STAT3 inhibitor - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	STAT3 inhibitor	go back to main search page
Accession:	CHEBI:87183	browse the term
Definition:	An inhibitor of signal transducer and activator of transcription 3 (STAT3)
Synonyms:	related_synonym:	STAT3 inhibitors; signal transducer and activator of transcription 3 inhibitor; signal transducer and activator of transcription 3 inhibitors
	xref:	Wikipedia:STAT3

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Rat (902) Mouse (902) Human (957) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (902)

niclosamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

increases expression

Niclosamide results in increased expression of A1BG mRNA

NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097

G

ATP binding cassette subfamily A member 12

decreases expression

Niclosamide results in decreased expression of ABCA12 mRNA

NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049

G

ATP binding cassette subfamily C member 9

decreases expression

Niclosamide results in decreased expression of ABCC9 mRNA

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ATP binding cassette subfamily G member 4

increases expression

Niclosamide results in increased expression of ABCG4 mRNA

NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881

G

abhydrolase domain containing 1

increases expression

Niclosamide results in increased expression of ABHD1 mRNA

NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514

G

abhydrolase domain containing 14b

increases expression

Niclosamide results in increased expression of ABHD14B mRNA

NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119

G

acetyl-CoA carboxylase alpha

decreases expression

Niclosamide results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

acid phosphatase 5, tartrate resistant

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]

PMID:26792726 PMID:28824321

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

acyl-CoA synthetase long-chain family member 1

decreases expression

Niclosamide results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

actin alpha 2, smooth muscle

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ACTA2 protein]
Niclosamide results in decreased expression of ACTA2 protein
Niclosamide results in decreased expression of ACTA2 mRNA; Niclosamide results in decreased expression of ACTA2 protein
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of ACTA2 protein]; Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of ACTA2 protein]

PMID:26643609 PMID:28318631 PMID:34118929 PMID:35115509 PMID:36870549

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

ADAM metallopeptidase with thrombospondin type 1 motif, 17

decreases expression

Niclosamide results in decreased expression of ADAMTS17 mRNA

NCBI chr 1:120,445,800...120,768,204
Ensembl chr 1:120,445,749...120,768,202

G

alcohol dehydrogenase 4 (class II), pi polypeptide

decreases expression

Niclosamide results in decreased expression of ADH4 mRNA

NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591

G

adrenomedullin 2

increases expression

Niclosamide results in increased expression of ADM2 mRNA

NCBI chr 7:120,393,179...120,394,965
Ensembl chr 7:120,393,179...120,396,331

G

adrenoceptor alpha 2A

decreases expression

Niclosamide results in decreased expression of ADRA2A mRNA

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

alpha-fetoprotein

multiple interactions

Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of AFP protein]]

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

AGBL carboxypeptidase 3

decreases expression

Niclosamide results in decreased expression of AGBL3 mRNA

NCBI chr 4:63,448,789...63,535,538
Ensembl chr 4:63,453,940...63,531,188

G

apoptosis inducing factor, mitochondria associated 1

increases cleavage

Niclosamide results in increased cleavage of AIFM1 protein

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AT-hook transcription factor

increases expression

Niclosamide results in increased expression of AKNA mRNA

NCBI chr 5:76,777,415...76,824,380
Ensembl chr 5:76,777,415...76,816,017

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

Niclosamide results in increased expression of AKT1 mRNA
Niclosamide inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased phosphorylation of AKT1 protein]

PMID:20215516 PMID:26792726 PMID:29843133

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

decreases expression

Niclosamide results in decreased expression of ALDH1A1 protein

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 6 family, member A1

increases expression

Niclosamide results in increased expression of ALDH6A1 mRNA

NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656

G

aldolase, fructose-bisphosphate B

increases expression

Niclosamide results in increased expression of ALDOB mRNA

NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116

G

aldolase, fructose-bisphosphate C

decreases expression
increases expression

Niclosamide results in decreased expression of ALDOC mRNA
Niclosamide results in increased expression of ALDOC mRNA

PMID:22576131 PMID:36318118

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alkB homolog 7

increases expression

Niclosamide results in increased expression of ALKBH7 mRNA

NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044

G

arachidonate 12-lipoxygenase, 12R type

increases expression
multiple interactions
decreases response to substance

Niclosamide results in increased expression of ALOX12B mRNA
TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX12B mRNA]
ALOX12B protein results in decreased susceptibility to Niclosamide

NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938

G

arachidonate 5-lipoxygenase

multiple interactions
decreases response to substance
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of ALOX5 mRNA]
ALOX5 protein results in decreased susceptibility to Niclosamide

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

alkaline phosphatase, biomineralization associated

decreases expression

Niclosamide results in decreased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

anti-Mullerian hormone receptor type 2

increases expression

Niclosamide results in increased expression of AMHR2 mRNA

NCBI chr 7:133,579,152...133,588,874
Ensembl chr 7:133,579,393...133,588,258

G

angiomotin

increases expression

Niclosamide results in increased expression of AMOT mRNA

NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272

G

ankyrin 3

increases expression

Niclosamide results in increased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat and MYND domain containing 2

increases expression

Niclosamide results in increased expression of ANKMY2 mRNA

NCBI chr 6:52,888,959...52,930,343
Ensembl chr 6:52,888,963...52,930,394

G

ankyrin repeat domain 12

increases expression

Niclosamide results in increased expression of ANKRD12 mRNA

NCBI chr 9:105,583,273...105,687,957
Ensembl chr 9:105,584,065...105,687,911

G

ankyrin repeat domain 34A

increases expression

Niclosamide results in increased expression of ANKRD34A mRNA

NCBI chr 2:184,129,830...184,135,075
Ensembl chr 2:184,129,238...184,135,116

G

annexin A4

increases expression

Niclosamide results in increased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

adaptor related protein complex 1 subunit sigma 3

decreases expression

Niclosamide results in decreased expression of AP1S3 mRNA

NCBI chr 9:80,950,402...81,009,889
Ensembl chr 9:80,950,715...81,009,798

G

apelin receptor

decreases expression

Niclosamide results in decreased expression of APLNR mRNA

NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050

G

apolipoprotein F

decreases expression

Niclosamide results in decreased expression of APOF mRNA

NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946

G

androgen receptor

multiple interactions
decreases expression

[enzalutamide co-treated with Niclosamide] results in decreased expression of AR protein; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein alternative form]; bicalutamide promotes the reaction [Niclosamide results in decreased expression of AR protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Niclosamide results in decreased expression of and results in increased degradation of AR protein alternative form
Niclosamide results in decreased expression of AR protein; Niclosamide results in decreased expression of AR protein alternative form

PMID:24740322 PMID:25970160 PMID:28500234

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

A-Raf proto-oncogene, serine/threonine kinase

decreases expression

Niclosamide analog results in decreased expression of ARAF protein; Niclosamide results in decreased expression of ARAF protein

NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073

G

Rho GDP dissociation inhibitor beta

increases expression

Niclosamide results in increased expression of ARHGDIB mRNA

NCBI chr 4:169,822,951...169,841,884
Ensembl chr 4:169,822,952...169,841,658

G

armadillo repeat containing, X-linked 1

increases expression

Niclosamide results in increased expression of ARMCX1 mRNA

NCBI chr X:97,898,969...97,902,874
Ensembl chr X:97,898,883...97,903,299

G

arrestin domain containing 2

increases expression

Niclosamide results in increased expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

anti-silencing function 1B histone chaperone

decreases expression

Niclosamide results in decreased expression of ASF1B mRNA

NCBI chr19:24,181,024...24,195,604
Ensembl chr19:24,181,028...24,195,549

G

ATCAY kinesin light chain interacting caytaxin

increases expression

Niclosamide results in increased expression of ATCAY mRNA

NCBI chr 7:8,487,763...8,511,527
Ensembl chr 7:8,487,763...8,512,663

G

activating transcription factor 3

increases expression
multiple interactions

Niclosamide results in increased expression of ATF3 mRNA; Niclosamide results in increased expression of ATF3 protein
ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]; ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

increases expression

Niclosamide results in increased expression of ATF4 mRNA; Niclosamide results in increased expression of ATF4 protein

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

atos homolog B

increases expression

Niclosamide results in increased expression of ATOSB mRNA

NCBI chr 5:57,260,839...57,274,524
Ensembl chr 5:57,260,841...57,268,892

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

increases expression

Niclosamide results in increased expression of ATP2A3 mRNA

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATP synthase F1 subunit alpha

increases expression

Niclosamide results in increased expression of ATP5F1A mRNA

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

ATP synthase F1 subunit delta

increases expression

Niclosamide results in increased expression of ATP5F1D mRNA

NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929

G

ATP synthase membrane subunit c locus 3

decreases expression

Niclosamide results in decreased expression of ATP5MC3 mRNA

NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279

G

ATP synthase membrane subunit f

decreases expression

Niclosamide results in decreased expression of ATP5MF mRNA

NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236

G

ATP synthase membrane subunit G

decreases expression

Niclosamide results in decreased expression of ATP5MG mRNA

NCBI chr 8:45,225,680...45,233,630
Ensembl chr 8:45,225,686...45,233,559

G

ATP synthase peripheral stalk-membrane subunit b

decreases expression

Niclosamide results in decreased expression of ATP5PB mRNA

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATPase H+ transporting accessory protein 1

decreases expression

Niclosamide results in decreased expression of ATP6AP1 mRNA

NCBI chr X:152,079,954...152,087,034
Ensembl chr X:152,079,865...152,087,034

G

ATPase H+ transporting V0 subunit D2

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ATP6V0D2 mRNA]

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

ATP synthase c subunit lysine N-methyltransferase

decreases expression

Niclosamide results in decreased expression of ATPSCKMT mRNA

NCBI chr 2:82,603,086...82,618,325
Ensembl chr 2:82,603,009...82,618,308

G

aurora kinase B

decreases expression

Niclosamide results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

G

arginine vasopressin-induced 1

increases expression

Niclosamide results in increased expression of AVPI1 mRNA

NCBI chr 1:240,930,236...240,936,154
Ensembl chr 1:240,930,236...240,936,154

G

axin 2

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA]
Niclosamide results in decreased expression of AXIN2 mRNA; Niclosamide results in decreased expression of AXIN2 protein

PMID:22576131 PMID:24534281 PMID:24552774 PMID:24736023

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7

increases expression

Niclosamide results in increased expression of B3GNT7 mRNA

NCBI chr 9:86,956,220...86,960,171
Ensembl chr 9:86,956,220...86,960,170

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9

increases expression

Niclosamide results in increased expression of B3GNT9 mRNA

NCBI chr19:33,129,740...33,134,048
Ensembl chr19:33,128,142...33,132,344

G

BCL2-associated agonist of cell death

multiple interactions

[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

multiple interactions

[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions
decreases expression

Niclosamide results in increased expression of BAX protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of BAX mRNA; [Niclosamide co-treated with bicalutamide] results in increased expression of BAX protein; bicalutamide inhibits the reaction [Niclosamide results in decreased expression of BAX protein]

