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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:risperidone
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Accession:CHEBI:8871 term browser browse the term
Definition:A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2.
Synonyms:exact_synonym: 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
 related_synonym: Formula=C23H27FN4O2;   InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3;   InChIKey=RAPZEAPATHNIPO-UHFFFAOYSA-N;   Risperdal;   Risperin;   Rispolept;   Rispolin;   SMILES=Cc1nc2CCCCn2c(=O)c1CCN1CCC(CC1)c1noc2cc(F)ccc12;   Sequinan;   risperidona;   risperidonum
 xref: CAS:106266-06-2;   DrugBank:DB00734;   Drug_Central:2389;   HMDB:HMDB0005020;   KEGG:D00426;   LINCS:LSM-3193
 xref_mesh: MESH:D018967
 xref: PMID:11229618;   PMID:11476125;   PMID:14687852;   PMID:14728058;   PMID:15096074;   PMID:17054229;   PMID:18545060;   PMID:18722468;   PMID:19412457;   PMID:20825390;   PMID:23327578;   Patent:EP196132;   Patent:US4804663;   Reaxys:4891881;   Wikipedia:Risperidone



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risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects abundance
affects response to substance
increases response to substance
multiple interactions
increases transport
increases export
decreases activity
ISO
EXP
ABCB1 gene polymorphism affects the abundance of Risperidone; ABCB1 protein affects the abundance of Risperidone
ABCB1 gene polymorphism affects the susceptibility to Risperidone; ABCB1 protein affects the susceptibility to Risperidone
ABCB1 protein results in increased susceptibility to Risperidone
Risperidone inhibits the reaction [ABCB1 protein results in decreased export of Doxorubicin]
ABCB1 protein results in increased transport of Risperidone
ABCB1A protein affects the susceptibility to Risperidone
ABCB1A protein results in increased export of Risperidone
Risperidone results in decreased activity of ABCB1 protein
ABCB1A protein results in increased transport of Risperidone
Cyclosporine inhibits the reaction [ABCB1A protein results in increased export of Risperidone]
CTD PMID:15502009 PMID:16118767 PMID:16810505 PMID:16936711 PMID:17054409 More... NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Risperidone CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156 JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Risperidone inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone]; Risperidone inhibits the reaction [ABCG2 protein results in increased uptake of estrone sulfate] CTD PMID:18834354 NCBI chr 4:89,006,056...89,132,915 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
increases expression
ISO Berberine inhibits the reaction [Risperidone results in increased expression of ADIPOQ mRNA] CTD PMID:20564506 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
EXP
ISO
Risperidone results in decreased expression of BDNF mRNA
Risperidone inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA]
BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
CTD PMID:12393228 PMID:17442543 PMID:19997080 NCBI chr 3:116,619,633...116,670,212 JBrowse link
G Calm2 calmodulin 2 increases expression EXP Risperidone results in increased expression of CALM2 mRNA CTD PMID:19289156 NCBI chr 6:12,845,170...12,857,830 JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha decreases expression EXP Risperidone results in decreased expression of CAMK2A protein CTD PMID:19289156 NCBI chr18:56,648,779...56,711,505 JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression EXP Risperidone results in decreased expression of CAMK4 protein CTD PMID:19289156 NCBI chr18:24,857,152...25,076,054 JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 decreases expression EXP Risperidone results in decreased expression of CAMKK1 protein CTD PMID:19289156 NCBI chr10:57,637,335...57,660,498 JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 decreases expression EXP Risperidone results in decreased expression of CAMKK2 protein CTD PMID:19289156 NCBI chr12:33,791,023...33,845,000 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP3 protein] CTD PMID:22700542 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP7 protein] CTD PMID:22700542 NCBI chr 1:265,442,647...265,481,938 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions
increases expression
ISO Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of CEBPA protein]
Risperidone results in increased expression of CEBPA mRNA; Risperidone results in increased expression of CEBPA protein
CTD PMID:20564506 NCBI chr 1:96,896,584...96,899,256 JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects response to substance ISO CHRM4 affects the susceptibility to Risperidone CTD PMID:21269601 NCBI chr 3:77,893,425...77,901,166 JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Risperidone results in increased expression of COMT mRNA CTD PMID:15964593 NCBI chr11:96,072,371...96,091,956 JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Risperidone results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,059,184...104,061,048 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
EXP DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein] CTD PMID:16144542 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
