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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester
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Accession:CHEBI:91642 term browser browse the term
Definition:A benzoate ester that has formula C16H22O3.
Synonyms:related_synonym: homomenthyl salicylate;   kemester
 xref: CAS:118-56-9
 xref_mesh: MESH:C060446
 xref: drugcentral:3279;   lincs.smallmolecule:LSM-1475
 chemrof_formula: C16H22O3
 chemrof_smiles: CC1CC(OC(=O)c2ccccc2O)CC(C)(C)C1
 chemrof_inchi: InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3
 chemrof_inchikey: WSSJONWNBBTCMG-UHFFFAOYSA-N
 cyclic_relationship: has_functional_parent CHEBI:16914


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2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO homosalate binds to and results in decreased activity of AR protein; homosalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:12730620 PMID:15537743 PMID:18324785 PMID:24004914 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Areg amphiregulin increases expression
multiple interactions 		ISO homosalate results in increased expression of AREG mRNA
Polystyrenes promotes the reaction [homosalate results in increased expression of AREG mRNA] 		CTD PMID:38381479 NCBI chr14:17,256,384...17,265,641
Ensembl chr14:17,256,384...17,265,641 		JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression
multiple interactions 		ISO homosalate results in increased expression of BHLHE40 mRNA
Polystyrenes promotes the reaction [homosalate results in increased expression of BHLHE40 mRNA] 		CTD PMID:38381479 NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:143,174,048...143,180,783 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of BIRC2 mRNA CTD PMID:38381479 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Capns1 calpain, small subunit 1 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of CAPNS1 mRNA CTD PMID:38381479 NCBI chr 1:94,572,083...94,582,332
Ensembl chr 1:94,572,083...94,583,368 		JBrowse link
G Cep295 centrosomal protein 295 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of CEP295 mRNA CTD PMID:38381479 NCBI chr 8:20,437,967...20,475,968
Ensembl chr 8:20,437,338...20,476,115 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of DPYSL2 mRNA CTD PMID:38381479 NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression 		ISO homosalate binds to and results in increased activity of ESR1 protein; Polystyrenes promotes the reaction [homosalate results in increased expression of ESR1 mRNA] CTD PMID:24004914 PMID:38381479 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO homosalate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705 		JBrowse link
G H2bc21 H2B clustered histone 21 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of H2BC11 mRNA CTD PMID:38381479 NCBI chr 2:186,469,452...186,471,899 JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases activity ISO homosalate results in decreased activity of HSD3B1 protein CTD PMID:39159849 NCBI chr 2:188,858,574...188,864,694 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO homosalate results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Krt86 keratin 86 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of KRT86 mRNA CTD PMID:38381479 NCBI chr 7:134,470,224...134,476,873
Ensembl chr 7:134,470,224...134,476,873 		JBrowse link
G Mex3b mex-3 RNA binding family member B multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of MEX3B mRNA CTD PMID:38381479 NCBI chr 1:146,264,319...146,268,554
Ensembl chr 1:146,264,318...146,268,543 		JBrowse link
G N4bp3 Nedd4 binding protein 3 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of N4BP3 mRNA CTD PMID:38381479 NCBI chr10:36,400,053...36,407,609
Ensembl chr10:36,400,057...36,407,637 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of NRIP1 mRNA CTD PMID:38381479 NCBI chr11:28,382,835...28,466,483
Ensembl chr11:28,378,878...28,467,353 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO homosalate binds to and results in decreased activity of PGR protein CTD PMID:15537743 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271 		JBrowse link
G Psen2 presenilin 2 multiple interactions
increases expression 		ISO Polystyrenes promotes the reaction [homosalate results in increased expression of PSEN2 mRNA] CTD PMID:38381479 NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116 		JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of RASGRP1 mRNA CTD PMID:38381479 NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
increases expression 		ISO [Polystyrenes co-treated with homosalate] results in increased expression of SGK1 protein; Fulvestrant inhibits the reaction [[Polystyrenes co-treated with homosalate] results in increased expression of SGK1 protein]
homosalate results in increased expression of SGK1 mRNA; Polystyrenes results in increased expression of [homosalate results in increased expression of SGK1 mRNA] 		CTD PMID:38381479 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231 		JBrowse link
G Stc1 stanniocalcin 1 increases expression ISO homosalate results in increased expression of STC1 mRNA; Polystyrenes results in increased expression of [homosalate results in increased expression of STC1 mRNA] CTD PMID:38381479 NCBI chr15:50,709,439...50,720,093
Ensembl chr15:50,709,415...50,720,082 		JBrowse link
G Tmtc1 transmembrane O-mannosyltransferase targeting cadherins 1 multiple interactions
increases expression 		ISO Polystyrenes promotes the reaction [homosalate results in increased expression of TMTC1 mRNA] CTD PMID:38381479 NCBI chr 4:182,874,350...183,089,408
Ensembl chr 4:182,878,802...183,102,532 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression
multiple interactions 		ISO homosalate results in increased expression of TPR mRNA
Polystyrenes promotes the reaction [homosalate results in increased expression of TPR mRNA] 		CTD PMID:38381479 NCBI chr13:64,974,419...65,037,604
Ensembl chr13:64,974,419...65,037,602 		JBrowse link
G Vasn vasorin multiple interactions ISO [homosalate co-treated with Polystyrenes] results in decreased expression of VASN mRNA CTD PMID:38381479 NCBI chr10:11,424,174...11,434,681
Ensembl chr10:11,417,327...11,450,704 		JBrowse link
G Yy2 YY2 transcription factor multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of YY2 mRNA CTD PMID:38381479 NCBI chr  X:41,253,481...41,257,103
Ensembl chr  X:41,254,335...41,277,701 		JBrowse link
G Zdhhc20 zinc finger DHHC-type palmitoyltransferase 20 multiple interactions ISO [homosalate co-treated with Polystyrenes] results in increased expression of ZDHHC20 mRNA CTD PMID:38381479 NCBI chr15:36,095,624...36,154,546
Ensembl chr15:36,098,282...36,154,532 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      molecular entity 20871
        polyatomic entity 20745
          heteroatomic molecular entity 20606
            hydroxides 19922
              organic hydroxy compound 19685
                phenols 19382
                  2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  ester 17841
                                    carboxylic ester 17347
                                      benzoate ester 5458
                                        2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester 26
paths to the root