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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sertraline
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Accession:CHEBI:9123 term browser browse the term
Definition:A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.
Synonyms:exact_synonym: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
 related_synonym: (1S,4S)-sertraline;   (1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine;   CP 51974;   Formula=C17H17Cl2N;   InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1;   InChIKey=VGKDLMBJGBXTGI-SJCJKPOMSA-N;   SMILES=[H][C@]1(CC[C@H](NC)c2ccccc12)c1ccc(Cl)c(Cl)c1;   cis-(+)-sertraline;   sertralina;   sertralinum
 xref: CAS:79617-96-2;   DrugBank:DB01104;   Drug_Central:2436;   HMDB:HMDB0005010;   KEGG:C07246;   KEGG:D02360;   LINCS:LSM-3843
 xref_mesh: MESH:D020280
 xref: PDBeChem:SRE;   PMID:19502000;   PMID:21823671;   Patent:US4536518;   Reaxys:5753709;   Wikipedia:Sertraline
 cyclic_relationship: is_conjugate_base_of CHEBI:64214


show annotations for term's descendants           Sort by:
sertraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases activity ISO Sertraline results in increased activity of ABCB1 protein CTD PMID:23273999 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases phosphorylation ISO Sertraline results in increased phosphorylation of ACACA protein CTD PMID:33124469 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Sertraline inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:17728140 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin affects binding ISO Sertraline binds to ALB protein CTD PMID:26471709 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Sertraline results in increased expression of ASAH1 mRNA CTD PMID:15342952 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Sertraline results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf2 activating transcription factor 2 increases expression ISO Sertraline results in increased expression of ATF2 mRNA CTD PMID:24865413 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Sertraline results in increased expression of ATF4 protein CTD PMID:24865413 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression		 ISO Sertraline affects the expression of BCL2 protein
Sertraline results in decreased expression of BCL2 protein		 CTD PMID:18403212 PMID:24194395 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Sertraline results in increased expression of BDNF protein CTD PMID:18403212 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP3 protein]; Sertraline results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:24194395 PMID:24865413 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 increases cleavage
multiple interactions		 ISO Sertraline results in increased cleavage of CASP4 protein
MAP4K4 mutant form inhibits the reaction [Sertraline results in increased cleavage of CASP4 protein]		 CTD PMID:24865413 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity		 ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased activity of CASP7 protein] CTD PMID:24865413 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Sertraline results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:24194395 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP Nitric Oxide promotes the reaction [Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein] CTD PMID:20305041 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cd14 CD14 molecule decreases expression ISO Sertraline results in decreased expression of CD14 mRNA CTD PMID:24865413 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression EXP Sertraline results in increased expression of CREB1 mRNA CTD PMID:8601816 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO [Cannabidiol co-treated with Sertraline] results in decreased expression of CRH mRNA CTD PMID:34262461 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cryaa crystallin, alpha A increases expression ISO Sertraline results in increased expression of CRYAA mRNA CTD PMID:24865413 NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349 		JBrowse link
G Cul1 cullin 1 decreases expression ISO Sertraline results in decreased expression of CUL1 mRNA CTD PMID:24865413 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Sertraline results in decreased expression of CYP11A1 mRNA CTD PMID:29850907 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Sertraline results in decreased expression of CYP17A1 mRNA CTD PMID:29850907 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO Sertraline results in decreased activity of CYP19A1 protein CTD PMID:26162595 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity		 ISO [Sertraline results in decreased activity of CYP2B6 protein] which results in decreased metabolism of Bupropion; CYP2B6 protein results in decreased methylation of and results in increased metabolism of Sertraline CTD PMID:15547048 PMID:26599973 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects metabolic processing
increases metabolic processing
decreases methylation
multiple interactions		 ISO CYP2C19 gene polymorphism affects the metabolism of Sertraline
CYP2C19 protein results in increased metabolism of Sertraline
CYP2C19 protein results in decreased methylation of Sertraline
