CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: rofecoxib
Accession: CHEBI:8887
browse the term
Definition: A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Synonyms: exact_synonym: 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one
related_synonym: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone; Ceoxx; Formula=C17H14O4S; InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3; InChIKey=RZJQGNCSTQAWON-UHFFFAOYSA-N; SMILES=CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1; Vioxx; rofecoxibum
xref: CAS:162011-90-7; DrugBank:DB00533; Drug_Central:2397; KEGG:C07590; KEGG:D00568; LINCS:LSM-2482
xref_mesh: MESH:C116926
xref: PMID:10859630; PMID:11014111; PMID:12069696; PMID:16934051; PMID:20162413; PMID:28166217; Reaxys:8269007; Wikipedia:Rofecoxib
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Adamts8
ADAM metallopeptidase with thrombospondin type 1 motif, 8
affects expression
ISO
rofecoxib affects the expression of ADAMTS8 mRNA
CTD
PMID:17070997
NCBI chr 8:29,349,078...29,368,413
Ensembl chr 8:29,349,114...29,368,404
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Adgrf1
adhesion G protein-coupled receptor F1
affects expression
ISO
rofecoxib affects the expression of ADGRF1 mRNA
CTD
PMID:17070997
NCBI chr 9:17,661,258...17,696,359
Ensembl chr 9:17,660,930...17,711,704
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Adgrg6
adhesion G protein-coupled receptor G6
affects expression
ISO
rofecoxib affects the expression of ADGRG6 mRNA
CTD
PMID:17070997
NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123
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Afdn
afadin, adherens junction formation factor
affects expression
ISO
rofecoxib affects the expression of AFDN mRNA
CTD
PMID:17070997
NCBI chr 1:53,905,344...54,034,216
Ensembl chr 1:53,905,373...54,034,216
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Alox15b
arachidonate 15-lipoxygenase, type B
affects expression
ISO
rofecoxib affects the expression of ALOX15B mRNA
CTD
PMID:17070997
NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
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Angpt1
angiopoietin 1
decreases expression
ISO
rofecoxib results in decreased expression of ANGPT1 mRNA
CTD
PMID:17070997
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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Angptl1
angiopoietin-like 1
decreases expression
ISO
rofecoxib results in decreased expression of ANGPTL1 mRNA
CTD
PMID:17070997
NCBI chr13:68,963,186...68,981,649
Ensembl chr13:68,962,991...68,992,570
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Anxa1
annexin A1
affects expression
ISO
rofecoxib affects the expression of ANXA1 mRNA
CTD
PMID:17070997
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Anxa3
annexin A3
increases expression
ISO
rofecoxib results in increased expression of ANXA3 mRNA
CTD
PMID:17070997
NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
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Anxa9
annexin A9
decreases expression
ISO
rofecoxib results in decreased expression of ANXA9 mRNA
CTD
PMID:17070997
NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374
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Aox1
aldehyde oxidase 1
decreases expression
ISO
rofecoxib results in decreased expression of AOX1 mRNA
CTD
PMID:17070997
NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
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Arhgap29
Rho GTPase activating protein 29
decreases expression
ISO
rofecoxib results in decreased expression of ARHGAP29 mRNA
CTD
PMID:17070997
NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028
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C3
complement C3
increases expression
ISO
rofecoxib results in increased expression of C3 mRNA
CTD
PMID:17070997
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Cacna2d3
calcium voltage-gated channel auxiliary subunit alpha2delta 3
decreases expression
ISO
rofecoxib results in decreased expression of CACNA2D3 mRNA
CTD
PMID:17070997
NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351
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Calca
calcitonin-related polypeptide alpha
multiple interactions
EXP
rofecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of CALCA protein]
CTD
PMID:16690336
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Cat
catalase
multiple interactions
EXP
rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein]
CTD
PMID:20043943
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
rofecoxib results in increased expression of CCL2 mRNA
CTD
PMID:17070997
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl20
C-C motif chemokine ligand 20
multiple interactions increases expression
ISO
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein] rofecoxib results in increased expression of CCL20 mRNA; rofecoxib results in increased expression of CCL20 protein
CTD
PMID:17667525
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl3
C-C motif chemokine ligand 3
increases expression multiple interactions
ISO
rofecoxib results in increased expression of CCL3 mRNA; rofecoxib results in increased expression of CCL3 protein Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein]
CTD
PMID:17667525
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl5
C-C motif chemokine ligand 5
