The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.
4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of ABCG2 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of ABCG2 protein]
AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AGRP mRNA] AM 251 results in increased expression of AGRP mRNA
AM 251 inhibits the reaction [Cannabidiol results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of AKT1 protein] AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of AKT1 protein]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of AKT1 protein]
AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA] AM 251 results in increased expression of AVP mRNA
AM 251 results in increased expression of CARTPT mRNA [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CARTPT mRNA
AM 251 results in increased expression of CDH1 protein AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
[AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-(5-fluoropentyl)-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 1-pentyl-3-(1-naphthoyl)indole; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to 4-ethylnaphthalen-1-yl-(1-pentylindol-3-yl)methanone; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to CP 47497 analog; [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased susceptibility to HU 211; AM 251 inhibits the reaction [Dietary Fats results in increased expression of CNR1 protein]; AM 251 inhibits the reaction [Ethanol results in increased expression of CNR1 mRNA] [AM 251 binds to and results in decreased activity of CNR1 protein] which results in decreased activity of nimesulide; AM 251 binds to and results in decreased activity of CNR1 protein; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of CNR1 mRNA]; AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone results in decreased expression of CNR1 protein]; AM 251 inhibits the reaction [1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester binds to and results in increased activity of CNR1 protein]; AM 251 inhibits the reaction [1-pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester binds to and results in increased activity of CNR1 protein]; AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of CNR1 protein]; AM 251 inhibits the reaction [HU 211 results in decreased expression of CNR1 protein]; AM 251 inhibits the reaction [Methylazoxymethanol Acetate results in increased expression of CNR1 mRNA]; AM 251 inhibits the reaction [N-(1-adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide binds to and results in increased activity of CNR1 protein]; AM 251 inhibits the reaction [N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide binds to and results in increased activity of CNR1 protein] AM 251 results in decreased activity of CNR1 protein AM 251 results in increased methylation of CNR1 promoter AM 251 inhibits the reaction [Cannabidiol results in increased expression of CNR1 protein]
AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of COX4I1 mRNA]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of COX4I1 mRNA]
AM 251 inhibits the reaction [Ethanol results in increased cleavage of and results in increased activity of CREB3L3 protein]; AM 251 inhibits the reaction [Ethanol results in increased expression of CREB3L3 mRNA] AM 251 results in decreased expression of CREB3L3 mRNA
[AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CRH mRNA AM 251 results in increased expression of CRH mRNA
AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]; AM 251 promotes the reaction [iodopravadoline inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]; iodopravadoline promotes the reaction [AM 251 inhibits the reaction [Ceruletide results in increased expression of CXCL1 mRNA]]
AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of DLD mRNA]; AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of DLD protein] AM 251 results in increased activity of DLD protein AM 251 results in decreased expression of DLD mRNA AM 251 promotes the reaction [INS1 protein results in increased activity of DLD protein]
4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased expression of EGFR protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased expression of EGFR protein]
[AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]
AM 251 inhibits the reaction [Dietary Fats results in increased expression of FOS protein]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of FOS protein]
AM 251 results in decreased expression of GLO1 protein AM 251 inhibits the reaction [Dietary Carbohydrates results in decreased expression of GLO1 protein]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of GLO1 protein]
AM 251 inhibits the reaction [Dietary Carbohydrates results in increased expression of GPI protein] AM 251 results in decreased expression of GPI protein
4'-methoxy-1-naphthylfenoterol inhibits the reaction [AM 251 results in increased activity of GPR55 protein]; 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activity of GPR55 protein]
AM 251 inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of HCRT mRNA] AM 251 inhibits the reaction [Dietary Fats results in increased expression of HCRT protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC mRNA]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of and results in increased activity of STAT3 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of HCRT protein modified form]
[AM 251 co-treated with iodopravadoline] promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]; [AM 251 co-treated with iodopravadoline] promotes the reaction [methanandamide promotes the reaction [IL1B protein results in increased expression of and results in increased activity of F3 protein]]
AM 251 inhibits the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone promotes the reaction [Carbon Monoxide results in increased expression of IL33 protein]]
AM 251 inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; AM 251 promotes the reaction [INS1 protein results in increased activity of DLD protein]; AM 251 promotes the reaction [INS1 protein results in increased activity of GSR protein]
AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC protein]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased secretion of POMC protein modified form]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of FOS protein]; AM 251 inhibits the reaction [LEP gene mutant form results in increased expression of HCRT protein modified form]
AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein] AM 251 results in increased phosphorylation of MAPK1 protein AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK1 protein]; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
AM 251 inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; AM 251 inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein] AM 251 results in increased phosphorylation of MAPK3 protein AM 251 inhibits the reaction [[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [[JZL 184 co-treated with Glutamic Acid] results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of MAPK3 protein]; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 mRNA]; AM 251 inhibits the reaction [Dronabinol results in decreased expression of OPRL1 protein]
AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA] AM 251 results in increased expression of OXT mRNA AM 251 results in increased secretion of OXT protein
AM 251 inhibits the reaction [Dietary Fats results in increased expression of PCK1 mRNA]; AM 251 inhibits the reaction [Dietary Fats results in increased expression of PCK1 protein]
AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA] AM 251 results in increased expression of POMC mRNA AM 251 inhibits the reaction [Dietary Fats results in decreased expression of POMC mRNA]; AM 251 inhibits the reaction [Dietary Fats results in decreased expression of POMC protein]; AM 251 inhibits the reaction [Dietary Fats results in decreased secretion of POMC protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC mRNA]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein modified form]; AM 251 inhibits the reaction [HCRT protein modified form results in increased expression of POMC protein]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC mRNA]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased expression of POMC protein]; AM 251 inhibits the reaction [LEP gene mutant form results in decreased secretion of POMC protein modified form]
AM 251 affects the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone affects the expression of SLC6A3 mRNA]
AM 251 results in decreased expression of STAT3 mRNA AM 251 inhibits the reaction [HCRT protein modified form results in increased phosphorylation of and results in increased activity of STAT3 protein] AM 251 inhibits the reaction [Cannabidiol results in increased phosphorylation of STAT3 protein]
AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of COL4A1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of FOSB mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of JUNB mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of MMP2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFB2 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFB3 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased expression of TGFBR1 mRNA]; AM 251 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]
AM 251 affects the reaction [(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone affects the expression of TH mRNA]
[iodopravadoline co-treated with AM 251] inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; [iodopravadoline co-treated with AM 251] inhibits the reaction [methanandamide results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [Dronabinol results in increased expression of TIMP1 protein]; AM 251 inhibits the reaction [methanandamide results in increased expression of TIMP1 protein]
AM 251 inhibits the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFA protein]]
AM 251 inhibits the reaction [arachidonyl-2-chloroethylamide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of VEGFC protein]]
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