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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:semaxanib
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Accession:CHEBI:91083 term browser browse the term
Definition:An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group.
Synonyms:exact_synonym: (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
 related_synonym: (Z)-SU 5416;   3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone;   3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole;   3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone;   Formula=C15H14N2O;   InChI=1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-;   InChIKey=WUWDLXZGHZSWQZ-WQLSENKSSA-N;   SMILES=N1C(/C(/C=2C=CC=CC12)=C\\C=3NC(=CC3C)C)=O;   SU 5416;   SU5416;   Sugen-5416;   TSU 16
 xref: CAS:194413-58-6;   KEGG:D05819;   PDBeChem:X2M;   PMID:25391620;   PMID:25450973;   PMID:25521760;   PMID:25665868;   PMID:25886469;   PMID:26291195;   PMID:26314590;   PMID:26418615;   PMID:26421302;   PMID:26593399;   PMID:26727223;   PMID:26790474;   PMID:26804178;   PMID:26813102;   Reaxys:7995521;   Wikipedia:Semaxanib


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semaxanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il2 interleukin 2 increases expression EXP semaxanib (SUGEN) increases expression of IL2 mRNA in rat whole lung RGD PMID:23867624 RGD:329848996 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672 		JBrowse link
G Kdr kinase insert domain receptor EXP su5416, semaxanib, decreases phosphorylation of kdr (vegfr2) protein in rat lung RGD PMID:33836606 RGD:401940192 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192 		JBrowse link
G Rfc1 replication factor C subunit 1 multiple interactions EXP [Sugen-5416 co-treated with hypoxia] increases expression of Rfc1 protein in the heart right ventricle RGD PMID:22720015 RGD:401940165 NCBI chr14:43,319,768...43,395,028
Ensembl chr14:43,319,935...43,395,026 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            antineoplastic agent 18066
              semaxanib 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              lactam 8438
                                                gamma-lactam 6681
                                                  oxindoles 5892
                                                    3-methyleneoxindole 5835
                                                      semaxanib 3
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