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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:azaperone
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Accession:CHEBI:88301 term browser browse the term
Definition:An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.
Synonyms:exact_synonym: 1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one
 related_synonym: 1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine;   1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone;   4'-Fluoro-4-(4-(2-pyridyl)-1-piperazinyl)butyrophenone;   Azaperon;   Formula=C19H22FN3O;   InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2;   InChIKey=XTKDAFGWCDAMPY-UHFFFAOYSA-N;   NSC 170976;   SMILES=C1=C(C=CC(=C1)C(CCCN2CCN(CC2)C3=CC=CC=N3)=O)F;   Stresnil;   azaperona;   azaperonum
 xref: CAS:1649-18-9;   KEGG:D02620;   LINCS:LSM-3012
 xref_mesh: MESH:D001376
 xref: PMID:10982132;   PMID:12398308;   PMID:17186408;   PMID:17386737;   PMID:17929705;   PMID:17939346;   PMID:18689666;   PMID:18817017;   PMID:19111512;   PMID:19395755;   PMID:19395756;   PMID:19579764;   PMID:20006891;   PMID:21210371;   PMID:22287670;   PMID:23140663;   PMID:24490337;   PMID:24712163;   PMID:24807358;   PMID:25105814;   PMID:25655411;   PMID:26056882;   Reaxys:565491;   VSDB:1871;   Wikipedia:Azaperone


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azaperone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Azaperone results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        pharmacological role 19072
          antagonist 17233
            dopaminergic antagonist 1639
              azaperone 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        aromatic amine 15478
                                          aminopyridine 516
                                            azaperone 1
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