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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rofecoxib
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Accession:CHEBI:8887 term browser browse the term
Definition:A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke.
Synonyms:related_synonym: 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone;   4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one;   Ceoxx;   Vioxx;   rofecoxibum
 xref: CAS:162011-90-7;   DrugBank:DB00533
 xref_mesh: MESH:C116926
 xref: Reaxys:8269007;   drugcentral:2397;   kegg.compound:C07590;   kegg.drug:D00568;   lincs.smallmolecule:LSM-2482;   pubmed:10859630;   pubmed:11014111;   pubmed:12069696;   pubmed:16934051;   pubmed:20162413;   pubmed:28166217;   wikipedia.en:Rofecoxib
 chemrof_formula: C17H14O4S
 chemrof_smiles: CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1
 chemrof_inchi: InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
 chemrof_inchikey: RZJQGNCSTQAWON-UHFFFAOYSA-N


show annotations for term's descendants           Sort by:
rofecoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 affects expression ISO rofecoxib affects the expression of ADAMTS8 mRNA CTD PMID:17070997 NCBI chr 8:37,607,001...37,626,597
Ensembl chr 8:37,607,001...37,626,597 		JBrowse link
G Adgrf1 adhesion G protein-coupled receptor F1 affects expression ISO rofecoxib affects the expression of ADGRF1 mRNA CTD PMID:17070997 NCBI chr 9:25,158,198...25,210,744
Ensembl chr 9:25,147,588...25,208,916 		JBrowse link
G Adgrg6 adhesion G protein-coupled receptor G6 affects expression ISO rofecoxib affects the expression of ADGRG6 mRNA CTD PMID:17070997 NCBI chr 1:10,633,004...10,774,685
Ensembl chr 1:10,631,829...10,774,023 		JBrowse link
G Afdn afadin, adherens junction formation factor affects expression ISO rofecoxib affects the expression of AFDN mRNA CTD PMID:17070997 NCBI chr 1:58,041,065...58,170,505
Ensembl chr 1:58,041,641...58,170,505 		JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B affects expression ISO rofecoxib affects the expression of ALOX15B mRNA CTD PMID:17070997 NCBI chr10:54,391,331...54,400,648
Ensembl chr10:54,391,302...54,400,648 		JBrowse link
G Angpt1 angiopoietin 1 decreases expression ISO rofecoxib results in decreased expression of ANGPT1 mRNA CTD PMID:17070997 NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696 		JBrowse link
G Angptl1 angiopoietin-like 1 decreases expression ISO rofecoxib results in decreased expression of ANGPTL1 mRNA CTD PMID:17070997 NCBI chr13:71,463,913...71,531,810
Ensembl chr13:71,511,727...71,531,818 		JBrowse link
G Anxa1 annexin A1 affects expression ISO rofecoxib affects the expression of ANXA1 mRNA CTD PMID:17070997 NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:227,287,717...227,306,831 		JBrowse link
G Anxa3 annexin A3 increases expression ISO rofecoxib results in increased expression of ANXA3 mRNA CTD PMID:17070997 NCBI chr14:13,031,675...13,085,678
Ensembl chr14:13,023,762...13,085,849 		JBrowse link
G Anxa9 annexin A9 decreases expression ISO rofecoxib results in decreased expression of ANXA9 mRNA CTD PMID:17070997 NCBI chr 2:185,562,174...185,572,560
Ensembl chr 2:185,562,174...185,572,560 		JBrowse link
G Aox1 aldehyde oxidase 1 decreases expression ISO rofecoxib results in decreased expression of AOX1 mRNA CTD PMID:17070997 NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:67,073,821...67,152,980 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 decreases expression ISO rofecoxib results in decreased expression of ARHGAP29 mRNA CTD PMID:17070997 NCBI chr 2:212,744,626...212,816,710
Ensembl chr 2:212,755,803...212,986,729 		JBrowse link
G C3 complement C3 increases expression ISO rofecoxib results in increased expression of C3 mRNA CTD PMID:17070997 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339 		JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 decreases expression ISO rofecoxib results in decreased expression of CACNA2D3 mRNA CTD PMID:17070997 NCBI chr16:4,105,048...4,919,037
