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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:xylazine
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Accession:CHEBI:92386 term browser browse the term
Definition:A methyl benzene that is 1,3-dimethylbenzene which is substituted by a 5,6-dihydro-4H-1,3-thiazin-2-ylnitrilo group at position 2. It is an alpha2 adrenergic receptor agonist and frequently used in veterinary medicine as an emetic and sedative with analgesic and muscle relaxant properties.
Synonyms:exact_synonym: N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
 related_synonym: 2-(2,6-dimethylanilino)-5,6-dihydro-4H-1,3-thiazine;   2-(2,6-dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine;   5,6-dihydro-2-(2,6-xylidino)-4H-1,3-thiazine;   BAY 1470;   Chanazine;   Formula=C12H16N2S;   InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);   InChIKey=BPICBUSOMSTKRF-UHFFFAOYSA-N;   N-(5,6-dihydro-4H-1,3-thiazinyl)-2,6-xylidine;   Rompun;   SMILES=C=1(C=CC=C(C1NC2=NCCCS2)C)C;   WH 7286;   xilazina;   xilazine;   xylazinum
 xref: CAS:7361-61-7;   DrugBank:DB11477;   KEGG:D08683;   LINCS:LSM-2477
 xref_mesh: MESH:D014991
 xref: PMID:27049320;   PMID:31652007;   PMID:31778611;   PMID:31863505;   PMID:31890977;   PMID:31945776;   PMID:31952632;   PMID:31965616;   PMID:31985287;   PMID:31992523;   PMID:32016857;   PMID:32048309;   PMID:32059754;   PMID:32119148;   PMID:32166760;   PMID:32278647;   PMID:32299311;   Wikipedia:Xylazine
 cyclic_relationship: is_conjugate_base_of CHEBI:149565


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xylazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra2a adrenoceptor alpha 2A multiple interactions EXP [BRL 44408 binds to and results in decreased activity of ADRA2A protein] inhibits the reaction [Xylazine inhibits the reaction [Potassium results in increased secretion of Norepinephrine]] CTD PMID:11312645 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO [Ketamine co-treated with Xylazine] results in increased secretion of HAVCR1 protein CTD PMID:30538007 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Ketamine co-treated with Xylazine] results in decreased secretion of LCN2 protein CTD PMID:30538007 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA CTD PMID:31276069 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA CTD PMID:31276069 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        pharmacological role 19110
          analgesic 14787
            xylazine 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    main group molecular entity 19855
                      s-block molecular entity 19666
                        hydrogen molecular entity 19668
                          hydrides 19176
                            organic hydride 18697
                              organic fundamental parent 18715
                                hydrocarbon 18459
                                  cyclic hydrocarbon 17240
                                    monocyclic hydrocarbon 6164
                                      annulene 5817
                                        aromatic annulene 5817
                                          benzene 5817
                                            alkylbenzene 3538
                                              methylbenzene 3390
                                                xylazine 5
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