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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prasugrel hydrochloride
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Accession:CHEBI:87697 term browser browse the term
Definition:A racemate comprising equal amounts of (R)- and (S)-prasugrel hydrochloride. Used to prevent blood clots in people with acute coronary syndrome who are undergoing a procedure after a recent heart attack or stroke, and in people with certain disorders of the heart or blood vessels.
Synonyms:related_synonym: (RS)-prasugrel hydrochloride;   5-((1RS)-2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridin-2-yl acetate hydrochloride;   Effient;   LY 640315;   LY640315;   rac-2-(acetyloxy)-5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-ium chloride;   rac-5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate hydrochloride;   rac-prasugrel hydrochloride;   racemic prasugrel hydrochloride
 xref: CAS:389574-19-0;   DrugBank:DB06209
 xref_mesh: MESH:D000068799
 xref: Reaxys:11182898;   kegg.drug:D05597;   pubmed:25527979;   pubmed:25633751;   pubmed:26051687;   pubmed:26114771;   wikipedia.en:Prasugrel


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prasugrel hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of BDNF protein] CTD PMID:34174262 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased phosphorylation of CREB1 protein] CTD PMID:34174262 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Mir22 microRNA 22 multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of MIR22 mRNA] CTD PMID:34174262 NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,805,331...60,805,425 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased sumoylation of NFKBIA protein] CTD PMID:34174262 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G P2ry12 purinergic receptor P2Y12 multiple interactions ISO Prasugrel Hydrochloride binds to and results in decreased activity of P2RY12 protein CTD PMID:17681285 NCBI chr 2:145,631,487...145,673,194
Ensembl chr 2:145,629,967...145,633,410 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of SIRT1 protein] CTD PMID:34174262 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I multiple interactions EXP Prasugrel Hydrochloride inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of UBE2I protein] CTD PMID:34174262 NCBI chr10:14,782,245...14,802,911
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      chemical substance 14602
        mixture 13915
          racemate 12303
            prasugrel hydrochloride 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      halogen 19174
                        chlorine atom 18936
                          chlorine molecular entity 18936
                            elemental chlorine 10248
                              monoatomic chlorine 10235
                                chloride 10235
                                  chloride salt 10235
                                    organic chloride salt 1119
                                      hydrochloride 749
                                        (S)-prasugrel hydrochloride 7
                                          prasugrel hydrochloride 7
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