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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5-hydroxyindole
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Accession:CHEBI:89649 term browser browse the term
Definition:A member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group.
Synonyms:exact_synonym: 1H-indol-5-ol
 related_synonym: 5-hydroxy-1H-indole;   Formula=C8H7NO;   InChI=1S/C8H7NO/c10-7-1-2-8-6(5-7)3-4-9-8/h1-5,9-10H;   InChIKey=LMIQERWZRIFWNZ-UHFFFAOYSA-N;   SMILES=C=1C=C2C(C=CN2)=CC1O;   indol-5-ol
 xref: CAS:1953-54-4;   HMDB:HMDB0059805
 xref_mesh: MESH:C026785
 xref: MetaCyc:CPD-16174;   PMID:21784895;   PMID:24029555;   PMID:5294372;   PMID:5294373;   Reaxys:112349


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5-hydroxyindole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP 5-hydroxyindole binds to and results in increased activity of CHRNA7 protein; [3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein; methyllycaconitine inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein]; Tetrodotoxin inhibits the reaction [[3-(4-hydroxy-2-methoxybenzylidene)anabaseine co-treated with 5-hydroxyindole] results in increased activity of CHRNA7 protein] CTD PMID:18321476 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation EXP
ISO		 SULT1A1 protein results in increased sulfation of 5-hydroxyindole CTD PMID:11181495 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    chemical entity 19909
      molecular entity 19880
        polyatomic entity 19862
          heteroatomic molecular entity 19818
            hydroxides 19374
              organic hydroxy compound 18978
                hydroxyindoles 174
                  5-hydroxyindole 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic molecule 19737
                              organic cyclic compound 19526
                                organic heterocyclic compound 18870
                                  organic heteropolycyclic compound 18315
                                    organic heterobicyclic compound 17265
                                      benzopyrrole 9738
                                        indoles 9426
                                          hydroxyindoles 174
                                            5-hydroxyindole 2
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