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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol
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Accession:CHEBI:91704 term browser browse the term
Definition:An aromatic ether that has formula C15H23NO3.
Synonyms:related_synonym: (+/-)-Oxprenolol;   Formula=C15H23NO3;   InChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3;   InChIKey=CEMAWMOMDPGJMB-UHFFFAOYSA-N;   SMILES=CC(C)NCC(COC1=CC=CC=C1OCC=C)O;   dl-Oxprenolol;   oxprenolol HCl;   oxprenolol hydrochloride
 xref: CAS:6452-71-7;   Drug_Central:2027;   HMDB:HMDB0015520;   LINCS:LSM-1554
 xref_mesh: MESH:D010096


show annotations for term's descendants           Sort by:
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Oxprenolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased abundance of Cyclic AMP; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein; [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions ISO Oxprenolol binds to and results in increased activity of ADRB3 protein CTD PMID:1682311 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Avp arginine vasopressin decreases expression ISO Oxprenolol results in decreased expression of AVP protein CTD PMID:6367368 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK1 protein CTD PMID:17925438 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Oxprenolol binds to ADRB2 protein] which results in increased phosphorylation of MAPK3 protein CTD PMID:17925438 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ren renin multiple interactions
decreases activity		 ISO [Oxprenolol co-treated with Indomethacin] results in decreased activity of REN protein
Oxprenolol results in decreased activity of REN protein		 CTD PMID:6173514 PMID:6344036 PMID:7023672 PMID:7049707 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    chemical entity 19872
      group 19825
        polyatomic entity 19824
          molecule 19715
            organic molecule 19700
              organic cyclic compound 19490
                organic aromatic compound 19355
                  aromatic ether 16593
                    1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      p-block molecular entity 19811
                        carbon group molecular entity 19751
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  ether 17306
                                    aromatic ether 16593
                                      1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol 7
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