CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 18-hydroxycortisol
Accession: CHEBI:89455
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Definition: A 18-hydroxy steroid that is cortisol carrying a hydroxy group at position 18. Its urinary excretion is increased in patients with aldosterone-producing adenoma.
Synonyms: exact_synonym: 11beta,17,18,21-tetrahydroxypregn-4-ene-3,20-dione
related_synonym: (11beta)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione; (11beta,17alpha)-11,17,18,21-tetrahydroxypregn-4-ene-3,20-dione; 4-pregnene-11beta,17,18,21-tetrol-3,20-dione; Formula=C21H30O6; InChI=1S/C21H30O6/c1-19-6-4-13(24)8-12(19)2-3-14-15-5-7-21(27,17(26)10-22)20(15,11-23)9-16(25)18(14)19/h8,14-16,18,22-23,25,27H,2-7,9-11H2,1H3/t14-,15-,16-,18+,19-,20+,21+/m0/s1; InChIKey=HESFZGWRDUVOMS-UKSDXMLSSA-N; SMILES=[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
xref: CAS:86002-90-6; FooDB:FDB022033; HMDB:HMDB0000418; LIPID_MAPS_instance:LMST02030295
xref_mesh: MESH:C033689
xref: PMID:10778083; PMID:11566957; PMID:12429142; PMID:15062555; PMID:15356073; PMID:1560187; PMID:1567095; PMID:15941931; PMID:16149517; PMID:1879399; PMID:20963880; PMID:22238407; PMID:23847032; PMID:2811370; PMID:28904009; PMID:3002670; PMID:34871919; PMID:35778951; PMID:3995762; PMID:8001289; PMID:8038908; PMID:8049145; PMID:8516344; PMID:8753282; PMID:9090795; PMID:9279964; PMID:9814482; PMID:9831489; Wikipedia:18-Hydroxycortisol
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
affects chemical synthesis
ISO
CYP11B1 protein affects the chemical synthesis of 18-hydroxycortisol
CTD
PMID:15356073
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
affects chemical synthesis
ISO
CYP11B2 protein affects the chemical synthesis of 18-hydroxycortisol
CTD
PMID:15356073
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Pomc
proopiomelanocortin
increases abundance
ISO
POMC protein results in increased abundance of 18-hydroxycortisol
CTD
PMID:3015796
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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