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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tolonium chloride
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Accession:CHEBI:87647 term browser browse the term
Definition:An organic chloride salt having 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium (tolonium) as the counterion. It is a blue nuclear counterstain that can be used to demonstrate Nissl substance and is also useful for staining mast cell granules, both in metachromatic and orthochromatic techniques.
Synonyms:exact_synonym: 3-amino-7-(dimethylamino)-2-methylphenothiazin-5-ium chloride
 related_synonym: 3-Amino-7-(dimethylamino)-2-(methylphenazathionium) chloride;   Blutene chloride;   C.I. 52040;   C.I. 925;   C.I. Basic Blue 17;   Dimethyltoluthionine chloride;   Formula=C15H16ClN3S;   InChI=1S/C15H16N3S.ClH/c1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13;/h4-8H,16H2,1-3H3;1H/q+1;/p-1;   InChIKey=HNONEKILPDHFOL-UHFFFAOYSA-M;   SMILES=[Cl-].CN(C)c1ccc2nc3cc(C)c(N)cc3[s+]c2c1;   Toluidene Blue O Chloride;   Toluidinblau;   basic blue 17;   chlorure de tolonium;   cloruro de tolonio;   toloni chloridum;   tolonii chloridum;   toluidine blue;   toluidine blue O
 xref: CAS:92-31-9
 xref_mesh: MESH:D014048
 xref: PMID:23884903;   PMID:24981641;   PMID:25463317;   PMID:25670474;   PMID:25752750;   PMID:25910445;   PMID:25972050;   PMID:26055566;   Reaxys:3580048;   Wikipedia:Tolonium_chloride


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tolonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Tolonium Chloride results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G App amyloid beta precursor protein decreases secretion ISO Tolonium Chloride results in decreased secretion of APP protein modified form CTD PMID:36027949 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Tolonium Chloride results in decreased expression of and results in decreased activity of BACE1 protein CTD PMID:36027949 NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918 		JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Tolonium Chloride results in decreased expression of CDK5 protein CTD PMID:36027949 NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:11,647,141...11,652,777 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase decreases expression ISO Tolonium Chloride results in decreased expression of FYN protein CTD PMID:36027949 NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
increases phosphorylation 		ISO Tolonium Chloride results in decreased expression of GSK3B protein
Tolonium Chloride results in increased phosphorylation of GSK3B protein 		CTD PMID:36027949 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Tolonium Chloride results in decreased expression of and results in decreased phosphorylation of MAPT protein CTD PMID:36027949 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha decreases phosphorylation ISO Tolonium Chloride results in decreased phosphorylation of PPP2CA protein CTD PMID:36027949 NCBI chr10:36,856,534...36,878,789 JBrowse link
G Psen1 presenilin 1 decreases expression ISO Tolonium Chloride results in decreased expression of PSEN1 protein modified form CTD PMID:36027949 NCBI chr 6:109,054,160...109,106,191
Ensembl chr 6:109,060,352...109,106,189 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        dye 3069
          histological dye 341
            tolonium chloride 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      halogen 19194
                        chlorine atom 18961
                          chlorine molecular entity 18961
                            elemental chlorine 10247
                              monoatomic chlorine 10234
                                chloride 10234
                                  chloride salt 10234
                                    organic chloride salt 1119
                                      tolonium chloride 9
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