Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulfasalazine
go back to main search page
Accession:CHEBI:9334 term browser browse the term
Definition:An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
Synonyms:exact_synonym: 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid
 related_synonym: 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid;   2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid;   4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene;   5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid;   5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid;   5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid;   Azulfidine;   Formula=C18H14N4O5S;   InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+;   InChIKey=NCEXYHBECQHGNR-QZQOTICOSA-N;   SMILES=OC(=O)c1cc(ccc1O)\\N=N\\c1ccc(cc1)S(=O)(=O)Nc1ccccn1;   Salazosulfapiridina;   Salazosulfapyridine;   Salazosulfapyridinum;   Salicylazosulfapyridine;   Sulfasalazina;   Sulfasalazinum
 alt_id: CHEBI:101223
 xref: Beilstein:356241;   CAS:599-79-1;   DrugBank:DB00795;   Gmelin:2666050;   KEGG:C07316;   KEGG:D00448
 xref_mesh: MESH:D012460
 xref: PDBeChem:SAS;   PMID:11362329;   PMID:11485124;   PMID:11587223;   PMID:14981898;   PMID:15248210;   PMID:16322111;   PMID:17386570;   PMID:2434548;   PMID:7720170;   Patent:US2396145;   Reaxys:8132868


show annotations for term's descendants           Sort by:
sulfasalazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase increases expression ISO Sulfasalazine results in increased expression of AADAT mRNA CTD PMID:22016648 NCBI chr16:34,520,236...34,566,388
Ensembl chr16:29,509,394...29,544,332 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium CTD PMID:19853032 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases transport
increases activity
affects transport
multiple interactions
decreases methylation		 ISO ABCG2 protein results in increased transport of Sulfasalazine
Sulfasalazine results in increased activity of ABCG2 protein
ABCG2 gene polymorphism affects the transport of Sulfasalazine
[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]; yu ping feng san inhibits the reaction [Sulfasalazine results in increased activity of ABCG2 protein]		 CTD PMID:18167504 PMID:18408567 PMID:20019844 PMID:27475308 PMID:30083819 More... NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B increases expression ISO Sulfasalazine results in increased expression of ACAA1B mRNA CTD PMID:31830553 NCBI chr 8:127,750,771...127,759,589
Ensembl chr 8:118,872,997...118,881,825 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Sulfasalazine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Sulfasalazine results in increased expression of ACOT1 mRNA CTD PMID:31830553 NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression ISO Sulfasalazine results in increased expression of ACOT3 mRNA CTD PMID:31830553 NCBI chr 6:109,413,617...109,419,840
Ensembl chr 6:103,682,596...103,688,427
Ensembl chr 6:103,682,596...103,688,427 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Sulfasalazine results in increased expression of ACOX1 mRNA CTD PMID:31830553 NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein] CTD PMID:15633128 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Adrm1 ADRM1 26S proteasome ubiquitin receptor increases expression EXP Sulfasalazine results in increased expression of ADRM1 protein CTD PMID:15928459 NCBI chr 3:187,643,043...187,647,805
Ensembl chr 3:167,265,296...167,270,195 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions
affects localization		 ISO BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein] CTD PMID:12381674 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of AKT1 protein] CTD PMID:36806191 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression
increases expression		 ISO
EXP		 Sulfasalazine results in decreased expression of ALDH1A1 mRNA
Sulfasalazine results in increased expression of ALDH1A1 protein		 CTD PMID:15928459 PMID:31830553 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member increases expression EXP Sulfasalazine results in increased expression of ALDH2 protein CTD PMID:15928459 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:34,901,219...34,982,521 		JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression EXP Sulfasalazine results in decreased expression of ALDH6A1 protein CTD PMID:15928459 NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
G Alpi alkaline phosphatase, intestinal multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of ALPI protein] CTD PMID:15867298 NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:87,773,411...87,776,877 		JBrowse link
G Anxa2 annexin A2 increases expression ISO Sulfasalazine results in increased expression of ANXA2 mRNA CTD PMID:22016648 NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Apoa4 apolipoprotein A4 decreases expression ISO Sulfasalazine results in decreased expression of APOA4 mRNA CTD PMID:31830553 NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha increases expression EXP Sulfasalazine results in increased expression of ATP5F1A protein CTD PMID:15928459 NCBI chr18:73,567,537...73,575,473
Ensembl chr18:71,292,374...71,300,794 		JBrowse link
G Azin1 antizyme inhibitor 1 increases expression ISO Sulfasalazine results in increased expression of AZIN1 mRNA CTD PMID:22016648 NCBI chr 7:71,539,711...71,566,515
