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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:azure B
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Accession:CHEBI:87639 term browser browse the term
Definition:An organic chloride salt having 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium as the counterion. It is used in making azure eosin stains for blood smear staining and is an active metabolite of methylene blue.
Synonyms:exact_synonym: 3-(dimethylamino)-7-(methylamino)phenothiazin-5-ium chloride
 related_synonym: 3-(Dimethylamino)-7-(methylimino)-3H-phenothiazine hydrochloride;   3-Methylamino-7-dimethylaminophenzathonium chloride;   C.I. 52010;   Formula=C15H16ClN3S;   InChI=1S/C15H16N3S.ClH/c1-16-10-4-6-12-14(8-10)19-15-9-11(18(2)3)5-7-13(15)17-12;/h4-9,16H,1-3H3;1H/q+1;/p-1;   InChIKey=KFZNPGQYVZZSNV-UHFFFAOYSA-M;   SMILES=[Cl-].CNc1ccc2nc3ccc(cc3[s+]c2c1)N(C)C;   Trimethylthionine chloride;   methylene azure B
 xref: CAS:531-55-5
 xref_mesh: MESH:C025819
 xref: PMID:24122875;   PMID:24161345;   PMID:24682678;   PMID:24953877;   PMID:25162947;   PMID:25445435;   PMID:25613051;   PMID:25965774;   PMID:26241827;   Reaxys:3922630


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azure B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Azure B affects the cleavage of APP protein] which results in decreased secretion of APP protein modified form; Azure B results in decreased expression of and affects the cleavage of APP protein CTD PMID:30500345 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bace1 beta-secretase 1 decreases activity ISO Azure B results in decreased activity of BACE1 protein CTD PMID:30500345 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        dye 3004
          histological dye 259
            azure B 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      halogen 18673
                        chlorine atom 18457
                          chlorine molecular entity 18457
                            elemental chlorine 8778
                              monoatomic chlorine 8763
                                chloride 8763
                                  chloride salt 8763
                                    organic chloride salt 1103
                                      azure B 2
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