Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:18-hydroxycortisol
go back to main search page
Accession:CHEBI:89455 term browser browse the term
Definition:A 18-hydroxy steroid that is cortisol carrying a hydroxy group at position 18. Its urinary excretion is increased in patients with aldosterone-producing adenoma.
Synonyms:exact_synonym: 11beta,17,18,21-tetrahydroxypregn-4-ene-3,20-dione
 related_synonym: (11beta)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione;   (11beta,17alpha)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione;   4-pregnene-11beta,17,18,21-tetrol-3,20-dione;   Formula=C21H30O6;   InChI=1S/C21H30O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21+/m0/s1;   InChIKey=HESFZGWRDUVOMS-UKSDXMLSSA-N;   SMILES=[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
 xref: CAS:86002-90-6;   FooDB:FDB022033;   HMDB:HMDB0000418;   LIPID_MAPS_instance:LMST02030295
 xref_mesh: MESH:C033689
 xref: PMID:10778083;   PMID:11566957;   PMID:12429142;   PMID:15062555;   PMID:15356073;   PMID:1560187;   PMID:1567095;   PMID:15941931;   PMID:16149517;   PMID:1879399;   PMID:20963880;   PMID:22238407;   PMID:23847032;   PMID:2811370;   PMID:28904009;   PMID:3002670;   PMID:34871919;   PMID:35778951;   PMID:3995762;   PMID:8001289;   PMID:8038908;   PMID:8049145;   PMID:8516344;   PMID:8753282;   PMID:9090795;   PMID:9279964;   PMID:9814482;   PMID:9831489;   Wikipedia:18-Hydroxycortisol



show annotations for term's descendants           Sort by:
18-hydroxycortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 affects chemical synthesis ISO CYP11B1 protein affects the chemical synthesis of 18-hydroxycortisol CTD PMID:15356073 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects chemical synthesis ISO CYP11B2 protein affects the chemical synthesis of 18-hydroxycortisol CTD PMID:15356073 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Pomc proopiomelanocortin increases abundance ISO POMC protein results in increased abundance of 18-hydroxycortisol CTD PMID:3015796 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19878
    role 19848
      application 19690
        anti-inflammatory agent 16670
          anti-inflammatory drug 14956
            cortisol 276
              18-hydroxycortisol 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19878
    subatomic particle 19876
      composite particle 19876
        hadron 19876
          baryon 19876
            nucleon 19876
              atomic nucleus 19876
                atom 19876
                  main group element atom 19815
                    p-block element atom 19815
                      carbon group element atom 19755
                        carbon atom 19752
                          organic molecular entity 19752
                            heteroorganic entity 19509
                              organochalcogen compound 19270
                                organooxygen compound 19186
                                  carbonyl compound 18908
                                    ketone 17253
                                      oxyketone 8914
                                        alpha-oxyketone 8914
                                          alpha-hydroxy ketone 8914
                                            primary alpha-hydroxy ketone 7794
                                              cortisol 276
                                                18-hydroxycortisol 3
paths to the root