Ensembl chr 7:69,654,663...69,681,578 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
multiple interactions		 ISO
EXP		 Sulfasalazine affects the localization of BAX protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]		 CTD PMID:12381674 PMID:31428839 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]		 CTD
RGD		 PMID:12381674 PMID:31428839 PMID:29572553 RGD:152995414 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C6 complement C6 decreases expression ISO Sulfasalazine results in decreased expression of C6 mRNA CTD PMID:31830553 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G Calr calreticulin decreases expression EXP Sulfasalazine results in decreased expression of CALR protein CTD PMID:15928459 NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased cleavage of CASP1 protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein] CTD PMID:30408459 PMID:35595039 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO
EXP		 Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Sulfasalazine results in increased cleavage of and results in increased activity of CASP3 protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
Sulfasalazine results in increased activity of CASP3 protein		 CTD PMID:12381674 PMID:16322111 PMID:17051331 PMID:19473188 PMID:19859796 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP9 protein]
Sulfasalazine results in increased cleavage of CASP9 protein		 CTD PMID:16322111 PMID:19859796 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cat catalase increases activity
decreases activity
multiple interactions		 EXP
ISO		 Sulfasalazine results in increased activity of CAT protein
Sulfasalazine results in decreased activity of CAT protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]		 CTD PMID:19028562 PMID:19071188 PMID:28421826 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA CTD PMID:19015640 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases expression EXP Sulfasalazine results in decreased expression of CBR1 protein CTD PMID:15928459 NCBI chr11:46,346,405...46,348,815
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL2 mRNA] CTD PMID:17449585 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression		 ISO
EXP		 [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA
Sulfasalazine results in decreased expression of CCND1 mRNA		 CTD PMID:17202759 PMID:19015640 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccng1 cyclin G1 increases expression ISO Sulfasalazine results in increased expression of CCNG1 mRNA CTD PMID:22016648 NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641 		JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA CTD PMID:28863153 NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Cd19 CD19 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA CTD PMID:28863153 NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:180,987,286...180,993,975 		JBrowse link
G Cd27 CD27 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA CTD PMID:28863153 NCBI chr 4:159,716,932...159,721,823
Ensembl chr 4:158,030,703...158,035,592 		JBrowse link
G Cd38 CD38 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA CTD PMID:28863153 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd3d CD3 delta subunit of T-cell receptor complex multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA CTD PMID:28863153 NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:45,288,749...45,301,809 		JBrowse link
G Cd46 CD46 molecule decreases expression EXP Sulfasalazine results in decreased expression of CD46 mRNA CTD PMID:15625186 NCBI chr13:109,104,122...109,134,903
Ensembl chr13:106,574,858...106,660,445 		JBrowse link
G Cd55 CD55 molecule (Cromer blood group) decreases expression EXP Sulfasalazine results in decreased expression of CD55 mRNA CTD PMID:15625186 PMID:17166698 NCBI chr13:44,409,574...44,438,913
Ensembl chr13:41,857,395...41,885,831 		JBrowse link
G Cd59b CD59b molecule decreases expression EXP Sulfasalazine results in decreased expression of CD59 mRNA; Sulfasalazine results in decreased expression of CD59 protein CTD PMID:15625186 PMID:17166698 NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cd74 CD74 molecule multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA CTD PMID:28863153 NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA CTD PMID:19015640 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein] CTD PMID:19234301 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cldn2 claudin 2 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 protein] CTD PMID:35290143 NCBI chr  X:108,248,383...108,258,847
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Clu clusterin increases expression ISO Sulfasalazine results in increased expression of CLU mRNA CTD PMID:22016648 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein] CTD PMID:15633128 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein] CTD PMID:17051331 NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA CTD PMID:28863153 NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO
EXP		 [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein]		 CTD PMID:19015640 PMID:26165751 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
affects secretion		 ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein] CTD PMID:12231210 PMID:28863153 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects secretion
