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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rivastigmine
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Accession:CHEBI:8874 term browser browse the term
Definition:A carbamate ester obtained by formal condensation of the carboxy group of ethyl(methyl)carbamic acid with the phenolic OH group of 3-[(1S)-1-(dimethylamino)ethyl]phenol. A reversible cholinesterase inhibitor.
Synonyms:exact_synonym: 3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
 related_synonym: (S)-3-(1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate;   Formula=C14H22N2O2;   InChI=1S/C14H22N2O2/c1-6-16(5)14(17)18-13-9-7-8-12(10-13)11(2)15(3)4/h7-11H,6H2,1-5H3/t11-/m0/s1;   InChIKey=XSVMFMHYUFZWBK-NSHDSACASA-N;   SMILES=CCN(C)C(=O)Oc1cccc(c1)[C@H](C)N(C)C;   m-((S)-1-(Dimethylamino)ethyl)phenyl ethylmethylcarbamate
 xref: CAS:123441-03-2;   DrugBank:DB00989;   Drug_Central:2392;   KEGG:C11766;   KEGG:D03822;   LINCS:LSM-5280
 xref_mesh: MESH:C072506
 xref: PMID:19032006;   PMID:19370562;   PMID:19392927;   PMID:19619073;   PMID:19893314;   PMID:20070789;   PMID:20370805;   PMID:20865460;   PMID:21131668;   PMID:21246897;   PMID:21977379;   PMID:21996001;   PMID:22009228;   PMID:22010358;   PMID:22044027;   PMID:22054233;   PMID:22068922;   PMID:22087207;   PMID:22163241;   PMID:22163242;   PMID:22163243;   PMID:22173266;   PMID:22195801;   PMID:22224039;   PMID:22230648;   PMID:22230878;   PMID:22290743;   PMID:22362231;   PMID:22409834;   PMID:22451057;   Patent:DE3805744;   Patent:EP1980552;   Patent:EP2233465;   Patent:US2008255383;   Patent:US2009298817;   Patent:US5602176;   Reaxys:7875788;   Wikipedia:Rivastigmine
 cyclic_relationship: is_conjugate_base_of CHEBI:64363


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rivastigmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions EXP Rivastigmine inhibits the reaction [Colchicine results in decreased expression of ACE protein] CTD PMID:17652827 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ache acetylcholinesterase affects activity
multiple interactions
decreases activity		 EXP
ISO		 Rivastigmine affects the activity of ACHE protein
AFDX 384 affects the reaction [Rivastigmine affects the activity of ACHE protein]; Rivastigmine inhibits the reaction [[Botulinum Toxins, Type A results in increased expression of and results in increased activity of ACHE protein] which results in decreased abundance of Acetylcholine]; Rivastigmine inhibits the reaction [Aluminum Chloride results in increased activity of ACHE protein]; Rivastigmine inhibits the reaction [Aluminum Chloride results in increased expression of ACHE mRNA]; Rivastigmine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
Rivastigmine results in decreased activity of ACHE protein		 CTD PMID:12111444 PMID:15135892 PMID:18571635 PMID:19345205 PMID:30588862 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA] CTD PMID:32805344 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in increased expression of BAX protein] CTD PMID:32805344 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase decreases activity EXP
ISO		 Rivastigmine results in decreased activity of BCHE protein CTD PMID:14535624 PMID:19345205 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein] CTD PMID:32805344 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of BDNF protein] CTD PMID:32805344 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein] CTD PMID:32805344 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Rivastigmine inhibits the reaction [Aluminum Chloride results in decreased activity of CAT protein] CTD PMID:30588862 PMID:34663170 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO Rivastigmine results in decreased activity of CES1 protein CTD PMID:23123248 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity ISO Rivastigmine results in decreased activity of CES2 protein CTD PMID:23123248 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chat choline O-acetyltransferase multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of CHAT protein] CTD PMID:32805344 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions
affects binding		 ISO Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]
Rivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein]		 CTD PMID:15733544 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit affects binding
multiple interactions		 ISO Rivastigmine binds to [CHRNA4 protein binds to CHRNB2 protein]
Rivastigmine inhibits the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]]		 CTD PMID:15733544 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Crp C-reactive protein multiple interactions EXP Rivastigmine inhibits the reaction [Botulinum Toxins, Type A results in increased expression of CRP protein] CTD PMID:29739252 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Rivastigmine results in increased activity of HSF1 protein CTD PMID:19218096 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein] CTD PMID:32805344 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Insr insulin receptor multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] CTD PMID:32805344 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA] CTD PMID:32805344 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP Rivastigmine inhibits the reaction [Homocysteine results in decreased expression of NTRK2 protein] CTD PMID:39357784 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA] CTD PMID:32805344 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA] CTD PMID:32805344 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [Rivastigmine co-treated with donepezil] results in decreased expression of PTGS1 mRNA; [Rivastigmine co-treated with donepezil] results in decreased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine co-treated with donepezil] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine co-treated with donepezil] results in increased expression of PTGS1 protein; [Sodium Fluoride co-treated with Rivastigmine] results in increased expression of PTGS1 mRNA; [Sodium Fluoride co-treated with Rivastigmine] results in increased expression of PTGS1 protein CTD PMID:29777723 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO [donepezil co-treated with Rivastigmine] results in decreased expression of PTGS2 protein; [Rivastigmine co-treated with donepezil] results in decreased expression of PTGS2 mRNA
Rivastigmine results in decreased expression of PTGS2 mRNA; Rivastigmine results in decreased expression of PTGS2 protein		 CTD PMID:29777723 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Rivastigmine inhibits the reaction [Streptozocin results in increased expression of RELA protein] CTD PMID:32805344 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Rivastigmine inhibits the reaction [Botulinum Toxins, Type A results in increased expression of TNF protein]; Rivastigmine inhibits the reaction [Streptozocin results in increased expression of TNF protein] CTD PMID:29739252 PMID:32805344 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Rivastigmine metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Rivastigmine inhibits the reaction [Homocysteine results in decreased expression of VEGFA protein] CTD PMID:39357784 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        pharmacological role 19080
          neurotransmitter agent 16797
            cholinergic drug 5361
              rivastigmine 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    main group molecular entity 19817
                      s-block molecular entity 19653
                        hydrogen molecular entity 19634
                          hydrides 19144
                            inorganic hydride 18161
                              pnictogen hydride 18151
                                nitrogen hydride 18064
                                  azane 17872
                                    ammonia 17871
                                      organic amino compound 17871
                                        tertiary amino compound 10153
                                          rivastigmine 26
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