Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:adavosertib
go back to main search page
Accession:CHEBI:91414 term browser browse the term
Definition:A member of the class of pyrazolopyrimidines that is 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one substituted by 6-(2-hydroxypropan-2-yl)pyridin-2-yl, prop-1-en-3-yl, [4-(4-methylpiperazin-1-yl)phenyl]amino groups at positions 1, 2, and 6, respectively. It is a potent and selective oral inhibitor of WEE1 kinase.
Synonyms:exact_synonym: 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
 related_synonym: AZD 1775;   AZD1775;   Formula=C27H32N8O2;   InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31);   InChIKey=BKWJAKQVGHWELA-UHFFFAOYSA-N;   MK-1775;   MK1775;   SMILES=CN1CCN(CC1)C1=CC=C(NC2=NC=C3C(=O)N(CC=C)N(C3=N2)C2=CC=CC(=N2)C(C)(C)O)C=C1;   adavosertibum
 xref: CAS:955365-80-7;   DrugBank:DB11740;   HMDB:HMDB0254782;   KEGG:D11361;   LINCS:LSM-1153
 xref_mesh: MESH:C549567
 xref: PDBeChem:8X7;   PMCID:PMC11183722;   PMID:19887545;   PMID:28792760;   PMID:31540690;   PMID:32556602;   PMID:33670166;   PMID:33863809;   PMID:34212455;   PMID:34379792;   PMID:34538072;   PMID:35672254;   PMID:36524815;   PMID:36612094;   PMID:37081608;   PMID:37197456;   PMID:37278879;   PMID:37279095;   PMID:37296592;   PMID:37368100;   PMID:37370065;   PMID:37380217;   PMID:37394627;   PMID:37426130;   PMID:37633054;   PMID:37659202;   PMID:37715172;   PMID:37758718;   PMID:38051741;   PMID:38085423;   PMID:38103761;   PMID:38167245;   PMID:38519399;   PMID:38593512;   PMID:38920407;   Wikipedia:Adavosertib


show annotations for term's descendants           Sort by:
adavosertib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO adavosertib results in decreased phosphorylation of CDK1 protein CTD PMID:25125259 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Tp53 tumor protein p53 increases response to substance ISO TP53 gene mutant form results in increased susceptibility to adavosertib
TRP53 gene mutant form results in increased susceptibility to adavosertib		 CTD PMID:25125259 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase decreases phosphorylation ISO adavosertib results in decreased phosphorylation of WEE1 protein CTD PMID:25125259 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            antineoplastic agent 17823
              adavosertib 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        tertiary amino compound 10153
                                          N-alkylpiperazine 3407
                                            N-methylpiperazine 1390
                                              adavosertib 3
paths to the root