PMID:25634333 PMID:25988281 PMID:26703449 PMID:28500234 PMID:35115509

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of BBC3 mRNA]

PMID:30258081 PMID:36318118

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

Bardet-Biedl syndrome 2

increases expression

Niclosamide results in increased expression of BBS2 mRNA

NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

Niclosamide analog results in decreased expression of BCL2 protein; Niclosamide results in decreased expression of BCL2 protein
[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2 mRNA; [Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2 protein]; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2 protein]

PMID:20215516 PMID:23894143 PMID:25634333 PMID:25988281 PMID:26116531 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions
decreases expression

[Niclosamide binds to Polyethyleneimine] which results in decreased expression of BCL2L1 mRNA; bicalutamide promotes the reaction [Niclosamide results in decreased expression of BCL2L1 protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of BCL2L1 protein]
Niclosamide analog results in decreased expression of BCL2L1 protein; Niclosamide results in decreased expression of BCL2L1 protein

PMID:20215516 PMID:25988281 PMID:26116531 PMID:28284560 PMID:28500234

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 2

decreases expression
multiple interactions

Niclosamide results in decreased expression of BCL2L2 protein
[Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]] which results in increased susceptibility to Erlotinib Hydrochloride; Niclosamide inhibits the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L2 protein]

NCBI chr15:28,346,449...28,361,627
Ensembl chr15:28,356,807...28,361,624

G

BCL3, transcription coactivator

increases expression

Niclosamide results in increased expression of BCL3 mRNA

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6, transcription repressor

multiple interactions
increases expression

Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]
Niclosamide results in increased expression of BCL6 mRNA

PMID:33632240 PMID:36318118

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BCL6B, transcription repressor

increases expression

Niclosamide results in increased expression of BCL6B mRNA

NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974

G

BCL9, transcription coactivator

decreases expression

Niclosamide results in decreased expression of BCL9 mRNA

NCBI chr 2:184,760,616...184,846,261
Ensembl chr 2:184,760,618...184,786,435

G

BCL6 co-repressor-like 1

increases expression

Niclosamide results in increased expression of BCORL1 mRNA

NCBI chr X:127,516,504...127,584,529
Ensembl chr X:127,537,538...127,584,087

G

Bet1 golgi vesicular membrane trafficking protein-like

increases expression

Niclosamide results in increased expression of BET1L mRNA

NCBI chr 1:195,931,407...195,935,072
Ensembl chr 1:195,931,411...195,935,040

G

biglycan

increases expression

Niclosamide results in increased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e40

increases expression

Niclosamide results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 5

multiple interactions
affects expression
decreases expression

enzalutamide promotes the reaction [Niclosamide results in decreased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]
Niclosamide affects the expression of BIRC5 protein
Niclosamide analog results in decreased expression of BIRC5 protein; Niclosamide results in decreased expression of BIRC5 mRNA; Niclosamide results in decreased expression of BIRC5 protein

PMID:24552774 PMID:24736023 PMID:25970160 PMID:28284560 PMID:28500234 More...

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

Bcl2 modifying factor

increases expression

Niclosamide results in increased expression of BMF mRNA

NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145

G

BLOC-1 related complex subunit 6

increases expression

Niclosamide results in increased expression of BORCS6 mRNA

NCBI chr10:53,760,504...53,762,358
Ensembl chr10:53,758,093...53,762,632

G

B-Raf proto-oncogene, serine/threonine kinase

decreases expression
decreases phosphorylation

Niclosamide analog results in decreased expression of BRAF protein; Niclosamide results in decreased expression of BRAF protein
Niclosamide analog results in decreased phosphorylation of BRAF protein

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

BTB domain containing 7

decreases expression

Niclosamide results in decreased expression of BTBD7 mRNA

NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405

G

BTG anti-proliferation factor 2

increases expression

Niclosamide results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

similar to human chromosome 1 open reading frame 105

decreases expression

Niclosamide results in decreased expression of C1ORF105 mRNA

NCBI chr13:74,313,320...74,356,322
Ensembl chr13:74,313,322...74,356,322

G

similar to human chromosome 8 open reading frame 48

decreases expression

Niclosamide results in decreased expression of C8ORF48 mRNA

NCBI chr16:55,244,744...55,246,642
Ensembl chr16:55,236,322...55,246,650

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similar to human chromosome 16 open reading frame 86

increases expression

Niclosamide results in increased expression of C16ORF86 mRNA

NCBI chr19:33,596,591...33,598,703
Ensembl chr19:33,595,995...33,598,521

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complement C1q like 4

increases expression

Niclosamide results in increased expression of C1QL4 mRNA

NCBI chr 7:130,243,606...130,246,678
Ensembl chr 7:130,243,606...130,246,678

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Cdk5 and Abl enzyme substrate 2

decreases expression

Niclosamide results in decreased expression of CABLES2 mRNA

NCBI chr 3:167,347,527...167,362,274
Ensembl chr 3:167,347,461...167,362,279

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calcium voltage-gated channel subunit alpha1 E

increases expression

Niclosamide results in increased expression of CACNA1E mRNA

NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450

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calcium voltage-gated channel subunit alpha1 H

increases expression

Niclosamide results in increased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

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calcium voltage-gated channel auxiliary subunit gamma 1

increases expression

Niclosamide results in increased expression of CACNG1 mRNA

NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783

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calcium/calmodulin-dependent protein kinase II alpha

increases expression

Niclosamide results in increased expression of CAMK2A mRNA

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

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calmodulin regulated spectrin-associated protein family, member 3

increases expression

Niclosamide results in increased expression of CAMSAP3 mRNA

NCBI chr12:1,643,062...1,666,685
Ensembl chr12:1,643,251...1,666,685

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calcyphosine

increases expression

Niclosamide results in increased expression of CAPS mRNA

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

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caspase 1

multiple interactions

[Niclosamide co-treated with Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of CASP1 protein
Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased cleavage of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

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caspase 3

increases cleavage
multiple interactions
increases expression
decreases expression

Niclosamide results in increased cleavage of CASP3 protein
Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in decreased expression of CASP3 mRNA]]
[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased expression of CASP3 protein modified form; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]
Niclosamide results in increased expression of CASP3 protein modified form
Niclosamide results in decreased expression of CASP3 protein
7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; [Niclosamide binds to Polyethyleneimine] which results in increased expression of CASP3 mRNA; ATF3 protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Niclosamide results in increased cleavage of CASP3 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP3 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of CASP3 protein]

PMID:20215516 PMID:21871175 PMID:24750999 PMID:25174399 PMID:25634333 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 7

multiple interactions
increases expression

bicalutamide promotes the reaction [Niclosamide results in increased expression of CASP7 protein modified form]

PMID:26116531 PMID:28500234

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

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caspase 8

increases cleavage

Niclosamide results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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caspase 9

multiple interactions
increases expression
increases cleavage

TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of CASP9 protein]
Niclosamide results in increased expression of CASP9 mRNA; Niclosamide results in increased expression of CASP9 protein modified form

PMID:26116531 PMID:26703449 PMID:30258081 PMID:36318118

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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chromobox 4

increases expression

Niclosamide results in increased expression of CBX4 mRNA

NCBI chr10:104,337,140...104,343,210
Ensembl chr10:104,336,876...104,356,706

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coiled-coil domain containing 113

increases expression

Niclosamide results in increased expression of CFAP263 mRNA

NCBI chr19:9,497,000...9,516,917
Ensembl chr19:9,496,886...9,516,923

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coiled-coil domain containing 188

increases expression

Niclosamide results in increased expression of CCDC188 mRNA

NCBI chr11:82,769,735...82,772,062
Ensembl chr11:82,769,473...82,772,114

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coiled-coil domain containing 68

decreases expression

Niclosamide results in decreased expression of CCDC68 mRNA

NCBI chr18:63,541,828...63,584,122
Ensembl chr18:63,541,896...63,584,119

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C-C motif chemokine ligand 2

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL2 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL2 mRNA]

PMID:24561310 PMID:28318631

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

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C-C motif chemokine ligand 20

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of CCL20 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CCL20 mRNA]

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

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C-C motif chemokine ligand 3

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

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C-C motif chemokine ligand 5

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin B1

decreases expression

Niclosamide results in decreased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B3

decreases expression

Niclosamide results in decreased expression of CCNB3 mRNA

NCBI chr X:15,478,050...15,543,292
Ensembl chr X:15,478,065...15,542,885

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cyclin D1

multiple interactions
decreases expression

Niclosamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 mRNA]]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CCND1 protein]]
Niclosamide results in decreased expression of CCND1 mRNA
Niclosamide analog results in decreased expression of CCND1 protein; Niclosamide results in decreased expression of CCND1 mRNA; Niclosamide results in decreased expression of CCND1 protein
Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [TNF protein results in increased expression of CCND1 mRNA]; Niclosamide promotes the reaction [bicalutamide results in decreased expression of CCND1 protein]

PMID:19160421 PMID:20215516 PMID:24552774 PMID:24736023 PMID:26297436 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

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cyclin D2

decreases expression
increases expression

Niclosamide results in decreased expression of CCND2 mRNA
Niclosamide results in increased expression of CCND2 mRNA

PMID:22576131 PMID:27226553 PMID:36318118

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

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cyclin D3

decreases expression

Niclosamide results in decreased expression of CCND3 mRNA

PMID:22576131 PMID:27226553

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

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cyclin E1

decreases expression

Niclosamide results in decreased expression of CCNE1 mRNA

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

multiple interactions
decreases expression

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]
Niclosamide results in decreased expression of CCNE2 mRNA

PMID:27542212 PMID:36318118

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

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cyclin G2

multiple interactions
increases expression

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]
Niclosamide results in increased expression of CCNG2 mRNA

PMID:27542212 PMID:36318118

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

C-C motif chemokine receptor 10

increases expression

Niclosamide results in increased expression of CCR10 mRNA

NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988

G

CD27 molecule

increases expression

Niclosamide results in increased expression of CD27 mRNA

NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592

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CD274 molecule

decreases expression

Niclosamide results in decreased expression of CD274 mRNA; Niclosamide results in decreased expression of CD274 protein

NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450

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CD40 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD40 protein]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

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CD55 molecule (Cromer blood group)

increases expression

Niclosamide results in increased expression of CD55 mRNA

NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831

G

Cd68 molecule

increases expression

Niclosamide results in increased expression of CD68 mRNA

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

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Cd80 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD80 protein]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

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CD86 molecule

multiple interactions

Niclosamide inhibits the reaction [Lipopolysaccharides affects the expression of CD86 protein]