multiple interactions		 ISO Sulfasalazine affects the secretion of CXCL1 protein
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]		 CTD PMID:12231210 PMID:28863153 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP Sulfasalazine results in increased expression of CYP1A1 mRNA CTD PMID:17202759 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 decreases expression ISO Sulfasalazine results in decreased expression of CYP27B1 mRNA CTD PMID:15243130 NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Sulfasalazine results in increased expression of CYP2B10 mRNA CTD PMID:31830553 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO Sulfasalazine results in increased expression of CYP2C55 mRNA; Sulfasalazine results in increased expression of CYP2C55 protein CTD PMID:31830553 NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:236,873,967...236,936,238 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases expression ISO Sulfasalazine results in increased expression of CYP2C29 mRNA CTD PMID:31830553 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Sulfasalazine results in increased expression of DDIT3 mRNA CTD PMID:22016648 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dio1 iodothyronine deiodinase 1 multiple interactions ISO [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA] CTD PMID:16614379 NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:122,074,279...122,090,970 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO
EXP		 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]		 CTD PMID:16728495 PMID:21068073 NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dnaja2 DnaJ heat shock protein family (Hsp40) member A2 increases expression ISO Sulfasalazine results in increased expression of DNAJA2 mRNA CTD PMID:22016648 NCBI chr19:37,671,019...37,689,163
Ensembl chr19:21,497,729...21,516,901 		JBrowse link
G Egf epidermal growth factor increases expression ISO Sulfasalazine results in increased expression of EGF mRNA CTD PMID:22016648 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression		 ISO [Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
Sulfasalazine results in decreased expression of EGFR mRNA; Sulfasalazine results in decreased expression of EGFR protein		 CTD PMID:20007406 PMID:31830553 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Egr1 early growth response 1 decreases expression ISO Sulfasalazine results in decreased expression of EGR1 mRNA CTD PMID:31830553 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression ISO Sulfasalazine results in increased expression of EPHX1 mRNA CTD PMID:22016648 PMID:31830553 NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA] CTD PMID:18983524 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Sulfasalazine results in increased expression of FABP4 mRNA CTD PMID:22016648 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fga fibrinogen alpha chain increases expression ISO Sulfasalazine results in increased expression of FGA mRNA CTD PMID:22016648 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fh fumarate hydratase decreases expression EXP Sulfasalazine results in decreased expression of FH protein CTD PMID:15928459 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression ISO Sulfasalazine results in decreased expression of FMC1 mRNA CTD PMID:31830553 NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein] CTD PMID:28421826 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Ftl1 ferritin light chain 1 increases expression ISO Sulfasalazine results in increased expression of FTL1 mRNA CTD PMID:22016648 NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G G0s2 G0/G1switch 2 increases expression ISO Sulfasalazine results in increased expression of G0S2 mRNA CTD PMID:31830553 NCBI chr13:107,335,036...107,335,948
Ensembl chr13:104,806,156...104,807,451 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta decreases expression EXP Sulfasalazine results in decreased expression of GADD45B mRNA CTD PMID:15633128 NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Sulfasalazine results in decreased expression of GAPDH protein CTD PMID:15928459 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein] CTD PMID:14687604 NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Sulfasalazine results in increased expression of GPT protein CTD PMID:31830553 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx3 glutathione peroxidase 3 decreases expression ISO Sulfasalazine results in decreased expression of GPX3 mRNA CTD PMID:31830553 NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein] CTD PMID:26165751 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Sulfasalazine results in decreased activity of GSR protein CTD PMID:19028562 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Sulfasalazine results in increased expression of GSTA5 mRNA CTD PMID:17202759 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:79,105,661...79,117,472 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP Sulfasalazine results in decreased expression of GSTM1 protein CTD PMID:15928459 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Sulfasalazine results in increased expression of GSTM2 mRNA CTD PMID:31830553 NCBI chr 2:198,312,179...198,316,962