Ensembl chr16:4,105,048...4,919,098 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP rofecoxib inhibits the reaction [Freund's Adjuvant results in increased expression of CALCA protein] CTD PMID:16690336 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529 		JBrowse link
G Cat catalase multiple interactions EXP rofecoxib inhibits the reaction [Quinolinic Acid results in decreased expression of CAT protein] CTD PMID:20043943 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO rofecoxib results in increased expression of CCL2 mRNA CTD PMID:17070997 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions
increases expression 		ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL20 protein]
rofecoxib results in increased expression of CCL20 mRNA; rofecoxib results in increased expression of CCL20 protein 		CTD PMID:17667525 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions 		ISO rofecoxib results in increased expression of CCL3 mRNA; rofecoxib results in increased expression of CCL3 protein
Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL3 protein] 		CTD PMID:17667525 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression 		ISO Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 mRNA]; Dinoprostone inhibits the reaction [rofecoxib results in increased expression of CCL5 protein]
rofecoxib results in increased expression of CCL5 mRNA; rofecoxib results in increased expression of CCL5 protein 		CTD PMID:17667525 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO rofecoxib inhibits the reaction [Carbon Tetrachloride results in increased expression of CCN2 protein] CTD PMID:17565644 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:22,621,501...22,624,976 		JBrowse link
G Cdh2 cadherin 2 affects expression ISO rofecoxib affects the expression of CDH2 mRNA CTD PMID:17070997 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:8,051,097...8,265,288 		JBrowse link
G Cdh3 cadherin 3 increases expression ISO rofecoxib results in increased expression of CDH3 mRNA CTD PMID:17070997 NCBI chr19:51,303,414...51,353,900
Ensembl chr19:51,300,083...51,354,257 		JBrowse link
G Cdsn corneodesmosin affects expression ISO rofecoxib affects the expression of CDSN mRNA CTD PMID:17070997 NCBI chr20:3,184,142...3,188,962
Ensembl chr20:3,183,808...3,188,962 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 affects expression ISO rofecoxib affects the expression of CEACAM1 mRNA CTD PMID:17070997 NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798 		JBrowse link
G Clu clusterin increases expression ISO rofecoxib results in increased expression of CLU mRNA CTD PMID:17070997 NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860 		JBrowse link
G Col14a1 collagen type XIV alpha 1 chain decreases expression ISO rofecoxib results in decreased expression of COL14A1 mRNA CTD PMID:17070997 NCBI chr 7:88,611,827...88,826,939
Ensembl chr 7:88,611,828...88,826,938 		JBrowse link
G Colec12 collectin sub-family member 12 decreases expression ISO rofecoxib results in decreased expression of COLEC12 mRNA CTD PMID:17070997 NCBI chr18:1,005,787...1,193,455
Ensembl chr18:1,005,741...1,195,297 		JBrowse link
G Crisp3 cysteine-rich secretory protein 3 increases expression ISO rofecoxib results in increased expression of CRISP3 mRNA CTD PMID:17070997 NCBI chr 9:27,928,591...27,969,205
Ensembl chr 9:27,895,536...27,969,198 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CX3CL1 mRNA CTD PMID:17070997 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO rofecoxib affects the expression of CXCL1 mRNA CTD PMID:17070997 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity 		ISO rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of Caffeine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]
rofecoxib results in decreased activity of CYP1A2 protein 		CTD PMID:15834531 PMID:16934051 PMID:18816299 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149 		JBrowse link
G Defb5 defensin beta 5 increases expression ISO rofecoxib results in increased expression of DEFB4 mRNA CTD PMID:17070997 NCBI chr16:77,315,424...77,317,828
Ensembl chr16:77,315,424...77,317,828 		JBrowse link
G Dsc1 desmocollin 1 affects expression ISO rofecoxib affects the expression of DSC1 mRNA CTD PMID:17070997 NCBI chr18:11,774,711...11,831,868