CYP2C19 protein results in decreased amination of and results in increased metabolism of Sertraline; CYP2C19 protein results in decreased methylation of and results in increased metabolism of Sertraline		 CTD PMID:11452243 PMID:15547048 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in decreased methylation of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein results in decreased amination of and results in increased metabolism of Sertraline; CYP3A4 protein results in decreased methylation of and results in increased metabolism of Sertraline; Sertraline promotes the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:15547048 PMID:19299527 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to Sertraline CTD PMID:15148402 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO 4-phenylbutyric acid inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; MAP4K4 mutant form inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]
Sertraline results in increased expression of DDIT3 mRNA; Sertraline results in increased expression of DDIT3 protein		 CTD PMID:24865413 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Sertraline results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Dnajc5 DnaJ heat shock protein family (Hsp40) member C5 increases expression ISO Sertraline results in increased expression of DNAJC5 mRNA; Sertraline results in increased expression of DNAJC5 protein CTD PMID:11257428 NCBI chr 3:168,621,905...168,656,570
Ensembl chr 3:168,621,969...168,655,935 		JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Sertraline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Sertraline results in increased expression of DUSP1 mRNA CTD PMID:24865413 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Sertraline results in increased expression of DUSP10 mRNA CTD PMID:24865413 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716 		JBrowse link
G Dusp14 dual specificity phosphatase 14 increases expression ISO Sertraline results in increased expression of DUSP14 mRNA CTD PMID:24865413 NCBI chr10:68,936,483...68,966,347
Ensembl chr10:68,935,330...68,965,329 		JBrowse link
G Dusp16 dual specificity phosphatase 16 increases expression ISO Sertraline results in increased expression of DUSP16 mRNA CTD PMID:24865413 NCBI chr 4:167,546,780...167,630,173
Ensembl chr 4:167,548,155...167,629,980 		JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Sertraline results in increased expression of DUSP8 mRNA CTD PMID:24865413 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921 		JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Sertraline results in increased expression of EGFR mRNA CTD PMID:24865413 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases expression		 ISO MAP4K4 mutant form inhibits the reaction [Sertraline results in increased phosphorylation of EIF2AK3 protein]; Sertraline results in increased expression of and results in increased phosphorylation of EIF2AK3 protein
Sertraline results in increased expression of EIF2AK3 mRNA		 CTD PMID:24865413 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Sertraline results in increased phosphorylation of EIF2S1 protein CTD PMID:24865413 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases expression ISO Sertraline results in increased expression of ERN1 mRNA CTD PMID:24865413 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Sertraline results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Sertraline results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression
increases expression		 EXP
ISO		 Sertraline results in decreased expression of FOS mRNA
Sertraline results in increased expression of FOS mRNA		 CTD PMID:7612155 PMID:24865413 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Sertraline results in increased expression of GADD45A mRNA CTD PMID:24865413 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO Sertraline results in increased expression of GADD45B mRNA CTD PMID:24865413 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Sertraline results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Sertraline results in increased expression of HERPUD1 mRNA CTD PMID:24865413 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hpn hepsin increases expression ISO Sertraline results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression EXP Sertraline results in decreased expression of HSD3B1 mRNA CTD PMID:29850907 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Sertraline results in increased expression of HSPA1A mRNA CTD PMID:24865413 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression ISO Sertraline results in increased expression of HSPA1B mRNA CTD PMID:24865413 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa6l-ps1 heat shock protein family A (Hsp70) member 6 like, pseudogene 1 increases expression ISO Sertraline results in increased expression of HSPA6 mRNA CTD PMID:24865413 NCBI chr13:83,273,176...83,274,317 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression
decreases expression		 EXP
ISO		 Sertraline results in increased expression of HSPA8 mRNA alternative form; Sertraline results in increased expression of HSPA8 protein alternative form
Sertraline results in decreased expression of HSPA8 mRNA		 CTD PMID:10425221 PMID:24865413 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
increases expression		 EXP [Estradiol co-treated with Sertraline] affects the expression of HTR1A mRNA
Sertraline results in increased expression of HTR1A mRNA		 CTD PMID:18650020 NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression		 EXP [Estradiol co-treated with Sertraline] affects the expression of HTR2A mRNA; Estradiol promotes the reaction [Sertraline results in increased expression of HTR2A mRNA] CTD PMID:18650020 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions
