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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dilazep
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Accession:CHEBI:92842 term browser browse the term
Definition:A member of the class of diazepanes that is 1,4-diazepane substituted by 3-[(3,4,5-trimethoxybenzoyl)oxy]propyl groups at positions 1 and 4. It is a potent adenosine uptake inhibitor that exhibits antiplatelet, antianginal and vasodilator properties.
Synonyms:exact_synonym: 1,4-diazepane-1,4-diyldipropane-3,1-diyl bis(3,4,5-trimethoxybenzoate)
 related_synonym: Formula=C31H44N2O10;   InChI=1S/C31H44N2O10/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4/h18-21H,7-17H2,1-6H3;   InChIKey=QVZCXCJXTMIDME-UHFFFAOYSA-N;   N,N'-bis[3-(3,4,5-trimethoxybenzoyloxy)propyl]homopiperazine;   SMILES=COC1=CC(=CC(OC)=C1OC)C(=O)OCCCN1CCCN(CCCOC(=O)C2=CC(OC)=C(OC)C(OC)=C2)CC1;   dilazepum;   tetrahydro-1H-1,4-diazepine-1,4(5H)-dipropanediyl-3,4,5-trimethoxybenzoate
 xref: CAS:35898-87-4;   Chemspider:2965;   DrugBank:DB13715;   Drug_Central:893;   KEGG:D07843;   LINCS:LSM-3068
 xref_mesh: MESH:D004109
 xref: PDBeChem:8DZ;   PMID:12358150;   PMID:12627880;   PMID:12954370;   PMID:14551048;   PMID:15386824;   PMID:15456541;   PMID:18360052;   PMID:20424118;   PMID:20647687;   PMID:22562044;   PMID:23318848;   PMID:25091947;   PMID:31235912;   PMID:6136584;   PMID:7630041;   PMID:8531061;   PMID:9824428;   Wikipedia:Dilazep
 cyclic_relationship: is_conjugate_base_of CHEBI:170000


show annotations for term's descendants           Sort by:
dilazep term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Dilazep results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO Dilazep inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:9353301 PMID:9396714 PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19730
        pharmaceutical 19564
          drug 19564
            cardiovascular drug 8638
              vasodilator agent 6034
                dilazep 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organooxygen compound 19204
                                  carbon oxoacid 18689
                                    carboxylic acid 18686
                                      aromatic carboxylic acid 12711
                                        benzoic acids 12688
                                          benzoate ester 5736
                                            dilazep 2
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