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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:9-(tetrahydrofuryl)adenine
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Accession:CHEBI:90232 term browser browse the term
Definition:A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.
Synonyms:exact_synonym: 9-(tetrahydrofuran-2-yl)-9H-purin-6-amine
 related_synonym: 6-amino-9-(tetrahydro-2-furyl)-9H-purine;   9-(tetrahydro-2-furanyl)-9H-purin-6-amine;   9-(tetrahydro-2-furyl)-adenine;   Formula=C9H11N5O;   InChI=1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12);   InChIKey=UKHMZCMKHPHFOT-UHFFFAOYSA-N;   SMILES=C12=C(N=CN1C3OCCC3)C(=NC=N2)N;   SQ 22,536;   SQ-22536;   SQ22536
 xref: CAS:17318-31-9;   LINCS:LSM-1656
 xref_mesh: MESH:C017759
 xref: PMID:10193763;   PMID:11334872;   PMID:11858802;   PMID:1669444;   PMID:1711430;   PMID:26350463;   PMID:6326343;   Reaxys:534250


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9-(tetrahydrofuryl)adenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon multiple interactions ISO 9-(tetrahydro-2-furyl)-adenine inhibits the reaction [geraniol results in increased secretion of GCG protein] CTD PMID:29070885 NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO 9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 mRNA; 9-(tetrahydro-2-furyl)-adenine results in decreased expression of PNPLA6 protein CTD PMID:20380879 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 9-(tetrahydro-2-furyl)-adenine inhibits the reaction [methylmercuric chloride results in increased expression of PTGS2 protein] CTD PMID:28958600 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        inhibitor 18918
          enzyme inhibitor 18744
            EC 4.* (lyase) inhibitor 7396
              EC 4.6.* (P-O lyase) inhibitor 75
                EC 4.6.1.1 (adenylate cyclase) inhibitor 5
                  9-(tetrahydrofuryl)adenine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      imidazopyrimidine 7756
                                        purines 7755
                                          aminopurine 6726
                                            6-aminopurines 1047
                                              adenine 1044
                                                9-(tetrahydrofuryl)adenine 3
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