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Sulfasalazine results in increased expression of GSTM3 mRNA CTD PMID:31830553 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:195,531,495...195,534,553 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Sulfasalazine results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA] CTD PMID:12745093 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]
Sulfasalazine results in increased activity of HIF1A protein		 CTD PMID:12808024 PMID:19502547 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO Sulfasalazine results in increased expression of HINT1 mRNA CTD PMID:22016648 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions		 EXP Sulfasalazine results in increased expression of HMGB1 mRNA
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon		 CTD
RGD		 PMID:16141653 PMID:29572553 RGD:152995414 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 increases response to substance
increases expression
multiple interactions		 EXP HMOX1 protein results in increased susceptibility to Sulfasalazine
[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein; Sulfasalazine results in increased expression of HMOX1 mRNA; Sulfasalazine results in increased expression of HMOX1 protein
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]		 CTD PMID:19234301 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 decreases expression EXP Sulfasalazine results in decreased expression of HSD17B3 mRNA CTD PMID:29197623 NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,027,229...1,058,554 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Sulfasalazine results in increased expression of HSD17B4 mRNA CTD PMID:22016648 NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Sulfasalazine results in decreased expression of HSD3B1 mRNA CTD PMID:29197623 NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Sulfasalazine results in increased expression of HSP90AB1 mRNA CTD PMID:22016648 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Sulfasalazine results in increased expression of HSPA1A mRNA CTD PMID:22016648 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression EXP Sulfasalazine results in decreased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression EXP Sulfasalazine results in decreased expression of HSPA2 protein CTD PMID:15928459 NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
increases expression		 ISO
EXP		 Sulfasalazine results in decreased expression of ICAM1 mRNA; Sulfasalazine results in decreased expression of ICAM1 protein
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]
Sulfasalazine results in increased expression of ICAM1 protein		 CTD
RGD		 PMID:11264155 PMID:15553846 PMID:17259377 PMID:20823682 PMID:26165751 More... RGD:152995414 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta increases expression ISO Sulfasalazine results in increased expression of IDH3B mRNA CTD PMID:22016648 NCBI chr 3:137,934,971...137,940,275
Ensembl chr 3:117,481,845...117,486,982 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA] CTD PMID:20884048 NCBI chr16:74,133,259...74,145,328
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]		 CTD PMID:11529938 PMID:15269287 PMID:17051331 PMID:25231984 PMID:29594315 More... NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression EXP Sulfasalazine affects the expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO Sulfasalazine results in decreased expression of IKBKB protein CTD PMID:15564333 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP		 Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Sulfasalazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]		 CTD
RGD		 PMID:15604057 PMID:17051331 PMID:25231984 PMID:25727887 PMID:29731490 More... RGD:152995414 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA CTD PMID:28863153 NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:45,563,137...45,578,061 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]] CTD PMID:11529938 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11529938 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein] CTD PMID:31428839 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL18 protein] CTD PMID:35595039 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 [Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
Sulfasalazine results in decreased expression of IL1B mRNA
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]		 CTD PMID:12133438 PMID:12231210 PMID:15604057 PMID:15793857 PMID:15867298 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA] CTD PMID:17449585 NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA] CTD PMID:15867298 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL2 protein]		 CTD PMID:17051331 PMID:29594315 PMID:32272095 PMID:35362542 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein] CTD PMID:7815356 NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]		 CTD PMID:12135912 PMID:17051331 PMID:19956958 PMID:20884048 PMID:21070844 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insr insulin receptor increases expression ISO Sulfasalazine results in increased expression of INSR protein CTD PMID:15564333 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA CTD PMID:28863153 NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression ISO Sulfasalazine results in decreased expression of IRS2 mRNA CTD PMID:31830553 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein] CTD PMID:8094364 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein] CTD PMID:8094364 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Itk IL2-inducible T-cell kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA CTD PMID:28863153 NCBI chr10:31,254,667...31,316,004