increases expression		 EXP [Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNA; Estradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA] CTD PMID:18650020 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Sertraline results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP [Sertraline binds to 2-Hydroxypropyl-beta-cyclodextrin] inhibits the reaction [Alloxan results in decreased expression of INS1 protein]; Sertraline inhibits the reaction [Alloxan results in decreased expression of INS1 protein] CTD PMID:26593071 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 multiple interactions EXP Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein]; Sertraline inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:17728140 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases activity		 EXP Sertraline affects the reaction [INS protein affects the phosphorylation of IRS1 protein]
Sertraline results in decreased activity of IRS1 protein		 CTD PMID:17728140 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Sertraline results in increased expression of and results in increased phosphorylation of JUN protein
Sertraline results in increased expression of JUN mRNA		 CTD PMID:24194395 PMID:24865413 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Sertraline results in increased expression of JUND mRNA CTD PMID:24865413 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Sertraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 multiple interactions ISO Sertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]]; Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]; Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124 		JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 multiple interactions ISO Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA] CTD PMID:22164246 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518 		JBrowse link
G Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 multiple interactions ISO Sertraline inhibits the reaction [Ethanol results in increased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA]]; Sertraline results in decreased activity of [KCNJ3 mRNA co-treated with KCNJ6 mRNA] CTD PMID:22164246 NCBI chr11:34,061,702...34,308,758
Ensembl chr11:34,061,708...34,308,758 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Sertraline results in increased expression of LHB protein CTD PMID:29850907 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lss lanosterol synthase increases expression ISO Sertraline results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17567588 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762 		JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO MAOA protein results in decreased amination of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593 		JBrowse link
G Maob monoamine oxidase B multiple interactions ISO MAOB protein results in decreased amination of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases lipidation
multiple interactions		 ISO Sertraline results in increased lipidation of MAP1LC3B protein
dorsomorphin inhibits the reaction [Sertraline results in increased lipidation of MAP1LC3B protein]		 CTD PMID:33124469 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 increases expression ISO Sertraline results in increased expression of MAP3K13 mRNA CTD PMID:24865413 NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO Sertraline results in increased expression of MAP3K8 mRNA CTD PMID:24865413 NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216 		JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 multiple interactions
decreases expression		 ISO MAP4K4 mutant form inhibits the reaction [Sertraline results in increased cleavage of CASP4 protein]; MAP4K4 mutant form inhibits the reaction [Sertraline results in increased expression of DDIT3 protein]; MAP4K4 mutant form inhibits the reaction [Sertraline results in increased phosphorylation of EIF2AK3 protein]
Sertraline results in decreased expression of MAP4K4 mRNA		 CTD PMID:24865413 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Sertraline results in increased phosphorylation of and results in increased activity of MAPK1 protein
Sertraline results in increased phosphorylation of MAPK1 protein
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Sertraline results in increased phosphorylation of MAPK1 protein]		 CTD PMID:17728140 PMID:24194395 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Sertraline results in increased phosphorylation of and results in increased activity of MAPK3 protein
Sertraline results in increased phosphorylation of MAPK3 protein		 CTD PMID:17728140 PMID:24194395 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Sertraline results in increased phosphorylation of and results in increased activity of MAPK8 protein CTD PMID:17728140 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 increases expression ISO Sertraline results in increased expression of MAPK8IP3 mRNA CTD PMID:24865413 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Chloroquine inhibits the reaction [Sertraline results in decreased expression of and results in decreased cleavage of MAPT protein]; dorsomorphin inhibits the reaction [Sertraline results in decreased expression of and results in decreased cleavage of MAPT protein]; Sertraline results in decreased expression of and results in decreased cleavage of MAPT protein CTD PMID:33124469 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Sertraline