multiple interactions increases expression
ISO
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein] rofecoxib results in increased expression of CCL5 mRNA; rofecoxib results in increased expression of CCL5 protein
CTD
PMID:17667525
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccn2
cellular communication network factor 2
multiple interactions
ISO
rofecoxib inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein]
CTD
PMID:17565644
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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Cdh2
cadherin 2
affects expression
ISO
rofecoxib affects the expression of CDH2 mRNA
CTD
PMID:17070997
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdh3
cadherin 3
increases expression
ISO
rofecoxib results in increased expression of CDH3 mRNA
CTD
PMID:17070997
NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084
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Cdsn
corneodesmosin
affects expression
ISO
rofecoxib affects the expression of CDSN mRNA
CTD
PMID:17070997
NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250
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Ceacam1
CEA cell adhesion molecule 1
affects expression
ISO
rofecoxib affects the expression of CEACAM1 mRNA
CTD
PMID:17070997
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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Clu
clusterin
increases expression
ISO
rofecoxib results in increased expression of CLU mRNA
CTD
PMID:17070997
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Col14a1
collagen type XIV alpha 1 chain
decreases expression
ISO
rofecoxib results in decreased expression of COL14A1 mRNA
CTD
PMID:17070997
NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214
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Colec12
collectin sub-family member 12
decreases expression
ISO
rofecoxib results in decreased expression of COLEC12 mRNA
CTD
PMID:17070997
NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
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Crisp3
cysteine-rich secretory protein 3
increases expression
ISO
rofecoxib results in increased expression of CRISP3 mRNA
CTD
PMID:17070997
NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658
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Cx3cl1
C-X3-C motif chemokine ligand 1
affects expression
ISO
rofecoxib affects the expression of CX3CL1 mRNA
CTD
PMID:17070997
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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Cxcl1
C-X-C motif chemokine ligand 1
affects expression
ISO
rofecoxib affects the expression of CXCL1 mRNA
CTD
PMID:17070997
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl3
C-X-C motif chemokine ligand 3
affects expression
ISO
rofecoxib affects the expression of CXCL1 mRNA
CTD
PMID:17070997
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases activity
ISO
rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine] rofecoxib results in decreased activity of CYP1A2 protein
CTD
PMID:15834531 PMID:16934051 PMID:18816299
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Defb5
defensin beta 5
increases expression
ISO
rofecoxib results in increased expression of DEFB4 mRNA
CTD
PMID:17070997
NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
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Dsc1
desmocollin 1
affects expression
ISO
rofecoxib affects the expression of DSC1 mRNA
CTD
PMID:17070997
NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494
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Ednrb
endothelin receptor type B
multiple interactions
ISO
rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]
CTD
PMID:12126971
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Epha3
Eph receptor A3
decreases expression
ISO
rofecoxib results in decreased expression of EPHA3 mRNA
CTD
PMID:17070997
NCBI chr11:1,138,485...1,474,102
Ensembl chr11:1,140,985...1,473,900
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Ephb6
Eph receptor B6
decreases expression
ISO
rofecoxib results in decreased expression of EPHB6 mRNA
CTD
PMID:17070997
NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
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Etv5
ETS variant transcription factor 5
decreases expression
ISO
rofecoxib results in decreased expression of ETV5 mRNA
CTD
PMID:17070997
NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215
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Fabp4
fatty acid binding protein 4
decreases expression
ISO
rofecoxib results in decreased expression of FABP4 mRNA
CTD
PMID:17070997
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
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Faf1
Fas associated factor 1
affects expression
ISO
rofecoxib affects the expression of FAF1 mRNA
CTD
PMID:17070997
NCBI chr 5:124,426,032...124,790,014
Ensembl chr 5:124,426,062...124,789,977
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Faim2
Fas apoptotic inhibitory molecule 2
decreases expression
ISO
rofecoxib results in decreased expression of FAIM2 mRNA
CTD
PMID:17070997
NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168
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Flnb
filamin B
increases expression
ISO
rofecoxib results in increased expression of FLNB mRNA
CTD
PMID:17070997
NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006
