mRNA CTD PMID:11906190 PMID:24136188 NCBI chr10:82,296,824...82,309,472
Ensembl chr10:82,292,508...82,309,375 		JBrowse link
G Nfib nuclear factor I/B multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of NFIB mRNA CTD PMID:20371263 NCBI chr 5:101,805,168...102,020,618
Ensembl chr 5:101,805,168...102,019,945 		JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated increases expression ISO Sulindac results in increased expression of NFIL3 mRNA CTD PMID:11906190 NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,432,198...12,450,826 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases activity 		ISO Acetylcysteine inhibits the reaction [Sulindac analog results in decreased activity of NFKB1 protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15489888 PMID:18922898 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation 		ISO
EXP 		[[Sulindac co-treated with arsenic trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein] which affects the localization of RELA protein; [Sulindac co-treated with arsenic trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein; Sulindac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Sulindac results in increased degradation of and results in decreased expression of NFKBIA protein
Sulindac results in decreased phosphorylation of NFKBIA protein
[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of NFKBIA mRNA 		CTD PMID:11591705 PMID:15489888 PMID:18059344 PMID:18575716 PMID:20371263 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold decreases expression EXP Sulindac results in decreased expression of NFU1 mRNA CTD PMID:24136188 NCBI chr 4:121,016,316...121,036,925
Ensembl chr 4:121,016,393...121,037,493 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 increases expression ISO Sulindac results in increased expression of NPC1 mRNA CTD PMID:11906190 NCBI chr18:3,654,237...3,699,853
Ensembl chr18:3,654,237...3,699,800 		JBrowse link
G Nphp1 nephrocystin 1 increases expression EXP Sulindac results in increased expression of NPHP1 mRNA CTD PMID:24136188 NCBI chr 3:135,413,927...135,469,505
Ensembl chr 3:135,413,927...135,469,505 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression 		ISO Sulindac results in increased activity of NQO1 protein
Sulindac results in increased expression of NQO1 mRNA 		CTD PMID:11093808 PMID:17985343 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nsmf NMDA receptor synaptonuclear signaling and neuronal migration factor decreases expression EXP Sulindac results in decreased expression of NSMF mRNA CTD PMID:24136188 NCBI chr 3:28,260,018...28,268,790
Ensembl chr 3:28,260,004...28,268,789 		JBrowse link
G Nudt16l1 nudix hydrolase 16 like 1 increases expression EXP Sulindac results in increased expression of NUDT16L1 mRNA CTD PMID:24136188 NCBI chr10:11,142,626...11,144,542
Ensembl chr10:11,142,627...11,144,764 		JBrowse link
G Numb NUMB, endocytic adaptor protein increases expression EXP Sulindac results in increased expression of NUMB mRNA CTD PMID:24136188 NCBI chr 6:109,162,499...109,284,527
Ensembl chr 6:109,162,499...109,284,463 		JBrowse link
G Nup37 nucleoporin 37 increases expression EXP Sulindac results in increased expression of NUP37 mRNA CTD PMID:24136188 NCBI chr 7:24,443,998...24,497,088
Ensembl chr 7:24,463,301...24,508,741 		JBrowse link
G Nupr2 nuclear protein 2, transcriptional regulator increases expression EXP Sulindac results in increased expression of NUPR2 mRNA CTD PMID:24136188 NCBI chr12:32,436,233...32,439,391
Ensembl chr12:32,433,966...32,439,487 		JBrowse link
G Orc4 origin recognition complex, subunit 4 decreases expression ISO Sulindac results in decreased expression of ORC4 mRNA CTD PMID:11906190 NCBI chr 3:53,700,046...53,743,293
Ensembl chr 3:53,703,615...53,742,264 		JBrowse link
G Osbpl9 oxysterol binding protein-like 9 decreases expression EXP Sulindac results in decreased expression of OSBPL9 mRNA CTD PMID:24136188 NCBI chr 5:129,047,776...129,190,838
Ensembl chr 5:129,047,781...129,190,836 		JBrowse link
G Ostf1 osteoclast stimulating factor 1 increases expression ISO Sulindac results in increased expression of OSTF1 mRNA CTD PMID:11906190 NCBI chr 1:225,428,661...225,475,851
Ensembl chr 1:225,428,661...225,541,027 		JBrowse link
G Ostm1 osteoclastogenesis associated transmembrane protein 1 increases expression EXP Sulindac results in increased expression of OSTM1 mRNA CTD PMID:24136188 NCBI chr20:47,653,696...47,769,248
Ensembl chr20:47,653,670...47,769,237 		JBrowse link
G Otud1 OTU deubiquitinase 1 increases expression ISO Sulindac results in increased expression of OTUD1 mRNA CTD PMID:11906190 NCBI chr17:87,168,248...87,171,098
Ensembl chr17:87,149,175...87,330,706 		JBrowse link
G P4hb prolyl 4-hydroxylase subunit beta decreases expression ISO Sulindac results in decreased expression of P4HB mRNA CTD PMID:32535746 NCBI chr10:106,335,300...106,346,911
Ensembl chr10:106,335,300...106,346,911 		JBrowse link
G Pacsin3 protein kinase C and casein kinase substrate in neurons 3 increases expression EXP Sulindac results in increased expression of PACSIN3 mRNA CTD PMID:24136188 NCBI chr 3:97,683,054...97,691,619
Ensembl chr 3:97,679,244...97,691,628 		JBrowse link
G Pak6 p21 (RAC1) activated kinase 6 decreases expression EXP Sulindac results in decreased expression of PAK6 mRNA CTD PMID:24136188 NCBI chr 3:126,092,576...126,128,320
Ensembl chr 3:126,093,013...126,128,318 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases activity 		ISO [Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein; Acetylcysteine inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [[Sulindac co-treated with arsenic trioxide] results in increased cleavage of PARP1 protein]; Sulindac promotes the reaction [Deferoxamine results in increased cleavage of PARP1 protein]
Sulindac results in increased activity of PARP1 protein 		CTD PMID:15713900 PMID:18281123 PMID:21882223 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Parp14 poly (ADP-ribose) polymerase family, member 14 decreases expression EXP Sulindac results in decreased expression of PARP14 mRNA CTD PMID:24136188 NCBI chr11:78,408,134...78,440,201
Ensembl chr11:78,408,058...78,440,195 		JBrowse link
G Pbrm1 polybromo 1 decreases expression EXP Sulindac results in decreased expression of PBRM1 mRNA CTD PMID:24136188 NCBI chr16:6,219,933...6,319,336
Ensembl chr16:6,219,917...6,319,336 		JBrowse link
G Pcbp1 poly(rC) binding protein 1 increases expression EXP Sulindac results in increased expression of PCBP1 mRNA CTD PMID:24136188 NCBI chr 4:120,530,100...120,532,107
Ensembl chr 4:120,529,172...120,539,111 		JBrowse link
G Pcdh17 protocadherin 17 decreases expression ISO Sulindac results in decreased expression of PCDH17 mRNA CTD PMID:11906190 NCBI chr15:66,631,549...66,725,007
Ensembl chr15:66,633,142...66,722,105 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) increases expression ISO Sulindac results in increased expression of PCK2 mRNA CTD PMID:11906190 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:32,997,834...33,016,864 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions 		ISO
EXP 		Sulindac results in decreased expression of PCNA protein
epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]]; kaempferol promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] 		CTD PMID:15020200 PMID:29999212 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PDGFA mRNA CTD PMID:20371263 NCBI chr12:20,759,366...20,780,337
Ensembl chr12:20,754,208...20,780,322 		JBrowse link
G Pdlim7 PDZ and LIM domain 7 increases expression ISO Sulindac results in increased expression of PDLIM7 mRNA CTD PMID:11906190 NCBI chr17:9,129,603...9,144,956
Ensembl chr17:9,129,525...9,144,956 		JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Sulindac results in decreased expression of PER1 mRNA CTD PMID:24136188 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211 		JBrowse link
G Pex2 peroxisomal biogenesis factor 2 increases expression EXP Sulindac results in increased expression of PEX2 mRNA CTD PMID:24136188 NCBI chr 2:97,957,479...97,973,767
Ensembl chr 2:97,948,443...97,981,092 		JBrowse link
G Pfdn6 prefoldin subunit 6 increases expression EXP Sulindac results in increased expression of PFDN6 mRNA CTD PMID:24136188 NCBI chr20:4,947,844...4,949,318
Ensembl chr20:4,947,844...4,949,318 		JBrowse link
G Pgap2 post-GPI attachment to proteins 2 decreases expression EXP Sulindac results in decreased expression of PGAP2 mRNA CTD PMID:24136188 NCBI chr 1:166,003,593...166,030,088
Ensembl chr 1:166,003,523...166,030,088 		JBrowse link
G Pi4k2b phosphatidylinositol 4-kinase type 2 beta increases expression EXP Sulindac results in increased expression of PI4K2B mRNA CTD PMID:24136188 NCBI chr14:62,434,589...62,461,507
Ensembl chr14:62,424,511...62,461,446 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha increases expression EXP Sulindac results in increased expression of PI4KA mRNA CTD PMID:24136188 NCBI chr11:97,113,390...97,234,374
Ensembl chr11:97,113,245...97,228,315 		JBrowse link
G Pigc phosphatidylinositol glycan anchor biosynthesis, class C increases expression EXP Sulindac results in increased expression of PIGC mRNA CTD PMID:24136188 NCBI chr13:76,876,894...76,879,420
Ensembl chr13:76,872,922...76,880,224 		JBrowse link
G Pigy phosphatidylinositol glycan anchor biosynthesis, class Y increases expression EXP Sulindac results in increased expression of PIGY mRNA CTD PMID:24136188 NCBI chr 8:28,965,634...28,967,876
Ensembl chr 8:28,965,617...28,968,508 		JBrowse link
G Pisd phosphatidylserine decarboxylase decreases expression EXP Sulindac results in decreased expression of PISD mRNA CTD PMID:24136188 NCBI chr14:82,166,401...82,215,479
Ensembl chr14:82,166,412...82,215,913 		JBrowse link
G Pithd1 PITH domain containing 1 increases expression EXP Sulindac results in increased expression of PITHD1 mRNA CTD PMID:24136188 NCBI chr 5:153,489,529...153,500,025
Ensembl chr 5:153,489,529...153,500,261 		JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting increases expression ISO Sulindac results in increased expression of PKD1 mRNA CTD PMID:11906190 NCBI chr10:14,077,733...14,125,682
Ensembl chr10:14,078,679...14,125,681 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions
decreases expression 		ISO Sulindac inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]
Sulindac results in decreased expression of PLA2G4A mRNA 		CTD PMID:10706128 PMID:15816863 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of PLAT mRNA CTD PMID:12628509 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PLCG1 mRNA CTD PMID:20371263 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plec plectin increases expression EXP Sulindac results in increased expression of PLEC mRNA CTD PMID:24136188 NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089 		JBrowse link
G Plekhb2 pleckstrin homology domain containing B2 decreases expression EXP Sulindac results in decreased expression of PLEKHB2 mRNA CTD PMID:24136188 NCBI chr 9:44,545,473...44,578,122
Ensembl chr 9:44,534,539...44,578,119 		JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 increases expression ISO Sulindac results in increased expression of PLEKHF1 mRNA CTD PMID:11906190 NCBI chr 1:100,045,340...100,046,817
Ensembl chr 1:100,027,056...100,053,452 		JBrowse link
G Plxna3 plexin A3 increases expression ISO Sulindac results in increased expression of PLXNA3 mRNA CTD PMID:11906190 NCBI chr  X:157,266,986...157,282,896
Ensembl chr  X:157,267,107...157,282,891 		JBrowse link
G Pml PML nuclear body scaffold increases expression ISO Sulindac results in increased expression of PML mRNA CTD PMID:16273229 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit decreases expression EXP Sulindac results in decreased expression of POLE4 mRNA CTD PMID:24136188 NCBI chr 4:116,723,040...116,728,873
Ensembl chr 4:116,716,719...116,728,851 		JBrowse link
G Polr2c RNA polymerase II subunit C decreases expression EXP Sulindac results in decreased expression of POLR2C mRNA CTD PMID:24136188 NCBI chr19:10,164,148...10,170,930
Ensembl chr19:10,164,145...10,170,971 		JBrowse link
G Pomp proteasome maturation protein decreases expression EXP Sulindac results in decreased expression of POMP mRNA CTD PMID:24136188 NCBI chr12:12,198,262...12,212,132
Ensembl chr12:12,198,263...12,210,880 		JBrowse link
G Pon3 paraoxonase 3 decreases expression EXP Sulindac results in decreased expression of PON3 mRNA CTD PMID:24136188 NCBI chr 4:34,323,546...34,350,244
Ensembl chr 4:34,315,889...34,350,244 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression
affects response to substance 		ISO Sulindac results in increased expression of PPARD protein
PPARD protein affects the susceptibility to Sulindac 		CTD PMID:10866668 PMID:21400612 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta increases expression EXP Sulindac results in increased expression of PPP2CB mRNA CTD PMID:24136188 NCBI chr16:65,261,178...65,282,658
Ensembl chr16:65,261,181...65,282,634 		JBrowse link
G Ppp6r1 protein phosphatase 6, regulatory subunit 1 decreases expression EXP Sulindac results in decreased expression of PPP6R1 mRNA CTD PMID:24136188 NCBI chr 1:78,218,629...78,246,360
Ensembl chr 1:78,219,154...78,246,350 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression EXP Sulindac results in decreased expression of PPT1 mRNA CTD PMID:24136188 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:140,406,214...140,427,200 		JBrowse link
G Prdm15 PR/SET domain 15 increases expression EXP Sulindac results in increased expression of PRDM15 mRNA CTD PMID:24136188 NCBI chr11:50,633,973...50,691,624
Ensembl chr11:50,633,973...50,691,823 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP Sulindac results in increased expression of PRDX1 mRNA CTD PMID:24136188 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKAA2 mRNA CTD PMID:20371263 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKACA mRNA CTD PMID:20371263 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PRKACB mRNA CTD PMID:20371263 NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:238,300,127...238,386,315 		JBrowse link
G Prkci protein kinase C, iota increases expression EXP Sulindac results in increased expression of PRKCI mRNA CTD PMID:24136188 NCBI chr 2:114,250,398...114,310,784
Ensembl chr 2:114,250,398...114,310,784 		JBrowse link
G Prodh proline dehydrogenase decreases expression EXP Sulindac results in decreased expression of PRODH mRNA CTD PMID:24136188 NCBI chr11:96,414,275...96,431,604
Ensembl chr11:96,414,224...96,433,418 		JBrowse link
G Prorp protein only RNase P catalytic subunit increases expression EXP Sulindac results in increased expression of PRORP mRNA CTD PMID:24136188 NCBI chr 6:78,404,821...78,497,562
Ensembl chr 6:78,405,980...78,497,761 		JBrowse link