results in decreased expression of MCL1 protein CTD PMID:24194395 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation		 ISO VDAC1 protein affects the reaction [Sertraline results in decreased phosphorylation of MTOR protein] CTD PMID:33124469 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Sertraline results in increased expression of MYC mRNA CTD PMID:24865413 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression ISO Sertraline results in increased expression of NFE2L2 mRNA CTD PMID:24865413 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Sertraline results in increased expression of NFKB1 mRNA CTD PMID:24865413 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 increases expression ISO Sertraline results in increased expression of NFKB2 mRNA CTD PMID:24865413 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Sertraline results in increased expression of NR0B2 mRNA CTD PMID:15342952 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Sertraline results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Sertraline results in decreased expression of PECAM1 protein CTD PMID:15932816 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pf4 platelet factor 4 decreases expression ISO Sertraline results in decreased expression of PF4 protein CTD PMID:15932816 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Sertraline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409 		JBrowse link
G Ppbp pro-platelet basic protein decreases expression ISO Sertraline results in decreased expression of PPBP protein CTD PMID:12912814 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Sertraline results in increased expression of PPP1R15A mRNA CTD PMID:24865413 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Sertraline results in decreased expression of PTGS2 mRNA; Sertraline results in decreased expression of PTGS2 protein CTD PMID:17499975 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rbx1 ring-box 1 decreases expression ISO Sertraline results in decreased expression of RBX1 mRNA CTD PMID:24865413 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Sertraline results in increased expression of RELB mRNA CTD PMID:24865413 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Rnf103 ring finger protein 103 increases expression EXP Sertraline results in increased expression of RNF103 mRNA CTD PMID:11071867 NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases expression ISO Sertraline results in decreased expression of RPS6KA3 mRNA CTD PMID:24865413 NCBI chr  X:35,517,306...35,623,296
Ensembl chr  X:35,517,306...35,623,207 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation		 EXP
ISO		 Sertraline results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; Sirolimus inhibits the reaction [Sertraline results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]
Sertraline results in decreased phosphorylation of RPS6KB1 protein
VDAC1 protein affects the reaction [Sertraline results in decreased phosphorylation of RPS6KB1 protein]		 CTD PMID:17728140 PMID:33124469 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Sec61g Sec61 translocon subunit gamma decreases expression ISO Sertraline results in decreased expression of SEC61G mRNA CTD PMID:24865413 NCBI chr14:90,899,766...90,906,143
Ensembl chr14:90,899,768...90,906,162
Ensembl chr 9:90,899,768...90,906,162 		JBrowse link
G Sele selectin E decreases expression ISO Sertraline results in decreased expression of SELE protein CTD PMID:12912814 PMID:15932816 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selenos selenoprotein S increases expression ISO Sertraline results in increased expression of SELS mRNA CTD PMID:24865413 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833 		JBrowse link
G Selp selectin P decreases expression ISO Sertraline results in decreased expression of SELP protein CTD PMID:12912814 PMID:15932816 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Sertraline results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Serpini1 serpin family I member 1 increases expression EXP Sertraline results in increased expression of SERPINI1 mRNA CTD PMID:16637596 NCBI chr 2:160,346,403...160,433,135
Ensembl chr 2:160,346,758...160,433,135 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 decreases expression ISO Sertraline results in decreased expression of SKP1 mRNA CTD PMID:24865413 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Sertraline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions
affects binding
increases expression
decreases expression
affects response to substance
increases response to substance		 ISO
EXP		 Sertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA]
Sertraline binds to SLC6A4 protein
Sertraline results in increased expression of SLC6A4 mRNA
[Cannabidiol co-treated with Sertraline] results in increased expression of SLC6A4 mRNA
Sertraline results in decreased expression of SLC6A4 protein
SLC6A4 protein affects the susceptibility to Sertraline
[Estradiol co-treated with Sertraline] affects the expression of SLC6A4 mRNA; [Sertraline results in decreased expression of SLC6A4 protein] which results in decreased metabolism of Selective Serotonin Reuptake Inhibitors; Estradiol promotes the reaction [Sertraline results in increased expression of SLC6A4 mRNA]
SLC6A4 promoter polymorphism results in increased susceptibility to Sertraline		 CTD PMID:12151556 PMID:12955294 PMID:17042913 PMID:18650020 PMID:18923402 More... NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO Sertraline results in increased expression of SQSTM1 protein