Ensembl chr10:30,753,344...30,814,685 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of JAK2 protein] CTD PMID:32272095 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jchain joining chain of multimeric IgA and IgM multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA CTD PMID:28863153 NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,538,952...19,546,298 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA CTD PMID:28863153 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Ldhc lactate dehydrogenase C multiple interactions
increases activity		 ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein]
Sulfasalazine results in increased activity of LDHC protein		 CTD PMID:28421826 NCBI chr 1:106,522,140...106,539,649
Ensembl chr 1:97,382,379...97,403,378 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein] CTD PMID:28421826 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lsm10 LSM10, U7 small nuclear RNA associated decreases expression ISO Sulfasalazine results in decreased expression of LSM10 mRNA CTD PMID:31830553 NCBI chr 5:143,649,817...143,660,391
Ensembl chr 5:138,373,119...138,377,505 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein] CTD PMID:36806191 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein] CTD PMID:36806191 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation EXP Sulfasalazine results in increased phosphorylation of MAPK9 protein CTD PMID:15633128 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mill1 MHC I like leukocyte 1 decreases expression ISO Sulfasalazine results in decreased expression of MICA mRNA; Sulfasalazine results in decreased expression of MICA protein CTD PMID:15494508 NCBI chr 1:87,500,591...87,526,983
Ensembl chr 1:78,372,802...78,398,930 		JBrowse link
G Mir223 microRNA 223 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in decreased expression of MIR223 mRNA] CTD PMID:35595039 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA CTD PMID:28863153 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Sulfasalazine promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein] CTD PMID:15633128 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP		 Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein]		 CTD PMID:12745093 PMID:22119283 PMID:30972795 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity		 EXP
ISO		 Sulfasalazine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
Sulfasalazine results in decreased activity of MPO protein		 CTD
RGD		 PMID:17373747 PMID:20380826 PMID:22119283 PMID:23665423 PMID:25231984 More... RGD:152995414 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Sulfasalazine affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:67,299,585...67,317,970 		JBrowse link
G Ms4a1 membrane spanning 4-domains A1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA CTD PMID:28863153 NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:207,906,374...207,918,512 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; MTHFR protein results in increased susceptibility to Sulfasalazine CTD PMID:19578646 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Muc2 mucin 2, oligomeric mucus/gel-forming multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA] CTD PMID:17449585 NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:196,799,517...196,831,756 		JBrowse link
G Muc4 mucin 4, cell surface associated multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA] CTD PMID:17449585 NCBI chr11:81,513,321...81,575,200 JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP
ISO		 Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MYD88 protein]		 CTD PMID:35290143 PMID:35362542 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nat2 N-acetyltransferase 2 affects metabolic processing
increases acetylation
increases metabolic processing
affects response to substance		 ISO NAT2 gene polymorphism affects the metabolism of Sulfasalazine; NAT2 protein affects the metabolism of Sulfasalazine; NAT2 protein polymorphism affects the metabolism of Sulfasalazine
NAT2 protein results in increased acetylation of Sulfasalazine
NAT2 protein results in increased metabolism of Sulfasalazine
NAT2 protein affects the susceptibility to Sulfasalazine		 CTD PMID:12465141 PMID:15032315 PMID:17377643 PMID:17502830 PMID:19560446 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ncl nucleolin decreases expression EXP Sulfasalazine results in decreased expression of NCL protein CTD PMID:15928459 NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:86,998,019...87,008,136 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP		 [Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]		 CTD PMID:19234301 PMID:31428839 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases localization
decreases expression		 ISO
EXP		 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]
Sulfasalazine results in decreased localization of NFKB1 protein
Sulfasalazine results in decreased expression of NFKB1 protein		 CTD PMID:9486988 PMID:12135912 PMID:15269287 PMID:17259377 PMID:26165751 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
