antidote to cyanide poisoning - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	antidote to cyanide poisoning	go back to main search page
Accession:	CHEBI:90749	browse the term
Definition:	A role borne by a molecule that acts to counteract or neutralize the deleterious effects of cyanide.

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Rat (38) Mouse (39) Human (39) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (38)

hydroxocobalamin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 2:169,716,684...169,780,360
Ensembl chr 2:167,418,640...167,481,671

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:167,348,825...167,398,916

G

metabolism of cobalamin associated C

affects binding

Hydroxocobalamin binds to MMACHC protein

NCBI chr 5:135,403,094...135,409,285
Ensembl chr 5:130,166,451...130,172,601

G

5-methyltetrahydrofolate-homocysteine methyltransferase

multiple interactions

[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]

NCBI chr17:62,911,705...62,996,544
Ensembl chr17:58,220,071...58,304,822

sodium nitrite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

[Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein
Sodium Nitrite results in decreased activity of ACHE protein

PMID:12414318 PMID:26231821

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651

G

acid phosphatase 1

increases activity

Sodium Nitrite results in increased activity of ACP1 protein

NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021

G

actin alpha 2, smooth muscle

increases expression
multiple interactions

Sodium Nitrite results in increased expression of ACTA2 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

Sodium Nitrite results in increased expression of AKT1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

adenosine monophosphate deaminase 3

increases activity

Sodium Nitrite results in increased activity of AMPD3 protein

NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:164,885,320...164,929,887

G

amyloid beta precursor protein

multiple interactions

[Hydrogen Peroxide co-treated with Sodium Nitrite] promotes the reaction [APP protein modified form binds to Heme]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

Sodium Nitrite results in increased expression of BAX mRNA; Sodium Nitrite results in increased expression of BAX protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX mRNA]; Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of BAX protein]

PMID:28000380 PMID:28266762 PMID:28833918

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Sodium Nitrite results in decreased expression of BCL2 mRNA; Sodium Nitrite results in decreased expression of BCL2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in decreased expression of BCL2 protein]

PMID:28000380 PMID:28266762 PMID:28833918

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
multiple interactions

Sodium Nitrite results in increased activity of CASP3 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases activity
increases activity

Sodium Nitrite results in decreased activity of CAT protein
Sodium Nitrite results in increased activity of CAT protein

PMID:26231821 PMID:31476334

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

cyclin B1

increases expression

Sodium Nitrite results in increased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172

G

Cd68 molecule

increases expression
multiple interactions

Sodium Nitrite results in increased expression of CD68 protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of CD68 protein]

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697

G

checkpoint kinase 1

increases expression

Sodium Nitrite results in increased expression of CHEK1 protein

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009

G

C-reactive protein

multiple interactions
increases expression

Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of CRP protein]

PMID:28266762 PMID:28833918

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178

G

glucose-6-phosphate dehydrogenase

decreases activity

Sodium Nitrite results in decreased activity of G6PD protein

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801

G

glutamic--pyruvic transaminase

multiple interactions
increases activity

Carnosine inhibits the reaction [Sodium Nitrite results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

decreases activity

Sodium Nitrite results in decreased activity of GSR protein

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

H2A.X variant histone

increases expression

Sodium Nitrite results in increased expression of H2AX protein modified form

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

helicase, lymphoid specific

increases expression

Sodium Nitrite results in increased expression of HELLS protein

NCBI chr 1:246,113,580...246,159,230
Ensembl chr 1:236,701,758...236,746,844

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

Sodium Nitrite results in increased expression of HIF1A protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of HIF1A protein]

PMID:28000380 PMID:28266762

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

interleukin 1 beta

increases expression
increases secretion
multiple interactions

Sodium Nitrite results in increased expression of IL1B mRNA
Sodium Nitrite results in increased secretion of IL1B protein
Sodium Nitrite results in increased expression of IL1B protein
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of IL1B protein]

PMID:16581224 PMID:33030083

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

increases expression

Sodium Nitrite results in increased expression of IL1RL1 protein

NCBI chr 9:50,157,326...50,222,888
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 6

increases secretion
multiple interactions
increases expression

Sodium Nitrite results in increased secretion of IL6 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of IL6 protein]

PMID:16581224 PMID:28266762

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

lactate dehydrogenase B

increases activity

Sodium Nitrite results in increased activity of LDHB protein

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:175,428,385...175,446,403

G

minichromosome maintenance complex component 3

increases expression

Sodium Nitrite results in increased expression of MCM3 protein

NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:23,219,169...23,237,314

G

NFKB inhibitor alpha

multiple interactions
decreases expression

Carnosine inhibits the reaction [Sodium Nitrite results in decreased expression of NFKBIA mRNA]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941

G

RAD51 associated protein 1

increases expression

Sodium Nitrite results in increased expression of RAD51AP1 protein

NCBI chr 4:161,445,610...161,458,661
Ensembl chr 4:159,759,459...159,772,524

G

SMAD family member 2

increases expression
multiple interactions

Sodium Nitrite results in increased expression of SMAD2 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]; Quercetin inhibits the reaction [Sodium Nitrite results in increased expression of SMAD2 protein]

PMID:28000380 PMID:28266762

NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323

G

stathmin 1

increases expression

Sodium Nitrite results in increased expression of STMN1 protein

NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154

G

transforming growth factor, beta 1

increases expression
multiple interactions

Sodium Nitrite results in increased expression of TGFB1 protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]

PMID:28266762 PMID:33030083

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

increases expression
increases secretion
multiple interactions

Sodium Nitrite results in increased expression of TNF mRNA
Sodium Nitrite results in increased secretion of TNF protein
Sodium Nitrite results in increased expression of TNF protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]

PMID:16581224 PMID:28266762 PMID:28833918 PMID:33030083

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

vascular endothelial growth factor A

increases expression
multiple interactions

Sodium Nitrite results in increased expression of VEGFA protein
Carnosine inhibits the reaction [Sodium Nitrite results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

sodium thiosulfate pentahydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of CASP9 protein]

Ensembl chr 5:154,109,046...154,126,626

G

myeloperoxidase

multiple interactions

sodium thiosulfate inhibits the reaction [Isoproterenol results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19899
role	19870
application	19713
pharmaceutical	19549
drug	19549
protective agent	18260
antidote	9636
antidote to cyanide poisoning	38
3-mercaptopyruvic acid	0
hydroxocobalamin	4
sodium nitrite	32
sodium thiosulfate +	3
sodium thiosulfate pentahydrate	3
sulfanegen	0

paths to the root