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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gamendazole
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Accession:CHEBI:90703 term browser browse the term
Definition:A member of the class of indazoles that is 3-(indazol-3-yl}prop-2-enoic acid carrying additional 2,4-dichlorobenzyl and trifluoromethyl substituents at positions 1 and 6 respectively. An orally active antispermatogenic compound with antifertility effects that is a potential male contraceptive drug.
Synonyms:exact_synonym: (2E)-3-{1-[(2,4-dichlorophenyl)methyl]-6-(trifluoromethyl)-1H-indazol-3-yl}prop-2-enoic acid
 related_synonym: Formula=C18H11Cl2F3N2O2;   InChI=1S/C18H11Cl2F3N2O2/c19-12-3-1-10(14(20)8-12)9-25-16-7-11(18(21,22)23)2-4-13(16)15(24-25)5-6-17(26)27/h1-8H,9H2,(H,26,27)/b6-5+;   InChIKey=KYYQMVUKYQCSQY-AATRIKPKSA-N;   SMILES=N=1N(C2=C(C1\\C=C\\C(O)=O)C=CC(=C2)C(F)(F)F)CC3=CC=C(C=C3Cl)Cl;   trans-3-(1-benzyl-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid
 xref: PMID:18218611;   PMID:18218612;   PMID:21129982;   PMID:22995542;   PMID:26308587;   PMID:26413399;   Reaxys:12542895;   Wikipedia:Gamendazole


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gamendazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 affects binding EXP Gamendazole binds to Eef1a1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 affects binding EXP gamendazole binds to Hsp90ab1 protein RGD PMID:18218611 RGD:10401123 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        antispermatogenic agent 1164
          gamendazole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18008
                                    benzenes 17873
                                      chlorobenzenes 15046
                                        dichlorobenzene 11550
                                          lonidamine 26
                                            gamendazole 2
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