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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ixazomib
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Accession:CHEBI:90942 term browser browse the term
Definition:A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of [(1R)-1-amino-3-methylbutyl]boronic acid. The active metabolite of ixazomib citrate, it is used in combination therapy for treatment of multiple myeloma.
Synonyms:exact_synonym: N-[(1R)-1-borono-3-methylbutyl]-N(2)-(2,5-dichlorobenzoyl)glycinamide
 related_synonym: Formula=C14H19BCl2N2O4;   InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1;   InChIKey=MXAYKZJJDUDWDS-LBPRGKRZSA-N;   MLN 2238;   MLN2238;   SMILES=C(NCC(=O)N[C@@H](CC(C)C)B(O)O)(C1=CC(=CC=C1Cl)Cl)=O
 xref: CAS:1072833-77-2;   Drug_Central:5067;   KEGG:D10130;   LINCS:LSM-4944
 xref_mesh: MESH:C548400
 xref: PMID:23514361;   PMID:24239172;   PMID:24292417;   PMID:24467634;   PMID:24904120;   PMID:24920586;   PMID:25124778;   PMID:25302026;   PMID:25325301;   PMID:25377318;   PMID:25456369;   PMID:25777468;   PMID:25832873;   PMID:25919767;   PMID:26141494;   PMID:26275080;   PMID:26337806;   PMID:26588946;   PMID:26634271;   PMID:26667773;   PMID:26709701;   Reaxys:18302358;   Wikipedia:Ixazomib



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ixazomib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lat2 linker for activation of T cells family, member 2 multiple interactions ISO ixazomib inhibits the reaction [10-(octyloxy)decyl-2-(trimethylammonium)ethyl phosphate results in decreased expression of LAT2 protein]; ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein] CTD PMID:23001822 NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288
JBrowse link
G Zfand2a zinc finger AN1-type containing 2A increases expression ISO ixazomib results in increased expression of ZFAND2A protein CTD PMID:31540997 NCBI chr12:15,161,601...15,172,679
Ensembl chr12:15,161,639...15,172,677
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          apoptosis inducer 13663
            ixazomib 2
              ixazomib citrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbon oxoacid 18658
                                    carboxylic acid 18655
                                      carboacyl group 17699
                                        univalent carboacyl group 17699
                                          carbamoyl group 17550
                                            carboxamide 17550
                                              monocarboxylic acid amide 15732
                                                arenecarboxamide 8256
                                                  benzamides 8256
                                                    ixazomib 2
                                                      ixazomib citrate 0
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