affects abundance
decreases metabolic processing
decreases hydroxylation
affects response to substance
increases response to substance
increases metabolic processing
ISO CYP2D6 gene polymorphism affects the metabolism of Risperidone; CYP2D6 protein affects the metabolism of Risperidone
CYP2D6 gene polymorphism affects the metabolism of and affects the abundance of Risperidone; CYP2D6 protein affects the metabolism of and affects the abundance of Risperidone
CYP2D6 gene polymorphism affects the abundance of Risperidone; CYP2D6 protein affects the abundance of Risperidone
CYP2D6 gene polymorphism results in decreased metabolism of Risperidone
CYP2D6 gene polymorphism results in decreased hydroxylation of Risperidone
CYP2D6 gene polymorphism affects the susceptibility to Risperidone; CYP2D6 protein polymorphism affects the susceptibility to Risperidone
CYP2D6 protein results in increased susceptibility to Risperidone
CYP2D6 protein results in increased metabolism of Risperidone
CTD PMID:10639689 PMID:15089809 PMID:15260906 PMID:15565299 PMID:15669884 More... NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects response to substance
ISO N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]
CYP3A4 gene polymorphism affects the susceptibility to Risperidone; CYP3A4 protein affects the susceptibility to Risperidone
CTD PMID:19395426 PMID:21402137 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects abundance
increases metabolic processing
ISO CYP3A5 gene polymorphism affects the abundance of Risperidone; CYP3A5 protein affects the abundance of Risperidone
CYP3A5 protein results in increased metabolism of Risperidone
CTD PMID:18708991 PMID:20332423 NCBI chr12:21,919,955...21,960,160 JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
affects response to substance
increases response to substance
affects binding
ISO
EXP
Risperidone binds to and results in decreased activity of DRD2 protein
DRD2 gene polymorphism affects the susceptibility to Risperidone
DRD2 gene polymorphism results in increased susceptibility to Risperidone; DRD2 gene SNP results in increased susceptibility to Risperidone; DRD2 protein results in increased susceptibility to Risperidone
Risperidone binds to DRD2 protein
[Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; DRD2 protein affects the reaction [Risperidone results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]; Risperidone binds to and results in decreased activity of DRD2 protein; Risperidone inhibits the reaction [Apomorphine binds to and results in increased activity of DRD2 protein]; Risperidone promotes the reaction [Dopamine binds to DRD2 protein]
CTD PMID:1380082 PMID:7520908 PMID:8804920 PMID:10831489 PMID:12191584 More... NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Drd3 dopamine receptor D3 increases response to substance ISO DRD3 gene SNP results in increased susceptibility to Risperidone; DRD3 protein results in increased susceptibility to Risperidone CTD PMID:19506579 PMID:19997080 NCBI chr11:70,385,586...70,437,793 JBrowse link
G Dvl3 dishevelled segment polarity protein 3 multiple interactions
increases expression
EXP DRD2 protein affects the reaction [Risperidone results in increased expression of DVL3 protein] CTD PMID:16144542 NCBI chr11:80,365,446...80,382,641 JBrowse link
G Egr1 early growth response 1 decreases expression EXP Risperidone results in decreased expression of EGR1 protein CTD PMID:17028028 NCBI chr18:26,737,078...26,740,877 JBrowse link
G Egr2 early growth response 2 decreases expression
multiple interactions
EXP
ISO
Risperidone results in decreased expression of EGR2 protein
Risperidone inhibits the reaction [Toluene promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR2 protein]]
CTD PMID:17028028 PMID:32980479 NCBI chr20:21,050,149...21,055,201 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases phosphorylation EXP Risperidone results in increased phosphorylation of ERBB2 protein CTD PMID:26961615 NCBI chr10:83,907,491...83,931,365 JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 multiple interactions EXP Risperidone results in increased expression of and results in increased phosphorylation of ERBB4 protein CTD PMID:26961615 NCBI chr 9:76,973,386...78,045,633 JBrowse link
G Fads2 fatty acid desaturase 2 increases expression
multiple interactions
EXP Risperidone results in increased expression of FADS2 mRNA
[Risperidone results in increased expression of FADS2 mRNA] which results in increased abundance of Fatty Acids, Unsaturated
CTD PMID:21458237 NCBI chr 1:216,132,277...216,172,190 JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Risperidone results in increased expression of FAS mRNA] CTD PMID:20564506 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Risperidone promotes the reaction [Rotenone results in increased expression of FOS mRNA]
Risperidone results in increased expression of FOS mRNA
Risperidone results in increased expression of FOS protein
Dronabinol inhibits the reaction [Risperidone results in increased expression of FOS protein]; Risperidone inhibits the reaction [Toluene promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of FOS protein]]