G Psma5 proteasome 20S subunit alpha 5 decreases expression EXP Sulindac results in decreased expression of PSMA5 mRNA CTD PMID:24136188 NCBI chr 2:198,584,502...198,607,867
Ensembl chr 2:198,584,505...198,607,867 		JBrowse link
G Psmb5 proteasome 20S subunit beta 5 increases expression EXP Sulindac results in increased expression of PSMB5 mRNA CTD PMID:24136188 NCBI chr15:32,042,784...32,047,379
Ensembl chr15:32,042,787...32,047,379 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 increases expression EXP Sulindac results in increased expression of PSMC2 mRNA CTD PMID:24136188 NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:14,148,090...14,162,390 		JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 decreases expression EXP Sulindac results in decreased expression of PSMC5 mRNA CTD PMID:24136188 NCBI chr10:91,687,553...91,693,487
Ensembl chr10:91,686,295...91,695,921 		JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression EXP Sulindac results in increased expression of PSMC6 mRNA CTD PMID:24136188 NCBI chr15:21,022,314...21,043,785
Ensembl chr15:21,022,314...21,043,785 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
increases expression 		EXP Sulindac results in decreased expression of PTGS1 mRNA alternative form
Sulindac results in increased expression of PTGS1 mRNA 		CTD PMID:11375891 PMID:12586211 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
decreases activity 		ISO
EXP 		[Sulindac co-treated with Deferoxamine] results in increased expression of PTGS2 protein; Sulindac inhibits the reaction [Mitomycin results in increased expression of PTGS2 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Sulindac promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]
Sulindac results in decreased expression of PTGS2 protein
Sulindac results in increased expression of PTGS2 mRNA
[Olive Oil co-treated with Sulindac] results in decreased expression of PTGS2 protein; epigallocatechin gallate promotes the reaction [Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]]; Sulindac inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]
Sulindac results in decreased activity of PTGS2 protein
Sulindac results in decreased expression of PTGS2 mRNA 		CTD PMID:10706128 PMID:11375891 PMID:11504793 PMID:11910360 PMID:12586211 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptp4a2 protein tyrosine phosphatase 4A2 increases expression EXP Sulindac results in increased expression of PTP4A2 mRNA CTD PMID:24136188 NCBI chr 5:147,449,733...147,476,739
Ensembl chr 5:147,449,490...147,476,738 		JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N decreases expression EXP Sulindac results in decreased expression of PTPRN mRNA CTD PMID:24136188 NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:84,189,676...84,204,850 		JBrowse link
G Pus10 pseudouridine synthase 10 increases expression EXP Sulindac results in increased expression of PUS10 mRNA CTD PMID:24136188 NCBI chr14:101,822,525...101,885,187
Ensembl chr14:101,822,458...101,885,190 		JBrowse link
G Qtrt1 queuine tRNA-ribosyltransferase catalytic subunit 1 decreases expression EXP Sulindac results in decreased expression of QTRT1 mRNA CTD PMID:24136188 NCBI chr 8:28,239,993...28,249,983
Ensembl chr 8:28,242,472...28,250,398 		JBrowse link
G Rab28 RAB28, member RAS oncogene family increases expression EXP Sulindac results in increased expression of RAB28 mRNA CTD PMID:24136188 NCBI chr14:73,458,386...73,535,367
Ensembl chr14:73,458,249...73,535,369 		JBrowse link
G Rab2b RAB2B, member RAS oncogene family increases expression EXP Sulindac results in increased expression of RAB2B mRNA CTD PMID:24136188 NCBI chr15:27,441,860...27,462,479
Ensembl chr15:27,442,816...27,462,479 		JBrowse link
G Rac2 Rac family small GTPase 2 decreases expression EXP Sulindac results in decreased expression of RAC2 mRNA CTD PMID:24136188 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267 		JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit decreases expression EXP Sulindac results in decreased expression of RAMAC mRNA CTD PMID:24136188 NCBI chr 1:145,117,752...145,123,640
Ensembl chr 1:145,117,736...145,124,256 		JBrowse link
G Rasa1 RAS p21 protein activator 1 decreases expression EXP Sulindac results in decreased expression of RASA1 mRNA CTD PMID:24136188 NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161 		JBrowse link
G Rassf6 Ras association domain family member 6 increases expression EXP Sulindac results in increased expression of RASSF6 mRNA CTD PMID:24136188 NCBI chr14:17,717,505...17,757,507
Ensembl chr14:17,717,567...17,760,378 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO Sulindac results in decreased expression of RB1 protein CTD PMID:16488075 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rbbp7 RB binding protein 7, chromatin remodeling factor increases expression EXP Sulindac results in increased expression of RBBP7 mRNA CTD PMID:24136188 NCBI chr  X:35,544,873...35,563,030
Ensembl chr  X:35,544,873...35,563,030 		JBrowse link
G Rbm42 RNA binding motif protein 42 decreases expression EXP Sulindac results in decreased expression of RBM42 mRNA CTD PMID:24136188 NCBI chr 1:95,026,050...95,036,020
Ensembl chr 1:95,026,050...95,035,980 		JBrowse link
G Rbm45 RNA binding motif protein 45 increases expression EXP Sulindac results in increased expression of RBM45 mRNA CTD PMID:24136188 NCBI chr 3:81,713,214...81,728,190
Ensembl chr 3:81,713,176...81,728,190 		JBrowse link
G Rbm47 RNA binding motif protein 47 decreases expression EXP Sulindac results in decreased expression of RBM47 mRNA CTD PMID:24136188 NCBI chr14:42,407,226...42,545,304
Ensembl chr14:42,466,335...42,543,163 		JBrowse link
G Rbx1 ring-box 1 increases expression EXP Sulindac results in increased expression of RBX1 mRNA CTD PMID:24136188 NCBI chr 7:114,870,893...114,881,194
Ensembl chr 7:114,870,972...114,881,191 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization
multiple interactions
increases expression
increases activity 		ISO Sulindac affects the localization of RELA protein
[[Sulindac co-treated with Arsenic Trioxide] results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein] which affects the localization of RELA protein; Sulindac inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of RELA protein]
Sulindac results in increased expression of RELA mRNA
Sulindac results in increased activity of RELA protein 		CTD PMID:10328874 PMID:15489888 PMID:16159934 PMID:16273229 PMID:18059344 More... NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Ren renin multiple interactions
decreases activity 		ISO Sulindac inhibits the reaction [Furosemide results in increased expression of REN protein]
Sulindac results in decreased activity of REN protein 		CTD PMID:2203262 PMID:3884224 PMID:4028619 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543 		JBrowse link
G Ret ret proto-oncogene affects expression ISO Sulindac affects the expression of RET protein CTD PMID:12388792 NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556 		JBrowse link
G RGD1311745 similar to RIKEN cDNA 1110059G10 increases expression EXP Sulindac results in increased expression of RGD1311745 mRNA CTD PMID:24136188 NCBI chr 8:131,475,903...131,486,619
Ensembl chr 8:131,475,906...131,482,865 		JBrowse link
G Rgp1 RGP1 homolog, RAB6A GEF complex partner 1 increases expression EXP Sulindac results in increased expression of RGP1 mRNA CTD PMID:24136188 NCBI chr 5:62,630,253...62,638,872
Ensembl chr 5:62,630,133...62,638,864 		JBrowse link
G Rmdn3 regulator of microtubule dynamics 3 decreases expression EXP Sulindac results in decreased expression of RMDN3 mRNA CTD PMID:24136188 NCBI chr 3:126,579,811...126,601,016
Ensembl chr 3:126,579,812...126,600,418 		JBrowse link
G Rnase1 ribonuclease A family member 1, pancreatic decreases expression ISO Sulindac results in decreased expression of RNASE1 mRNA CTD PMID:11906190 NCBI chr15:26,835,436...26,837,145
Ensembl chr15:26,835,463...26,837,248 		JBrowse link
G Rnf220 ring finger protein 220 increases expression EXP Sulindac results in increased expression of RNF220 mRNA CTD PMID:24136188 NCBI chr 5:135,975,739...136,198,017
Ensembl chr 5:135,975,739...136,197,858 		JBrowse link
G Rnf26 ring finger protein 26 decreases expression ISO Sulindac results in decreased expression of RNF26 mRNA CTD PMID:11906190 NCBI chr 8:53,351,388...53,353,586
Ensembl chr 8:53,341,487...53,355,777 		JBrowse link
G Rnpepl1 arginyl aminopeptidase like 1 decreases expression EXP Sulindac results in decreased expression of RNPEPL1 mRNA CTD PMID:24136188 NCBI chr 9:100,921,053...100,933,748
Ensembl chr 9:100,923,856...100,933,485 		JBrowse link
G Rpia ribose 5-phosphate isomerase A decreases expression EXP Sulindac results in decreased expression of RPIA mRNA CTD PMID:24136188 NCBI chr 4:104,282,081...104,307,732
Ensembl chr 4:104,282,081...104,307,718 		JBrowse link
G Rragc Ras-related GTP binding C decreases expression EXP Sulindac results in decreased expression of RRAGC mRNA CTD PMID:24136188 NCBI chr 5:141,433,014...141,452,546
Ensembl chr 5:141,433,040...141,452,548 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of RXRA mRNA CTD PMID:20371263 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 decreases expression EXP Sulindac results in decreased expression of SAE1 mRNA CTD PMID:24136188 NCBI chr 1:86,159,114...86,215,089
Ensembl chr 1:86,159,114...86,215,089 		JBrowse link
G Sap30l SAP30-like decreases expression EXP Sulindac results in decreased expression of SAP30L mRNA CTD PMID:24136188 NCBI chr10:42,480,201...42,488,139
Ensembl chr10:42,480,201...42,488,139 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO Sulindac results in increased expression of SAT1 mRNA CTD PMID:14506281 PMID:16262603 NCBI chr  X:44,008,089...44,011,376
Ensembl chr  X:44,006,781...44,011,374 		JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 increases activity
increases expression 		ISO Sulindac results in increased activity of SAT2 protein
Sulindac results in increased expression of SAT2 mRNA 		CTD PMID:17474863 NCBI chr10:54,839,531...54,841,651
Ensembl chr10:54,839,189...54,841,958 		JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression EXP Sulindac results in increased expression of SCAMP1 mRNA CTD PMID:24136188 NCBI chr 2:27,168,863...27,251,637
Ensembl chr 2:27,168,864...27,251,742 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 increases expression EXP Sulindac results in increased expression of SCO1 mRNA CTD PMID:24136188 NCBI chr10:52,243,664...52,256,250
Ensembl chr10:52,243,648...52,260,861 		JBrowse link
G Sdhaf3 succinate dehydrogenase complex assembly factor 3 increases expression EXP Sulindac results in increased expression of SDHAF3 mRNA CTD PMID:24136188 NCBI chr 4:36,066,963...36,127,168
Ensembl chr 4:36,066,963...36,127,175 		JBrowse link
G Sec62 SEC62 homolog, preprotein translocation factor decreases expression EXP Sulindac results in decreased expression of SEC62 mRNA CTD PMID:24136188 NCBI chr 2:114,499,317...114,526,705
Ensembl chr 2:114,499,317...114,530,321 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator decreases expression EXP Sulindac results in decreased expression of SEC63 mRNA CTD PMID:24136188 NCBI chr20:47,827,291...47,896,248
Ensembl chr20:47,827,291...47,896,248 		JBrowse link
G Septin10 septin 10 decreases expression EXP Sulindac results in decreased expression of SEPTIN10 mRNA CTD PMID:24136188 NCBI chr20:27,644,862...27,737,817
Ensembl chr20:27,643,876...27,737,902 		JBrowse link
G Serpinb1a serpin family B member 1A increases expression ISO Sulindac results in increased expression of SERPINB1 mRNA CTD PMID:11507085 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,799,415...31,808,166 		JBrowse link
G Set Set nuclear proto-oncogene decreases expression EXP Sulindac results in decreased expression of SET mRNA CTD PMID:24136188 NCBI chr 3:33,732,319...33,743,433 JBrowse link
G Sft2d2 SFT2 domain containing 2 increases expression EXP Sulindac results in increased expression of SFT2D2 mRNA CTD PMID:24136188 NCBI chr13:80,017,854...80,037,144
Ensembl chr13:80,008,480...80,037,473 		JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SHC1 mRNA] CTD PMID:15190207 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 increases expression EXP Sulindac results in increased expression of SHMT2 mRNA CTD PMID:24136188 NCBI chr 7:65,244,247...65,249,580
Ensembl chr 7:65,244,247...65,249,567 		JBrowse link
G Sirt1 sirtuin 1 increases expression ISO Sulindac results in increased expression of SIRT1 mRNA CTD PMID:11906190 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Skic8 SKI8 subunit of superkiller complex decreases expression EXP Sulindac results in decreased expression of SKIC8 mRNA CTD PMID:24136188 NCBI chr 8:63,999,669...64,016,959
Ensembl chr 8:63,999,671...64,016,846 		JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression ISO Sulindac results in increased expression of SLC16A6 mRNA CTD PMID:11906190 NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,923,888...94,947,965 		JBrowse link
G Slc18b1 solute carrier family 18 member B1 increases expression EXP Sulindac results in increased expression of SLC18B1 mRNA CTD PMID:24136188 NCBI chr 1:23,447,462...23,490,043
Ensembl chr 1:23,447,462...23,489,962 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Sulindac results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:50,624,377...50,651,436 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity ISO Sulindac results in decreased activity of SLC22A2 protein CTD PMID:12388633 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity ISO Sulindac results in decreased activity of SLC22A9 protein CTD PMID:12388633 NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:214,767,837...214,862,340 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity ISO Sulindac results in decreased activity of SLC22A6 protein CTD PMID:12388633 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases activity ISO Sulindac results in decreased activity of SLC22A7 protein CTD PMID:12388633 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681 		JBrowse link
G Slc27a4 solute carrier family 27 member 4 decreases expression EXP Sulindac results in decreased expression of SLC27A4 mRNA CTD PMID:24136188 NCBI chr 3:33,472,903...33,485,824
Ensembl chr 3:33,472,903...33,485,824 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 increases expression ISO Sulindac results in increased expression of SLC30A1 mRNA CTD PMID:11906190 NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892 		JBrowse link
G Slc30a5 solute carrier family 30 member 5 decreases expression EXP Sulindac results in decreased expression of SLC30A5 mRNA CTD PMID:24136188 NCBI chr 2:33,679,800...33,710,025
Ensembl chr 2:33,679,800...33,712,596 		JBrowse link