Ensembl chr18:11,775,010...11,803,522 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions ISO rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB] CTD PMID:12126971 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765 		JBrowse link
G Epha3 Eph receptor A3 decreases expression ISO rofecoxib results in decreased expression of EPHA3 mRNA CTD PMID:17070997 NCBI chr11:14,585,041...14,920,721
Ensembl chr11:14,586,727...14,920,425 		JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO rofecoxib results in decreased expression of EPHB6 mRNA CTD PMID:17070997 NCBI chr 4:71,458,632...71,473,889
Ensembl chr 4:71,458,971...71,476,659 		JBrowse link
G Etv5 ETS variant transcription factor 5 decreases expression ISO rofecoxib results in decreased expression of ETV5 mRNA CTD PMID:17070997 NCBI chr11:92,113,171...92,170,758
Ensembl chr11:92,113,224...92,170,767 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO rofecoxib results in decreased expression of FABP4 mRNA CTD PMID:17070997 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972 		JBrowse link
G Faf1 Fas associated factor 1 affects expression ISO rofecoxib affects the expression of FAF1 mRNA CTD PMID:17070997 NCBI chr 5:129,654,677...130,018,604
Ensembl chr 5:129,654,445...130,020,516 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 decreases expression ISO rofecoxib results in decreased expression of FAIM2 mRNA CTD PMID:17070997 NCBI chr 7:132,512,095...132,539,192
Ensembl chr 7:132,512,210...132,538,026 		JBrowse link
G Flnb filamin B increases expression ISO rofecoxib results in increased expression of FLNB mRNA CTD PMID:17070997 NCBI chr15:19,392,212...19,525,278
Ensembl chr15:19,392,216...19,525,209 		JBrowse link
G Foxd1 forkhead box D1 decreases expression ISO rofecoxib results in decreased expression of FOXD1 mRNA CTD PMID:17070997 NCBI chr 2:31,436,802...31,439,222
Ensembl chr 2:31,436,813...31,439,399 		JBrowse link
G Frzb frizzled-related protein affects expression ISO rofecoxib affects the expression of FRZB mRNA CTD PMID:17070997 NCBI chr 3:85,739,162...85,772,168
Ensembl chr 3:85,739,165...85,772,096 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO rofecoxib results in decreased expression of GATA3 mRNA CTD PMID:17070997 NCBI chr17:73,544,234...73,575,670
Ensembl chr17:73,553,548...73,575,670 		JBrowse link
G Hgf hepatocyte growth factor decreases expression ISO rofecoxib results in decreased expression of HGF mRNA CTD PMID:17070997 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase decreases expression ISO rofecoxib results in decreased expression of HPGD mRNA CTD PMID:17070997 NCBI chr16:38,996,876...39,034,831
Ensembl chr16:38,996,876...39,034,831 		JBrowse link
G Il1a interleukin 1 alpha affects expression
decreases expression 		ISO rofecoxib affects the expression of IL1A mRNA
rofecoxib results in decreased expression of IL1A mRNA 		CTD PMID:17070997 PMID:32816093 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP 		rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; rofecoxib inhibits the reaction [IL1B results in increased activity of EDNRB]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib promotes the reaction [Acetic Acid results in increased expression of IL1B protein] 		CTD PMID:11376495 PMID:12126971 PMID:14762100 PMID:15705740 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO rofecoxib results in increased expression of IL1RN mRNA CTD PMID:17070997 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732 		JBrowse link
G Il6 interleukin 6 increases expression ISO rofecoxib results in increased expression of IL6 mRNA; rofecoxib results in increased expression of IL6 protein CTD PMID:17070997 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Insm1 INSM transcriptional repressor 1 decreases expression ISO rofecoxib results in decreased expression of INSM1 mRNA CTD PMID:17070997 NCBI chr 3:154,093,310...154,096,243
Ensembl chr 3:154,092,734...154,096,047 		JBrowse link
G Itgbl1 integrin subunit beta like 1 affects expression ISO rofecoxib affects the expression of ITGBL1 mRNA CTD PMID:17070997 NCBI chr15:107,186,792...107,448,335
Ensembl chr15:107,186,689...107,451,098 		JBrowse link
