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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:GSK690693
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Accession:CHEBI:90677 term browser browse the term
Definition:A member of the class of imidazopyridines that is 4-(1-ethylimidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol carrying additional 2-(4-amino-1,2,5-oxadiazol-3-yl and [(3S)-piperidin-3-yl]methoxy substituents at positions 4 and 7 respectively.
Synonyms:exact_synonym: 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-piperidin-3-yl]methoxy}-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
 related_synonym: Formula=C21H27N7O3;   GSK 690693;   InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1;   InChIKey=KGPGFQWBCSZGEL-ZDUSSCGKSA-N;   SMILES=C=1(C(N)=NON1)C2=NC3=C(C#CC(O)(C)C)N=CC(=C3N2CC)OC[C@@H]4CNCCC4
 xref: CAS:937174-76-0
 xref_mesh: MESH:C528328
 xref: PDBeChem:G93;   PMID:18800763;   PMID:23892718;   PMID:24394624;   PMID:24715717;   PMID:25757752;   PMID:25788264;   PMID:26181325;   Reaxys:18301457


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GSK690693 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation		 ISO GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]
GSK690693 results in decreased phosphorylation of AKT1 protein
GSK690693 results in increased phosphorylation of AKT1 protein		 CTD PMID:30871965 PMID:31445927 PMID:31962201 PMID:34784199 PMID:35259468 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO GSK690693 results in increased expression of BBC3 protein CTD PMID:35259468 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased expression of BCL2 protein] CTD PMID:30871965 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of CASP3 protein] CTD PMID:30871965 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ctnnb1 catenin beta 1 decreases phosphorylation ISO GSK690693 results in decreased phosphorylation of CTNNB1 protein CTD PMID:35639300 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions		 ISO GSK690693 results in decreased phosphorylation of EIF4EBP1 protein
[sunitinib co-treated with GSK690693] results in decreased phosphorylation of EIF4EBP1 protein		 CTD PMID:22532600 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO GSK690693 affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Foxo3 forkhead box O3 decreases phosphorylation ISO GSK690693 results in decreased phosphorylation of FOXO3 protein CTD PMID:35259468 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
increases expression		 ISO GSK690693 results in decreased phosphorylation of GSK3B protein
GSK690693 results in increased expression of GSK3B protein		 CTD PMID:31962201 PMID:35639300 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in increased cleavage of PARP1 protein] CTD PMID:30871965 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Srsf4 serine and arginine rich splicing factor 4 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF4 protein CTD PMID:31962201 NCBI chr 5:144,060,981...144,090,798
Ensembl chr 5:144,061,463...144,089,229 		JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF5 protein CTD PMID:31962201 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177 		JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 multiple interactions ISO [SRPIN340 co-treated with GSK690693] results in decreased phosphorylation of SRSF6 protein CTD PMID:31962201 NCBI chr 3:151,589,546...151,594,869
Ensembl chr 3:151,589,535...151,594,860 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO GSK690693 promotes the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of STAT3 protein] CTD PMID:30871965 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO GSK690693 results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions
decreases phosphorylation		 ISO [sunitinib co-treated with GSK690693] results in decreased phosphorylation of TSC2 protein
GSK690693 results in decreased phosphorylation of TSC2 protein		 CTD PMID:22532600 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
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  CHEBI ontology 19880
    role 19850
      application 19695
        pharmaceutical 19532
          drug 19532
            antineoplastic agent 17823
              GSK690693 17
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        primary amino compound 9347
                                          GSK690693 17
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