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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:abexinostat
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Accession:CHEBI:92223 term browser browse the term
Definition:A 1-benzofuran substituted by {2-[4-(hydroxycarbamoyl)phenoxy]ethyl}aminocarbonyl and (dimethylamino)methyl groups at positions 2 and 3, respectively. It is a potent pan-HDAC inhibitor whose major target is HDAC1 (Ki = 7 nM).
Synonyms:related_synonym: 3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide;   3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide;   3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide;   CRA 24781;   CRA-024781;   Formula=C21H23N3O5;   InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25);   InChIKey=MAUCONCHVWBMHK-UHFFFAOYSA-N;   PCI-24781;   PZP-115891;   PZP115891;   S-78454;   S78454;   SMILES=CN(C)CC1=C(OC2=CC=CC=C12)C(=O)NCCOC1=CC=C(C=C1)C(=O)NO;   abexinostatum
 xref: AGR:IND605480874;   CAS:783355-60-2;   DrugBank:DB12565;   HMDB:HMDB0256171;   KEGG:D10060;   LINCS:LSM-2269
 xref_mesh: MESH:C512352
 xref: PMCID:PMC4144576;   PMID:16731764;   PMID:18006784;   PMID:18042714;   PMID:19417021;   PMID:19417023;   PMID:20145726;   PMID:20461381;   PMID:21508354;   PMID:22326466;   PMID:23724141;   PMID:23737346;   PMID:23790467;   PMID:23977108;   PMID:24312289;   PMID:25110436;   PMID:25505847;   PMID:25520806;   PMID:25782916;   PMID:26750740;   PMID:27095947;   PMID:27271328;   PMID:28915585;   PMID:32534122;   PMID:33500709;   PMID:34696786;   PMID:38378603;   Wikipedia:Abexinostat


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abexinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated decreases expression ISO abexinostat results in decreased expression of BRCA2 mRNA CTD PMID:18042714 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Bortezomib co-treated with abexinostat] results in increased activity of CASP3 protein CTD PMID:19417023 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage		 ISO Bortezomib promotes the reaction [abexinostat results in increased cleavage of CASP8 protein] CTD PMID:19417023 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage		 ISO Bortezomib promotes the reaction [abexinostat results in increased cleavage of CASP9 protein] CTD PMID:19417023 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO abexinostat results in decreased expression of CCL3 mRNA CTD PMID:19417023 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO abexinostat results in decreased expression of CCL7 mRNA CTD PMID:19417023 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO Bortezomib promotes the reaction [abexinostat results in increased expression of CDKN1A protein] CTD PMID:19417023 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma increases expression ISO abexinostat results in increased expression of GADD45G mRNA CTD PMID:18042714 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO abexinostat promotes the reaction [Bortezomib results in increased expression of HMOX1 mRNA]
abexinostat results in increased expression of HMOX1 mRNA		 CTD PMID:19417023 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 decreases expression
multiple interactions		 ISO abexinostat results in decreased expression of HMOX2 mRNA
abexinostat promotes the reaction [Bortezomib results in decreased expression of HMOX2 mRNA]		 CTD PMID:19417023 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases expression		 ISO Bortezomib promotes the reaction [abexinostat results in decreased expression of IKBKB mRNA] CTD PMID:19417023 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression		 ISO [Bortezomib co-treated with abexinostat] results in decreased expression of MYC mRNA; Bortezomib promotes the reaction [abexinostat results in decreased expression of MYC protein] CTD PMID:19417023 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO abexinostat results in decreased expression of NFKB1 mRNA CTD PMID:19417023 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO [Bortezomib co-treated with abexinostat] results in increased activity of PARP1 protein; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [abexinostat results in increased cleavage of PARP1 protein] CTD PMID:18042714 PMID:19417023 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rad51 RAD51 recombinase decreases expression ISO abexinostat results in decreased expression of RAD51 mRNA; abexinostat results in decreased expression of RAD51 protein CTD PMID:18042714 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit decreases expression ISO abexinostat results in decreased expression of RELB mRNA CTD PMID:19417023 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Txn2 thioredoxin 2 decreases expression
multiple interactions		 ISO abexinostat results in decreased expression of TXN2 mRNA
abexinostat promotes the reaction [Bortezomib results in decreased expression of TXN2 mRNA]		 CTD PMID:19417023 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression
multiple interactions		 ISO abexinostat results in decreased expression of TXNRD2 mRNA
abexinostat promotes the reaction [Bortezomib results in decreased expression of TXNRD2 mRNA]		 CTD PMID:19417023 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        biochemical role 19571
          autophagy inducer 2096
            abexinostat 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbon oxoacid 18675
                                    carboxylic acid 18672
                                      carboacyl group 17712
                                        univalent carboacyl group 17712
                                          carbamoyl group 17563
                                            carboxamide 17563
                                              secondary carboxamide 1252
                                                abexinostat 18
paths to the root