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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ropinirole
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Accession:CHEBI:8888 term browser browse the term
Definition:An indolone that has formula C16H24N2O.
Synonyms:exact_synonym: 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one
 related_synonym: Formula=C16H24N2O;   InChI=1S/C16H24N2O/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);   InChIKey=UHSKFQJFRQCDBE-UHFFFAOYSA-N;   SMILES=CCCN(CCC)CCc1cccc2NC(=O)Cc12;   ropinirol;   ropinirolum
 xref: Beilstein:6062222;   CAS:91374-21-9;   DrugBank:DB00268;   Drug_Central:2402;   KEGG:C07564;   KEGG:D08489;   LINCS:LSM-2351
 xref_mesh: MESH:C046649
 xref: Patent:US4452808;   Wikipedia:Ropinirole


show annotations for term's descendants           Sort by:
ropinirole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator increases expression ISO ropinirole results in increased expression of BCL2 protein CTD PMID:18242171 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein] CTD PMID:18242171 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO ropinirole inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] CTD PMID:18242171 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions EXP ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased activity of CAT protein]] CTD PMID:25053526 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO ropinirole binds to and results in increased activity of DRD2 protein CTD PMID:18393062 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 multiple interactions ISO ropinirole binds to and results in increased activity of DRD3 protein CTD PMID:18242171 PMID:18393062 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO ropinirole binds to and results in increased activity of DRD4 protein CTD PMID:18393062 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Egr1 early growth response 1 decreases expression EXP ropinirole results in decreased expression of EGR1 mRNA CTD PMID:20452347 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]] CTD PMID:25053526 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO ropinirole inhibits the reaction [Rotenone results in increased phosphorylation of JUN protein] CTD PMID:18242171 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO ropinirole results in increased phosphorylation of MAPK1 protein CTD PMID:18242171 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO ropinirole results in increased phosphorylation of MAPK3 protein CTD PMID:18242171 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP ropinirole inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; ropinirole promotes the reaction [Ceftriaxone inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]] CTD PMID:25053526 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            central nervous system drug 16771
              ropinirole 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteropolycyclic compound 18294
                                    organic heterobicyclic compound 17237
                                      benzopyrrole 9739
                                        indoles 9427
                                          indolones 5937
                                            ropinirole 13
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