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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PF-670462
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Accession:CHEBI:87236 term browser browse the term
Definition:A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selective inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).
Synonyms:exact_synonym: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride
 related_synonym: Formula=C19H22Cl2FN5;   InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H;   InChIKey=PSNKGVAXBSAHCH-UHFFFAOYSA-N;   SMILES=Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
 xref: CAS:950912-80-8
 xref_mesh: MESH:C522839
 xref: PMID:17502429;   PMID:20407760;   PMID:21927596;   PMID:22168824;   PMID:22549116;   PMID:22743604;   PMID:22832921;   PMID:23349822;   PMID:23863866;   PMID:23936135;   PMID:24076244;   PMID:25245819;   Reaxys:11152377


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PF-670462 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tardbp TAR DNA binding protein multiple interactions ISO PF-670462 inhibits the reaction [arsenite results in increased phosphorylation of TARDBP protein] CTD PMID:29109149 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19901
    role 19871
      biological role 19869
        biochemical role 19576
          cofactor 16590
            ammonium 8318
              ammonium ion derivative 8313
                PF-670462 free base(2+) 1
                  PF-670462 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19901
    subatomic particle 19899
      composite particle 19899
        hadron 19899
          baryon 19899
            nucleon 19899
              atomic nucleus 19899
                atom 19899
                  main group element atom 19838
                    p-block element atom 19838
                      halogen 18706
                        chlorine atom 18490
                          chlorine molecular entity 18490
                            elemental chlorine 8788
                              monoatomic chlorine 8773
                                chloride 8773
                                  chloride salt 8773
                                    organic chloride salt 1107
                                      hydrochloride 739
                                        PF-670462 1
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