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Foxd1
forkhead box D1
decreases expression
ISO
rofecoxib results in decreased expression of FOXD1 mRNA
CTD
PMID:17070997
NCBI chr 2:29,702,558...29,704,978
Ensembl chr 2:29,702,558...29,704,978
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Frzb
frizzled-related protein
affects expression
ISO
rofecoxib affects the expression of FRZB mRNA
CTD
PMID:17070997
NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208
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Gata3
GATA binding protein 3
decreases expression
ISO
rofecoxib results in decreased expression of GATA3 mRNA
CTD
PMID:17070997
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
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Hgf
hepatocyte growth factor
decreases expression
ISO
rofecoxib results in decreased expression of HGF mRNA
CTD
PMID:17070997
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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Hpgd
15-hydroxyprostaglandin dehydrogenase
decreases expression
ISO
rofecoxib results in decreased expression of HPGD mRNA
CTD
PMID:17070997
NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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Il1a
interleukin 1 alpha
affects expression decreases expression
ISO
rofecoxib affects the expression of IL1A mRNA rofecoxib results in decreased expression of IL1A mRNA
CTD
PMID:17070997 PMID:32816093
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
multiple interactions
ISO EXP
rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]] rofecoxib promotes the reaction [Acetic Acid results in increased expression of IL1B protein]
CTD
PMID:11376495 PMID:12126971 PMID:14762100 PMID:15705740
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
increases expression
ISO
rofecoxib results in increased expression of IL1RN mRNA
CTD
PMID:17070997
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il6
interleukin 6
increases expression
ISO
rofecoxib results in increased expression of IL6 mRNA; rofecoxib results in increased expression of IL6 protein
CTD
PMID:17070997
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Insm1
INSM transcriptional repressor 1
decreases expression
ISO
rofecoxib results in decreased expression of INSM1 mRNA
CTD
PMID:17070997
NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003
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Itgbl1
integrin subunit beta like 1
affects expression
ISO
rofecoxib affects the expression of ITGBL1 mRNA
CTD
PMID:17070997
NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733
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Klf12
KLF transcription factor 12
affects expression
ISO
rofecoxib affects the expression of KLF12 mRNA
CTD
PMID:17070997
NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056
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Lhb
luteinizing hormone subunit beta
multiple interactions
EXP
rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein]
CTD
PMID:19579042
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Lifr
LIF receptor subunit alpha
decreases expression
ISO
rofecoxib results in decreased expression of LIFR mRNA
CTD
PMID:17070997
NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699
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Lmx1a
LIM homeobox transcription factor 1 alpha
increases expression
ISO
rofecoxib results in increased expression of LMX1A mRNA
CTD
PMID:17070997
NCBI chr13:79,834,614...79,978,253
Ensembl chr13:79,835,019...79,978,253
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Mal
mal, T-cell differentiation protein
increases expression
ISO
rofecoxib results in increased expression of MAL mRNA
CTD
PMID:17070997
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
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Mapre2
microtubule-associated protein, RP/EB family, member 2
decreases expression
ISO
rofecoxib results in decreased expression of MAPRE2 mRNA
CTD
PMID:17070997
NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044
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Mbtd1
mbt domain containing 1
decreases expression
ISO
rofecoxib results in decreased expression of MBTD1 mRNA
CTD
PMID:17070997
NCBI chr10:78,839,140...78,895,413
Ensembl chr10:78,839,036...78,893,720
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Mef2c
myocyte enhancer factor 2C
affects expression
ISO
rofecoxib affects the expression of MEF2C mRNA
CTD
PMID:17070997
NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
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Meox2
mesenchyme homeobox 2
decreases expression
ISO
rofecoxib results in decreased expression of MEOX2 mRNA
CTD
PMID:17070997
NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467
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Mmp1
matrix metallopeptidase 1
increases expression
ISO
rofecoxib results in increased expression of MMP1 mRNA
CTD
PMID:16580899
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp3
matrix metallopeptidase 3
increases expression
ISO
rofecoxib results in increased expression of MMP3 mRNA
CTD
PMID:16580899
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mr1
major histocompatibility complex, class I-related
affects expression
ISO
rofecoxib affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
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Mta2
