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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester
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Accession:CHEBI:91642 term browser browse the term
Definition:A benzoate ester that has formula C16H22O3.
Synonyms:related_synonym: Formula=C16H22O3;   InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3;   InChIKey=WSSJONWNBBTCMG-UHFFFAOYSA-N;   SMILES=CC1CC(CC(C1)(C)C)OC(=O)C2=CC=CC=C2O;   homomenthyl salicylate;   kemester
 xref: CAS:118-56-9;   Drug_Central:3279;   LINCS:LSM-1475
 xref_mesh: MESH:C060446


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2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO homosalate binds to and results in decreased activity of AR protein; homosalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:12730620 PMID:15537743 PMID:18324785 PMID:24004914 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Areg amphiregulin increases expression
multiple interactions		 ISO homosalate results in increased expression of AREG mRNA
Polystyrenes promotes the reaction [homosalate results in increased expression of AREG mRNA]		 CTD PMID:38381479 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression
multiple interactions		 ISO homosalate results in increased expression of BHLHE40 mRNA
Polystyrenes promotes the reaction [homosalate results in increased expression of BHLHE40 mRNA]		 CTD PMID:38381479 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of BIRC2 mRNA CTD PMID:38381479 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Capns1 calpain, small subunit 1 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of CAPNS1 mRNA CTD PMID:38381479 NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795 		JBrowse link
G Cep295 centrosomal protein 295 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of CEP295 mRNA CTD PMID:38381479 NCBI chr 8:12,156,568...12,194,542
Ensembl chr 8:12,156,554...12,194,552 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of DPYSL2 mRNA CTD PMID:38381479 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression		 ISO homosalate binds to and results in increased activity of ESR1 protein; Polystyrenes promotes the reaction [homosalate results in increased expression of ESR1 mRNA] CTD PMID:24004914 PMID:38381479 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO homosalate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of H2BC11 mRNA CTD PMID:38381479 NCBI chr 2:183,780,583...183,783,030 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO homosalate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Krt86 keratin 86 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of KRT86 mRNA CTD PMID:38381479 NCBI chr 7:132,591,489...132,598,142
Ensembl chr 7:132,591,545...132,598,021 		JBrowse link
G Mex3b mex-3 RNA binding family member B multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of MEX3B mRNA CTD PMID:38381479 NCBI chr 1:136,855,130...136,859,365
Ensembl chr 1:136,855,130...136,859,354 		JBrowse link
G N4bp3 Nedd4 binding protein 3 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of N4BP3 mRNA CTD PMID:38381479 NCBI chr10:35,898,031...35,906,704
Ensembl chr10:35,899,096...35,907,001 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of NRIP1 mRNA CTD PMID:38381479 NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO homosalate binds to and results in decreased activity of PGR protein CTD PMID:15537743 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Psen2 presenilin 2 multiple interactions
increases expression		 ISO Polystyrenes promotes the reaction [homosalate results in increased expression of PSEN2 mRNA] CTD PMID:38381479 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of RASGRP1 mRNA CTD PMID:38381479 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression		 ISO [Polystyrenes co-treated with homosalate] results in increased expression of SGK1 protein; Fulvestrant inhibits the reaction [[Polystyrenes co-treated with homosalate] results in increased expression of SGK1 protein]
homosalate results in increased expression of SGK1 mRNA; Polystyrenes results in increased expression of [homosalate results in increased expression of SGK1 mRNA]		 CTD PMID:38381479 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Stc1 stanniocalcin 1 increases expression ISO homosalate results in increased expression of STC1 mRNA; Polystyrenes results in increased expression of [homosalate results in increased expression of STC1 mRNA] CTD PMID:38381479 NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264 		JBrowse link
G Tmtc1 transmembrane O-mannosyltransferase targeting cadherins 1 multiple interactions
increases expression		 ISO Polystyrenes promotes the reaction [homosalate results in increased expression of TMTC1 mRNA] CTD PMID:38381479 NCBI chr 4:181,142,937...181,357,979
Ensembl chr 4:181,146,251...181,359,289 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression
multiple interactions		 ISO homosalate results in increased expression of TPR mRNA
Polystyrenes promotes the reaction [homosalate results in increased expression of TPR mRNA]		 CTD PMID:38381479 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Vasn vasorin multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of VASN mRNA CTD PMID:38381479 NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357 		JBrowse link
G Yy2 YY2 transcription factor multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of YY2 mRNA CTD PMID:38381479 NCBI chr  X:37,438,425...37,442,047
Ensembl chr  X:37,410,811...37,464,430 		JBrowse link
G Zdhhc20 zinc finger DHHC-type palmitoyltransferase 20 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of ZDHHC20 mRNA CTD PMID:38381479 NCBI chr15:31,980,057...32,039,006
Ensembl chr15:31,983,155...32,038,989 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        antimicrobial agent 18240
          antifungal agent 17158
            salicylic acid 1566
              2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      aromatic carboxylic acid 12686
                                        benzoic acids 12663
                                          benzoic acid 5503
                                            hydroxybenzoic acid 4978
                                              monohydroxybenzoic acid 2813
                                                salicylic acid 1566
                                                  2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester 25
paths to the root