aloxistatin promotes the reaction [Sertraline results in increased expression of SQSTM1 protein]		 CTD PMID:33124469 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Ssr2 signal sequence receptor subunit 2 increases expression ISO Sertraline results in increased expression of SSR2 mRNA CTD PMID:24865413 NCBI chr 2:174,048,291...174,057,043
Ensembl chr 2:174,048,460...174,057,042 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Sertraline results in decreased expression of STAR mRNA CTD PMID:29850907 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression ISO Sertraline results in decreased expression of STAT3 mRNA; Sertraline results in decreased expression of STAT3 protein CTD PMID:17499975 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stk11 serine/threonine kinase 11 increases phosphorylation ISO Sertraline results in increased phosphorylation of STK11 protein CTD PMID:33124469 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Stmn1 stathmin 1 decreases expression ISO Sertraline results in decreased expression of STMN1 mRNA CTD PMID:24865413 NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154 		JBrowse link
G Syvn1 synoviolin 1 increases expression ISO Sertraline results in increased expression of SYVN1 mRNA CTD PMID:24865413 NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152 		JBrowse link
G Tagln transgelin decreases expression ISO Sertraline results in decreased expression of TAGLN mRNA CTD PMID:15342952 NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668 		JBrowse link
G Taok2 TAO kinase 2 increases expression ISO Sertraline results in increased expression of TAOK2 mRNA CTD PMID:24865413 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613 		JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO Sertraline results in increased expression of TFAP2A protein CTD PMID:28844482 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tnf tumor necrosis factor decreases secretion
increases expression		 ISO Sertraline results in decreased secretion of TNF protein
Sertraline results in increased expression of TNF mRNA		 CTD PMID:17499975 PMID:24194395 PMID:24865413 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions
increases expression
increases activity		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA]
Sertraline results in increased expression of TPH2 mRNA; Sertraline results in increased expression of TPH2 protein
Sertraline results in increased activity of TPH2 protein		 CTD PMID:11901216 NCBI chr 7:50,685,694...50,789,424
Ensembl chr 7:50,685,694...50,789,424 		JBrowse link
G Txndc5 thioredoxin domain containing 5 decreases expression ISO Sertraline results in decreased expression of TXNDC5 mRNA CTD PMID:24865413 NCBI chr17:26,289,880...26,318,025
Ensembl chr17:26,289,880...26,318,025 		JBrowse link
G Ube2d2b ubiquitin-conjugating enzyme E2D 2B decreases expression ISO Sertraline results in decreased expression of UBE2D4 mRNA CTD PMID:24865413 NCBI chr14:1,915,999...1,917,473
Ensembl chr14:1,916,845...1,917,416 		JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 decreases expression ISO Sertraline results in decreased expression of UBE2G1 mRNA CTD PMID:24865413 NCBI chr10:57,225,963...57,306,748
Ensembl chr10:57,225,952...57,308,568 		JBrowse link
G Ube4b ubiquitination factor E4B decreases expression ISO Sertraline results in decreased expression of UBE4B mRNA CTD PMID:24865413 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509 		JBrowse link
G Ubqln1 ubiquilin 1 increases expression ISO Sertraline results in increased expression of UBQLN1 mRNA CTD PMID:24865413 NCBI chr17:6,439,002...6,477,096
Ensembl chr17:6,439,002...6,477,090 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO UGT2B7 protein results in increased glucuronidation of and results in increased metabolism of Sertraline CTD PMID:15547048 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Sertraline results in increased expression of VCAM1 protein CTD PMID:15932816 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions
affects binding		 ISO VDAC1 protein affects the reaction [Sertraline results in decreased phosphorylation of MTOR protein]; VDAC1 protein affects the reaction [Sertraline results in decreased phosphorylation of RPS6KB1 protein]
Sertraline binds to VDAC1 protein		 CTD PMID:33124469 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Sertraline results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17567588 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Sertraline results in increased splicing of XBP1 mRNA CTD PMID:24865413 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      chemical role 19473
        environmental contaminant 18852
          naphthalene 2376
            tetralin 156
              sertraline 130
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            organic hydride 18687
                              organic fundamental parent 18687
                                hydrocarbon 18438
                                  cyclic hydrocarbon 17231
                                    arene 17212
                                      polycyclic arene 17037
                                        ortho-fused polycyclic arene 9836
                                          ortho-fused bicyclic arene 2432
                                            naphthalene 2376
                                              tetralin 156
                                                sertraline 130
paths to the root