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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tiazofurine
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Accession:CHEBI:90239 term browser browse the term
Definition:A C-glycosyl compound that is 1,3-thiazole-4-carboxamide in which the hydrogen at position 2 has been replaced by a beta-D-ribofuranosyl group. It is metabolised to thiazole-4-carboxamide adenine dinucleotide (TAD), a selective inhibitor of inosine monophosphate dehydrogenase (IMP dehydrogenase).
Synonyms:exact_synonym: (1R)-1,4-anhydro-1-(4-carbamoyl-1,3-thiazol-2-yl)-D-ribitol
 related_synonym: 2-beta-D-ribofuranosyl-4-thiazolecarboxamide;   CI-909;   Formula=C9H12N2O5S;   InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1;   InChIKey=FVRDYQYEVDDKCR-DBRKOABJSA-N;   SMILES=O1[C@@H](C=2SC=C(N2)C(N)=O)[C@H](O)[C@H](O)[C@H]1CO;   TCAR;   riboxamide;   tiazofurin;   tiazofurina;   tiazofurinum
 xref: CAS:60084-10-8;   KEGG:D06130
 xref_mesh: MESH:C033706
 xref: PDBeChem:TIZ;   PMID:11249583;   PMID:23764899;   PMID:2712550;   PMID:8667040;   Reaxys:1084555;   Wikipedia:Tiazofurin


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tiazofurine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase multiple interactions
decreases expression		 ISO Guanosine inhibits the reaction [tiazofurin results in decreased expression of KRAS] CTD PMID:9381980 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
multiple interactions		 ISO tiazofurin results in decreased expression of MYC
Guanosine inhibits the reaction [tiazofurin results in decreased expression of MYC]		 CTD PMID:9381980 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pro-agent 11549
          prodrug 11293
            tiazofurine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organooxygen compound 19184
                                  carbohydrates and carbohydrate derivatives 15285
                                    carbohydrate 15285
                                      monosaccharide 4875
                                        aldose 3231
                                          aldopentose 764
                                            ribose 762
                                              D-ribose 760
                                                D-ribofuranose 760
                                                  beta-D-ribose 408
                                                    tiazofurine 2
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