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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ryanodine
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Accession:CHEBI:8925 term browser browse the term
Definition:An insecticide alkaloid isolated from South American plant Ryania speciosa.
Synonyms:exact_synonym: (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(propan-2-yl)dodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate
 related_synonym: (3S,4R,4aR,6S,6aR,7S,8R,8aS,8bR,9S,9aS)-4,6,7,8a,8b,9a-hexahydroxy-7-isopropyl-3,6a,9-trimethyldodecahydro-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl 1H-pyrrole-2-carboxylate;   Formula=C25H35NO9;   InChI=1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19+,20-,21-,22+,23+,24+,25+/m0/s1;   InChIKey=JJSYXNQGLHBRRK-SFEDZAPPSA-N;   Ryania;   Ryanodin;   SMILES=CC(C)[C@@]1(O)[C@@H](OC(=O)c2ccc[nH]2)[C@@]2(O)[C@@]3(C)C[C@]4(O)O[C@@]5([C@H](O)[C@@H](C)CC[C@]35O)[C@@]2(O)[C@@]14C;   ryanodol, 3-(1H-pyrrole-2-carboxylate)
 xref: BPDB:2067;   Beilstein:6079034;   CAS:15662-33-6;   KEGG:C08705;   KNApSAcK:C00001661
 xref_mesh: MESH:D012433


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ryanodine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Ryanodine co-treated with Halothane] results in increased expression of BAX mRNA CTD PMID:32795494 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2l11 Bcl2-like 11 multiple interactions ISO [Ryanodine co-treated with Halothane] results in increased expression of BCL2L11 mRNA CTD PMID:32795494 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Ryanodine co-treated with Thioctic Acid] results in decreased activity of CASP3 protein; Ryanodine inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein] CTD PMID:17079870 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP [bastadin 12 co-treated with Ryanodine co-treated with Dizocilpine Maleate] inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein] CTD PMID:27718046 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Ryanodine inhibits the reaction [Nicotine results in increased phosphorylation of CREB1 protein] CTD PMID:21113126 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of CXCL2 mRNA] CTD PMID:32795494 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of DDIT3 mRNA] CTD PMID:32795494 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Faslg Fas ligand multiple interactions ISO Ryanodine inhibits the reaction [FASL protein affects the localization of Calcium] CTD PMID:20200208 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of FKBP1A mRNA] CTD PMID:32795494 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743 		JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B multiple interactions ISO [Ryanodine co-treated with Halothane] results in increased expression of FKBP1B mRNA; Ryanodine inhibits the reaction [FKBP1B gene mutant form inhibits the reaction [Acetylcholine affects the localization of and affects the abundance of Calcium]] CTD PMID:17261647 PMID:32795494 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of GPT protein] CTD PMID:32795494 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO [Ryanodine co-treated with Halothane] results in increased expression of HMOX1 mRNA CTD PMID:32795494 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of HOMER1 mRNA] CTD PMID:32795494 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Ryanodine co-treated with Halothane] results in increased expression of IL1B mRNA CTD PMID:32795494 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of ITGAM mRNA] CTD PMID:32795494 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of NR4A1 protein] CTD PMID:23183170 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO Ryanodine promotes the reaction [Mustard Gas results in increased activity of PLAU protein] CTD PMID:9101041 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Triclosan promotes the reaction [Ryanodine binds to RYR1 protein]
2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR1 protein]; chlorantranilipole promotes the reaction [Ryanodine binds to RYR1 protein]; flubendiamide promotes the reaction [Ryanodine binds to RYR1 protein]		 CTD PMID:18795164 PMID:18954145 PMID:30329129 NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812 		JBrowse link
G Ryr2 ryanodine receptor 2 affects binding
multiple interactions		 ISO
EXP		 Ryanodine binds to RYR2 protein
2,3,6,2',3',6'-hexachlorobiphenyl affects the reaction [Ryanodine binds to RYR2 protein]
decamethrin promotes the reaction [Ryanodine binds to RYR2 protein]		 CTD PMID:11278295 PMID:18954145 PMID:31166131 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of S100A8 mRNA] CTD PMID:32795494 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of S100A9 mRNA] CTD PMID:32795494 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO NR4A1 protein inhibits the reaction [Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein]]; Ryanodine inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR mRNA]; Ryanodine inhibits the reaction [Colforsin results in increased expression of STAR protein] CTD PMID:23183170 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of TNF mRNA] CTD PMID:32795494 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Ryanodine promotes the reaction [Halothane results in increased expression of VCAM1 mRNA] CTD PMID:32795494 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        biochemical role 19571
          metabolite 19558
            alkaloid 8020
              ryanodine 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      chalcogen 19586
                        oxygen atom 19558
                          oxygen molecular entity 19558
                            hydroxides 19365
                              organic hydroxy compound 18978
                                alcohol 15732
                                  hemiacetal 239
                                    lactol 239
                                      cyclic hemiketal 182
                                        ryanodine 24
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