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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol
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Accession:CHEBI:92278 term browser browse the term
Definition:A diarylmethane that has formula C28H27ClF5NO.
Synonyms:related_synonym: Formula=C28H27ClF5NO;   InChI=1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2;   InChIKey=MDLAAYDRRZXJIF-UHFFFAOYSA-N;   R-16341;   SMILES=C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
 xref: CAS:26864-56-2;   Drug_Central:2080;   LINCS:LSM-2334
 xref_mesh: MESH:D010395


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1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 Bcl2-like 11 increases expression
multiple interactions		 ISO Penfluridol results in increased expression of BCL2L11 mRNA; Penfluridol results in increased expression of BCL2L11 protein
dorsomorphin inhibits the reaction [Penfluridol results in increased expression of BCL2L11 mRNA]; Penfluridol promotes the reaction [FOXO3A protein binds to BCL2L11 promoter]; PFKL protein affects the reaction [Penfluridol results in increased expression of BCL2L11 mRNA]; PFKL protein affects the reaction [Penfluridol results in increased expression of BCL2L11 protein]		 CTD PMID:35530161 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage		 ISO dorsomorphin inhibits the reaction [Penfluridol results in increased cleavage of CASP3 protein]; PFKL protein affects the reaction [Penfluridol results in increased cleavage of CASP3 protein] CTD PMID:35530161 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Pfkl phosphofructokinase, liver type decreases activity
multiple interactions
increases response to substance		 ISO Penfluridol results in decreased activity of PFKL protein
Penfluridol binds to and results in decreased activity of PFKL protein; PFKL protein affects the reaction [Penfluridol affects the localization of FOXO3A protein]; PFKL protein affects the reaction [Penfluridol results in increased cleavage of CASP3 protein]; PFKL protein affects the reaction [Penfluridol results in increased expression of BCL2L11 mRNA]; PFKL protein affects the reaction [Penfluridol results in increased expression of BCL2L11 protein]
PFKL protein results in increased susceptibility to Penfluridol		 CTD PMID:35530161 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Penfluridol results in decreased phosphorylation of RPS6KB1 protein CTD PMID:35530161 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      group 19863
        polyatomic entity 19862
          molecule 19752
            cyclic compound 19523
              organic cyclic compound 19526
                organic aromatic compound 19390
                  diarylmethane 9440
                    1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      p-block molecular entity 19826
                        carbon group molecular entity 19766
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic aromatic compound 19390
                                  diarylmethane 9440
                                    1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol 4
paths to the root