G Slc38a2 solute carrier family 38, member 2 increases expression ISO Sulindac results in increased expression of SLC38A2 mRNA CTD PMID:11906190 NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:129,730,450...129,742,619 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Sulindac results in increased expression of SLC3A2 mRNA CTD PMID:11906190 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Slc4a1ap solute carrier family 4 member 1 adaptor protein decreases expression EXP Sulindac results in decreased expression of SLC4A1AP mRNA CTD PMID:24136188 NCBI chr 6:30,625,931...30,653,859
Ensembl chr 6:30,625,931...30,653,792 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 increases expression ISO Sulindac results in increased expression of SLC7A1 mRNA CTD PMID:11906190 NCBI chr12:11,664,488...11,740,030
Ensembl chr12:11,664,399...11,740,030 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SLCO1A2 mRNA CTD PMID:20371263 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816 		JBrowse link
G Slfn3 schlafen 3 decreases expression EXP Sulindac results in decreased expression of SLFN3 mRNA CTD PMID:24136188 NCBI chr10:68,515,815...68,557,674 JBrowse link
G Smc1a structural maintenance of chromosomes 1A decreases expression EXP Sulindac results in decreased expression of SMC1A mRNA CTD PMID:24136188 NCBI chr  X:24,582,732...24,627,462
Ensembl chr  X:24,582,690...24,627,462 		JBrowse link
G Smu1 SMU1, DNA replication regulator and spliceosomal factor decreases expression EXP Sulindac results in decreased expression of SMU1 mRNA CTD PMID:24136188 NCBI chr 5:60,652,680...60,671,251
Ensembl chr 5:60,652,680...60,671,251 		JBrowse link
G Snrnp27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 increases expression EXP Sulindac results in increased expression of SNRNP27 mRNA CTD PMID:24136188 NCBI chr 4:120,681,054...120,691,343
Ensembl chr 4:120,679,255...120,690,656 		JBrowse link
G Snx21 sorting nexin family member 21 increases expression ISO Sulindac results in increased expression of SNX21 mRNA CTD PMID:11906190 NCBI chr 3:173,941,634...173,951,571 JBrowse link
G Snx25 sorting nexin 25 increases expression ISO Sulindac results in increased expression of SNX25 mRNA CTD PMID:11906190 NCBI chr16:52,867,102...52,971,028
Ensembl chr16:52,858,532...52,971,008 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Sulindac inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of SOD2 mRNA] CTD PMID:15190207 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 decreases expression EXP Sulindac results in decreased expression of SPRED3 mRNA CTD PMID:24136188 NCBI chr 1:93,586,259...93,597,692
Ensembl chr 1:93,586,259...93,598,254 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO Sulindac results in increased expression of SQSTM1 mRNA CTD PMID:11906190 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP
ISO 		[[Azoxymethane co-treated with Sulindac] results in increased expression of CSK protein] which results in increased phosphorylation of and results in decreased activity of SRC protein
Sulindac results in increased phosphorylation of and results in decreased activity of SRC protein 		CTD PMID:18644992 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Sulindac results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765 		JBrowse link
G Ss18 SS18 subunit of BAF chromatin remodeling complex decreases expression EXP Sulindac results in decreased expression of SS18 mRNA CTD PMID:24136188 NCBI chr18:6,047,619...6,169,151
Ensembl chr18:6,047,619...6,109,913 		JBrowse link
G Ssu72 SSU72 homolog, RNA polymerase II CTD phosphatase decreases expression EXP Sulindac results in decreased expression of SSU72 mRNA CTD PMID:24136188 NCBI chr 5:171,595,919...171,625,675
Ensembl chr 5:171,595,851...171,625,268 		JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP Sulindac results in decreased expression of STAC3 mRNA CTD PMID:24136188 NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:65,228,352...65,235,878 		JBrowse link
G Stard3 StAR-related lipid transfer domain containing 3 increases expression EXP Sulindac results in increased expression of STARD3 mRNA CTD PMID:24136188 NCBI chr10:83,853,622...83,876,162
Ensembl chr10:83,862,707...83,876,131 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
decreases expression 		ISO BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein modified form]; BIRC5 protein inhibits the reaction [Sulindac results in decreased expression of STAT3 protein]
Sulindac results in decreased phosphorylation of STAT3 protein
Sulindac results in decreased expression of STAT3 protein; Sulindac results in decreased expression of STAT3 protein modified form 		CTD PMID:11861373 PMID:17401459 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO Sulindac results in increased expression of STC2 mRNA CTD PMID:11906190 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447 		JBrowse link
G Stoml2 stomatin like 2 increases expression EXP Sulindac results in increased expression of STOML2 mRNA CTD PMID:24136188 NCBI chr 5:62,052,042...62,055,639
Ensembl chr 5:62,052,045...62,055,670 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP Sulindac results in increased expression of STRBP mRNA CTD PMID:24136188 NCBI chr 3:41,738,096...41,879,054
Ensembl chr 3:41,712,311...41,824,707 		JBrowse link
G Stx7 syntaxin 7 decreases expression EXP Sulindac results in decreased expression of STX7 mRNA CTD PMID:24136188 NCBI chr 1:23,016,330...23,056,579
Ensembl chr 1:23,016,336...23,056,465 		JBrowse link
G Stxbp2 syntaxin binding protein 2 increases expression ISO Sulindac results in increased expression of STXBP2 mRNA CTD PMID:11906190 NCBI chr12:6,487,265...6,498,351
Ensembl chr12:6,487,297...6,504,212 		JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha increases expression EXP Sulindac results in increased expression of SUCLG1 mRNA CTD PMID:24136188 NCBI chr 4:106,866,329...106,895,686
Ensembl chr 4:106,866,114...106,895,689 		JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1B1 mRNA CTD PMID:20371263 NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,771,868...20,785,549 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions
decreases activity 		EXP
ISO 		[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT1E1 mRNA
Sulindac results in decreased activity of SULT1E1 protein 		CTD PMID:17073578 PMID:20371263 NCBI chr14:20,700,444...20,718,719
Ensembl chr14:20,700,292...20,718,716 		JBrowse link
G Sult2a6 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of SULT2A6 mRNA CTD PMID:20371263 NCBI chr 1:84,046,685...84,097,808
Ensembl chr 1:84,046,685...84,097,808 		JBrowse link
G Sumo3 small ubiquitin-like modifier 3 decreases expression ISO Sulindac results in decreased expression of SUMO3 mRNA CTD PMID:11906190 NCBI chr20:11,009,730...11,020,502
Ensembl chr20:11,009,734...11,020,287 		JBrowse link
G Sun2 Sad1 and UNC84 domain containing 2 decreases expression ISO Sulindac results in decreased expression of SUN2 mRNA CTD PMID:11906190 NCBI chr 7:113,155,766...113,172,950
Ensembl chr 7:113,155,766...113,172,940 		JBrowse link
G Supt7l SPT7 like, STAGA complex subunit gamma decreases expression EXP Sulindac results in decreased expression of SUPT7L mRNA CTD PMID:24136188 NCBI chr 6:30,653,928...30,664,066
Ensembl chr 6:30,653,888...30,664,642 		JBrowse link
G Syp synaptophysin decreases expression EXP Sulindac results in decreased expression of SYP mRNA CTD PMID:24136188 NCBI chr  X:17,521,348...17,536,449
Ensembl chr  X:17,521,348...17,536,984 		JBrowse link
G Syt15 synaptotagmin 15 decreases expression EXP Sulindac results in decreased expression of SYT15 mRNA CTD PMID:24136188 NCBI chr16:9,538,740...9,549,548
Ensembl chr16:9,538,748...9,549,558 		JBrowse link
G Tbc1d10b TBC1 domain family, member 10b increases expression ISO Sulindac results in increased expression of TBC1D10B mRNA CTD PMID:11906190 NCBI chr 1:191,245,472...191,257,128
Ensembl chr 1:191,239,615...191,257,128 		JBrowse link
G Tbk1 TANK-binding kinase 1 increases expression ISO Sulindac results in increased expression of TBK1 mRNA CTD PMID:11093808 NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357 		JBrowse link
G Tbx3 T-box transcription factor 3 increases expression ISO Sulindac results in increased expression of TBX3 mRNA CTD PMID:11906190 NCBI chr12:42,540,378...42,555,490
Ensembl chr12:42,540,378...42,554,171 		JBrowse link
G Tceanc2 transcription elongation factor A N-terminal and central domain containing 2 increases expression EXP Sulindac results in increased expression of TCEANC2 mRNA CTD PMID:24136188 NCBI chr 5:127,152,776...127,197,405
Ensembl chr 5:127,152,778...127,190,985 		JBrowse link
G Tcf4 transcription factor 4 decreases activity
multiple interactions 		ISO Sulindac results in decreased activity of TCF4 protein
TCF4 protein promotes the reaction [Sulindac results in increased susceptibility to TNFSF10 protein] 		CTD PMID:11593435 PMID:21171083 NCBI chr18:65,216,840...65,563,186
Ensembl chr18:65,216,849...65,558,401 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases activity
multiple interactions 		EXP Sulindac results in decreased activity of TDO2 protein
[Sulindac results in decreased activity of TDO2 protein] which results in decreased abundance of Dopamine; [Sulindac results in decreased activity of TDO2 protein] which results in increased abundance of Serotonin 		CTD PMID:16952380 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586 		JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions ISO Sulindac analog results in decreased phosphorylation of and results in decreased activity of TEK protein CTD PMID:16215210 NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991 		JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression EXP Sulindac results in decreased expression of TFDP1 mRNA CTD PMID:24136188 NCBI chr16:82,864,220...82,903,166
Ensembl chr16:82,864,226...82,902,996 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Sulindac results in increased expression of TGFB1 protein CTD PMID:11496082 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgm2 transglutaminase 2 multiple interactions ISO Sulindac inhibits the reaction [CDKN1A protein results in increased expression of TGM2 mRNA] CTD PMID:15190207 NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240 		JBrowse link
G Thap7 THAP domain containing 7 increases expression EXP Sulindac results in increased expression of THAP7 mRNA CTD PMID:24136188 NCBI chr11:96,986,720...96,990,375
Ensembl chr11:96,987,275...96,990,371 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Sulindac results in decreased expression of THRSP mRNA CTD PMID:24136188 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827 		JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 increases expression EXP Sulindac results in increased expression of TIMM10 mRNA CTD PMID:24136188 NCBI chr 3:90,315,048...90,318,613
Ensembl chr 3:90,315,092...90,318,614 		JBrowse link
G Timmdc1 translocase of inner mitochondrial membrane domain containing 1 increases expression EXP Sulindac results in increased expression of TIMMDC1 mRNA CTD PMID:24136188 NCBI chr11:75,734,554...75,759,026
Ensembl chr11:75,731,895...75,758,707 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 affects expression ISO Sulindac affects the expression of TIMP1 protein CTD PMID:12388792 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 multiple interactions ISO [Sulindac co-treated with epigallocatechin gallate] results in decreased expression of TIMP3 mRNA CTD PMID:12628509 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Tjp2 tight junction protein 2 increases expression EXP Sulindac results in increased expression of TJP2 mRNA CTD PMID:24136188 NCBI chr 1:231,136,218...231,264,750
Ensembl chr 1:231,136,243...231,264,750 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA CTD PMID:20371263 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194 		JBrowse link
G Tm2d1 TM2 domain containing 1 increases expression EXP Sulindac results in increased expression of TM2D1 mRNA CTD PMID:24136188 NCBI chr 5:118,136,299...118,177,639
Ensembl chr 5:118,136,299...118,170,283 		JBrowse link
G Tm7sf3 transmembrane 7 superfamily member 3 decreases expression ISO Sulindac results in decreased expression of TM7SF3 mRNA CTD PMID:11093808 NCBI chr 4:181,248,819...181,280,844
Ensembl chr 4:181,248,822...181,280,844 		JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 decreases expression ISO Sulindac results in decreased expression of TMED9 mRNA CTD PMID:11906190 NCBI chr17:9,034,797...9,039,311
Ensembl chr17:9,034,823...9,039,319 		JBrowse link
G Tmem127 transmembrane protein 127 increases expression ISO Sulindac results in increased expression of TMEM127 mRNA CTD PMID:11906190 NCBI chr 3:134,919,416...134,932,210
Ensembl chr 3:134,919,414...134,932,550 		JBrowse link
G Tmem141 transmembrane protein 141 increases expression EXP Sulindac results in increased expression of TMEM141 mRNA CTD PMID:24136188 NCBI chr 3:28,837,665...28,839,623
Ensembl chr 3:28,836,576...28,839,623 		JBrowse link
G Tmem209 transmembrane protein 209 decreases expression EXP Sulindac results in decreased expression of TMEM209 mRNA CTD PMID:24136188 NCBI chr 4:60,070,346...60,096,039
Ensembl chr 4:60,069,060...60,105,946 		JBrowse link
G Tmem39a transmembrane protein 39a increases expression ISO Sulindac results in increased expression of TMEM39A mRNA CTD PMID:11906190 NCBI chr11:75,666,154...75,695,486
Ensembl chr11:75,666,154...75,695,486 		JBrowse link
G Tmem60 transmembrane protein 60 increases expression EXP Sulindac results in increased expression of TMEM60 mRNA CTD PMID:24136188 NCBI chr 4:15,102,168...15,107,023
Ensembl chr 4:15,100,348...15,107,139 		JBrowse link
G Tmx1 thioredoxin-related transmembrane protein 1 increases expression EXP Sulindac results in increased expression of TMX1 mRNA CTD PMID:24136188 NCBI chr 6:94,696,699...94,707,751
Ensembl chr 6:94,696,358...94,708,618 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		Sulindac inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Sulindac inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulindac inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulindac inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Sulindac inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Sulindac inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
[Sulindac co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; Sulindac inhibits the reaction [Okadaic Acid results in increased expression of TNF protein]
Sulindac results in increased expression of TNF 		CTD PMID:10328874 PMID:10757128 PMID:15489888 PMID:16159934 PMID:17328244 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance
multiple interactions 		ISO Sulindac results in increased susceptibility to TNFSF10 protein