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

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cell division cycle 37, HSP90 cochaperone

multiple interactions

CDC37 protein binds to and results in increased susceptibility to Niclosamide analog

NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809

G

cell division cycle 42

decreases expression
decreases phosphorylation

Niclosamide results in decreased expression of CDC42 mRNA
Niclosamide results in decreased phosphorylation of CDC42 protein

NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111

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CDC42 effector protein 1

increases expression

Niclosamide results in increased expression of CDC42EP1 mRNA

NCBI chr 7:110,395,287...110,403,203
Ensembl chr 7:110,395,332...110,403,200

G

cell division cycle 6

decreases expression

Niclosamide results in decreased expression of CDC6 mRNA

PMID:28284560 PMID:36318118

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

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cell division cycle associated 2

decreases expression

Niclosamide results in decreased expression of CDCA2 mRNA

NCBI chr15:41,895,946...41,942,226
Ensembl chr15:41,895,901...41,941,611

G

cell division cycle associated 5

decreases expression

Niclosamide results in decreased expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

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cell division cycle associated 8

decreases expression

Niclosamide results in decreased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

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cadherin 1

multiple interactions
increases expression

CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in decreased expression of CDH1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased expression of CDH1 protein]
Niclosamide results in increased expression of CDH1 mRNA; Niclosamide results in increased expression of CDH1 protein

PMID:25174399 PMID:26643609 PMID:30143678 PMID:35115509

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

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cadherin 11

decreases expression

Niclosamide results in decreased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

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cadherin 12

multiple interactions

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of CDH12 protein]

NCBI chr 2:70,474,679...71,705,369
Ensembl chr 2:70,475,043...71,700,572

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cadherin 2

multiple interactions
decreases expression

Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CDH2 protein]
Niclosamide results in decreased expression of CDH2 protein

PMID:26643609 PMID:34118929

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cadherin 4

increases expression

Niclosamide results in increased expression of CDH4 mRNA

NCBI chr 3:166,525,092...167,003,380
Ensembl chr 3:166,525,099...167,003,371

G

cadherin 6

decreases expression

Niclosamide results in decreased expression of CDH6 mRNA

NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228

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cadherin-related family member 1

increases expression

Niclosamide results in increased expression of CDHR1 mRNA

NCBI chr16:12,843,436...12,863,321
Ensembl chr16:12,843,437...12,863,396

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cadherin-related family member 2

decreases expression

Niclosamide results in decreased expression of CDHR2 mRNA

NCBI chr17:9,876,853...9,913,356
Ensembl chr17:9,876,860...9,912,575

G

cyclin-dependent kinase 15

decreases expression

Niclosamide results in decreased expression of CDK15 mRNA

NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777

G

cyclin dependent kinase 2

decreases expression

Niclosamide results in decreased expression of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases expression

Niclosamide results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase-like 3

increases expression

Niclosamide results in increased expression of CDKL3 mRNA

NCBI chr10:36,263,212...36,349,268
Ensembl chr10:36,266,977...36,349,268

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

TP53 gene mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]; TP53 protein mutant form inhibits the reaction [Niclosamide results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 3

decreases expression

Niclosamide results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

G

CCAAT/enhancer binding protein beta

increases expression

Niclosamide results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

CUGBP, Elav-like family member 6

increases expression

Niclosamide results in increased expression of CELF6 mRNA

NCBI chr 8:59,975,095...60,006,060
Ensembl chr 8:59,975,088...60,005,041

G

cadherin, EGF LAG seven-pass G-type receptor 3

increases expression

Niclosamide results in increased expression of CELSR3 mRNA

NCBI chr 8:109,530,597...109,558,360
Ensembl chr 8:109,530,641...109,558,354

G

centromere protein A

decreases expression

Niclosamide results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

centromere protein O

decreases expression

Niclosamide results in decreased expression of CENPO mRNA

NCBI chr 6:27,203,642...27,218,394
Ensembl chr 6:27,188,537...27,218,314

G

centromere protein U

decreases expression

Niclosamide results in decreased expression of CENPU mRNA

NCBI chr16:45,715,821...45,739,038
Ensembl chr16:45,714,294...45,738,823

G

cilia and flagella associated protein 70

increases expression

Niclosamide results in increased expression of CFAP70 mRNA

NCBI chr15:3,852,381...3,918,036
Ensembl chr15:3,852,509...3,918,014

G

complement factor properdin

increases expression

Niclosamide results in increased expression of CFP mRNA

NCBI chr X:1,162,014...1,167,576
Ensembl chr X:1,161,979...1,167,573

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

Niclosamide results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

decreases expression

Niclosamide results in decreased expression of CHAC2 mRNA

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

chromatin assembly factor 1 subunit A

decreases expression

Niclosamide results in decreased expression of CHAF1A mRNA

NCBI chr 9:873,953...900,701
Ensembl chr 9:874,051...900,654

G

cholinergic receptor nicotinic beta 1 subunit

increases expression

Niclosamide results in increased expression of CHRNB1 mRNA

NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345

G

carbohydrate sulfotransferase 8

increases expression

Niclosamide results in increased expression of CHST8 mRNA

NCBI chr 1:87,294,144...87,435,900
Ensembl chr 1:87,294,540...87,435,900

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Niclosamide results in decreased phosphorylation of and affects the localization of CHUK protein

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytokine inducible SH2-containing protein

increases expression

Niclosamide results in increased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

C-type lectin domain containing 11A

increases expression

Niclosamide results in increased expression of CLEC11A mRNA

NCBI chr 1:94,800,456...94,809,002
Ensembl chr 1:94,801,496...94,804,633

G

CAP-GLY domain containing linker protein 2

increases expression

Niclosamide results in increased expression of CLIP2 mRNA

NCBI chr12:22,163,044...22,227,023
Ensembl chr12:22,163,218...22,227,023

G

CAP-GLY domain containing linker protein 3

increases expression

Niclosamide results in increased expression of CLIP3 mRNA

NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184

G

claspin

decreases expression

Niclosamide results in decreased expression of CLSPN mRNA

NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034

G

calsyntenin 3

increases expression

Niclosamide results in increased expression of CLSTN3 mRNA

NCBI chr 4:157,331,494...157,364,769
Ensembl chr 4:157,331,494...157,364,769

G

chemerin chemokine-like receptor 1

decreases expression

Niclosamide results in decreased expression of CMKLR1 mRNA

NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129

G

cytidine/uridine monophosphate kinase 2

decreases expression

Niclosamide results in decreased expression of CMPK2 mRNA

NCBI chr 6:43,073,706...43,085,183
Ensembl chr 6:43,073,796...43,085,183

G

cyclic nucleotide binding domain containing 2

increases expression

Niclosamide results in increased expression of CNBD2 mRNA

NCBI chr 3:144,819,166...144,884,825
Ensembl chr 3:144,819,195...144,901,583

G

calponin 1

increases expression

Niclosamide results in increased expression of CNN1 mRNA

NCBI chr 8:20,632,434...20,641,097
Ensembl chr 8:20,632,338...20,641,098

G

calponin 2

increases expression

Niclosamide results in increased expression of CNN2 mRNA

NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

Niclosamide results in decreased expression of COL1A1 mRNA
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Gemcitabine inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; Niclosamide inhibits the reaction [Gemcitabine results in decreased expression of COL1A1 protein]

PMID:28824321 PMID:35115509

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

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collagen type VI alpha 2 chain

increases expression

Niclosamide results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collectin subfamily member 10

increases expression

Niclosamide results in increased expression of COLEC10 mRNA

NCBI chr 7:85,744,895...85,806,368
Ensembl chr 7:85,744,895...85,805,675

G

cytochrome c oxidase subunit 8C

increases expression

Niclosamide results in increased expression of COX8C mRNA

NCBI chr 6:122,028,566...122,029,889
Ensembl chr 6:122,028,566...122,029,889

G

crumbs cell polarity complex component 2

increases expression

Niclosamide results in increased expression of CRB2 mRNA

NCBI chr 3:21,542,138...21,564,876
Ensembl chr 3:21,542,221...21,563,294

G

CREB binding protein

increases expression

Niclosamide results in increased expression of CREBBP mRNA

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

CREB3 regulatory factor

increases expression

Niclosamide results in increased expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

G

cytokine receptor-like factor 1

decreases expression

Niclosamide results in decreased expression of CRLF1 mRNA

NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,924,722...18,935,997

G

carnitine O-octanoyltransferase

decreases expression

Niclosamide results in decreased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

crystallin, beta B1

increases expression

Niclosamide results in increased expression of CRYBB1 mRNA

NCBI chr12:44,369,734...44,383,344
Ensembl chr12:44,369,735...44,383,344

G

crystallin, lambda 1

increases expression

Niclosamide results in increased expression of CRYL1 mRNA

NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997

G

colony stimulating factor 1

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ACP5 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of CASP3 protein modified form]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of TRAF6 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

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chondroitin sulfate N-acetylgalactosaminyltransferase 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]

NCBI chr16:20,995,210...21,330,586
Ensembl chr16:21,235,784...21,330,319

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casein kinase 1, epsilon

increases expression

Niclosamide results in increased expression of CSNK1E mRNA

NCBI chr 7:110,983,322...111,006,926
Ensembl chr 7:110,983,318...111,006,794

G

cysteine and serine rich nuclear protein 1

increases expression

Niclosamide results in increased expression of CSRNP1 mRNA

NCBI chr 8:119,704,712...119,717,767
Ensembl chr 8:119,704,713...119,718,183

G

C-terminal binding protein 1

increases expression

Niclosamide results in increased expression of CTBP1 mRNA

NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821

G

catenin beta 1

increases expression
affects localization
decreases expression
increases ubiquitination
decreases activity
multiple interactions

Niclosamide results in increased expression of CTNNB1 mRNA
Niclosamide affects the localization of CTNNB1 protein
Niclosamide results in decreased expression of CTNNB1 mRNA
Niclosamide results in increased ubiquitination of CTNNB1 protein
Niclosamide results in decreased activity of CTNNB1 protein
Niclosamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of CTNNB1 protein]]
Niclosamide analog results in decreased expression of CTNNB1 protein; Niclosamide results in decreased expression of CTNNB1 protein
CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of ACTA2 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in decreased expression of COL1A1 protein]; CTNNB1 protein inhibits the reaction [Niclosamide results in increased expression of CDH1 protein]; Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of CTNNB1 protein]; Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; Niclosamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of CTNNB1 protein]; Niclosamide inhibits the reaction [WNT3A protein results in increased stability of CTNNB1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of CTNNB1 protein]; Niclosamide results in decreased expression of and results in increased phosphorylation of CTNNB1 protein

PMID:19772353 PMID:21531761 PMID:22576131 PMID:24534281 PMID:24552774 More...