metastasis associated 1 family, member 2
decreases expression
ISO
rofecoxib results in decreased expression of MTA2 mRNA
CTD
PMID:17070997
NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946
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Naaladl2
N-acetylated alpha-linked acidic dipeptidase-like 2
decreases expression
ISO
rofecoxib results in decreased expression of NAALADL2 mRNA
CTD
PMID:17070997
NCBI chr 2:106,639,146...107,992,218
Ensembl chr 2:106,645,608...107,991,689
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Nfasc
neurofascin
decreases expression
ISO
rofecoxib results in decreased expression of NFASC mRNA
CTD
PMID:17070997
NCBI chr13:43,997,223...44,183,863
Ensembl chr13:43,997,224...44,183,880
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Ngf
nerve growth factor
multiple interactions
EXP
rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein]
CTD
PMID:16879691
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nos1
nitric oxide synthase 1
affects expression
ISO
rofecoxib affects the expression of NOS1 mRNA
CTD
PMID:17070997
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
CTD
PMID:16879691
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nox1
NADPH oxidase 1
multiple interactions
EXP
rofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; rofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA]
CTD
PMID:23415682 PMID:25596430
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Npas3
neuronal PAS domain protein 3
increases expression
ISO
rofecoxib results in increased expression of NPAS3 mRNA
CTD
PMID:17070997
NCBI chr 6:70,702,773...71,527,928
Ensembl chr 6:70,703,170...71,524,884
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Npr2
natriuretic peptide receptor 2
decreases expression
ISO
rofecoxib results in decreased expression of NPR2 mRNA
CTD
PMID:17070997
NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580
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Nqo1
NAD(P)H quinone dehydrogenase 1
affects expression
ISO
rofecoxib affects the expression of NQO1 mRNA
CTD
PMID:17070997
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Pi4ka
phosphatidylinositol 4-kinase alpha
decreases expression
ISO
rofecoxib results in decreased expression of PI4KA mRNA
CTD
PMID:17070997
NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080
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Pla2g2a
phospholipase A2 group IIA
affects expression
ISO
rofecoxib affects the expression of PLA2G2A mRNA
CTD
PMID:17070997
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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Pla2g4a
phospholipase A2 group 4A
multiple interactions
ISO
rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]
CTD
PMID:15816863
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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Plat
plasminogen activator, tissue type
increases expression
ISO
rofecoxib results in increased expression of PLAT mRNA
CTD
PMID:16580899
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Pml
PML nuclear body scaffold
increases expression
ISO
rofecoxib results in increased expression of PML mRNA
CTD
PMID:17070997
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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Postn
periostin
affects expression
ISO
rofecoxib affects the expression of POSTN mRNA
CTD
PMID:17070997
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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Prrx1
paired related homeobox 1
affects expression
ISO
rofecoxib affects the expression of PRRX1 mRNA
CTD
PMID:17070997
NCBI chr13:75,600,777...75,671,896
Ensembl chr13:75,601,706...75,670,866
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Ptger3
prostaglandin E receptor 3
decreases expression
ISO
rofecoxib results in decreased expression of PTGER3 mRNA
CTD
PMID:17070997
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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Ptgis
prostaglandin I2 synthase
decreases expression
ISO
rofecoxib results in decreased expression of PTGIS mRNA
CTD
PMID:17175104
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
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Ptgs1
prostaglandin-endoperoxide synthase 1
decreases activity decreases expression
ISO
rofecoxib analog results in decreased activity of PTGS1 protein; rofecoxib results in decreased activity of PTGS1 protein rofecoxib results in decreased expression of PTGS1 mRNA
CTD
PMID:16141368 PMID:17175104
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases response to substance multiple interactions decreases expression decreases activity increases expression
ISO EXP
PTGS2 promoter SNP results in increased susceptibility to rofecoxib [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Lipopolysaccharides; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein] rofecoxib results in decreased expression of PTGS2 mRNA PTGS2 inhibits the reaction [rofecoxib results in increased uptake of Hexoses] rofecoxib results in increased expression of PTGS2 mRNA [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
CTD
PMID:10594344 PMID:11245490 PMID:11321505 PMID:11703585 PMID:12110471 PMID:12417326 PMID:15705740 PMID:15718289 PMID:16249722 PMID:16447059 PMID:16678543 PMID:16944022 PMID:17070997 PMID:17164136 More...