[Sulindac co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; TCF4 protein promotes the reaction [Sulindac results in increased susceptibility to TNFSF10 protein] 		CTD PMID:21171083 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tns3 tensin 3 decreases expression ISO Sulindac results in decreased expression of TNS3 mRNA CTD PMID:11906190 NCBI chr14:87,387,441...87,619,457
Ensembl chr14:87,387,441...87,619,712 		JBrowse link
G Tor1a torsin family 1, member A decreases expression EXP Sulindac results in decreased expression of TOR1A mRNA CTD PMID:24136188 NCBI chr 3:34,648,421...34,655,453
Ensembl chr 3:34,648,422...34,655,417 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects localization
increases expression
decreases expression 		ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in increased activity of TP53 protein; SB 203580 inhibits the reaction [Sulindac affects the localization of TP53 protein]
Sulindac results in increased expression of TP53 protein
Sulindac results in decreased expression of TRP53 protein 		CTD PMID:15020200 PMID:15713900 PMID:17136320 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tpra1 transmembrane protein adipocyte associated 1 increases expression ISO Sulindac results in increased expression of TPRA1 mRNA CTD PMID:11906190 NCBI chr 4:122,921,304...122,932,519
Ensembl chr 4:122,921,323...122,932,517 		JBrowse link
G Trim2 tripartite motif-containing 2 increases expression ISO Sulindac results in increased expression of TRIM2 mRNA CTD PMID:11906190 NCBI chr 2:171,798,654...171,950,193
Ensembl chr 2:171,798,660...171,913,468 		JBrowse link
G Trit1 tRNA isopentenyltransferase 1 decreases expression ISO Sulindac results in decreased expression of TRIT1 mRNA CTD PMID:11906190 NCBI chr 5:140,578,459...140,623,881
Ensembl chr 5:140,580,453...140,623,881 		JBrowse link
G Trub2 TruB pseudouridine synthase family member 2 increases expression EXP Sulindac results in increased expression of TRUB2 mRNA CTD PMID:24136188 NCBI chr 3:33,447,101...33,457,712
Ensembl chr 3:33,431,628...33,457,726 		JBrowse link
G Tsnax translin-associated factor X decreases expression ISO Sulindac results in decreased expression of TSNAX mRNA CTD PMID:11906190 NCBI chr19:69,873,210...69,887,244
Ensembl chr19:69,872,987...69,887,224 		JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator increases expression EXP Sulindac results in increased expression of TUSC2 mRNA CTD PMID:24136188 NCBI chr 8:117,115,479...117,118,697
Ensembl chr 8:117,115,479...117,118,697 		JBrowse link
G Txn1 thioredoxin 1 increases response to substance ISO TXN1 results in increased susceptibility to Sulindac analog CTD PMID:18922898 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307 		JBrowse link
G Txnl1 thioredoxin-like 1 increases expression EXP Sulindac results in increased expression of TXNL1 mRNA CTD PMID:24136188 NCBI chr18:59,397,275...59,428,072
Ensembl chr18:59,398,535...59,435,518 		JBrowse link
G Tyw1 tRNA-yW synthesizing protein 1 homolog increases expression EXP Sulindac results in increased expression of TYW1 mRNA CTD PMID:24136188 NCBI chr12:31,968,198...32,054,454
Ensembl chr12:31,968,198...32,054,647 		JBrowse link
G Ube2e3 ubiquitin-conjugating enzyme E2E 3 decreases expression EXP Sulindac results in decreased expression of UBE2E3 mRNA CTD PMID:24136188 NCBI chr 3:84,194,246...84,250,232
Ensembl chr 3:84,193,659...84,250,224 		JBrowse link
G Ube3a ubiquitin protein ligase E3A increases expression EXP Sulindac results in increased expression of UBE3A mRNA CTD PMID:24136188 NCBI chr 1:119,204,244...119,297,097
Ensembl chr 1:119,206,148...119,297,097 		JBrowse link
G Ubl5 ubiquitin-like 5 decreases expression EXP Sulindac results in decreased expression of UBL5 mRNA CTD PMID:24136188 NCBI chr 8:27,457,738...27,461,458 JBrowse link
G Ubqln2 ubiquilin 2 increases expression EXP Sulindac results in increased expression of UBQLN2 mRNA CTD PMID:24136188 NCBI chr  X:21,228,809...21,232,228
Ensembl chr  X:21,229,197...21,232,268 		JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 decreases expression EXP Sulindac results in decreased expression of UFD1 mRNA CTD PMID:24136188 NCBI chr11:95,665,971...95,689,423
Ensembl chr11:95,665,972...95,689,434 		JBrowse link
G Ufl1 Ufm1-specific ligase 1 increases expression EXP Sulindac results in increased expression of UFL1 mRNA CTD PMID:24136188 NCBI chr 5:43,759,271...43,791,682
Ensembl chr 5:43,758,098...43,791,682 		JBrowse link
G Uggt2 UDP-glucose glycoprotein glucosyltransferase 2 increases expression ISO Sulindac results in increased expression of UGGT2 mRNA CTD PMID:11906190 NCBI chr15:102,480,239...102,646,291
Ensembl chr15:102,480,781...102,646,410 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases expression
increases glucuronidation 		ISO Sulindac results in increased activity of UGT1A1 protein
Sulindac results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of Sulindac 		CTD PMID:15843492 PMID:17985343 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Sulindac CTD PMID:15843492 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451 		JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Sulindac results in decreased expression of UNG mRNA CTD PMID:11906190 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257 		JBrowse link
G Uqcc2 ubiquinol-cytochrome c reductase complex assembly factor 2 decreases expression EXP Sulindac results in decreased expression of UQCC2 mRNA CTD PMID:24136188 NCBI chr20:5,204,682...5,217,080
Ensembl chr17:12,088,037...12,088,606
Ensembl chr20:12,088,037...12,088,606 		JBrowse link
G Uqcc4 ubiquinol-cytochrome c reductase complex assembly factor 4 increases expression EXP Sulindac results in increased expression of UQCC4 mRNA CTD PMID:24136188 NCBI chr10:14,706,720...14,708,022
Ensembl chr10:14,706,709...14,708,555 		JBrowse link
G Vapb VAMP associated protein B and C increases expression EXP Sulindac results in increased expression of VAPB mRNA CTD PMID:24136188 NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:182,954,240...183,028,619 		JBrowse link
G Vash1 vasohibin 1 decreases expression EXP Sulindac results in decreased expression of VASH1 mRNA CTD PMID:24136188 NCBI chr 6:112,060,086...112,076,689
Ensembl chr 6:112,060,086...112,076,689 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of VCAM1 mRNA CTD PMID:20371263 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vcp valosin-containing protein decreases expression EXP Sulindac results in decreased expression of VCP mRNA CTD PMID:24136188 NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:62,005,985...62,025,387 		JBrowse link
G Vps26b VPS26 retromer complex component B decreases expression EXP Sulindac results in decreased expression of VPS26B mRNA CTD PMID:24136188 NCBI chr 8:33,675,025...33,696,132
Ensembl chr 8:33,675,025...33,696,132 		JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C increases expression EXP Sulindac results in increased expression of VPS26C mRNA CTD PMID:24136188 NCBI chr11:47,283,764...47,311,105
Ensembl chr11:47,262,071...47,311,045 		JBrowse link
G Vps29 VPS29 retromer complex component increases expression EXP Sulindac results in increased expression of VPS29 mRNA CTD PMID:24136188 NCBI chr12:39,869,688...39,878,732
Ensembl chr12:39,869,688...39,878,848 		JBrowse link
G Vps35 VPS35 retromer complex component decreases expression EXP Sulindac results in decreased expression of VPS35 mRNA CTD PMID:24136188 NCBI chr19:37,938,989...37,974,887
Ensembl chr19:37,938,720...37,974,886 		JBrowse link
G Vps53 VPS53 subunit of GARP complex increases expression EXP Sulindac results in increased expression of VPS53 mRNA CTD PMID:24136188 NCBI chr10:61,418,076...61,536,912
Ensembl chr10:61,418,076...61,531,760 		JBrowse link
G Wdr3 WD repeat domain 3 increases expression ISO Sulindac results in increased expression of WDR3 mRNA CTD PMID:11906190 NCBI chr 2:190,194,474...190,217,087
Ensembl chr 2:190,194,474...190,217,087 		JBrowse link
G Wdr83os WD repeat domain 83 opposite strand increases expression EXP Sulindac results in increased expression of WDR83OS mRNA CTD PMID:24136188 NCBI chr19:39,980,247...39,981,619
Ensembl chr19:39,980,247...39,982,737 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 decreases expression EXP Sulindac results in decreased expression of WWP1 mRNA CTD PMID:24136188 NCBI chr 5:37,889,280...37,982,743
Ensembl chr 5:37,895,398...37,982,959 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO Sulindac results in increased expression of XBP1 mRNA CTD PMID:11906190 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO [Sulindac results in increased abundance of Reactive Oxygen Species] which results in decreased expression of XIAP protein CTD PMID:17136320 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
G Xpo1 exportin 1 multiple interactions EXP [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of XPO1 mRNA CTD PMID:20371263 NCBI chr14:101,434,450...101,476,705
Ensembl chr14:101,434,517...101,476,714 		JBrowse link
G Xpr1 xenotropic and polytropic retrovirus receptor 1 increases expression EXP Sulindac results in increased expression of XPR1 mRNA CTD PMID:24136188 NCBI chr13:69,991,517...70,136,249
Ensembl chr13:69,996,692...70,136,164 		JBrowse link
G Xrcc5 X-ray repair cross complementing 5 decreases expression EXP Sulindac results in decreased expression of XRCC5 mRNA CTD PMID:24136188 NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:81,375,863...81,493,293 		JBrowse link
G Yme1l1 YME1-like 1 ATPase decreases expression EXP Sulindac results in decreased expression of YME1L1 mRNA CTD PMID:24136188 NCBI chr17:90,195,485...90,235,675
Ensembl chr17:90,195,584...90,356,331 		JBrowse link
G Ythdf3 YTH N6-methyladenosine RNA binding protein F3 increases expression EXP Sulindac results in increased expression of YTHDF3 mRNA CTD PMID:24136188 NCBI chr 2:100,266,942...100,300,896
Ensembl chr 2:100,266,875...100,300,509 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression EXP Sulindac results in increased expression of YWHAB mRNA CTD PMID:24136188 NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon increases expression EXP Sulindac results in increased expression of YWHAE mRNA CTD PMID:24136188 NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291 		JBrowse link
G Zc3h13 zinc finger CCCH type containing 13 increases expression EXP Sulindac results in increased expression of ZC3H13 mRNA CTD PMID:24136188 NCBI chr15:57,016,686...57,081,201
Ensembl chr15:57,016,781...57,081,201 		JBrowse link
G Zfp106 zinc finger protein 106 decreases expression EXP Sulindac results in decreased expression of ZFP106 mRNA CTD PMID:24136188 NCBI chr 3:127,912,981...127,964,254
Ensembl chr 3:127,912,981...127,964,254 		JBrowse link
G Zfp148 zinc finger protein 148 decreases expression EXP Sulindac results in decreased expression of ZFP148 mRNA CTD PMID:24136188 NCBI chr11:80,780,865...80,890,877
Ensembl chr11:80,786,087...80,890,877 		JBrowse link
G Zfp281 zinc finger protein 281 increases expression EXP Sulindac results in increased expression of ZFP281 mRNA CTD PMID:24136188 NCBI chr13:50,647,750...50,655,912
Ensembl chr13:50,588,874...50,675,781 		JBrowse link
G Zfp354a zinc finger protein 354A increases expression ISO Sulindac results in increased expression of ZNF354A mRNA CTD PMID:11906190 NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,897,228...35,909,510 		JBrowse link
G Zfp423 zinc finger protein 423 decreases expression EXP Sulindac results in decreased expression of ZFP423 mRNA CTD PMID:24136188 NCBI chr19:35,282,149...35,580,775
Ensembl chr19:35,282,110...35,580,773 		JBrowse link
G Znhit1 zinc finger, HIT-type containing 1 increases expression EXP Sulindac results in increased expression of ZNHIT1 mRNA CTD PMID:24136188 NCBI chr12:25,323,292...25,329,566
Ensembl chr12:25,323,114...25,329,563 		JBrowse link
G Znhit3 zinc finger, HIT-type containing 3 increases expression EXP Sulindac results in increased expression of ZNHIT3 mRNA CTD PMID:24136188 NCBI chr10:70,246,749...70,287,927 JBrowse link
sulindac sulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO sulindac sulfide results in increased expression of ABCG2 mRNA CTD PMID:16184548 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493 		JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of ACTN1 mRNA CTD PMID:16184548 NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 decreases expression ISO sulindac sulfide results in decreased expression of ADAM9 mRNA CTD PMID:16184548 NCBI chr16:73,725,186...73,804,284
Ensembl chr16:73,725,114...73,804,646 		JBrowse link
G Adm adrenomedullin increases expression ISO sulindac sulfide results in increased expression of ADM mRNA CTD PMID:16184548 NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:174,178,773...174,182,371 		JBrowse link
G Adra2c adrenoceptor alpha 2C decreases expression ISO sulindac sulfide results in decreased expression of ADRA2C mRNA CTD PMID:12734198 NCBI chr14:79,695,514...79,697,476
Ensembl chr14:79,694,995...79,706,656 		JBrowse link
G Ahr aryl hydrocarbon receptor increases localization ISO sulindac sulfide results in increased localization of AHR protein CTD PMID:17985343 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Akap12 A-kinase anchoring protein 12 increases expression ISO sulindac sulfide results in increased expression of AKAP12 mRNA CTD PMID:12734198 NCBI chr 1:43,135,515...43,225,245
Ensembl chr 1:43,199,008...43,225,557 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO sulindac sulfide results in increased expression of AKR1C1 mRNA CTD PMID:16184548 NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247 		JBrowse link
G Aldoc aldolase, fructose-bisphosphate C decreases expression ISO sulindac sulfide results in decreased expression of ALDOC mRNA CTD PMID:16184548 NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,715,489...63,719,133 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase increases expression ISO sulindac sulfide results in increased expression of ALOX15 protein CTD PMID:16166323 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Anxa5 annexin A5 increases expression ISO sulindac sulfide results in increased expression of ANXA5 protein CTD PMID:18678619 NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:121,242,136...121,281,400 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO sulindac sulfide inhibits the reaction [Phosphatidylinositols results in increased expression of APOA1 protein] CTD PMID:19013290 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729 		JBrowse link
G App amyloid beta precursor protein multiple interactions
affects cleavage 		ISO
EXP 		[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the cleavage of and affects the localization of APP protein; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein]
