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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xylazine
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Accession:CHEBI:92386 term browser browse the term
Definition:A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.
Synonyms:exact_synonym: N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
 related_synonym: 2-(2,6-dimethylanilino)-5,6-dihydro-4H-1,3-thiazine;   2-(2,6-dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine;   5,6-dihydro-2-(2,6-xylidino)-4H-1,3-thiazine;   BAY 1470;   Chanazine;   Formula=C12H16N2S;   InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);   InChIKey=BPICBUSOMSTKRF-UHFFFAOYSA-N;   N-(5,6-dihydro-4H-1,3-thiazinyl)-2,6-xylidine;   Rompun;   SMILES=C=1(C=CC=C(C1NC2=NCCCS2)C)C;   WH 7286;   xilazina;   xilazine;   xylazinum
 xref: CAS:7361-61-7;   DrugBank:DB11477;   KEGG:D08683;   LINCS:LSM-2477
 xref_mesh: MESH:D014991
 xref: PMID:27049320;   PMID:31652007;   PMID:31778611;   PMID:31863505;   PMID:31890977;   PMID:31945776;   PMID:31952632;   PMID:31965616;   PMID:31985287;   PMID:31992523;   PMID:32016857;   PMID:32048309;   PMID:32059754;   PMID:32119148;   PMID:32166760;   PMID:32278647;   PMID:32299311;   Wikipedia:Xylazine
 cyclic_relationship: is_conjugate_base_of CHEBI:149565


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xylazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions EXP [BRL 44408 binds to and results in decreased activity of ADRA2A protein] inhibits the reaction [Xylazine inhibits the reaction [Potassium results in increased secretion of Norepinephrine]] CTD PMID:11312645 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Ketamine co-treated with Xylazine] results in increased secretion of HAVCR1 protein CTD PMID:30538007 NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Ketamine co-treated with Xylazine] results in decreased secretion of LCN2 protein CTD PMID:30538007 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA CTD PMID:31276069 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA CTD PMID:31276069 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20849
    role 20820
      biological role 20805
        pharmacological role 19895
          analgesic 14904
            xylazine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20849
    subatomic particle 20847
      composite particle 20860
        hadron 20847
          baryon 20860
            nucleon 20847
              atomic nucleus 20847
                atom 20860
                  main group element atom 20781
                    main group molecular entity 20781
                      s-block molecular entity 20565
                        hydrogen molecular entity 20549
                          hydrides 19684
                            organic hydride 19084
                              organic fundamental parent 19071
                                hydrocarbon 18736
                                  cyclic hydrocarbon 17326
                                    monocyclic hydrocarbon 6381
                                      annulene 6041
                                        aromatic annulene 6043
                                          benzene 6043
                                            alkylbenzene 3755
                                              methylbenzene 3593
                                                xylazine 5
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