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

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catenin, beta-interacting protein 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]
Niclosamide results in increased expression of CTNNBIP1 mRNA

PMID:24534281 PMID:36318118

NCBI chr 5:159,961,961...160,010,942
Ensembl chr 5:159,961,928...160,010,939

G

cathepsin C

decreases expression

Niclosamide results in decreased expression of CTSC protein

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cathepsin D

decreases expression

Niclosamide results in decreased expression of CTSD protein

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin K

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X-C motif chemokine ligand 12

decreases expression

Niclosamide results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine receptor 5

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]

NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893

G

cytochrome b-561

decreases expression

Niclosamide results in decreased expression of CYB561 mRNA

NCBI chr10:90,878,052...90,888,734
Ensembl chr10:90,878,054...90,884,787

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cytochrome c, somatic

increases expression

Niclosamide results in increased expression of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

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cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

Niclosamide results in increased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases expression

Niclosamide results in decreased activity of CYP1A2 protein
Niclosamide results in increased expression of CYP1A2 mRNA

PMID:11124226 PMID:28284560

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases expression

Niclosamide results in increased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

Niclosamide results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 39, subfamily a, polypeptide 1

increases expression

Niclosamide results in increased expression of CYP39A1 mRNA

NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

Niclosamide results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dishevelled-binding antagonist of beta-catenin 3

increases expression

Niclosamide results in increased expression of DACT3 mRNA

NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630

G

D-box binding PAR bZIP transcription factor

increases expression

Niclosamide results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

DDAH family member 2, ADMA-independent

increases expression

Niclosamide results in increased expression of DDAH2 mRNA

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

G

DNA damage-induced apoptosis suppressor

decreases expression

Niclosamide results in decreased expression of DDIAS mRNA

NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Niclosamide results in increased expression of DDIT3 mRNA; Niclosamide results in increased expression of DDIT3 protein
ATF3 protein affects the reaction [Niclosamide results in increased expression of DDIT3 mRNA]

PMID:26917416 PMID:36318118

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression

Niclosamide results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

discoidin domain receptor tyrosine kinase 1

increases expression

Niclosamide results in increased expression of DDR1 mRNA

NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468

G

2,4-dienoyl-CoA reductase 1

decreases expression

Niclosamide results in decreased expression of DECR1 mRNA

NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018

G

DGCR8 microprocessor complex subunit

decreases expression

Niclosamide results in decreased expression of DGCR8 mRNA

NCBI chr11:82,704,673...82,737,251
Ensembl chr11:82,704,729...82,737,242

G

diacylglycerol kinase, beta

increases expression

Niclosamide results in increased expression of DGKB mRNA

NCBI chr 6:54,640,948...55,397,210
Ensembl chr 6:54,641,614...55,397,043

G

dihydrofolate reductase

decreases expression

Niclosamide results in decreased expression of DHFR mRNA

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

dehydrogenase/reductase 3

increases expression

Niclosamide results in increased expression of DHRS3 mRNA

NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

Niclosamide results in decreased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

discs large MAGUK scaffold protein 4

increases expression

Niclosamide results in increased expression of DLG4 mRNA

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

distal membrane arm assembly component 2 like

decreases expression

Niclosamide results in decreased expression of DMAC2L mRNA

NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933

G

DnaJ heat shock protein family (Hsp40) member A1

decreases expression

Niclosamide results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member A4

decreases expression

Niclosamide results in decreased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

DnaJ heat shock protein family (Hsp40) member C22

increases expression

Niclosamide results in increased expression of DNAJC22 mRNA

NCBI chr 7:130,257,504...130,262,880
Ensembl chr 7:130,257,851...130,263,230

G

DnaJ heat shock protein family (Hsp40) member C9

decreases expression

Niclosamide results in decreased expression of DNAJC9 mRNA

NCBI chr15:3,923,842...3,928,118
Ensembl chr15:3,923,268...3,928,118

G

dedicator of cytokinesis 5

decreases expression

Niclosamide results in decreased expression of DOCK5 mRNA

NCBI chr15:41,979,728...42,158,733
Ensembl chr15:41,979,729...42,158,649

G

DEAQ box RNA-dependent ATPase 1

increases expression

Niclosamide results in increased expression of DQX1 mRNA

NCBI chr 4:115,563,497...115,572,598
Ensembl chr 4:115,563,752...115,572,590

G

dopamine receptor D4

increases expression

Niclosamide results in increased expression of DRD4 mRNA

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

DNA replication and sister chromatid cohesion 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]

NCBI chr 7:86,482,588...86,498,212
Ensembl chr 7:86,482,588...86,498,212

G

denticleless E3 ubiquitin protein ligase homolog

decreases expression

Niclosamide results in decreased expression of DTL mRNA

NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890

G

dual specificity phosphatase 4

increases expression

Niclosamide results in increased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 8

increases expression

Niclosamide results in increased expression of DUSP8 mRNA

NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921

G

dual specificity phosphatase 9

increases expression

Niclosamide results in increased expression of DUSP9 mRNA

NCBI chr X:151,351,897...151,355,822
Ensembl chr X:151,351,897...151,355,821

G

dishevelled segment polarity protein 1

increases expression

Niclosamide results in increased expression of DVL1 mRNA

NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664

G

dishevelled segment polarity protein 2

decreases expression
multiple interactions

Niclosamide results in decreased expression of DVL2 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of DVL2 mRNA]]

PMID:19772353 PMID:21531761 PMID:30143678 PMID:32961231

NCBI chr10:54,723,356...54,732,823
Ensembl chr10:54,723,411...54,732,820

G

dishevelled segment polarity protein 3

increases expression

Niclosamide results in increased expression of DVL3 mRNA

NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462

G

dual specificity tyrosine phosphorylation regulated kinase 1B

increases expression

Niclosamide results in increased expression of DYRK1B mRNA

NCBI chr 1:83,479,168...83,497,011
Ensembl chr 1:83,479,147...83,487,169

G

E2F transcription factor 1

decreases expression

Niclosamide results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

decreases expression

Niclosamide results in decreased expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

E2F transcription factor 7

decreases expression

Niclosamide results in decreased expression of E2F7 mRNA

NCBI chr 7:46,150,533...46,192,739
Ensembl chr 7:46,151,293...46,192,734

G

E2F transcription factor 8

decreases expression

Niclosamide results in decreased expression of E2F8 mRNA

PMID:28284560 PMID:36318118

NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098

G

ELL associated factor 2

decreases expression

Niclosamide results in decreased expression of EAF2 mRNA

NCBI chr11:63,960,200...64,004,610
Ensembl chr11:63,960,200...64,004,610

G

EBF transcription factor 1

decreases expression

Niclosamide results in decreased expression of EBF1 mRNA

NCBI chr10:29,095,858...29,489,142
Ensembl chr10:29,099,933...29,487,665

G

EBF family member 4

increases expression

Niclosamide results in increased expression of EBF4 mRNA

NCBI chr 3:117,498,186...117,566,566
Ensembl chr 3:117,498,319...117,566,566

G

ethylmalonyl-CoA decarboxylase 1

decreases expression

Niclosamide results in decreased expression of ECHDC1 mRNA

NCBI chr 1:28,476,354...28,507,173
Ensembl chr 1:28,476,200...28,507,319

G

enoyl CoA hydratase domain containing 2

decreases expression

Niclosamide results in decreased expression of ECHDC2 mRNA

NCBI chr 5:122,915,874...122,934,860
Ensembl chr 5:122,916,134...122,934,859

G

enoyl-CoA hydratase, short chain 1

decreases expression

Niclosamide results in decreased expression of ECHS1 mRNA

NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884

G

ephrin A1

increases expression

Niclosamide results in increased expression of EFNA1 mRNA

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

ephrin A3

increases expression

Niclosamide results in increased expression of EFNA3 mRNA

NCBI chr 2:174,729,192...174,738,111
Ensembl chr 2:174,729,764...174,738,736

G

ephrin B3

increases expression

Niclosamide results in increased expression of EFNB3 mRNA

NCBI chr10:54,274,506...54,281,951
Ensembl chr10:54,274,506...54,280,471

G

epidermal growth factor

decreases expression
multiple interactions

Niclosamide results in decreased expression of EGF mRNA; Niclosamide results in decreased expression of EGF protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]; Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]

PMID:30779072 PMID:38185387

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

decreases expression
multiple interactions
decreases phosphorylation

Niclosamide analog results in decreased expression of EGFR protein; Niclosamide results in decreased expression of EGFR mRNA; Niclosamide results in decreased expression of EGFR protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein binds to EGFR protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Atrazine co-treated with Niclosamide co-treated with nonachlor co-treated with bisphenol S] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Niclosamide inhibits the reaction [EGF protein binds to EGFR protein]
Niclosamide results in decreased phosphorylation of EGFR protein

PMID:28284560 PMID:28426875 PMID:30779072 PMID:38185387

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

early growth response 1

increases expression
decreases expression

Niclosamide results in increased expression of EGR1 mRNA
Niclosamide results in decreased expression of EGR1 mRNA

PMID:28284560 PMID:36318118

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression
multiple interactions

Niclosamide results in increased expression of EIF2AK3 mRNA
ATF3 protein affects the reaction [Niclosamide results in increased expression of EIF2AK3 mRNA]; Niclosamide results in increased expression of and results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Niclosamide results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 4A2

increases expression

Niclosamide results in increased expression of EIF4A2 mRNA

NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4E

multiple interactions

Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

decreases expression
multiple interactions
decreases phosphorylation

Niclosamide analog results in decreased expression of EIF4EBP1 protein modified form; Niclosamide results in decreased expression of EIF4EBP1 protein modified form
Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]; Niclosamide promotes the reaction [EIF4E protein binds to EIF4EBP1 protein]
Niclosamide results in decreased phosphorylation of EIF4EBP1 protein

PMID:19771169 PMID:28284560 PMID:30258081

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

E74 like ETS transcription factor 1

increases expression

Niclosamide results in increased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

G

extracellular leucine-rich repeat and fibronectin type III domain containing 1

increases expression

Niclosamide results in increased expression of ELFN1 mRNA

NCBI chr12:14,660,049...14,725,709
Ensembl chr12:14,660,083...14,724,580

G

EMAP like 2

increases expression

Niclosamide results in increased expression of EML2 mRNA

NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341

G

endonuclease domain containing 1

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]

NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892

G

endoglin

increases expression

Niclosamide results in increased expression of ENG mRNA

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

enolase 2

increases expression

Niclosamide results in increased expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

enolase 3

decreases expression

Niclosamide results in decreased expression of ENO3 mRNA

NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921

G

E1A binding protein p300

increases expression

Niclosamide results in increased expression of EP300 mRNA

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

endothelial PAS domain protein 1

multiple interactions

Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

Eph receptor A8

increases expression

Niclosamide results in increased expression of EPHA8 mRNA

NCBI chr 5:149,166,107...149,193,515
Ensembl chr 5:149,166,697...149,193,399

G

EPS8 like 3

increases expression

Niclosamide results in increased expression of EPS8L3 mRNA

NCBI chr 2:195,514,692...195,528,085
Ensembl chr 2:195,514,692...195,528,085

G

ETHE1, persulfide dioxygenase

increases expression

Niclosamide results in increased expression of ETHE1 mRNA

NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052

G

eva-1 homolog B

increases expression

Niclosamide results in increased expression of EVA1B mRNA

NCBI chr 5:138,427,088...138,429,602
Ensembl chr 5:138,427,151...138,432,433

G

exonuclease 5

decreases expression

Niclosamide results in decreased expression of EXO5 mRNA

NCBI chr 5:134,494,440...134,497,757
Ensembl chr 5:134,493,829...134,497,772

G

exo/endonuclease G

decreases expression

Niclosamide results in decreased expression of EXOG mRNA

NCBI chr 8:119,184,974...119,204,819
Ensembl chr 8:119,185,136...119,204,672

G

coagulation factor X

increases expression

Niclosamide results in increased expression of F10 mRNA

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor XII

increases expression

Niclosamide results in increased expression of F12 mRNA

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

G

family with sequence similarity 131, member C

increases expression

Niclosamide results in increased expression of FAM131C mRNA

NCBI chr 5:153,674,459...153,690,791
Ensembl chr 5:153,671,772...153,690,800

G

family with sequence similarity 135, member B

increases expression

Niclosamide results in increased expression of FAM135B mRNA

NCBI chr 7:103,380,981...103,649,802
Ensembl chr 7:103,386,915...103,649,708

G

family with sequence similarity 13, member B

decreases expression

Niclosamide results in decreased expression of FAM13B mRNA

NCBI chr18:26,040,285...26,107,112
Ensembl chr18:26,040,285...26,106,587

G

family with sequence similarity 221, member A

increases expression

Niclosamide results in increased expression of FAM221A mRNA

NCBI chr 4:78,337,296...78,358,918
Ensembl chr 4:78,337,296...78,358,909

G

family with sequence similarity 43, member A

increases expression

Niclosamide results in increased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

family with sequence similarity 43, member B

increases expression

Niclosamide results in increased expression of FAM43B mRNA

NCBI chr 5:150,610,656...150,613,054
Ensembl chr 5:150,611,609...150,612,601

G

family with sequence similarity 83, member D

decreases expression

Niclosamide results in decreased expression of FAM83D mRNA

NCBI chr 3:147,421,941...147,441,211
Ensembl chr 3:147,421,908...147,441,192

G

FA complementation group B

decreases expression

Niclosamide results in decreased expression of FANCB mRNA

NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192

G

Fas cell surface death receptor

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of BCL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of CXCR5 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]; Niclosamide affects the reaction [FAS protein mutant form affects the expression of TCF7 protein]; Niclosamide affects the reaction [FAS protein mutant form affects the phosphorylation of STAT3 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FAS mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FAS mRNA]

PMID:28318631 PMID:33632240

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

FAST kinase domains 3

decreases expression

Niclosamide results in decreased expression of FASTKD3 mRNA

NCBI chr 1:34,858,342...34,866,988
Ensembl chr 1:34,858,219...34,866,973

G

F-box protein 2

increases expression

Niclosamide results in increased expression of FBXO2 mRNA

NCBI chr 5:158,592,926...158,598,355
Ensembl chr 5:158,592,925...158,598,355

G

F-box protein 48

increases expression

Niclosamide results in increased expression of FBXO48 mRNA

NCBI chr14:91,380,857...91,382,314
Ensembl chr14:91,380,857...91,382,314

G

FCH and mu domain containing endocytic adaptor 1

increases expression

Niclosamide results in increased expression of FCHO1 mRNA

NCBI chr16:18,413,452...18,430,795
Ensembl chr16:18,413,363...18,435,104

G

Fc receptor-like B

increases expression

Niclosamide results in increased expression of FCRLB mRNA

NCBI chr13:83,148,685...83,157,157
Ensembl chr13:83,149,751...83,155,957

G

flap structure-specific endonuclease 1

decreases expression

Niclosamide results in decreased expression of FEN1 mRNA

NCBI chr 1:206,845,126...206,849,821
Ensembl chr 1:206,844,884...206,850,003

G

FYVE, RhoGEF and PH domain containing 1

increases expression

Niclosamide results in increased expression of FGD1 mRNA

NCBI chr X:20,023,746...20,066,734
Ensembl chr X:20,023,746...20,066,566

G

fibroblast growth factor 1

decreases expression

Niclosamide results in decreased expression of FGF1 mRNA; Niclosamide results in decreased expression of FGF1 protein

NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357

G

fibroblast growth factor 19

increases expression

Niclosamide results in increased expression of FGF19 mRNA

NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287

G

fibroblast growth factor receptor 4

increases expression

Niclosamide results in increased expression of FGFR4 mRNA

NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242

G

fidgetin-like 1

decreases expression

Niclosamide results in decreased expression of FIGNL1 mRNA

NCBI chr14:86,368,670...86,381,728
Ensembl chr14:86,368,675...86,377,455

G

FKBP prolyl isomerase 5

multiple interactions
decreases expression

[Niclosamide co-treated with bicalutamide] results in decreased expression of FKBP5 mRNA
Niclosamide results in decreased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

fibronectin leucine rich transmembrane protein 3

decreases expression

Niclosamide results in decreased expression of FLRT3 mRNA

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

formin 1

increases expression

Niclosamide results in increased expression of FMN1 mRNA

NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220

G

fibronectin 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of FN1 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

fibronectin type III domain containing 10

increases expression

Niclosamide results in increased expression of FNDC10 mRNA

NCBI chr 5:166,299,587...166,311,477
Ensembl chr 5:166,300,122...166,310,326

G

fibronectin type III domain containing 4

increases expression

Niclosamide results in increased expression of FNDC4 mRNA

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of FOS mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of FOS protein]

PMID:26792726 PMID:28824321

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Niclosamide results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

increases expression

Niclosamide results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

forkhead box L1

increases expression

Niclosamide results in increased expression of FOXL1 mRNA

NCBI chr19:49,197,269...49,200,682
Ensembl chr19:49,197,400...49,198,425

G

forkhead box M1

multiple interactions
decreases expression

Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of FOXM1 protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of FOXM1 protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of FOXM1 protein]

NCBI chr 4:161,639,538...161,652,012
Ensembl chr 4:161,638,816...161,650,684

G

forkhead box O4

increases expression

Niclosamide results in increased expression of FOXO4 mRNA

NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115

G

forkhead box O6

increases expression

Niclosamide results in increased expression of FOXO6 mRNA

NCBI chr 5:133,856,087...133,876,387
Ensembl chr 5:133,856,072...133,876,573

G

FRAT regulator of WNT signaling pathway 2

increases expression

Niclosamide results in increased expression of FRAT2 mRNA

NCBI chr 1:240,654,120...240,656,449
Ensembl chr 1:240,654,137...240,656,517

G

frizzled-related protein

increases expression

Niclosamide results in increased expression of FRZB mRNA

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

fascin actin-bundling protein 1

multiple interactions

Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of FSCN1 mRNA]

NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211

G

follistatin like 3

increases expression

Niclosamide results in increased expression of FSTL3 mRNA

NCBI chr 7:9,923,574...9,929,223
Ensembl chr 7:9,923,576...9,939,639

G

frizzled class receptor 1

affects localization

Niclosamide affects the localization of FZD1 protein

NCBI chr 4:29,310,303...29,314,701
Ensembl chr 4:29,310,091...29,312,643
Ensembl chr 4:29,310,091...29,312,643

G

frizzled class receptor 2

decreases expression
increases expression

Niclosamide results in decreased expression of FZD2 mRNA
Niclosamide results in increased expression of FZD2 mRNA

PMID:22576131 PMID:36318118

NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334

G

frizzled class receptor 5

increases expression

Niclosamide results in increased expression of FZD5 mRNA

NCBI chr 9:66,113,096...66,120,276
Ensembl chr 9:66,113,112...66,121,457

G

frizzled class receptor 9

decreases expression

Niclosamide results in decreased expression of FZD9 mRNA

NCBI chr12:21,427,084...21,429,398
Ensembl chr12:21,427,084...21,429,398

G

G4 protein

affects expression

Niclosamide affects the expression of C6ORF47 mRNA

NCBI chr20:3,693,691...3,696,194
Ensembl chr20:3,693,649...3,696,088

G

GRB2-associated binding protein 2

increases expression

Niclosamide results in increased expression of GAB2 mRNA

NCBI chr 1:151,429,844...151,625,708
Ensembl chr 1:151,429,695...151,625,031

G

GABA type A receptor associated protein like 1

increases expression

Niclosamide results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression

Niclosamide results in increased expression of GABRA4 mRNA

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit beta1

increases expression

Niclosamide results in increased expression of GABRB1 mRNA

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

growth arrest and DNA-damage-inducible, beta

increases expression

Niclosamide results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

golgi associated RAB2 interactor 1A

increases expression

Niclosamide results in increased expression of GARIN1A mRNA

NCBI chr 4:57,880,019...57,890,824
Ensembl chr 4:57,880,019...57,890,820

G

GATA binding protein 5

increases expression

Niclosamide results in increased expression of GATA5 mRNA

NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751

G

glucagon

multiple interactions

Niclosamide inhibits the reaction [GCG protein results in increased abundance of Cyclic AMP]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; Niclosamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]

NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929

G

glutamate cysteine ligase, modifier subunit

decreases expression

Niclosamide results in decreased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

growth differentiation factor 15

increases expression

Niclosamide results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

glycerophosphodiester phosphodiesterase domain containing 5

increases expression

Niclosamide results in increased expression of GDPD5 mRNA

NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446

G

GDP-D-glucose phosphorylase 1

decreases expression

Niclosamide results in decreased expression of GDPGP1 mRNA

NCBI chr 1:134,184,119...134,193,281
Ensembl chr 1:134,183,696...134,219,783

G

glial fibrillary acidic protein

decreases expression

Niclosamide results in decreased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

GID complex subunit 4

increases expression

Niclosamide results in increased expression of GID4 mRNA

NCBI chr10:45,221,556...45,247,627
Ensembl chr10:45,245,754...45,247,621
Ensembl chr10:45,245,754...45,247,621