CTD PMID:11516571 PMID:17442543 PMID:28272498 PMID:32980479 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Fshb follicle stimulating hormone subunit beta affects expression ISO Risperidone affects the expression of FSHB protein CTD PMID:18838228 NCBI chr 3:114,003,262...114,007,072 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GGT1 protein]; Risperidone results in increased expression of and results in increased secretion of GGT1 protein CTD PMID:27387968 NCBI chr20:13,074,141...13,103,551 JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GOT1 protein]; Risperidone results in increased expression of and results in increased secretion of GOT1 protein CTD PMID:27387968 NCBI chr 1:252,306,541...252,337,622 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Acetylcysteine inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; coenzyme Q10 inhibits the reaction [Risperidone results in increased expression of and results in increased secretion of GPT protein]; Risperidone results in increased expression of and results in increased secretion of GPT protein CTD PMID:27387968 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases expression
multiple interactions
EXP Risperidone results in increased expression of GSK3A protein
DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3A protein]
CTD PMID:16144542 NCBI chr 1:80,815,843...80,825,732 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases expression
EXP DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein] CTD PMID:16144542 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Risperidone results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:29,732,163...29,754,276 JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Risperidone results in increased expression of HOMER1 mRNA CTD PMID:20147574 NCBI chr 2:24,542,777...24,645,715 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases response to substance
multiple interactions
EXP HTR1A protein results in increased susceptibility to Risperidone
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Risperidone]
CTD PMID:17530476 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases response to substance
affects response to substance
multiple interactions
affects binding
ISO
EXP
HTR2A gene SNP results in increased susceptibility to Risperidone; HTR2A protein results in increased susceptibility to Risperidone
HTR2A protein affects the susceptibility to Risperidone
HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; Risperidone binds to and results in decreased activity of HTR2A protein
Risperidone binds to and results in decreased activity of HTR2A protein; Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]
Risperidone binds to HTR2A protein
CTD PMID:7520908 PMID:11927170 PMID:12191584 PMID:16314884 PMID:16948927 More... NCBI chr15:56,360,647...56,428,703 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects response to substance
increases response to substance
multiple interactions
ISO HTR2C gene polymorphism affects the susceptibility to Risperidone; HTR2C protein affects the susceptibility to Risperidone
HTR2C protein results in increased susceptibility to Risperidone
HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
CTD PMID:19142101 PMID:19997080 NCBI chr  X:110,640,777...110,870,288 JBrowse link
G Htr6 5-hydroxytryptamine receptor 6 multiple interactions ISO HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein] CTD PMID:19997080 NCBI chr 5:151,295,269...151,312,853 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO 2-((2-(dimethylamino)ethyl)thio)-3-phenylquinoline inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; [Risperidone binds to and results in decreased activity of HTR7 protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]; Clozapine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; mesulergine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Mianserin inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]; Risperidone binds to and results in decreased activity of HTR7 protein; SB 269970 inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein] CTD PMID:18996971 PMID:19509219 PMID:20827463 NCBI chr 1:243,049,064...243,173,636 JBrowse link
G Inha inhibin subunit alpha multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr 9:84,443,109...84,446,010 JBrowse link
G Inhbb inhibin subunit beta B multiple interactions ISO Risperidone results in increased expression of [INHA protein binds to INHBB protein] CTD PMID:18838228 NCBI chr13:33,083,671...33,089,373 JBrowse link
G Ins2 insulin 2 increases expression ISO Risperidone results in increased expression of INS protein CTD PMID:11927762 PMID:16601995 NCBI chr 1:207,272,738...207,421,998 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Risperidone inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:21158687 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions
increases expression
ISO Berberine inhibits the reaction [Risperidone results in increased expression of LDLR mRNA] CTD PMID:20564506 NCBI chr 8:28,546,191...28,569,075 JBrowse link
G Maoa monoamine oxidase A affects response to substance
increases response to substance
ISO MAOA gene polymorphism affects the susceptibility to Risperidone