sulindac sulfide inhibits the reaction [APP protein results in increased uptake of Calcium] 		CTD PMID:11700559 PMID:12637581 PMID:12777371 PMID:12805356 PMID:14690522 More... NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Ar androgen receptor multiple interactions ISO AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein]; sulindac sulfide results in decreased expression of and results in decreased activity of AR protein CTD PMID:14581372 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Areg amphiregulin increases expression ISO sulindac sulfide results in increased expression of AREG mRNA CTD PMID:16184548 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641 		JBrowse link
G Arl6ip1 ARL6 interacting reticulophagy regulator 1 decreases expression ISO sulindac sulfide results in decreased expression of ARL6IP1 mRNA CTD PMID:12734198 NCBI chr 1:181,864,717...181,874,232
Ensembl chr 1:181,864,746...181,874,232 		JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B decreases expression ISO sulindac sulfide results in decreased expression of ARPC1B mRNA CTD PMID:12734198 NCBI chr12:14,595,939...14,609,501
Ensembl chr12:14,595,678...14,609,504 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 decreases expression ISO sulindac sulfide results in decreased expression of ASAH1 mRNA CTD PMID:16184548 NCBI chr16:57,669,927...57,701,349
Ensembl chr16:57,669,750...57,718,305 		JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression 		ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]
sulindac sulfide results in increased expression of ATF3 mRNA; sulindac sulfide results in increased expression of ATF3 protein 		CTD PMID:12734198 PMID:15897233 PMID:16079301 PMID:16184548 PMID:21554132 More... NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 increases expression ISO sulindac sulfide results in increased expression of ATP6V0A1 mRNA CTD PMID:16184548 NCBI chr10:86,436,089...86,490,185
Ensembl chr10:86,436,141...86,490,181 		JBrowse link
G Aurka aurora kinase A decreases expression ISO sulindac sulfide results in decreased expression of AURKA mRNA CTD PMID:12734198 NCBI chr 3:181,546,742...181,562,890
Ensembl chr 3:181,546,742...181,562,771 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases expression
increases localization
multiple interactions 		ISO sulindac sulfide results in decreased expression of BAD protein
sulindac sulfide results in increased localization of BAD protein
[sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein] 		CTD PMID:17409426 PMID:18678619 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfide CTD PMID:18349538 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
affects response to substance 		ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]
sulindac sulfide results in increased expression of BAX mRNA
sulindac sulfide results in decreased expression of BAX protein
BAX protein affects the susceptibility to sulindac sulfide 		CTD PMID:12203115 PMID:16886631 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) decreases expression ISO sulindac sulfide results in decreased expression of BCAM mRNA CTD PMID:12734198 NCBI chr 1:88,542,971...88,557,358
Ensembl chr 1:88,542,972...88,557,888 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of BCAR1 protein CTD PMID:10741720 NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of BCL2 protein CTD PMID:18678619 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO sulindac sulfide results in decreased expression of BCL2L1 protein CTD PMID:11912124 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bid BH3 interacting domain death agonist decreases expression
increases cleavage 		ISO sulindac sulfide results in decreased expression of BID protein
sulindac sulfide results in increased cleavage of BID protein 		CTD PMID:12203115 PMID:16886631 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression ISO sulindac sulfide results in increased expression of BIRC3 mRNA CTD PMID:16184548 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B decreases expression ISO sulindac sulfide results in decreased expression of BUB1B mRNA CTD PMID:16184548 NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:126,017,045...126,069,796 		JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 increases expression ISO sulindac sulfide results in increased expression of CACNG3 mRNA CTD PMID:16184548 NCBI chr 1:186,632,334...186,728,220
Ensembl chr 1:186,632,323...186,728,214 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression
multiple interactions 		ISO sulindac sulfide results in increased activity of CASP3 protein
sulindac sulfide results in increased expression of CASP3 mRNA
[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein] 		CTD PMID:11051267 PMID:12203115 PMID:12414664 PMID:14555707 PMID:15548677 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:20371263 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity 		ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein] CTD PMID:11559570 PMID:12203115 PMID:12414664 PMID:16886631 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity 		ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 PMID:12414664 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccar1 cell division cycle and apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of CCAR1 mRNA CTD PMID:12734198 NCBI chr20:31,228,624...31,271,233
Ensembl chr20:31,228,624...31,271,227 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression
increases expression 		ISO sulindac sulfide results in decreased expression of CCN2 mRNA
sulindac sulfide results in increased expression of CCN2 mRNA 		CTD PMID:12734198 PMID:16184548 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression 		ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]
sulindac sulfide results in decreased expression of CCND1 mRNA; sulindac sulfide results in decreased expression of CCND1 protein 		CTD PMID:14710233 PMID:15188006 PMID:15767558 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cd4 Cd4 molecule increases expression ISO sulindac sulfide results in increased expression of CD4 mRNA CTD PMID:12734198 NCBI chr 4:159,355,147...159,381,636
Ensembl chr 4:159,356,337...159,381,461 		JBrowse link
G Cd46 CD46 molecule decreases expression ISO sulindac sulfide results in decreased expression of CD46 mRNA CTD PMID:16184548 NCBI chr13:109,104,122...109,134,903 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO sulindac sulfide results in increased expression of and results in increased activity of CDH1 protein CTD PMID:12391285 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Cdh17 cadherin 17 decreases expression ISO sulindac sulfide results in decreased expression of CDH17 mRNA CTD PMID:16184548 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:30,060,090...30,112,226 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
affects activity
increases expression 		ISO PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]
sulindac sulfide affects the activity of CDKN1A protein
sulindac sulfide results in increased expression of CDKN1A mRNA; sulindac sulfide results in increased expression of CDKN1A protein 		CTD PMID:15694660 PMID:15767558 PMID:16091736 PMID:16184548 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta increases expression ISO sulindac sulfide results in increased expression of CEBPB mRNA; sulindac sulfide results in increased expression of CEBPB protein CTD PMID:12734198 PMID:16184548 NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO sulindac sulfide results in decreased expression of CFLAR protein CTD PMID:11912124 NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:67,679,559...67,726,434 		JBrowse link
G Clp1 cleavage factor polyribonucleotide kinase subunit 1 decreases expression ISO sulindac sulfide results in decreased expression of CLP1 mRNA CTD PMID:12734198 NCBI chr 3:90,213,461...90,217,165
Ensembl chr 3:90,213,465...90,217,538 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO sulindac sulfide results in increased expression of CRYAB mRNA CTD PMID:16184548 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of CTNNB1 protein]; sulindac sulfide affects the localization of and results in decreased expression of CTNNB1 protein; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of CCND1 protein]; sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein]; sulindac sulfide results in decreased expression of and results in decreased localization of CTNNB1 protein CTD PMID:14555707 PMID:14710233 PMID:15188006 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Ctsc cathepsin C decreases expression ISO sulindac sulfide results in decreased expression of CTSC mRNA CTD PMID:16184548 NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082 		JBrowse link
G Cyb5b cytochrome b5 type B decreases expression ISO sulindac sulfide results in decreased expression of CYB5B mRNA CTD PMID:12734198 NCBI chr19:51,972,611...52,006,477
Ensembl chr19:51,972,547...52,026,980 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1A1 mRNA CTD PMID:12734198 PMID:16184548 PMID:17985343 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO sulindac sulfide results in increased expression of CYP1A2 mRNA CTD PMID:17985343 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO sulindac sulfide results in increased expression of CYP1B1 mRNA CTD PMID:12734198 PMID:17985343 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142 		JBrowse link
G Dcbld2 discoidin, CUB and LCCL domain containing 2 increases expression ISO sulindac sulfide results in increased expression of DCBLD2 mRNA CTD PMID:12734198 NCBI chr11:55,594,691...55,649,113
Ensembl chr11:55,594,691...55,649,085 		JBrowse link
G Ddx11 DEAD/H-box helicase 11 decreases expression ISO sulindac sulfide results in decreased expression of DDX11 mRNA CTD PMID:16184548 NCBI chr 9:113,204,886...113,309,692
Ensembl chr 9:113,276,985...113,316,152 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR24 mRNA CTD PMID:16184548 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase decreases expression ISO sulindac sulfide results in decreased expression of DHCR7 mRNA CTD PMID:16184548 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression ISO sulindac sulfide results in decreased expression of DYNLL1 mRNA CTD PMID:12734198 NCBI chr12:46,945,291...46,976,867
Ensembl chr12:46,973,050...46,976,861 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
increases ubiquitination
increases phosphorylation
decreases phosphorylation 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]
sulindac sulfide results in increased ubiquitination of EGFR protein
sulindac sulfide results in increased phosphorylation of EGFR protein
sulindac sulfide results in decreased phosphorylation of EGFR protein 		CTD PMID:20332299 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression 		ISO EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA]; EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]
sulindac sulfide results in increased expression of EGR1 mRNA; sulindac sulfide results in increased expression of EGR1 protein 		CTD PMID:15509713 PMID:16079301 PMID:16227405 PMID:17599376 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843 		JBrowse link
G Elk1 ETS transcription factor ELK1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; ELK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of ELK1 protein; U 0126 inhibits the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein] CTD PMID:17599376 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB2 protein] CTD PMID:20332299 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfide results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 affects cleavage ISO sulindac sulfide affects the cleavage of ERBB4 protein CTD PMID:12777371 NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:76,973,227...78,045,772 		JBrowse link
G Esd esterase D increases expression ISO sulindac sulfide results in increased expression of ESD mRNA CTD PMID:12734198 NCBI chr15:56,453,082...56,472,582
Ensembl chr15:56,453,044...56,473,508 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfide results in decreased expression of ESR1 mRNA; sulindac sulfide results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Etfb electron transfer flavoprotein subunit beta decreases expression ISO sulindac sulfide results in decreased expression of ETFB mRNA CTD PMID:16184548 NCBI chr 1:102,988,499...103,002,663
Ensembl chr 1:102,988,499...103,002,659 		JBrowse link
G Etnppl ethanolamine-phosphate phospho-lyase increases expression ISO sulindac sulfide results in increased expression of ETNPPL mRNA CTD PMID:12734198 NCBI chr 2:221,847,210...221,868,827
Ensembl chr 2:221,847,250...221,866,357 		JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions
increases expression 		ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:104,744,309...104,753,113 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression 		ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein] CTD PMID:17602619 PMID:18665581 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Fcgrt Fc gamma receptor and transporter decreases expression ISO sulindac sulfide results in decreased expression of FCGRT mRNA CTD PMID:16184548 NCBI chr 1:104,710,902...104,720,685
Ensembl chr 1:104,710,909...104,720,532 		JBrowse link
G Fdps farnesyl diphosphate synthase decreases expression ISO sulindac sulfide results in decreased expression of FDPS mRNA CTD PMID:16184548 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 decreases expression ISO sulindac sulfide results in decreased expression of FGFR4 mRNA CTD PMID:16184548 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,466,692...9,481,389 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing
increases metabolic processing 		ISO FMO3 gene polymorphism affects the metabolism of sulindac sulfide
FMO3 protein results in increased metabolism of sulindac sulfide 		CTD PMID:17142560 PMID:17559352 NCBI chr13:77,838,899...77,868,869
Ensembl chr13:77,842,602...77,861,256 		JBrowse link
G Foxm1 forkhead box M1 decreases expression ISO sulindac sulfide results in decreased expression of FOXM1 mRNA CTD PMID:16184548 NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:163,325,614...163,337,172 		JBrowse link
G Gal3st4 galactose-3-O-sulfotransferase 4 decreases expression ISO sulindac sulfide results in decreased expression of GAL3ST4 mRNA CTD PMID:16184548 NCBI chr12:22,381,576...22,390,566
Ensembl chr12:22,381,576...22,390,824 		JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression ISO sulindac sulfide results in increased expression of GARS1 mRNA CTD PMID:12734198 NCBI chr 4:85,484,939...85,542,876
Ensembl chr 4:85,493,753...85,542,876 		JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression 		ISO EGR1 protein promotes the reaction [sulindac sulfide results in increased expression of GDF15 mRNA]
sulindac sulfide results in increased expression of GDF15 mRNA; sulindac sulfide results in increased expression of GDF15 protein 		CTD PMID:11895857 PMID:11925476 PMID:12734198 PMID:15180942 PMID:15509713 More... NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022 		JBrowse link