G

GINS complex subunit 1

decreases expression

Niclosamide results in decreased expression of GINS1 mRNA

NCBI chr 3:139,724,513...139,745,930
Ensembl chr 3:139,724,490...139,745,936

G

GINS complex subunit 2

decreases expression

Niclosamide results in decreased expression of GINS2 mRNA

NCBI chr19:48,626,770...48,639,523
Ensembl chr19:48,626,770...48,639,339

G

GINS complex subunit 3

decreases expression

Niclosamide results in decreased expression of GINS3 mRNA

NCBI chr19:9,420,085...9,428,621
Ensembl chr19:9,420,086...9,428,687

G

GINS complex subunit 4

decreases expression

Niclosamide results in decreased expression of GINS4 mRNA

NCBI chr16:68,787,572...68,799,938
Ensembl chr16:68,767,339...68,802,273

G

galactosidase, beta 1-like 3

decreases expression

Niclosamide results in decreased expression of GLB1L3 mRNA

NCBI chr 8:25,179,165...25,220,904
Ensembl chr 8:25,179,165...25,220,904

G

GLIS family zinc finger 1

increases expression

Niclosamide results in increased expression of GLIS1 mRNA

NCBI chr 5:122,222,155...122,412,141
Ensembl chr 5:122,222,128...122,412,141

G

GLIS family zinc finger 2

increases expression

Niclosamide results in increased expression of GLIS2 mRNA

NCBI chr10:10,951,157...10,978,524
Ensembl chr10:10,951,371...10,971,578

G

G protein subunit gamma 7

increases expression

Niclosamide results in increased expression of GNG7 mRNA

NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240

G

golgin A2

increases expression

Niclosamide results in increased expression of GOLGA2 mRNA

NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279

G

golgi SNAP receptor complex member 2

decreases expression

Niclosamide results in decreased expression of GOSR2 mRNA

NCBI chr10:88,585,291...88,605,642
Ensembl chr10:88,586,299...88,605,625

G

glutamic-oxaloacetic transaminase 2

increases expression

Niclosamide results in increased expression of GOT2 mRNA

NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994

G

glycoprotein Ib platelet subunit beta

increases expression

Niclosamide results in increased expression of GP1BB mRNA

NCBI chr11:82,378,216...82,379,393
Ensembl chr11:82,378,199...82,379,392

G

glypican 2

increases expression

Niclosamide results in increased expression of GPC2 mRNA

NCBI chr12:17,277,875...17,284,297
Ensembl chr12:17,277,875...17,284,208

G

G protein-coupled receptor 153

increases expression

Niclosamide results in increased expression of GPR153 mRNA

NCBI chr 5:162,781,587...162,792,975
Ensembl chr 5:162,781,587...162,792,971

G

G protein-coupled receptor 75

decreases expression

Niclosamide results in decreased expression of GPR75 mRNA

NCBI chr14:104,609,542...104,618,885
Ensembl chr14:104,611,089...104,620,370

G

G protein-coupled receptor, class C, group 5, member C

increases expression

Niclosamide results in increased expression of GPRC5C mRNA

NCBI chr10:99,886,900...99,908,928
Ensembl chr10:99,887,077...99,908,926

G

gremlin 2, DAN family BMP antagonist

decreases expression

Niclosamide results in decreased expression of GREM2 mRNA

NCBI chr13:86,778,543...86,871,509
Ensembl chr13:86,778,500...86,871,615

G

glutamate ionotropic receptor kainate type subunit 5

increases expression

Niclosamide results in increased expression of GRIK5 mRNA

NCBI chr 1:80,605,878...80,667,896
Ensembl chr 1:80,605,892...80,667,125

G

glutamate ionotropic receptor NMDA type subunit 2D

increases expression

Niclosamide results in increased expression of GRIN2D mRNA

NCBI chr 1:96,306,871...96,346,994
Ensembl chr 1:96,308,365...96,344,793

G

glutamate receptor interacting protein 2

increases expression

Niclosamide results in increased expression of GRIP2 mRNA

NCBI chr 4:124,271,456...124,356,538
Ensembl chr 4:124,271,456...124,321,268

G

glycogen synthase kinase 3 beta

decreases expression
increases phosphorylation
decreases phosphorylation

Niclosamide results in decreased expression of GSK3B mRNA
Niclosamide results in increased phosphorylation of GSK3B protein
Niclosamide results in decreased phosphorylation of GSK3B protein

PMID:22576131 PMID:30143678 PMID:35115509

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

glutathione S-transferase theta 2

decreases expression

Niclosamide results in decreased expression of GSTT2 mRNA

NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288

G

general transcription factor 2H subunit 4

decreases expression
increases expression

Niclosamide results in decreased expression of GTF2H4 mRNA
Niclosamide results in increased expression of GTF2H4 mRNA

NCBI chr20:3,071,328...3,076,990
Ensembl chr20:3,071,328...3,076,984

G

G-2 and S-phase expressed 1

decreases expression

Niclosamide results in decreased expression of GTSE1 mRNA

NCBI chr 7:116,949,997...116,966,826
Ensembl chr 7:116,950,053...116,966,806

G

glucoside xylosyltransferase 2

increases expression

Niclosamide results in increased expression of GXYLT2 mRNA

NCBI chr 4:133,347,230...133,449,708
Ensembl chr 4:133,347,499...133,449,454

G

hydroxyacyl-CoA dehydrogenase

decreases expression

Niclosamide results in decreased expression of HADH mRNA

NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353

G

hepcidin antimicrobial peptide

decreases expression
increases expression

Niclosamide results in decreased expression of HAMP mRNA
Niclosamide results in increased expression of HAMP mRNA

PMID:25633564 PMID:28284560

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

G

HMG-box transcription factor 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]
Niclosamide results in increased expression of HBP1 mRNA

PMID:27542212 PMID:36318118

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

histone deacetylase 5

increases expression

Niclosamide results in increased expression of HDAC5 mRNA

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

helicase with zinc finger 2

increases expression

Niclosamide results in increased expression of HELZ2 mRNA

NCBI chr 3:168,338,813...168,353,219
Ensembl chr 3:168,338,813...168,353,159

G

hes family bHLH transcription factor 1

decreases expression
multiple interactions

Niclosamide results in decreased expression of HES1 protein
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HES1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HES1 mRNA]; Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of HES1 mRNA]]

PMID:19160421 PMID:28318631 PMID:32961231

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hes-related family bHLH transcription factor with YRPW motif 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY1 mRNA]
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]

PMID:27542212 PMID:28318631

NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions
increases expression

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HEY2 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HEY2 mRNA]
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [Niclosamide results in increased expression of HEY2 mRNA]

PMID:19160421 PMID:28318631

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

HHIP-like 1

increases expression

Niclosamide results in increased expression of HHIPL1 mRNA

NCBI chr 6:127,219,616...127,243,839
Ensembl chr 6:127,220,014...127,242,564

G

HID1 domain containing

increases expression

Niclosamide results in increased expression of HID1 mRNA

NCBI chr10:100,589,555...100,610,050
Ensembl chr10:100,589,555...100,610,041

G

hypoxia inducible factor 1 subunit alpha

decreases expression
multiple interactions

Niclosamide results in decreased expression of HIF1A mRNA; Niclosamide results in decreased expression of HIF1A protein
Niclosamide inhibits the reaction [EGF protein results in increased expression of HIF1A mRNA]; Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

PMID:30779072 PMID:36318118

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

homeodomain interacting protein kinase 2

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of HIPK2 protein]
HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]]; HIPK2 protein inhibits the reaction [Niclosamide inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; Niclosamide inhibits the reaction [TGFB1 protein promotes the reaction [SMAD3 protein binds to HIPK2 promoter]]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 mRNA]; Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of HIPK2 protein]

NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223

G

histone cluster 1, H2bc

increases expression

Niclosamide results in increased expression of H2BC21 mRNA

NCBI chr17:42,692,335...42,696,601
Ensembl chr17:42,694,723...42,696,642

G

HIVEP zinc finger 2

increases expression

Niclosamide results in increased expression of HIVEP2 mRNA

NCBI chr 1:8,358,205...8,555,993
Ensembl chr 1:8,359,289...8,555,993

G

hexokinase 3

decreases expression

Niclosamide results in decreased expression of HK3 mRNA

NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863

G

3-hydroxy-3-methylglutaryl-CoA lyase

increases expression

Niclosamide results in increased expression of HMGCL mRNA

NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068

G

hyaluronan-mediated motility receptor

decreases expression

Niclosamide results in decreased expression of HMMR mRNA

NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060

G

H6 family homeobox 2

increases expression

Niclosamide results in increased expression of HMX2 mRNA

NCBI chr 1:186,319,110...186,326,771
Ensembl chr 1:186,319,110...186,326,771

G

4-hydroxy-2-oxoglutarate aldolase 1

increases expression

Niclosamide results in increased expression of HOGA1 mRNA

NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568

G

homer scaffold protein 1

decreases expression

Niclosamide results in decreased expression of HOMER1 mRNA

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

homer scaffold protein 3

increases expression

Niclosamide results in increased expression of HOMER3 mRNA

NCBI chr16:19,132,177...19,142,739
Ensembl chr16:19,132,162...19,142,680

G

homeobox A1

increases expression

Niclosamide results in increased expression of HOXA1

NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504

G

HR, lysine demethylase and nuclear receptor corepressor

increases expression

Niclosamide results in increased expression of HR mRNA

NCBI chr15:45,626,835...45,646,313
Ensembl chr15:45,626,835...45,646,313

G

histamine receptor H 1

increases expression

Niclosamide results in increased expression of HRH1 mRNA

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

heparan sulfate 6-O-sulfotransferase 1

decreases expression

Niclosamide results in decreased expression of HS6ST1 mRNA

NCBI chr 9:38,283,502...38,322,684
Ensembl chr 9:38,282,395...38,322,683

G

hydroxysteroid (17-beta) dehydrogenase 14

increases expression

Niclosamide results in increased expression of HSD17B14 mRNA

NCBI chr 1:96,029,224...96,039,577
Ensembl chr 1:96,029,284...96,039,883

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

increases expression

Niclosamide results in increased expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

increases expression

Niclosamide results in increased expression of HSD3B2 mRNA

NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852

G

heat shock protein family A (Hsp70) member 6 like, pseudogene 1

increases expression

Niclosamide results in increased expression of HSPA6 mRNA

NCBI chr13:83,273,176...83,274,317

G

heat shock protein family B (small) member 7

increases expression

Niclosamide results in increased expression of HSPB7 mRNA

NCBI chr 5:153,727,782...153,731,268
Ensembl chr 5:153,727,588...153,731,266

G

hydrogen voltage-gated channel 1

increases expression

Niclosamide results in increased expression of HVCN1 mRNA

NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141

G

intercellular adhesion molecule 1

multiple interactions

Niclosamide inhibits the reaction [Doxorubicin results in increased expression of ICAM1 mRNA]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

intercellular adhesion molecule 5

increases expression

Niclosamide results in increased expression of ICAM5 mRNA

NCBI chr 8:19,567,390...19,575,588
Ensembl chr 8:19,568,600...19,575,588

G

inhibitor of DNA binding 1

increases expression

Niclosamide results in increased expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

immediate early response 5-like

increases expression

Niclosamide results in increased expression of IER5L mRNA

NCBI chr 3:13,744,056...13,745,647
Ensembl chr 3:13,744,078...13,745,647

G

insulin-like growth factor 1 receptor

affects response to substance

IGF1R protein affects the susceptibility to Niclosamide

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor binding protein 4

increases expression

Niclosamide results in increased expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

inhibitor of nuclear factor kappa B kinase subunit beta

affects localization

Niclosamide affects the localization of IKBKB protein

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

affects localization

Niclosamide affects the localization of IKBKG protein

NCBI chr X:152,216,485...152,241,476
Ensembl chr X:152,216,596...152,239,499

G

IKAROS family zinc finger 2

increases expression

Niclosamide results in increased expression of IKZF2 mRNA

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

interleukin 12A

multiple interactions

Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 17 receptor E

increases expression

Niclosamide results in increased expression of IL17RE mRNA

NCBI chr 4:146,604,547...146,618,206
Ensembl chr 4:146,605,526...146,618,206

G

interleukin 1 beta

multiple interactions

Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 21

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL21 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL21 protein]

