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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:homocysteic acid
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Accession:CHEBI:90324 term browser browse the term
Definition:A non-proteinogenic alpha-amino acid that is homocysteine in which the thiol group has benn oxidised to the corresponding sulfonic acid.
Synonyms:exact_synonym: 2-amino-4-sulfobutanoic acid
 related_synonym: 2-Amino-4-sulfobutyric acid;   Formula=C4H9NO5S;   InChI=1S/C4H9NO5S/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H,8,9,10);   InChIKey=VBOQYPQEPHKASR-UHFFFAOYSA-N;   SMILES=OC(C(CCS(O)(=O)=O)N)=O
 xref: CAS:1001-13-4
 xref_mesh: MESH:C007956
 xref: PMID:26335909;   PMID:27225950;   Reaxys:1783391


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homocysteic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP [homocysteic acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein CTD PMID:19046382 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression EXP homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions		 ISO homocysteic acid results in increased activity of SP1 protein
mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]		 CTD PMID:11261509 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity		 ISO mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19869
      biological role 19867
        biochemical role 19574
          metabolite 19561
            fundamental metabolite 14543
              homocysteine 139
                homocysteic acid 4
                  D-homocysteic acid + 0
                  L-homocysteic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19669
                        hydrogen molecular entity 19651
                          hydrides 19162
                            inorganic hydride 18183
                              pnictogen hydride 18173
                                nitrogen hydride 18086
                                  azane 17891
                                    ammonia 17890
                                      organic amino compound 17890
                                        amino acid 16079
                                          non-proteinogenic amino acid 3999
                                            non-proteinogenic alpha-amino acid 3805
                                              homocysteines 422
                                                homocysteine 139
                                                  homocysteic acid 4
                                                    D-homocysteic acid + 0
                                                    L-homocysteic acid + 0
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