G Gk glycerol kinase increases expression ISO sulindac sulfide results in increased expression of GK mRNA CTD PMID:16184548 NCBI chr  X:54,106,708...54,189,940
Ensembl chr  X:54,112,214...54,196,701 		JBrowse link
G Glcci1 glucocorticoid induced 1 increases expression ISO sulindac sulfide results in increased expression of GLCCI1 mRNA CTD PMID:16184548 NCBI chr 4:37,274,271...37,601,898
Ensembl chr 4:37,529,364...37,599,802
Ensembl chr 4:37,529,364...37,599,802 		JBrowse link
G Grn granulin precursor decreases expression ISO sulindac sulfide results in decreased expression of GRN mRNA CTD PMID:16184548 NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,886,122...87,893,936 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfide binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO sulindac sulfide results in decreased expression of HDAC1 mRNA CTD PMID:16184548 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO sulindac sulfide results in decreased expression of HGF mRNA CTD PMID:10807402 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hm13 histocompatibility minor 13 affects binding
multiple interactions 		ISO sulindac sulfide binds to HM13 protein
sulindac sulfide inhibits the reaction [L 685458 binds to HM13 protein] 		CTD PMID:17932033 NCBI chr 3:161,606,059...161,641,382
Ensembl chr 3:161,606,052...161,644,805 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO sulindac sulfide results in decreased expression of HSD3B1 mRNA CTD PMID:16184548 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO sulindac sulfide results in increased expression of HSPA1B mRNA CTD PMID:16184548 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO sulindac sulfide results in increased expression of HSPA6 mRNA CTD PMID:16184548 NCBI chr13:85,805,911...85,807,052 JBrowse link
G Icam2 intercellular adhesion molecule 2 increases expression ISO sulindac sulfide results in increased expression of ICAM2 mRNA CTD PMID:16184548 NCBI chr10:91,808,449...91,819,319
Ensembl chr10:91,808,316...91,815,072 		JBrowse link
G Id1 inhibitor of DNA binding 1 decreases expression ISO sulindac sulfide results in decreased expression of ID1 mRNA; sulindac sulfide results in decreased expression of ID1 protein CTD PMID:16184548 PMID:21554132 NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:161,671,538...161,672,685 		JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 decreases expression ISO sulindac sulfide results in decreased expression of IFITM1 mRNA CTD PMID:16184548 NCBI chr 1:205,496,757...205,498,796
Ensembl chr 1:205,496,807...205,498,776 		JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression ISO sulindac sulfide results in decreased expression of IFITM3 mRNA CTD PMID:16184548 NCBI chr 1:205,540,649...205,541,758
Ensembl chr 1:205,481,168...205,547,920 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 increases expression ISO sulindac sulfide results in increased expression of IFRD1 mRNA CTD PMID:12734198 NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:62,996,562...63,016,131 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases activity ISO sulindac sulfide results in decreased activity of IKBKB protein CTD PMID:11912124 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 decreases expression ISO sulindac sulfide results in decreased expression of IL13RA1 mRNA CTD PMID:16184548 NCBI chr  X:120,213,670...120,294,777
Ensembl chr  X:120,214,075...120,274,461 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO sulindac sulfide results in increased expression of IL1R1 mRNA CTD PMID:16184548 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579 		JBrowse link
G Ilf3 interleukin enhancer binding factor 3 decreases expression ISO sulindac sulfide results in decreased expression of ILF3 mRNA CTD PMID:16184548 NCBI chr 8:28,198,454...28,236,634
Ensembl chr 8:28,198,543...28,236,612 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO sulindac sulfide results in decreased expression of INSIG1 mRNA CTD PMID:12734198 NCBI chr 4:8,049,339...8,057,812
Ensembl chr 4:8,049,556...8,057,778 		JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression ISO sulindac sulfide results in increased expression of ISG20 mRNA CTD PMID:16184548 NCBI chr 1:142,234,729...142,246,403
Ensembl chr 1:142,236,137...142,246,401 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 decreases expression ISO sulindac sulfide results in decreased expression of ITPR1 mRNA CTD PMID:15767558 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 increases expression ISO sulindac sulfide results in increased expression of JAG2 mRNA CTD PMID:16184548 NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:137,804,133...137,826,738 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO sulindac sulfide results in increased expression of JUN mRNA CTD PMID:16704987 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kalrn kalirin, RhoGEF kinase decreases expression ISO sulindac sulfide results in decreased expression of KALRN mRNA CTD PMID:16184548 NCBI chr11:79,703,345...80,309,210
Ensembl chr11:79,703,366...80,133,329 		JBrowse link
G Klhl21 kelch-like family member 21 increases expression ISO sulindac sulfide results in increased expression of KLHL21 mRNA CTD PMID:16184548 NCBI chr 5:167,797,621...167,806,276
Ensembl chr 5:167,797,591...167,806,276 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 decreases expression
multiple interactions 		ISO sulindac sulfide results in decreased expression of KLK3 protein
AR protein affects the reaction [sulindac sulfide results in decreased expression of KLK3 protein] 		CTD PMID:14581372 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586 		JBrowse link
G Krt14 keratin 14 increases expression ISO sulindac sulfide results in increased expression of KRT14 mRNA CTD PMID:16184548 NCBI chr10:85,638,182...85,642,450 JBrowse link
G Krt16 keratin 16 increases expression ISO sulindac sulfide results in increased expression of KRT16 mRNA CTD PMID:16184548 NCBI chr10:85,669,276...85,672,211
Ensembl chr10:85,669,276...85,672,211 		JBrowse link
G Krt17 keratin 17 increases expression ISO sulindac sulfide results in increased expression of KRT17 mRNA CTD PMID:16184548 NCBI chr10:85,679,068...85,683,792
Ensembl chr10:85,679,070...85,683,787 		JBrowse link
G Krt19 keratin 19 decreases expression ISO sulindac sulfide results in decreased expression of KRT19 mRNA CTD PMID:12734198 NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,576,235...85,580,952 		JBrowse link
G Krt5 keratin 5 decreases expression ISO sulindac sulfide results in decreased expression of KRT5 mRNA CTD PMID:12734198 NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:134,724,840...134,730,569 		JBrowse link
G Lamc1 laminin subunit gamma 1 increases expression
decreases expression 		ISO sulindac sulfide results in increased expression of LAMC1 mRNA
sulindac sulfide results in decreased expression of LAMC1 protein 		CTD PMID:15561105 PMID:16184548 NCBI chr13:67,924,872...68,051,986
Ensembl chr13:67,924,872...68,051,986 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 decreases expression ISO sulindac sulfide results in decreased expression of LAMP1 mRNA CTD PMID:16184548 NCBI chr16:83,058,131...83,082,843
Ensembl chr16:83,058,385...83,075,159 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO sulindac sulfide results in decreased expression of LDHA mRNA CTD PMID:12734198 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521 		JBrowse link
G Ldlr low density lipoprotein receptor decreases expression ISO sulindac sulfide results in decreased expression of LDLR mRNA CTD PMID:16184548 NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675 		JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 decreases expression ISO sulindac sulfide results in decreased expression of MAD2L1 mRNA; sulindac sulfide results in decreased expression of MAD2L1 protein CTD PMID:12734198 NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:97,236,503...97,243,222 		JBrowse link
G Magi1 membrane associated guanylate kinase, WW and PDZ domain containing 1 increases expression ISO sulindac sulfide results in increased expression of MAGI1 mRNA CTD PMID:12734198 NCBI chr 4:127,762,590...128,368,228
Ensembl chr 4:127,762,590...128,367,833 		JBrowse link
G Mal mal, T-cell differentiation protein decreases expression ISO sulindac sulfide results in decreased expression of MAL mRNA CTD PMID:16184548 NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423 		JBrowse link
G Man2b2 mannosidase, alpha, class 2B, member 2 increases expression ISO sulindac sulfide results in increased expression of MAN2B2 mRNA CTD PMID:12734198 NCBI chr14:78,193,797...78,218,802
Ensembl chr14:78,193,725...78,227,724 		JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression ISO sulindac sulfide results in increased expression of MANF mRNA CTD PMID:16184548 NCBI chr 8:116,427,053...116,430,259
Ensembl chr 8:116,427,048...116,429,910 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; MAP2K1 protein promotes the reaction [sulindac sulfide results in increased expression of ATF3 mRNA] CTD PMID:15548677 PMID:16079301 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of MAP3K1 mRNA CTD PMID:12734198 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation 		ISO [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK1 protein]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK1 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK1 protein CTD PMID:15548677 PMID:16079301 PMID:17599376 PMID:18261746 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO sulindac sulfide results in increased expression of MAPK10 mRNA CTD PMID:12734198 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
decreases phosphorylation 		ISO [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of ATF3 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; MAP2K1 protein inhibits the reaction [sulindac sulfide results in decreased phosphorylation of MAPK3 protein]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased expression of EGR1 mRNA]; MAPK3 protein promotes the reaction [sulindac sulfide results in increased phosphorylation of and results in increased activity of ELK1 protein]; sulindac sulfide results in increased phosphorylation of and affects the activity of MAPK3 protein CTD PMID:15548677 PMID:16079301 PMID:17599376 PMID:18261746 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfide results in increased activity of MAPK8 protein CTD PMID:11051267 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mars2 methionyl-tRNA synthetase 2, mitochondrial increases expression ISO sulindac sulfide results in increased expression of MARS2 mRNA CTD PMID:16184548 NCBI chr 9:64,214,935...64,228,408
Ensembl chr 9:64,215,128...64,338,443 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO sulindac sulfide results in decreased expression of MCM2 mRNA CTD PMID:16184548 NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:122,903,682...122,918,094 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO sulindac sulfide inhibits the reaction [CTNNB1 protein results in increased expression of MET protein] CTD PMID:14710233 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression
increases expression 		ISO sulindac sulfide results in decreased expression of MMP1 mRNA
sulindac sulfide results in increased expression of MMP1 mRNA 		CTD PMID:15767558 PMID:16184548 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO sulindac sulfide results in increased expression of MMP10 mRNA CTD PMID:16184548 NCBI chr 8:12,974,707...12,982,613
Ensembl chr 8:12,974,707...12,982,613 		JBrowse link
G Mras muscle RAS oncogene homolog increases expression ISO sulindac sulfide results in increased expression of MRAS mRNA CTD PMID:16184548 NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:108,823,374...108,875,911 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 decreases expression ISO sulindac sulfide results in decreased expression of MSMO1 mRNA CTD PMID:12734198 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Msx1 msh homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of MSX1 mRNA; sulindac sulfide results in decreased expression of MSX1 protein CTD PMID:12734198 NCBI chr14:77,185,802...77,189,735
Ensembl chr14:77,185,802...77,189,735 		JBrowse link
G Mtfr1 mitochondrial fission regulator 1 increases expression ISO sulindac sulfide results in increased expression of MTFR1 mRNA CTD PMID:16184548 NCBI chr 2:103,594,458...103,629,697
Ensembl chr 2:103,594,497...103,629,690 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase increases expression ISO sulindac sulfide results in increased expression of MTHFD2 mRNA CTD PMID:12734198 NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:117,368,835...117,380,350 		JBrowse link
G Muc1 mucin 1, cell surface associated decreases expression ISO sulindac sulfide results in decreased expression of MUC1 mRNA CTD PMID:16184548 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:176,933,047...176,938,491 		JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO sulindac sulfide results in decreased expression of MX1 mRNA CTD PMID:16184548 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904 		JBrowse link
G Myh10 myosin heavy chain 10 increases expression ISO sulindac sulfide results in increased expression of MYH10 mRNA CTD PMID:12734198 NCBI chr10:53,891,955...54,024,032
Ensembl chr10:53,893,166...54,024,036 		JBrowse link
G Ncapd3 non-SMC condensin II complex, subunit D3 decreases expression ISO sulindac sulfide results in decreased expression of NCAPD3 mRNA CTD PMID:16184548 NCBI chr 8:33,696,214...33,765,520
Ensembl chr 8:33,696,270...33,765,518 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO sulindac sulfide results in decreased activity of NFKB1 protein CTD PMID:12085227 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of NFKBIA protein CTD PMID:12085227 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Niban1 niban apoptosis regulator 1 increases expression ISO sulindac sulfide results in increased expression of NIBAN1 mRNA CTD PMID:12734198 NCBI chr13:66,224,219...66,377,728
Ensembl chr13:66,224,021...66,377,724 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression 		ISO sulindac sulfide results in increased activity of NQO1 protein
sulindac sulfide results in increased expression of NQO1 mRNA 		CTD PMID:17985343 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nup133 nucleoporin 133 increases expression ISO sulindac sulfide results in increased expression of NUP133 mRNA CTD PMID:12734198 NCBI chr19:68,789,065...68,838,692
Ensembl chr19:68,789,065...68,838,692 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO sulindac sulfide results in increased expression of ODC1 mRNA CTD PMID:16184548 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases expression
