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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tacedinaline
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Accession:CHEBI:90195 term browser browse the term
Definition:A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Synonyms:exact_synonym: 4-acetamido-N-(2-aminophenyl)benzamide
 related_synonym: 4-(Acetylamino)-N-(2-aminophenyl)benzamide;   Acetyldinaline;   C.I. 994;   CI 994;   Formula=C15H15N3O2;   InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20);   InChIKey=VAZAPHZUAVEOMC-UHFFFAOYSA-N;   N-acetyldinaline;   SMILES=C1=C(C=CC(=C1)C(NC2=C(C=CC=C2)N)=O)NC(C)=O;   tacedinalina
 xref: CAS:112522-64-2;   KEGG:D05988;   LINCS:LSM-19036
 xref_mesh: MESH:C081895
 xref: PMID:25827403;   PMID:26365427;   Reaxys:8422586


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tacedinaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression ISO tacedinaline results in increased expression of ATP1B1 mRNA CTD PMID:33770205 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO tacedinaline promotes the reaction [Decitabine results in increased expression of CASP8 protein] CTD PMID:21771726 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cep68 centrosomal protein 68 increases expression ISO tacedinaline results in increased expression of CEP68 mRNA CTD PMID:33770205 NCBI chr14:94,447,973...94,470,533
Ensembl chr14:94,449,055...94,470,517 		JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 increases expression ISO tacedinaline results in increased expression of ERRFI1 mRNA CTD PMID:33770205 NCBI chr 5:161,323,981...161,337,289
Ensembl chr 5:161,323,998...161,337,282 		JBrowse link
G Gldc glycine decarboxylase increases expression ISO tacedinaline results in increased expression of GLDC mRNA CTD PMID:33770205 NCBI chr 1:227,883,249...227,962,119
Ensembl chr 1:227,883,249...227,962,097 		JBrowse link
G Gpr183 G protein-coupled receptor 183 decreases expression ISO tacedinaline results in decreased expression of GPR183 mRNA CTD PMID:33770205 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO tacedinaline results in increased expression of HEY1 mRNA CTD PMID:33770205 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO tacedinaline results in increased expression of IDI1 mRNA CTD PMID:33770205 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357 		JBrowse link
G Il3ra interleukin 3 receptor subunit alpha increases expression ISO tacedinaline results in increased expression of IL3RA mRNA CTD PMID:33770205 NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 increases expression ISO tacedinaline results in increased expression of NEDD9 mRNA CTD PMID:33770205 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Neu1 neuraminidase 1 decreases expression ISO tacedinaline results in decreased expression of NEU1 mRNA CTD PMID:33770205 NCBI chr20:3,897,480...3,901,745
Ensembl chr20:3,897,480...3,901,745 		JBrowse link
G Potem POTE ankyrin domain family member M increases expression ISO tacedinaline results in increased expression of POTEM mRNA CTD PMID:33770205 NCBI chr16:20,193,646...20,311,924
Ensembl chr16:19,949,230...19,976,541 		JBrowse link
G Psd3 pleckstrin and Sec7 domain containing 3 increases expression ISO tacedinaline results in increased expression of PSD3 mRNA CTD PMID:33770205 NCBI chr16:21,465,643...22,035,846
Ensembl chr16:21,465,639...22,034,547 		JBrowse link
G Ralgdsl1 ral guanine nucleotide dissociation stimulator like 1 increases expression ISO tacedinaline results in increased expression of RGL1 mRNA CTD PMID:33770205 NCBI chr13:64,634,489...64,904,170
Ensembl chr13:64,635,246...64,904,191 		JBrowse link
G Swt1 SWT1 RNA endoribonuclease homolog increases expression ISO tacedinaline results in increased expression of SWT1 mRNA CTD PMID:33770205 NCBI chr13:63,452,494...63,509,982
Ensembl chr13:63,452,496...63,509,980 		JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 increases expression ISO tacedinaline results in increased expression of TMCC3 mRNA CTD PMID:33770205 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:28,893,967...29,171,926 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase increases expression ISO tacedinaline results in increased expression of UGCG mRNA CTD PMID:33770205 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393 		JBrowse link
G Zfp280c zinc finger protein 280C increases expression ISO tacedinaline results in increased expression of ZNF280C mRNA CTD PMID:33770205 NCBI chr  X:127,716,403...127,807,600
Ensembl chr  X:127,717,983...127,779,825 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      chemical role 19495
        environmental contaminant 18864
          benzene 5805
            1,2-phenylenediamine 2588
              tacedinaline 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      carboacyl group 17723
                                        univalent carboacyl group 17723
                                          carbamoyl group 17576
                                            carboxamide 17576
                                              monocarboxylic acid amide 15748
                                                arenecarboxamide 8255
                                                  benzamides 8260
                                                    tacedinaline 18
paths to the root