MAOA protein results in increased susceptibility to Risperidone
CTD PMID:22544010 NCBI chr  X:8,615,239...8,681,372 JBrowse link
G Maob monoamine oxidase B increases expression EXP Risperidone results in increased expression of MAOB mRNA CTD PMID:15964593 NCBI chr  X:8,490,405...8,594,065 JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP Risperidone results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:75,173,038...75,431,606 JBrowse link
G Ngfr nerve growth factor receptor decreases expression EXP Risperidone results in decreased expression of NGFR mRNA CTD PMID:12111809 PMID:16513140 NCBI chr10:81,012,077...81,030,305 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA]]; Risperidone promotes the reaction [NR1I2 protein results in increased expression of CYP3A4 mRNA] CTD PMID:21402137 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Nrg1 neuregulin 1 increases expression EXP Risperidone results in increased expression of NRG1 protein CTD PMID:26961615 NCBI chr16:65,954,084...67,007,484 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions
ISO Risperidone results in increased expression of PPARG mRNA; Risperidone results in increased expression of PPARG protein
Berberine inhibits the reaction [Risperidone results in increased expression of PPARG mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of PPARG protein]
CTD PMID:20564506 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
decreases expression
EXP [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein
Risperidone results in decreased expression of PPP3CA mRNA; Risperidone results in decreased expression of PPP3CA protein
CTD PMID:16033416 NCBI chr 2:227,839,058...228,113,560 JBrowse link
G Prl prolactin multiple interactions
increases secretion
increases expression
ISO
EXP
[Risperidone co-treated with Clozapine] results in increased expression of PRL protein; Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein]; BDNF gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]; HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]
Risperidone inhibits the reaction [Dopamine results in decreased secretion of PRL protein]
CTD PMID:1380082 PMID:9696519 PMID:9989566 PMID:10084644 PMID:11048906 More... NCBI chr17:37,859,999...37,870,062 JBrowse link
G Rgs2 regulator of G-protein signaling 2 increases expression EXP Risperidone results in increased expression of RGS2 mRNA CTD PMID:11516571 NCBI chr13:58,350,063...58,352,666 JBrowse link
G S100b S100 calcium binding protein B increases secretion EXP Risperidone results in increased secretion of S100B protein CTD PMID:18421423 NCBI chr20:12,372,345...12,381,159 JBrowse link
G Slc17a6 solute carrier family 17 member 6 increases expression ISO Risperidone results in increased expression of SLC17A6 mRNA; Risperidone results in increased expression of SLC17A6 protein CTD PMID:18155072 NCBI chr 1:110,348,447...110,388,499 JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene SNP affects the susceptibility to Risperidone CTD PMID:15823421 NCBI chr 3:144,494,579...144,576,449 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
EXP Risperidone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SOD1 mRNA]; Risperidone inhibits the reaction [Haloperidol results in decreased expression of SOD1 protein]
Risperidone results in increased expression of SOD1 mRNA
CTD PMID:12111809 PMID:12752374 PMID:16564057 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression
ISO Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 mRNA]; Berberine inhibits the reaction [Risperidone results in increased expression of SREBF1 protein]
Risperidone results in increased expression of SREBF1 mRNA; Risperidone results in increased expression of SREBF1 protein
CTD PMID:20564506 NCBI chr10:45,507,152...45,529,164 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions EXP Risperidone inhibits the reaction [Rotenone results in decreased expression of STAT3 mRNA] CTD PMID:17442543 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Th tyrosine hydroxylase increases expression EXP Risperidone results in increased expression of TH protein CTD PMID:17028028 NCBI chr 1:207,500,959...207,508,276 JBrowse link

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  CHEBI ontology 19898
    role 19869
      biological role 19867
        pharmacological role 19102
          antagonist 17260
            dopaminergic antagonist 1641
              risperidone 65
Path 2
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  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19770
                          organic molecular entity 19770
                            organic molecule 19724
                              organic cyclic compound 19516
                                organic heterocyclic compound 18896
                                  organic heteropolycyclic compound 18323
                                    organic heterobicyclic compound 17262
                                      benzoxazole 136
                                        benzisoxazole 78
                                          1,2-benzoxazoles 78
                                            risperidone 65
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