increases cleavage 		ISO (4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid promotes the reaction [sulindac sulfide results in increased cleavage of PARP1 protein]
sulindac sulfide results in decreased expression of PARP1 mRNA 		CTD PMID:12663503 PMID:16184548 PMID:16886631 PMID:18678619 PMID:21400612 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pawr pro-apoptotic WT1 regulator increases expression ISO sulindac sulfide results in increased expression of PAWR mRNA CTD PMID:10833474 NCBI chr 7:45,531,480...45,611,492
Ensembl chr 7:45,531,637...45,611,492 		JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO sulindac sulfide results in decreased expression of PCSK9 mRNA CTD PMID:16184548 NCBI chr 5:126,440,102...126,462,507
Ensembl chr 5:126,440,102...126,462,507 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 decreases expression ISO sulindac sulfide results in decreased expression of PGAM1 mRNA CTD PMID:12734198 NCBI chr 1:250,673,152...250,680,762
Ensembl chr 1:250,673,049...250,690,203 		JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfide results in decreased expression of PGR mRNA; sulindac sulfide results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Pkm pyruvate kinase M1/2 decreases expression ISO sulindac sulfide results in decreased expression of PKM mRNA CTD PMID:16184548 NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:68,948,815...68,975,396 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO sulindac sulfide results in decreased expression of PLAU mRNA CTD PMID:15767558 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO sulindac sulfide results in increased expression of PMAIP1 mRNA CTD PMID:16184548 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Pold3 DNA polymerase delta 3, accessory subunit decreases expression ISO sulindac sulfide results in decreased expression of POLD3 mRNA CTD PMID:16184548 NCBI chr 1:163,830,217...163,870,015
Ensembl chr 1:163,830,437...163,869,202 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfide results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions
increases expression
decreases activity
decreases expression 		ISO PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; PPARD protein inhibits the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide binds to and results in decreased activity of PPARD protein
sulindac sulfide results in increased expression of PPARD mRNA; sulindac sulfide results in increased expression of PPARD protein
sulindac sulfide results in decreased activity of PPARD protein
sulindac sulfide results in decreased expression of PPARD mRNA; sulindac sulfide results in decreased expression of PPARD protein 		CTD PMID:10555149 PMID:11948457 PMID:16091736 PMID:17409426 PMID:18678619 More... NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
increases activity
affects binding 		ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP1 protein]; PPARG protein affects the reaction [sulindac sulfide analog results in increased expression of FABP4 protein]; PPARG protein promotes the reaction [sulindac sulfide results in increased expression of CDKN1A mRNA]; sulindac sulfide analog binds to and results in increased activity of PPARG protein; sulindac sulfide analog inhibits the reaction [troglitazone binds to PPARG protein]; sulindac sulfide binds to and results in increased activity of PPARG protein
sulindac sulfide results in increased expression of PPARG mRNA
sulindac sulfide analog binds to PPARG protein 		CTD PMID:10866999 PMID:11948457 PMID:16091736 PMID:17602619 PMID:18665581 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha decreases expression ISO sulindac sulfide results in decreased expression of PPP2R1A mRNA CTD PMID:12734198 NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:69,213,038...69,238,242 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 decreases expression ISO sulindac sulfide results in decreased expression of PPT1 mRNA CTD PMID:16184548 NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:140,406,214...140,427,200 		JBrowse link
G Prep prolyl endopeptidase increases expression ISO sulindac sulfide results in increased expression of PREP mRNA CTD PMID:12734198 NCBI chr20:50,138,588...50,235,549
Ensembl chr20:50,131,819...50,252,697 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases expression ISO sulindac sulfide results in increased expression of PRKACA mRNA CTD PMID:16184548 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494 		JBrowse link
G Prkcsh PRKCSH beta subunit of glucosidase II decreases expression ISO sulindac sulfide results in decreased expression of PRKCSH mRNA CTD PMID:16184548 NCBI chr 8:28,810,836...28,822,503
Ensembl chr 8:28,810,889...28,822,503 		JBrowse link
G Prrx1 paired related homeobox 1 decreases expression ISO sulindac sulfide results in decreased expression of PRRX1 mRNA CTD PMID:16184548 NCBI chr13:78,136,783...78,205,379
Ensembl chr13:78,136,783...78,204,058 		JBrowse link
G Prss23 serine protease 23 decreases expression ISO sulindac sulfide results in decreased expression of PRSS23 mRNA CTD PMID:12734198 NCBI chr 1:152,815,301...152,835,005
Ensembl chr 1:152,813,670...152,947,871 		JBrowse link
G Psen1 presenilin 1 decreases response to substance
decreases activity
multiple interactions 		ISO PSEN1 gene mutant form results in decreased susceptibility to sulindac sulfide
sulindac sulfide results in decreased activity of PSEN1 protein
[sulindac sulfide results in decreased activity of PSEN1 protein] which affects the cleavage of APP protein; PSEN1 protein affects the reaction [sulindac sulfide affects the cleavage of APP protein]; PSEN1 protein mutant form promotes the reaction [sulindac sulfide affects the cleavage of APP protein]; sulindac sulfide affects the reaction [PSEN1 protein affects the cleavage of APP protein] 		CTD PMID:12805356 PMID:17573346 PMID:17962197 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
G Psmc2 proteasome 26S subunit, ATPase 2 decreases expression ISO sulindac sulfide results in decreased expression of PSMC2 mRNA CTD PMID:16184548 NCBI chr 4:14,148,080...14,162,390
Ensembl chr 4:14,148,090...14,162,390 		JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 affects binding
multiple interactions 		ISO sulindac sulfide binds to PTGDR2 protein
[sulindac sulfide binds to PTGDR2 protein] which results in decreased abundance of Cyclic AMP; sulindac sulfide inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein] 		CTD PMID:15563582 NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:216,995,629...217,022,393 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO sulindac sulfide results in decreased activity of PTGS1 protein CTD PMID:11245490 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
decreases activity
increases response to substance 		ISO [sulindac sulfide results in increased activity of PPARG protein] which results in increased expression of PTGS2 protein; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP3 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP8 protein]; PTGS2 protein inhibits the reaction [sulindac sulfide results in increased activity of CASP9 protein]; sulindac sulfide inhibits the reaction [PTGS2 protein results in decreased expression of TNFRSF10B mRNA]; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
sulindac sulfide results in increased expression of PTGS2 mRNA; sulindac sulfide results in increased expression of PTGS2 protein
sulindac sulfide results in decreased activity of PTGS2 protein
PTGS2 protein results in increased susceptibility to sulindac sulfide 		CTD PMID:10485483 PMID:10866999 PMID:11245490 PMID:11948457 PMID:12208739 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation ISO sulindac sulfide results in decreased phosphorylation of PTK2 protein CTD PMID:10741720 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression ISO sulindac sulfide results in decreased expression of PTPRF mRNA CTD PMID:16184548 NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426 		JBrowse link
G Pvt1 Pvt1 oncogene increases expression ISO sulindac sulfide results in increased expression of PVT1 mRNA CTD PMID:12734198 NCBI chr 7:95,545,916...95,769,306 JBrowse link
G Ranbp1 RAN binding protein 1 increases expression ISO sulindac sulfide results in increased expression of RANBP1 mRNA CTD PMID:12734198 NCBI chr11:96,246,912...96,255,145
Ensembl chr11:96,246,740...96,255,145 		JBrowse link
G Rap1gap Rap1 GTPase-activating protein increases expression ISO sulindac sulfide results in increased expression of RAP1GAP mRNA CTD PMID:12734198 NCBI chr 5:155,157,511...155,222,622
Ensembl chr 5:155,157,558...155,222,622 		JBrowse link
G Rb1 RB transcriptional corepressor 1 affects activity ISO sulindac sulfide affects the activity of RB1 protein CTD PMID:15694660 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Recql4 RecQ like helicase 4 decreases expression ISO sulindac sulfide results in decreased expression of RECQL4 mRNA CTD PMID:16184548 NCBI chr 7:110,304,092...110,311,426
Ensembl chr 7:110,304,094...110,311,258 		JBrowse link
G Reg1a regenerating family member 1 alpha decreases expression ISO sulindac sulfide results in decreased expression of REG1A mRNA CTD PMID:16184548 NCBI chr 4:112,450,466...112,453,130
Ensembl chr 4:112,450,468...112,453,585 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO sulindac sulfide results in decreased activity of RELA protein CTD PMID:11912124 PMID:12085227 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rere arginine-glutamic acid dipeptide repeats decreases expression ISO sulindac sulfide results in decreased expression of RERE mRNA CTD PMID:12734198 NCBI chr 5:166,048,770...166,380,559
Ensembl chr 5:166,048,844...166,380,558 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO sulindac sulfide results in increased expression of RGS16 mRNA CTD PMID:16184548 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein] CTD PMID:18261746 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 decreases expression ISO sulindac sulfide results in decreased expression of RRM2 mRNA CTD PMID:12734198 NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:47,067,690...47,075,370 		JBrowse link
G Rrs1 ribosome biogenesis regulator 1 homolog increases expression ISO sulindac sulfide results in increased expression of RRS1 mRNA CTD PMID:12734198 NCBI chr 5:14,516,303...14,517,936
Ensembl chr 5:14,515,254...14,517,943 		JBrowse link
G Serpinb5 serpin family B member 5 decreases expression ISO sulindac sulfide results in decreased expression of SERPINB5 mRNA CTD PMID:15897233 NCBI chr13:23,500,203...23,520,401
Ensembl chr13:23,500,198...23,520,400 		JBrowse link
G Serpine1 serpin family E member 1 increases expression ISO sulindac sulfide results in increased expression of SERPINE1 mRNA CTD PMID:15897233 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357 		JBrowse link
G Skp2 S-phase kinase associated protein 2 decreases expression ISO sulindac sulfide results in decreased expression of SKP2 mRNA CTD PMID:16184548 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438 		JBrowse link
G Slc25a1 solute carrier family 25 member 1 decreases expression ISO sulindac sulfide results in decreased expression of SLC25A1 mRNA CTD PMID:16184548 NCBI chr11:96,560,054...96,563,071
Ensembl chr11:96,560,041...96,565,052 		JBrowse link
G Slc25a45 solute carrier family 25, member 45 increases expression ISO sulindac sulfide results in increased expression of SLC25A45 mRNA CTD PMID:12734198 NCBI chr 1:212,595,536...212,603,786
Ensembl chr 1:212,595,982...212,603,786 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO sulindac sulfide results in increased expression of SLC3A2 mRNA CTD PMID:16184548 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064 		JBrowse link
G Sprr1b small proline-rich protein 1B increases expression ISO sulindac sulfide results in increased expression of SPRR1B mRNA CTD PMID:16184548 NCBI chr 2:180,704,457...180,706,355
Ensembl chr 2:180,704,457...180,706,355 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 decreases expression ISO sulindac sulfide results in decreased expression of SPTBN1 mRNA CTD PMID:12734198 NCBI chr14:108,042,629...108,217,884
Ensembl chr14:108,042,629...108,217,836 		JBrowse link
G Sqstm1 sequestosome 1 increases expression ISO sulindac sulfide results in increased expression of SQSTM1 mRNA CTD PMID:16184548 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 decreases expression ISO sulindac sulfide results in decreased expression of SREBF2 mRNA CTD PMID:16184548 NCBI chr 7:115,542,774...115,600,945
Ensembl chr 7:115,543,290...115,600,943 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases expression 		ISO sulindac sulfide results in decreased expression of and results in decreased phosphorylation of STAT3 protein
sulindac sulfide results in decreased expression of STAT3 mRNA 		CTD PMID:17566705 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Stc2 stanniocalcin 2 increases expression ISO sulindac sulfide results in increased expression of STC2 mRNA CTD PMID:12734198 NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,755,267...16,767,447 		JBrowse link
G Stk17b serine/threonine kinase 17b increases expression ISO sulindac sulfide results in increased expression of STK17B mRNA CTD PMID:16184548 NCBI chr 9:62,801,912...62,832,511
Ensembl chr 9:62,803,005...62,832,511 		JBrowse link
G Syde1 synapse defective Rho GTPase homolog 1 increases expression ISO sulindac sulfide results in increased expression of SYDE1 mRNA CTD PMID:12734198 NCBI chr 7:11,683,505...11,689,491
Ensembl chr 7:11,681,111...11,690,443 		JBrowse link
G Tfap2b transcription factor AP-2 beta increases expression ISO sulindac sulfide results in increased expression of TFAP2B mRNA CTD PMID:16184548 NCBI chr 9:29,282,703...29,312,568
Ensembl chr 9:29,282,825...29,312,568 		JBrowse link
G Tff3 trefoil factor 3 decreases expression ISO sulindac sulfide results in decreased expression of TFF3 mRNA CTD PMID:16184548 NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,194,626...9,199,333 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions
increases expression 		ISO [sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein; [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein; EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA]; U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]
sulindac sulfide results in increased expression of THBS1 mRNA; sulindac sulfide results in increased expression of THBS1 protein 		CTD PMID:16227405 PMID:18261746 NCBI chr 3:125,510,250...125,525,402
Ensembl chr 3:125,510,250...125,525,402 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO sulindac sulfide results in decreased expression of TK1 mRNA CTD PMID:16184548 NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228 		JBrowse link