G Klf12 KLF transcription factor 12 affects expression ISO rofecoxib affects the expression of KLF12 mRNA CTD PMID:17070997 NCBI chr15:83,037,548...83,469,998
Ensembl chr15:83,045,463...83,670,640 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP rofecoxib inhibits the reaction [Dimethoate results in increased expression of LHB protein] CTD PMID:19579042 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445 		JBrowse link
G Lifr LIF receptor subunit alpha decreases expression ISO rofecoxib results in decreased expression of LIFR mRNA CTD PMID:17070997 NCBI chr 2:57,951,787...58,020,357
Ensembl chr 2:57,952,975...58,020,364 		JBrowse link
G Lmx1a LIM homeobox transcription factor 1 alpha increases expression ISO rofecoxib results in increased expression of LMX1A mRNA CTD PMID:17070997 NCBI chr13:82,367,493...82,511,157
Ensembl chr13:82,367,933...82,511,154 		JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO rofecoxib results in increased expression of MAL mRNA CTD PMID:17070997 NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:135,317,664...135,341,423 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 decreases expression ISO rofecoxib results in decreased expression of MAPRE2 mRNA CTD PMID:17070997 NCBI chr18:15,303,502...15,444,306
Ensembl chr18:15,303,533...15,442,796 		JBrowse link
G Mbtd1 mbt domain containing 1 decreases expression ISO rofecoxib results in decreased expression of MBTD1 mRNA CTD PMID:17070997 NCBI chr10:79,336,041...79,392,315
Ensembl chr10:79,335,235...79,392,315 		JBrowse link
G Mef2c myocyte enhancer factor 2C affects expression ISO rofecoxib affects the expression of MEF2C mRNA CTD PMID:17070997 NCBI chr 2:15,708,732...15,871,639
Ensembl chr 2:15,708,924...15,871,640 		JBrowse link
G Meox2 mesenchyme homeobox 2 decreases expression ISO rofecoxib results in decreased expression of MEOX2 mRNA CTD PMID:17070997 NCBI chr 6:59,584,025...59,644,722
Ensembl chr 6:59,583,785...59,644,700 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO rofecoxib results in increased expression of MMP1 mRNA CTD PMID:16580899 NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO rofecoxib results in increased expression of MMP3 mRNA CTD PMID:16580899 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:12,925,280...12,938,826 		JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO rofecoxib affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502 		JBrowse link
G Mta2 metastasis associated 1 family, member 2 decreases expression ISO rofecoxib results in decreased expression of MTA2 mRNA CTD PMID:17070997 NCBI chr 1:215,267,286...215,276,008
Ensembl chr 1:215,267,046...215,276,062 		JBrowse link
G Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 decreases expression ISO rofecoxib results in decreased expression of NAALADL2 mRNA CTD PMID:17070997 NCBI chr 2:108,568,000...109,920,650
Ensembl chr 2:108,573,985...109,920,756 		JBrowse link
G Nfasc neurofascin decreases expression ISO rofecoxib results in decreased expression of NFASC mRNA CTD PMID:17070997 NCBI chr13:46,549,369...46,735,989
Ensembl chr13:46,549,369...46,736,139 		JBrowse link
G Ngf nerve growth factor multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NGF protein] CTD PMID:16879691 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834 		JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO rofecoxib affects the expression of NOS1 mRNA CTD PMID:17070997 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP rofecoxib inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:16879691 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions EXP rofecoxib inhibits the reaction [Lead results in increased expression of NOX1 mRNA]; rofecoxib inhibits the reaction [Mercuric Chloride results in increased expression of NOX1 mRNA] CTD PMID:23415682 PMID:25596430 NCBI chr  X:101,572,338...101,625,571
Ensembl chr  X:101,572,340...101,595,520 		JBrowse link
G Npas3 neuronal PAS domain protein 3 increases expression ISO rofecoxib results in increased expression of NPAS3 mRNA CTD PMID:17070997 NCBI chr 6:76,438,064...77,263,185
Ensembl chr 6:76,438,260...77,263,185 		JBrowse link