decreases expression
increases degradation		 ISO
EXP		 Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased phosphorylation of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased expression of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sulfasalazine results in increased degradation of NFKBIA protein		 CTD PMID:9486988 PMID:11786414 PMID:15494508 PMID:15793857 PMID:16934226 More... NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 protein] CTD PMID:30408459 PMID:35595039 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO
EXP		 Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Sulfasalazine results in decreased expression of NOS2 mRNA
Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]		 CTD PMID:11529938 PMID:15867298 PMID:16925772 PMID:16934226 PMID:17259377 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP
ISO		 Sulfasalazine results in increased expression of NQO1 mRNA CTD PMID:19234301 PMID:22016648 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases expression ISO Sulfasalazine results in increased expression of NR3C1 mRNA; Sulfasalazine results in increased expression of NR3C1 protein CTD PMID:17267514 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nsfl1c NSFL1 cofactor increases expression EXP Sulfasalazine results in increased expression of NSFL1C protein CTD PMID:15928459 NCBI chr 3:160,438,708...160,463,261
Ensembl chr 3:139,978,301...140,002,870 		JBrowse link
G Oat ornithine aminotransferase increases expression ISO Sulfasalazine results in increased expression of OAT mRNA CTD PMID:22016648 NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:187,347,865...187,367,682 		JBrowse link
G Ocln occludin multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein] CTD PMID:35290143 NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression ISO Sulfasalazine results in increased expression of ODC1 mRNA CTD PMID:22016648 NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA] CTD PMID:11901219 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO Sulfasalazine results in increased expression of PCNA mRNA CTD PMID:22016648 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression EXP Sulfasalazine results in decreased expression of PEBP1 protein CTD PMID:15928459 NCBI chr12:44,946,307...44,967,890
Ensembl chr12:39,302,840...39,307,862 		JBrowse link
G Pgam2 phosphoglycerate mutase 2 increases expression ISO Sulfasalazine results in increased expression of PGAM2 mRNA CTD PMID:22016648 NCBI chr14:84,895,763...84,897,874
Ensembl chr14:80,681,776...80,683,940 		JBrowse link
G Pla2g1b phospholipase A2 group IB multiple interactions ISO Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein] CTD PMID:15528384 NCBI chr12:46,802,932...46,814,511
Ensembl chr12:41,142,200...41,153,226 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 EXP
ISO		 Sulfasalazine results in increased expression of PPARG mRNA
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]		 CTD PMID:19365232 PMID:26165751 PMID:31830553 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA CTD PMID:28863153 NCBI chr20:49,542,465...49,564,088
Ensembl chr20:47,959,858...47,981,488 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression EXP
ISO		 Sulfasalazine results in increased expression of PRDX1 mRNA CTD PMID:16141653 PMID:22016648 NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prdx3 peroxiredoxin 3 increases expression ISO Sulfasalazine results in increased expression of PRDX3 mRNA CTD PMID:22016648 NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:260,001,637...260,014,111 		JBrowse link
G Psma7 proteasome 20S subunit alpha 7 decreases expression EXP Sulfasalazine results in decreased expression of PSMA7 protein CTD PMID:15928459 NCBI chr 3:167,137,279...167,143,626
Ensembl chr 3:167,137,263...167,143,672 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 decreases expression EXP Sulfasalazine results in decreased expression of PSMB9 mRNA CTD PMID:17202759 NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
multiple interactions		 EXP
ISO		 Sulfasalazine results in decreased expression of PTGS2 mRNA
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]		 CTD PMID:17259377 PMID:19956958 PMID:25576893 PMID:29187079 PMID:30408459 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase, mitochondrial 1 increases expression ISO Sulfasalazine results in increased expression of PTPMT1 mRNA CTD PMID:22016648 NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:76,889,922...76,899,427 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA CTD PMID:28863153 NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Rbp4 retinol binding protein 4 affects expression ISO Sulfasalazine affects the expression of RBP4 mRNA CTD PMID:22016648 NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases localization
affects localization
increases localization
decreases activity		 ISO
EXP		 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine results in decreased expression of and results in decreased activity of RELA protein; Sulfasalazine results in decreased phosphorylation of and results in decreased activity of RELA protein
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon
Sulfasalazine results in decreased localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine affects the localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine results in increased localization of RELA protein