NCBI chr 2:120,117,105...120,127,012
Ensembl chr 2:120,119,444...120,126,996

G

interleukin 6

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of IL6 protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Niclosamide inhibits the reaction [resiquimod results in increased expression of IL6 protein]
Niclosamide inhibits the reaction [IL6 protein results in decreased susceptibility to enzalutamide]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of BIRC5 protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of CCND1 mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of SOCS1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; Niclosamide inhibits the reaction [IL6 protein results in increased phosphorylation of and results in increased activity of STAT3 protein]

PMID:24561310 PMID:25970160 PMID:26297436 PMID:28318631 PMID:33632240

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

InaF-motif containing 1

increases expression

Niclosamide results in increased expression of INAFM1 mRNA

NCBI chr 1:76,976,808...76,978,292

G

inhibitor of CDK, cyclin A1 interacting protein 1

increases expression

Niclosamide results in increased expression of INCA1 mRNA

NCBI chr10:55,401,989...55,414,364
Ensembl chr10:55,401,982...55,414,114

G

inhibin subunit beta E

increases expression

Niclosamide results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

inositol polyphosphate-5-phosphatase J

increases expression

Niclosamide results in increased expression of INPP5J mRNA

NCBI chr14:78,374,161...78,385,305
Ensembl chr14:78,374,161...78,385,326

G

insulin receptor-related receptor

decreases expression

Niclosamide results in decreased expression of INSRR mRNA

NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800

G

IQ motif and Sec7 domain ArfGEF 3

increases expression

Niclosamide results in increased expression of IQSEC3 mRNA

NCBI chr 4:154,610,933...154,707,310
Ensembl chr 4:154,610,934...154,707,310

G

interleukin-1 receptor-associated kinase 2

increases expression

Niclosamide results in increased expression of IRAK2 mRNA

NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602

G

interferon regulatory factor 2 binding protein 2

increases expression

Niclosamide results in increased expression of IRF2BP2 mRNA

NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642

G

integrin subunit alpha V

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGAV mRNA]

NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639

G

integrin subunit beta 3

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of ITGB3 mRNA]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of ITGB3 mRNA]

PMID:26792726 PMID:28824321

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

G

jade family PHD finger 2

increases expression

Niclosamide results in increased expression of JADE2 mRNA

NCBI chr10:36,075,239...36,124,210
Ensembl chr10:36,078,917...36,116,984

G

Janus kinase 3

increases expression

Niclosamide results in increased expression of JAK3 mRNA

NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536

G

janus kinase and microtubule interacting protein 3

increases expression

Niclosamide results in increased expression of JAKMIP3 mRNA

NCBI chr 1:193,753,134...193,881,105
Ensembl chr 1:193,811,513...193,881,104

G

Jun dimerization protein 2

increases expression

Niclosamide results in increased expression of JDP2 mRNA

NCBI chr 6:105,261,619...105,302,386
Ensembl chr 6:105,261,373...105,301,485

G

junctophilin 3

increases expression

Niclosamide results in increased expression of JPH3 mRNA

NCBI chr19:49,793,967...49,855,338
Ensembl chr19:49,793,092...49,855,338

G

junctophilin 4

increases expression

Niclosamide results in increased expression of JPH4 mRNA

NCBI chr15:28,579,579...28,588,903
Ensembl chr15:28,571,568...28,587,573

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects localization
multiple interactions
increases phosphorylation
increases expression

Niclosamide affects the localization of JUN protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
Niclosamide results in increased expression of JUN mRNA

PMID:24750999 PMID:27338550

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kelch repeat and BTB domain containing 11

increases expression

Niclosamide results in increased expression of KBTBD11 mRNA

NCBI chr16:74,618,291...74,638,010
Ensembl chr16:74,615,792...74,637,736

G

potassium voltage-gated channel modifier subfamily F member 1

increases expression

Niclosamide results in increased expression of KCNF1 mRNA

NCBI chr 6:39,962,301...39,964,979
Ensembl chr 6:39,962,307...39,964,979

G

potassium two pore domain channel subfamily K member 13

decreases expression

Niclosamide results in decreased expression of KCNK13 mRNA

NCBI chr 6:119,240,825...119,345,292
Ensembl chr 6:119,242,188...119,345,240

G

potassium calcium-activated channel subfamily N member 3

increases expression

Niclosamide results in increased expression of KCNN3 mRNA

NCBI chr 2:174,929,846...175,088,910
Ensembl chr 2:174,936,629...175,081,145

G

potassium voltage-gated channel modifier subfamily V member 1

decreases expression

Niclosamide results in decreased expression of KCNV1 mRNA

NCBI chr 7:76,260,695...76,269,170
Ensembl chr 7:76,260,695...76,269,170

G

potassium channel tetramerization domain containing 11

increases expression

Niclosamide results in increased expression of KCTD11 mRNA

NCBI chr10:54,602,575...54,604,738
Ensembl chr10:54,599,754...54,604,760

G

KDEL endoplasmic reticulum protein retention receptor 3

increases expression

Niclosamide results in increased expression of KDELR3 mRNA

NCBI chr 7:111,079,236...111,089,463
Ensembl chr 7:111,079,218...111,101,600

G

lysine demethylase 5B

increases expression

Niclosamide results in increased expression of KDM5B mRNA

NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872

G

lysine demethylase 6B

increases expression

Niclosamide results in increased expression of KDM6B mRNA

NCBI chr10:54,120,716...54,142,212
Ensembl chr10:54,121,848...54,130,794

G

lysine demethylase 7A

increases expression

Niclosamide results in increased expression of KDM7A mRNA

NCBI chr 4:67,899,407...67,974,264
Ensembl chr 4:67,904,307...67,966,998

G

KH and NYN domain containing

increases expression

Niclosamide results in increased expression of KHNYN mRNA

NCBI chr15:29,365,399...29,379,650
Ensembl chr15:29,365,260...29,376,967

G

KIAA1614 homolog

decreases expression

Niclosamide results in decreased expression of KIAA1614 mRNA

NCBI chr13:67,388,916...67,427,392
Ensembl chr13:67,389,044...67,421,272

G

kinesin family member 11

decreases expression

Niclosamide results in decreased expression of KIF11 mRNA

NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766

G

kinesin family member 20A

decreases expression

Niclosamide results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

G

kinesin family member C1

decreases expression

Niclosamide results in decreased expression of KIFC1 mRNA

NCBI chr20:4,998,832...5,017,107
Ensembl chr20:4,999,047...5,017,105

G

kirre like nephrin family adhesion molecule 2

increases expression

Niclosamide results in increased expression of KIRREL2 mRNA

NCBI chr 1:85,708,793...85,718,670
Ensembl chr 1:85,708,793...85,718,670

G

kizuna centrosomal protein

increases expression

Niclosamide results in increased expression of KIZ mRNA

NCBI chr 3:134,277,631...134,385,260
Ensembl chr 3:134,277,687...134,385,190

G

kinesin light chain 4

increases expression

Niclosamide results in increased expression of KLC4 mRNA

NCBI chr 9:14,337,164...14,351,075
Ensembl chr 9:14,337,534...14,351,066

G

KLF transcription factor 15

increases expression

Niclosamide results in increased expression of KLF15 mRNA

NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374

G

KLF transcription factor 9

increases expression

Niclosamide results in increased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

kelch domain containing 8A

increases expression

Niclosamide results in increased expression of KLHDC8A mRNA

NCBI chr13:43,735,702...43,744,277
Ensembl chr13:43,736,192...43,744,277

G

kelch domain containing 8B

increases expression

Niclosamide results in increased expression of KLHDC8B mRNA

NCBI chr 8:109,141,594...109,146,584
Ensembl chr 8:109,141,594...109,146,918

G

kelch-like family member 24

increases expression

Niclosamide results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

kelch-like family member 30

increases expression

Niclosamide results in increased expression of KLHL30 mRNA

NCBI chr 9:91,942,475...91,952,756
Ensembl chr 9:91,942,504...91,952,730

G

kelch-like family member 34

decreases expression

Niclosamide results in decreased expression of KLHL34 mRNA

NCBI chr X:37,151,298...37,154,053
Ensembl chr X:37,151,592...37,153,529

G

kallikrein 1-related peptidase C10

decreases expression
multiple interactions

Niclosamide results in decreased expression of KLK3 mRNA; Niclosamide results in decreased expression of KLK3 protein
[Niclosamide co-treated with bicalutamide] results in decreased expression of KLK3 mRNA; [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]] which results in decreased expression of KLK3 protein; bicalutamide promotes the reaction [Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]]; enzalutamide promotes the reaction [Niclosamide results in decreased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein alternative form binds to KLK3 promoter]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 mRNA]; Niclosamide inhibits the reaction [AR protein alternative form results in increased expression of KLK3 protein]; Niclosamide inhibits the reaction [AR protein binds to KLK3 promoter]; Niclosamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]

PMID:24740322 PMID:25970160 PMID:28500234

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

La ribonucleoprotein 6, translational regulator

increases expression

Niclosamide results in increased expression of LARP6 mRNA

NCBI chr 8:61,183,744...61,205,548
Ensembl chr 8:61,184,116...61,205,535

G

LBH regulator of WNT signaling pathway

increases expression

Niclosamide results in increased expression of LBH mRNA

NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079

G

ladybird homeobox 2

increases expression

Niclosamide results in increased expression of LBX2 mRNA

NCBI chr 4:115,591,974...115,593,859
Ensembl chr 4:115,591,974...115,594,132

G

lecithin cholesterol acyltransferase

increases expression

Niclosamide results in increased expression of LCAT mRNA

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

leucine carboxyl methyltransferase 2

decreases expression

Niclosamide results in decreased expression of LCMT2 mRNA

NCBI chr 3:108,099,960...108,102,084
Ensembl chr 3:108,099,961...108,102,084

G

ligand dependent nuclear receptor corepressor-like

increases expression

Niclosamide results in increased expression of LCORL mRNA

NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174

G

lactate dehydrogenase A

increases expression
decreases expression
multiple interactions

Niclosamide results in increased expression of LDHA mRNA
Niclosamide results in decreased expression of LDHA mRNA
Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of LDHA mRNA]