G Tmpo thymopoietin decreases expression ISO sulindac sulfide results in decreased expression of TMPO mRNA CTD PMID:16184548 NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:27,529,978...27,554,937 		JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO sulindac sulfide results in decreased expression of TMSB4X mRNA CTD PMID:15292456 NCBI chr  X:30,761,611...30,763,612
Ensembl chr  X:30,761,612...30,763,613 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein; [sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein; sulindac sulfide inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP3 protein]; tempol inhibits the reaction [[sulindac sulfide co-treated with TNF protein] results in increased activity of CASP7 protein] CTD PMID:10866999 PMID:20371263 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO sulindac sulfide results in increased expression of TNFRSF10A mRNA; sulindac sulfide results in increased expression of TNFRSF10A protein CTD PMID:15180942 NCBI chr15:51,249,883...51,278,091
Ensembl chr15:51,250,112...51,278,082 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein] CTD PMID:12203115 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tp53 tumor protein p53 decreases expression ISO sulindac sulfide results in decreased expression of TP53 protein CTD PMID:9192825 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Trip4 thyroid hormone receptor interactor 4 increases expression ISO sulindac sulfide results in increased expression of TRIP4 mRNA CTD PMID:16184548 NCBI chr 8:75,248,352...75,334,802
Ensembl chr 8:75,248,361...75,335,055 		JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO sulindac sulfide results in decreased expression of TSPAN8 mRNA CTD PMID:16184548 NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:53,330,963...53,365,401 		JBrowse link
G Tuba4a tubulin, alpha 4A decreases expression ISO sulindac sulfide results in decreased expression of TUBA4A mRNA CTD PMID:12734198 NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO sulindac sulfide results in increased expression of TXNRD1 mRNA CTD PMID:16184548 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Uba7 ubiquitin-like modifier activating enzyme 7 decreases expression ISO sulindac sulfide results in decreased expression of UBA7 mRNA CTD PMID:16184548 NCBI chr 8:117,543,902...117,552,709
Ensembl chr 8:117,543,957...117,556,142 		JBrowse link
G Ube2d1 ubiquitin-conjugating enzyme E2D 1 increases expression ISO sulindac sulfide results in increased expression of UBE2D1 mRNA CTD PMID:16184548 NCBI chr20:17,308,459...17,341,427
Ensembl chr20:17,331,646...17,341,427 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases expression 		ISO sulindac sulfide results in increased activity of UGT1A1 protein
sulindac sulfide results in increased expression of UGT1A1 mRNA 		CTD PMID:17985343 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Upp1 uridine phosphorylase 1 increases expression ISO sulindac sulfide results in increased expression of UPP1 mRNA CTD PMID:16184548 NCBI chr14:88,023,155...88,043,036
Ensembl chr14:88,023,351...88,043,034 		JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO sulindac sulfide results in increased expression of VMP1 mRNA CTD PMID:12734198 NCBI chr10:71,903,223...72,002,337
Ensembl chr10:71,903,227...72,002,319 		JBrowse link
G Xrcc6 X-ray repair cross complementing 6 increases expression ISO sulindac sulfide results in increased expression of XRCC6 mRNA CTD PMID:12734198 NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:115,422,662...115,443,884 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon multiple interactions
decreases expression 		ISO [sulindac sulfide results in decreased expression of YWHAE protein] which results in increased localization of BAD protein; PPARD protein affects the reaction [sulindac sulfide results in decreased expression of YWHAE protein]; sulindac sulfide promotes the reaction [BAD protein binds to YWHAE protein]
sulindac sulfide results in decreased expression of YWHAE mRNA; sulindac sulfide results in decreased expression of YWHAE protein 		CTD PMID:17409426 PMID:18678619 NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291 		JBrowse link
sulindac sulfone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B10 protein CTD PMID:25532697 NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation
multiple interactions 		ISO
EXP 		sulindac sulfone affects the phosphorylation of AKT1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form 		CTD PMID:15570007 PMID:17908994 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
increases expression 		ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [sulindac sulfone results in increased phosphorylation of ALOX15 protein]; GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in increased expression of ALOX15 mRNA; sulindac sulfone results in increased expression of ALOX15 protein 		CTD PMID:11861401 PMID:16166323 NCBI chr10:55,559,060...55,567,535
Ensembl chr10:55,559,061...55,567,723 		JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP 		AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein]; sulindac sulfone results in decreased expression of and results in decreased activity of AR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein 		CTD PMID:14581372 PMID:17908994 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfone CTD PMID:18349538 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein]; sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein
sulindac sulfone results in increased activity of CASP3 protein 		CTD PMID:11051267 PMID:14555707 PMID:15548677 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp8 caspase 8 increases activity ISO sulindac sulfone results in increased activity of CASP8 protein CTD PMID:11559570 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions 		ISO
EXP 		sulindac sulfone results in decreased expression of CCND1 mRNA; sulindac sulfone results in decreased expression of CCND1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein 		CTD PMID:12392815 PMID:15188006 PMID:17908994 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO sulindac sulfone results in increased expression of CDKN1A mRNA; sulindac sulfone results in increased expression of CDKN1A protein CTD PMID:18593937 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO sulindac sulfone results in increased expression of CDKN1B mRNA; sulindac sulfone results in increased expression of CDKN1B protein CTD PMID:18593937 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
decreases expression 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein]
sulindac sulfone results in increased expression of CTNNB1 protein 		CTD PMID:10910034 PMID:11602670 PMID:12392815 PMID:14555707 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases ubiquitination
increases phosphorylation
decreases phosphorylation
decreases expression 		ISO
EXP 		benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]
sulindac sulfone results in increased ubiquitination of EGFR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form
sulindac sulfone results in increased phosphorylation of EGFR protein
sulindac sulfone results in decreased phosphorylation of EGFR protein 		CTD PMID:17908994 PMID:20332299 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO sulindac sulfone results in decreased expression of ERBB2 protein CTD PMID:20332299 NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,907,460...83,931,481 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression 		ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfone results in decreased expression of ESR1 mRNA; sulindac sulfone results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gata6 GATA binding protein 6 multiple interactions
decreases expression 		ISO GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in decreased expression of GATA6 protein 		CTD PMID:11861401 NCBI chr18:2,460,909...2,492,322
Ensembl chr18:2,458,253...2,492,322 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO sulindac sulfone results in increased expression of HINT1 mRNA; sulindac sulfone results in increased expression of HINT1 protein CTD PMID:18593937 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
increases expression 		ISO sulindac sulfone results in increased activity of HPGD protein
sulindac sulfone results in increased expression of HPGD mRNA 		CTD PMID:19501039 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Il24 interleukin 24 increases expression ISO sulindac sulfone results in increased expression of IL24 protein CTD PMID:15713900 NCBI chr13:44,905,362...44,910,760
Ensembl chr13:44,905,363...44,910,760 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions
decreases expression 		ISO AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein] CTD PMID:11490238 PMID:14581372 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15548677 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO sulindac sulfone results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:11051267 NCBI chr10:50,842,348...50,947,063
Ensembl chr10:50,844,034...50,947,185 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation 		ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein] CTD PMID:15548677 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation 		ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein] CTD PMID:15548677 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfone results in increased activity of MAPK8 protein CTD PMID:11051267 PMID:11278263 PMID:15970671 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO sulindac sulfone results in decreased expression of MMP7 protein CTD PMID:15725655 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sulindac sulfone results in increased degradation of and results in decreased expression of NFKBIA protein CTD PMID:18059344 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO sulindac sulfone results in increased expression of NGFR mRNA; sulindac sulfone results in increased expression of NGFR protein CTD PMID:17447067 NCBI chr10:81,012,077...81,030,305
Ensembl chr10:81,012,089...81,030,305 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression 		ISO sulindac sulfone results in increased activity of NQO1 protein
sulindac sulfone results in increased expression of NQO1 mRNA 		CTD PMID:17985343 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO sulindac sulfone results in decreased expression of PCNA protein CTD PMID:15570007 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pde2a phosphodiesterase 2A decreases activity
multiple interactions 		ISO sulindac sulfone results in decreased activity of PDE2A protein
sulindac sulfone binds to and results in decreased activity of PDE2A protein 		CTD PMID:10910034 PMID:11602670 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466 		JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions
decreases activity 		ISO sulindac sulfone binds to and results in decreased activity of PDE5A protein
sulindac sulfone results in decreased activity of PDE5A protein 		CTD PMID:10910034 PMID:11602670 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfone results in decreased expression of PGR mRNA; sulindac sulfone results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfone results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO sulindac sulfone results in increased expression of PPARD mRNA CTD PMID:11948457 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression 		ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA]
sulindac sulfone results in increased expression of PPARG mRNA 		CTD PMID:11948457 PMID:14506281 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression ISO sulindac sulfone results in increased expression of PRKG1 protein CTD PMID:11602670 PMID:16731751 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005 		JBrowse link
G Psca prostate stem cell antigen increases expression ISO sulindac sulfone results in increased expression of PSCA mRNA CTD PMID:16949054 NCBI chr 7:108,483,974...108,492,098
Ensembl chr 7:108,484,184...108,492,097 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP sulindac sulfone results in decreased expression of PTGS1 mRNA alternative form CTD PMID:11375891 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions
increases expression 		ISO
EXP 		sulindac sulfone results in decreased expression of PTGS2 protein
sulindac sulfone results in decreased expression of PTGS2 mRNA
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]
[sulindac sulfone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
sulindac sulfone results in increased expression of PTGS2 mRNA 		CTD PMID:11118042 PMID:11375891 PMID:11948457 PMID:17908994 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO sulindac sulfone affects the localization of RELA protein CTD PMID:18059344 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression 		ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA] CTD PMID:14506281 PMID:16262603 NCBI chr  X:44,008,089...44,011,376
Ensembl chr  X:44,006,781...44,011,374 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein] CTD PMID:17908994 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases glucuronidation
increases expression 		ISO sulindac sulfone results in increased activity of UGT1A1 protein
UGT1A1 protein results in increased glucuronidation of sulindac sulfone
sulindac sulfone results in increased expression of UGT1A1 mRNA 		CTD PMID:15843492 PMID:17985343 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO sulindac sulfone results in increased phosphorylation of VASP protein CTD PMID:16166323 NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression ISO sulindac sulfone results in decreased expression of YWHAE protein CTD PMID:17409426 NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        pharmacological role 19895
          analgesic 14904
            sulindac 788
              nitrosulindac 0
              sulindac sulfide 219
              sulindac sulfone 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    p-block element atom 20768
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20207
                              organochalcogen compound 19905
                                organooxygen compound 19807
                                  carbon oxoacid 19157
                                    carboxylic acid 19154
                                      monocarboxylic acid 18301
                                        acetic acid 11175
                                          sulindac 788
                                            nitrosulindac 0
                                            sulindac sulfide 219
                                            sulindac sulfone 51
paths to the root