Sulfasalazine results in decreased activity of RELA protein		 CTD
RGD		 PMID:9486988 PMID:12135912 PMID:14687604 PMID:15269287 PMID:15564333 More... RGD:152995414 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Sulfasalazine results in increased expression of RGS16 mRNA CTD PMID:31830553 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA] CTD PMID:19693652 NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Rnf186 ring finger protein 186 decreases expression ISO Sulfasalazine results in decreased expression of RNF186 mRNA CTD PMID:31830553 NCBI chr 5:156,493,750...156,494,974
Ensembl chr 5:151,210,492...151,211,716 		JBrowse link
G RT1-Bb RT1 class II, locus Bb affects expression EXP Sulfasalazine affects the expression of RT1-BB mRNA CTD PMID:17202759 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of S100A9 protein] CTD PMID:35362542 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Sdc1 syndecan 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA CTD PMID:28863153 NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:31,562,739...31,585,264 		JBrowse link
G Sele selectin E increases expression ISO Sulfasalazine results in increased expression of SELE protein CTD PMID:11264155 NCBI chr13:78,935,997...78,945,905
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpina4 serpin family A member 4 decreases expression ISO Sulfasalazine results in decreased expression of SERPINA4-PS1 mRNA CTD PMID:31830553 NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Sulfasalazine results in increased expression of SERPINC1 mRNA CTD PMID:22016648 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression ISO Sulfasalazine results in decreased expression of SIK1 mRNA CTD PMID:31830553 NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Slamf7 SLAM family member 7 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA CTD PMID:28863153 NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 decreases expression ISO Sulfasalazine results in decreased expression of SLC22A7 mRNA CTD PMID:31830553 NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc25a24 solute carrier family 25 member 24 decreases expression ISO Sulfasalazine results in decreased expression of SLC25A24 mRNA CTD PMID:31830553 NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 increases expression ISO Sulfasalazine results in increased expression of SLC25A6 mRNA CTD PMID:22016648 NCBI chr  X:120,897,616...120,900,683
Ensembl chr  X:116,031,803...116,034,967 		JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression ISO Sulfasalazine results in decreased expression of SLC30A1 mRNA CTD PMID:31830553 NCBI chr13:106,022,019...106,025,892
Ensembl chr13:103,491,037...103,494,910 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions ISO Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine] CTD PMID:19576933 NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity		 ISO
EXP		 Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]
Sulfasalazine results in decreased activity of SLC46A1 protein
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]		 CTD PMID:17475902 PMID:18174275 PMID:19762432 NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases activity
multiple interactions		 ISO Sulfasalazine results in decreased activity of SLC7A11 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]		 CTD PMID:19015640 PMID:19576933 PMID:20007406 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 decreases expression ISO Sulfasalazine results in decreased expression of SOCS2 mRNA CTD PMID:31830553 NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:30,008,578...30,043,548 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions EXP sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon RGD PMID:29572553 RGD:152995414 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Sulfasalazine results in increased expression of SOD1 mRNA CTD PMID:22016648 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO Sulfasalazine results in decreased expression of SOD3 mRNA CTD PMID:31830553 NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Sulfasalazine results in increased expression of SPP1 mRNA CTD PMID:22016648 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 increases expression EXP Sulfasalazine results in increased expression of SRSF5 protein CTD PMID:15928459 NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:100,605,456...100,610,177 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
affects expression		 EXP Sulfasalazine results in decreased expression of STAR protein
Sulfasalazine affects the expression of STAR mRNA		 CTD PMID:29197623 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein] CTD PMID:32272095 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tbxas1 thromboxane A synthase 1 multiple interactions
decreases activity		 ISO [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2 CTD PMID:2572437 NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA] CTD PMID:20884048 NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
G Tff3 trefoil factor 3 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA] CTD PMID:17449585 NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,193,262...9,198,054 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions
decreases expression		 ISO [Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of THRA mRNA; Sulfasalazine results in decreased expression of THRA mRNA alternative form		 CTD PMID:17641275 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA] CTD PMID:16614379 NCBI chr15:10,115,954...10,465,231
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein] CTD PMID:15633128 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Sulfasalazine results in increased expression of TIMP2 mRNA CTD PMID:22016648 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression ISO Sulfasalazine results in increased expression of TIMP3 mRNA CTD PMID:22016648 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein] CTD PMID:35290143 NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein] CTD PMID:19956958 PMID:32272095 PMID:35362542 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions EXP Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR9 protein] CTD PMID:35290143 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
decreases expression
increases response to substance		 ISO
EXP		 [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Sulfasalazine results in decreased secretion of TNF protein
Sulfasalazine results in decreased expression of TNF mRNA
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine binds to and results in decreased activity of TNF protein; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased secretion of TNF protein]
Sulfasalazine results in increased susceptibility to TNF protein		 CTD
RGD		 PMID:8094364 PMID:8598465 PMID:9486988 PMID:11901219 PMID:12135912 More... RGD:152995414 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases secretion ISO Sulfasalazine results in increased secretion of TNFRSF11B protein CTD PMID:15593184 NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
G Tnfrsf17 TNF receptor superfamily member 17 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA CTD PMID:28863153 NCBI chr10:4,808,023...4,813,857
Ensembl chr10:4,301,038...4,306,788 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions EXP Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNFRSF1A protein] CTD PMID:35595039 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases expression ISO Sulfasalazine results in decreased expression of TNFSF11 mRNA; Sulfasalazine results in decreased expression of TNFSF11 protein CTD PMID:15593184 NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445 		JBrowse link
G Tpm3 tropomyosin 3 decreases expression ISO Sulfasalazine results in decreased expression of TPM3 mRNA alternative form; Sulfasalazine results in decreased expression of TPM3 protein alternative form CTD PMID:19369484 NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:175,517,226...175,545,013 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein] CTD PMID:32272095 NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Tshb thyroid stimulating hormone subunit beta increases secretion ISO Sulfasalazine results in increased secretion of TSHB protein CTD PMID:12587019 NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Sulfasalazine results in increased expression of TUBB5 mRNA CTD PMID:22016648 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tymp thymidine phosphorylase multiple interactions
decreases expression		 ISO Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine results in decreased expression of and results in decreased activity of TYMP protein
Sulfasalazine results in decreased expression of TYMP mRNA		 CTD PMID:15269287 NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:120,438,770...120,443,874
Ensembl chr 7:120,438,770...120,443,874 		JBrowse link
G Ubc ubiquitin C increases expression ISO Sulfasalazine results in increased expression of UBC mRNA CTD PMID:22016648 NCBI chr12:36,899,673...36,905,275
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
Sulfasalazine results in decreased expression of VCAM1 mRNA
Sulfasalazine results in increased expression of VCAM1 protein
Sulfasalazine results in decreased expression of VCAM1 mRNA; Sulfasalazine results in decreased expression of VCAM1 protein		 CTD PMID:11264155 PMID:15553846 PMID:17259377 PMID:19693652 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vim vimentin increases expression ISO Sulfasalazine results in increased expression of VIM mRNA CTD PMID:22016648 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions ISO [Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA CTD PMID:28863153 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      biological role 19878
        biochemical role 19586
          ferroptosis inducer 15750
            sulfasalazine 225
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    main group molecular entity 19846
                      s-block molecular entity 19679
                        hydrogen molecular entity 19661
                          hydrides 19163
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18079
                                  azane 17889
                                    ammonia 17888
                                      organic amino compound 17888
                                        aromatic amine 15500
                                          anilines 14440
                                            substituted aniline 14072
                                              sulfanilamide 2931
                                                sulfasalazine 225
paths to the root