G Npr2 natriuretic peptide receptor 2 decreases expression ISO rofecoxib results in decreased expression of NPR2 mRNA CTD PMID:17070997 NCBI chr 5:62,678,197...62,697,360
Ensembl chr 5:62,678,367...62,697,343 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO rofecoxib affects the expression of NQO1 mRNA CTD PMID:17070997 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha decreases expression ISO rofecoxib results in decreased expression of PI4KA mRNA CTD PMID:17070997 NCBI chr11:97,113,390...97,234,374
Ensembl chr11:97,113,245...97,228,315 		JBrowse link
G Pla2g2a phospholipase A2 group IIA affects expression ISO rofecoxib affects the expression of PLA2G2A mRNA CTD PMID:17070997 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
G Pla2g4a phospholipase A2 group 4A multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO rofecoxib results in increased expression of PLAT mRNA CTD PMID:16580899 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696 		JBrowse link
G Pml PML nuclear body scaffold increases expression ISO rofecoxib results in increased expression of PML mRNA CTD PMID:17070997 NCBI chr 8:67,523,164...67,557,801
Ensembl chr 8:67,523,164...67,576,083 		JBrowse link
G Postn periostin affects expression ISO rofecoxib affects the expression of POSTN mRNA CTD PMID:17070997 NCBI chr 2:140,677,774...140,709,304
Ensembl chr 2:140,677,754...140,709,300 		JBrowse link
G Prrx1 paired related homeobox 1 affects expression ISO rofecoxib affects the expression of PRRX1 mRNA CTD PMID:17070997 NCBI chr13:78,136,783...78,205,379
Ensembl chr13:78,136,783...78,204,058 		JBrowse link
G Ptger3 prostaglandin E receptor 3 decreases expression ISO rofecoxib results in decreased expression of PTGER3 mRNA CTD PMID:17070997 NCBI chr 2:249,264,985...249,409,966
Ensembl chr 2:249,264,985...249,409,846 		JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression ISO rofecoxib results in decreased expression of PTGIS mRNA CTD PMID:17175104 NCBI chr 3:176,347,589...176,383,251
Ensembl chr 3:176,335,437...176,407,650 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression 		ISO rofecoxib analog results in decreased activity of PTGS1 protein; rofecoxib results in decreased activity of PTGS1 protein
rofecoxib results in decreased expression of PTGS1 mRNA 		CTD PMID:16141368 PMID:17175104 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases response to substance
multiple interactions
decreases activity
increases expression
decreases expression 		ISO
EXP 		PTGS2 promoter SNP results in increased susceptibility to rofecoxib
[rofecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [rofecoxib inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
rofecoxib results in increased expression of PTGS2 mRNA
PTGS2 inhibits the reaction [rofecoxib results in increased uptake of Hexoses]
rofecoxib results in decreased expression of PTGS2 mRNA
[rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Furosemide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] inhibits the reaction [Hydrochlorothiazide results in increased abundance of Prostaglandins]; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone; [rofecoxib results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Lipopolysaccharides; Dinoprostone results in decreased susceptibility to [rofecoxib results in decreased activity of PTGS2 protein] 		CTD PMID:10594344 PMID:11245490 PMID:11321505 PMID:11703585 PMID:12110471 More... NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Rasa1 RAS p21 protein activator 1 affects expression ISO rofecoxib affects the expression of RASA1 mRNA CTD PMID:17070997 NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161 		JBrowse link
G Rnf144b ring finger protein 144B increases expression ISO rofecoxib results in increased expression of RNF144B mRNA CTD PMID:17070997 NCBI chr17:17,637,564...17,786,685
Ensembl chr17:17,639,079...17,769,037 		JBrowse link