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rasa1
RAS p21 protein activator 1
affects expression
ISO
rofecoxib affects the expression of RASA1 mRNA
CTD
PMID:17070997
NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
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Rnf144b
ring finger protein 144B
increases expression
ISO
rofecoxib results in increased expression of RNF144B mRNA
CTD
PMID:17070997
NCBI chr17:17,431,271...17,580,687
Ensembl chr17:17,432,786...17,562,760
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Rorc
RAR-related orphan receptor C
decreases expression
ISO
rofecoxib results in decreased expression of RORC mRNA
CTD
PMID:17070997
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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Scd
stearoyl-CoA desaturase
increases expression
ISO
rofecoxib results in increased expression of SCD mRNA
CTD
PMID:17070997
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Serpina3n
serpin family A member 3N
increases expression
ISO
rofecoxib results in increased expression of SERPINA3 mRNA
CTD
PMID:17070997
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Sh2d1a
SH2 domain containing 1A
decreases expression
ISO
rofecoxib results in decreased expression of SH2D1A mRNA
CTD
PMID:17070997
NCBI chr X:121,373,693...121,401,923
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Slc2a1
solute carrier family 2 member 1
multiple interactions
ISO
SLC2A1 inhibits the reaction [rofecoxib results in increased uptake of Hexoses]
CTD
PMID:16447059
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a4
solute carrier family 2 member 4
increases expression multiple interactions
ISO
rofecoxib results in increased expression of SLC2A4 mRNA; rofecoxib results in increased expression of SLC2A4 protein [rofecoxib results in increased expression of SLC2A4 protein] which results in increased uptake of Hexoses
CTD
PMID:16447059
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
rofecoxib results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Socs3
suppressor of cytokine signaling 3
increases expression
ISO
rofecoxib results in increased expression of SOCS3 mRNA; rofecoxib results in increased expression of SOCS3 protein
CTD
PMID:17070997
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Sod1
superoxide dismutase 1
multiple interactions
ISO
rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein]
CTD
PMID:15816863
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
increases expression
ISO
rofecoxib results in increased expression of SOD2 mRNA
CTD
PMID:17070997
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Stat3
signal transducer and activator of transcription 3
increases expression
ISO
rofecoxib results in increased expression of STAT3 mRNA
CTD
PMID:17070997
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tac1
tachykinin, precursor 1
increases expression
ISO
rofecoxib results in increased expression of TAC1 protein
CTD
PMID:16449370
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tead4
TEA domain transcription factor 4
increases expression
ISO
rofecoxib results in increased expression of TEAD4 mRNA
CTD
PMID:17070997
NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323
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Tfrc
transferrin receptor
affects expression
ISO
rofecoxib affects the expression of TFRC mRNA
CTD
PMID:17070997
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Timp3
TIMP metallopeptidase inhibitor 3
decreases expression
ISO
rofecoxib results in decreased expression of TIMP3 mRNA
CTD
PMID:16580899
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tmprss4
transmembrane serine protease 4
increases expression
ISO
rofecoxib results in increased expression of TMPRSS4 mRNA
CTD
PMID:17070997
NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
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Tnc
tenascin C
increases expression
ISO
rofecoxib results in increased expression of TNC mRNA
CTD
PMID:17070997
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Tnf
tumor necrosis factor
multiple interactions decreases expression
EXP ISO
rofecoxib promotes the reaction [Acetic Acid results in increased expression of TNF protein] rofecoxib results in decreased expression of TNF protein
CTD
PMID:11376495 PMID:17878525
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Trim17
tripartite motif-containing 17
affects expression
ISO
rofecoxib affects the expression of TRIM17 mRNA
CTD
PMID:17070997
NCBI chr10:43,743,111...43,750,929
Ensembl chr10:43,740,604...43,750,919
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Tspan2
tetraspanin 2
decreases expression
ISO
rofecoxib results in decreased expression of TSPAN2 mRNA
CTD
PMID:17070997
NCBI chr 2:190,177,717...190,234,994
Ensembl chr 2:190,177,741...190,219,660
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Vcan
versican
decreases expression
ISO
rofecoxib results in decreased expression of VCAN mRNA
CTD
PMID:17070997
NCBI chr 2:20,761,718...20,860,637
Ensembl chr 2:20,761,718...20,860,637
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