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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diaziquone
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Accession:CHEBI:90185 term browser browse the term
Definition:A 1,4-benzoquinone that is substituted at positions 2 and 5 have been replaced by aziridin-1-yl groups and at positions 3 and 6 by (ethoxycarbonyl)amino groups.
Synonyms:exact_synonym: diethyl [2,5-bis(aziridin-1-yl)-3,6-dioxocyclohexa-1,4-diene-1,4-diyl]biscarbamate
 related_synonym: 2,5-diaziridinyl-3,6-bis(carboethoxyamino)-1,4-benzoquinone;   3,6-bis(carboxyamino)-2,5-diaziridinyl-1,4-benzoquinone;   3,6-diaziridinyl-2,5-bis(ethoxycarbonylamino)-1,4-benzoquinone;   AZQ;   CI 904;   Formula=C16H20N4O6;   InChI=1S/C16H20N4O6/c1-3-25-15(23)17-9-11(19-5-6-19)14(22)10(18-16(24)26-4-2)12(13(9)21)20-7-8-20/h3-8H2,1-2H3,(H,17,23)(H,18,24);   InChIKey=WVYXNIXAMZOZFK-UHFFFAOYSA-N;   NSC 182968;   SMILES=C1(=C(C(C(=C(C1=O)N2CC2)NC(=O)OCC)=O)N3CC3)NC(=O)OCC;   aziridinylbenzoquinone;   diazicuona;   diaziquonum
 xref: CAS:57998-68-2;   Drug_Central:853;   KEGG:D03774
 xref_mesh: MESH:C029108
 xref: PMID:1301071;   PMID:1874603;   PMID:2651223;   PMID:2987424;   PMID:3440875;   PMID:6299094;   PMID:6381377;   PMID:6681775;   PMID:7180832;   Patent:US2913453;   Patent:US4146622;   Reaxys:1333277


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diaziquone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO diaziquone results in increased expression of CDKN1A mRNA
[NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; Acetylcysteine inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]; Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA]		 CTD PMID:8943236 PMID:9343371 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO diaziquone results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases activity
increases metabolic processing
multiple interactions		 ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone
NQO1 protein results in increased metabolism of diaziquone
[NQO1 protein results in increased metabolism of diaziquone] which results in increased abundance of Hydrogen Peroxide; [NQO1 protein results in increased metabolism of diaziquone] which results in increased expression of CDKN1A mRNA; NQO1 protein results in increased reduction of and results in increased activity of diaziquone		 CTD PMID:2113030 PMID:9343371 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
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  CHEBI ontology 19898
    role 19868
      application 19714
        pharmaceutical 19550
          drug 19550
            antineoplastic agent 17830
              diaziquone 3
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organochalcogen compound 19290
                                organooxygen compound 19206
                                  carbonyl compound 18929
                                    ketone 17272
                                      cyclic ketone 15920
                                        quinone 9904
                                          benzoquinones 798
                                            1,4-benzoquinones 795
                                              diaziquone 3
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