G Rorc RAR-related orphan receptor C decreases expression ISO rofecoxib results in decreased expression of RORC mRNA CTD PMID:17070997 NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:184,698,818...184,724,566 		JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO rofecoxib results in increased expression of SCD mRNA CTD PMID:17070997 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO rofecoxib results in increased expression of SERPINA3 mRNA CTD PMID:17070997 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:129,088,398...129,097,415 		JBrowse link
G Sh2d1a SH2 domain containing 1A decreases expression ISO rofecoxib results in decreased expression of SH2D1A mRNA CTD PMID:17070997 NCBI chr  X:126,239,191...126,267,425
Ensembl chr  X:126,239,200...126,267,424 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO SLC2A1 inhibits the reaction [rofecoxib results in increased uptake of Hexoses] CTD PMID:16447059 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
multiple interactions 		ISO rofecoxib results in increased expression of SLC2A4 mRNA; rofecoxib results in increased expression of SLC2A4 protein
[rofecoxib results in increased expression of SLC2A4 protein] which results in increased uptake of Hexoses 		CTD PMID:16447059 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO rofecoxib results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO rofecoxib results in increased expression of SOCS3 mRNA; rofecoxib results in increased expression of SOCS3 protein CTD PMID:17070997 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO rofecoxib inhibits the reaction [PLA2G4A gene mutant form results in decreased expression of SOD1 protein] CTD PMID:15816863 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO rofecoxib results in increased expression of SOD2 mRNA CTD PMID:17070997 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression ISO rofecoxib results in increased expression of STAT3 mRNA CTD PMID:17070997 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO rofecoxib results in increased expression of TAC1 protein CTD PMID:16449370 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546 		JBrowse link
G Tead4 TEA domain transcription factor 4 increases expression ISO rofecoxib results in increased expression of TEAD4 mRNA CTD PMID:17070997 NCBI chr 4:163,180,192...163,258,342
Ensembl chr 4:163,180,192...163,258,479 		JBrowse link
G Tfrc transferrin receptor affects expression ISO rofecoxib affects the expression of TFRC mRNA CTD PMID:17070997 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression ISO rofecoxib results in decreased expression of TIMP3 mRNA CTD PMID:16580899 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO rofecoxib results in increased expression of TMPRSS4 mRNA CTD PMID:17070997 NCBI chr 8:54,372,805...54,405,157
Ensembl chr 8:54,372,805...54,405,157 		JBrowse link
G Tnc tenascin C increases expression ISO rofecoxib results in increased expression of TNC mRNA CTD PMID:17070997 NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression 		EXP
ISO 		rofecoxib promotes the reaction [Acetic Acid results in increased expression of TNF protein]
rofecoxib results in decreased expression of TNF protein 		CTD PMID:11376495 PMID:17878525 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trim17 tripartite motif-containing 17 affects expression ISO rofecoxib affects the expression of TRIM17 mRNA CTD PMID:17070997 NCBI chr10:44,242,688...44,250,504
Ensembl chr10:44,240,184...44,250,494 		JBrowse link
G Tspan2 tetraspanin 2 decreases expression ISO rofecoxib results in decreased expression of TSPAN2 mRNA CTD PMID:17070997 NCBI chr 2:192,866,212...192,923,489
Ensembl chr 2:192,866,237...192,923,487 		JBrowse link
G Vcan versican decreases expression ISO rofecoxib results in decreased expression of VCAN mRNA CTD PMID:17070997 NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:22,497,035...22,595,955 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        pharmacological role 19772
          analgesic 14742
            rofecoxib 110
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  ester 17841
                                    carboxylic ester 17347
                                      lactone 13231
                                        gamma-lactone 6873
                                          butenolide 6418
                                            rofecoxib 110
paths to the root