PMID:22576131 PMID:36318118

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

leukocyte receptor cluster member 9

increases expression

Niclosamide results in increased expression of LENG9 mRNA

NCBI chr 1:70,039,099...70,041,559
Ensembl chr 1:70,035,791...70,044,509

G

galectin 3

increases expression

Niclosamide results in increased expression of LGALS3 mRNA

NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025

G

galectin 8

decreases expression

Niclosamide results in decreased expression of LGALS8 mRNA

NCBI chr17:58,024,652...58,052,764
Ensembl chr17:58,028,105...58,052,764

G

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

increases expression

Niclosamide results in increased expression of LHPP mRNA

NCBI chr 1:187,403,390...187,494,577
Ensembl chr 1:187,403,433...187,494,578

G

LIM homeobox 6

increases expression

Niclosamide results in increased expression of LHX6 mRNA

NCBI chr 3:19,432,439...19,456,268
Ensembl chr 3:19,433,494...19,456,061

G

leucine rich repeat and Ig domain containing 1

increases expression

Niclosamide results in increased expression of LINGO1 mRNA

NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544

G

lipase G, endothelial type

decreases expression

Niclosamide results in decreased expression of LIPG mRNA

NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260

G

limb and CNS expressed 1

decreases expression

Niclosamide results in decreased expression of LIX1 mRNA

NCBI chr 1:58,128,961...58,187,554
Ensembl chr 1:58,128,961...58,185,964

G

lemur tyrosine kinase 3

increases expression

Niclosamide results in increased expression of LMTK3 mRNA

NCBI chr 1:96,261,058...96,280,362
Ensembl chr 1:96,260,977...96,280,672

G

LON peptidase N-terminal domain and ring finger 1

increases expression

Niclosamide results in increased expression of LONRF1 mRNA

NCBI chr16:55,984,572...56,015,156
Ensembl chr16:55,984,463...56,015,156

G

lysyl oxidase-like 3

increases expression

Niclosamide results in increased expression of LOXL3 mRNA

NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466

G

lipin 3

increases expression

Niclosamide results in increased expression of LPIN3 mRNA

NCBI chr 3:149,533,719...149,558,494
Ensembl chr 3:149,534,051...149,558,327

G

LDL receptor related protein 1

increases expression

Niclosamide results in increased expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

LDL receptor related protein 10

increases expression

Niclosamide results in increased expression of LRP10 mRNA

NCBI chr15:27,921,335...27,927,507
Ensembl chr15:27,920,259...27,927,505

G

LDL receptor related protein 5

multiple interactions

Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP5 mRNA]]

NCBI chr 1:200,814,247...200,917,581
Ensembl chr 1:200,814,250...200,917,581

G

LDL receptor related protein 6

decreases expression
multiple interactions

Niclosamide analog results in decreased expression of LRP6 protein; Niclosamide results in decreased expression of LRP6 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of LRP6 mRNA]]
Niclosamide results in decreased expression of and results in decreased phosphorylation of LRP6 protein

PMID:24552774 PMID:24736023 PMID:28284560 PMID:32961231

NCBI chr 4:167,269,856...167,400,364
Ensembl chr 4:167,270,353...167,400,497

G

leucine rich repeat containing 2

increases expression

Niclosamide results in increased expression of LRRC2 mRNA

NCBI chr 8:110,936,119...110,969,189
Ensembl chr 8:110,938,165...110,969,185

G

leucine rich repeat containing 55

decreases expression

Niclosamide results in decreased expression of LRRC55 mRNA

NCBI chr 3:70,269,908...70,280,651
Ensembl chr 3:70,265,936...70,278,639

G

leucine rich repeat containing 73

increases expression

Niclosamide results in increased expression of LRRC73 mRNA

NCBI chr 9:14,726,157...14,730,144
Ensembl chr 9:14,726,158...14,729,158

G

leucine rich repeat containing 75B

increases expression

Niclosamide results in increased expression of LRRC75B mRNA

NCBI chr20:13,100,302...13,106,503
Ensembl chr20:13,100,302...13,106,503

G

lymphocyte-specific protein 1

decreases expression

Niclosamide results in decreased expression of LSP1 mRNA

NCBI chr 1:197,614,677...197,648,414
Ensembl chr 1:197,614,687...197,648,416

G

latent transforming growth factor beta binding protein 4

increases expression

Niclosamide results in increased expression of LTBP4 mRNA

NCBI chr 1:82,600,136...82,634,346
Ensembl chr 1:82,600,136...82,632,178

G

lymphocyte antigen 6 family member G5B

decreases expression

Niclosamide results in decreased expression of LY6G5B mRNA

NCBI chr20:3,705,464...3,707,830
Ensembl chr20:3,706,124...3,707,133

G

LYR motif containing 9

increases expression

Niclosamide results in increased expression of LYRM9 mRNA

NCBI chr10:63,725,718...63,739,772
Ensembl chr10:63,725,743...63,739,772

G

MET transcriptional regulator MACC1

multiple interactions

Niclosamide inhibits the reaction [MACC1 protein results in increased expression of S100A4 protein]

NCBI chr 6:140,352,690...140,430,255
Ensembl chr 6:140,352,755...140,430,255

G

mitotic arrest deficient 2 like 1

decreases expression

Niclosamide results in decreased expression of MAD2L1 mRNA

NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470

G

MAGI family member, X-linked

increases expression

Niclosamide results in increased expression of MAGIX mRNA

NCBI chr X:14,824,114...14,832,466
Ensembl chr X:14,824,188...14,831,045

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Niclosamide results in increased expression of MAP1LC3B protein modified form

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions

Niclosamide results in decreased phosphorylation of MAPK1 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK1 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]

PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK3 protein]; Niclosamide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
Niclosamide results in decreased phosphorylation of MAPK3 protein

PMID:24561310 PMID:26116531 PMID:28426875 PMID:28824321

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microtubule-associated protein tau

increases expression

Niclosamide results in increased expression of MAPT mRNA

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

MBL associated serine protease 1

increases expression

Niclosamide results in increased expression of MASP1 mRNA

NCBI chr11:77,334,794...77,405,271
Ensembl chr11:77,334,859...77,402,974

G

microtubule associated serine/threonine kinase 1

increases expression

Niclosamide results in increased expression of MAST1 mRNA

NCBI chr19:23,216,418...23,244,224
Ensembl chr19:23,207,991...23,244,235

G

methionine adenosyltransferase 2A

decreases expression

Niclosamide results in decreased expression of MAT2A mRNA

NCBI chr 4:104,489,877...104,495,447
Ensembl chr 4:104,488,466...104,495,493

G

matrilin 1

increases expression

Niclosamide results in increased expression of MATN1 mRNA

NCBI chr 5:143,117,198...143,127,140
Ensembl chr 5:143,117,504...143,127,059

G

membrane bound O-acyltransferase domain containing 7

increases expression

Niclosamide results in increased expression of MBOAT7 mRNA

NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

Niclosamide results in decreased expression of MCL1 protein

PMID:20215516 PMID:26116531

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

minichromosome maintenance 10 replication initiation factor

decreases expression

Niclosamide results in decreased expression of MCM10 mRNA

NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364

G

minichromosome maintenance complex component 2

decreases expression

Niclosamide results in decreased expression of MCM2 mRNA; Niclosamide results in decreased expression of MCM2 protein

PMID:28284560 PMID:29031202

NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847

G

minichromosome maintenance complex component 5

decreases expression

Niclosamide results in decreased expression of MCM5 mRNA

NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389

G

minichromosome maintenance complex component 6

decreases expression

Niclosamide results in decreased expression of MCM6 mRNA

NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960

G

minichromosome maintenance complex component 7

decreases expression

Niclosamide results in decreased expression of MCM7 protein

NCBI chr12:17,042,207...17,049,470
Ensembl chr12:17,042,212...17,050,063

G

malic enzyme 3

decreases expression

Niclosamide results in decreased expression of ME3 mRNA

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

G

mediator complex subunit 31

decreases expression

Niclosamide results in decreased expression of MED31 mRNA

NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326

G

myocyte enhancer factor 2D

increases expression

Niclosamide results in increased expression of MEF2D mRNA

NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457

G

Meis homeobox 3

increases expression

Niclosamide results in increased expression of MEIS3 mRNA

NCBI chr 1:76,861,267...76,872,691
Ensembl chr 1:76,861,924...76,872,691

G

mesoderm posterior bHLH transcription factor 1

increases expression

Niclosamide results in increased expression of MESP1 mRNA

NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

Niclosamide results in decreased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

meteorin-like, glial cell differentiation regulator

increases expression

Niclosamide results in increased expression of METRNL mRNA

NCBI chr10:106,963,880...106,977,875
Ensembl chr10:106,963,880...106,977,869

G

monoglyceride lipase

increases expression

Niclosamide results in increased expression of MGLL mRNA

NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179

G

membrane integral NOTCH2 associated receptor 2

decreases expression

Niclosamide results in decreased expression of MINAR2 mRNA

NCBI chr18:52,539,714...52,554,465
Ensembl chr18:52,539,917...52,554,461

G

marker of proliferation Ki-67

decreases expression

Niclosamide results in decreased expression of MKI67 mRNA; Niclosamide results in decreased expression of MKI67 protein

PMID:28284560 PMID:35115509

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

MAPK interacting serine/threonine kinase 2

increases expression

Niclosamide results in increased expression of MKNK2 mRNA

NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827

G

membrane metallo-endopeptidase

decreases expression

Niclosamide results in decreased expression of MME mRNA; Niclosamide results in decreased expression of MME protein

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 11

increases expression

Niclosamide results in increased expression of MMP11 mRNA

NCBI chr20:12,730,846...12,739,629
Ensembl chr20:12,730,836...12,739,628

G

matrix metallopeptidase 15

increases expression

Niclosamide results in increased expression of MMP15 mRNA

NCBI chr19:9,663,449...9,684,943
Ensembl chr19:9,663,449...9,684,943

G

matrix metallopeptidase 2

decreases expression

Niclosamide results in decreased expression of MMP2 mRNA; Niclosamide results in decreased expression of MMP2 protein

PMID:29251334 PMID:30143678

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 7

multiple interactions
decreases expression

Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of MMP7 mRNA]
Niclosamide inhibits the reaction [Doxorubicin results in increased expression of MMP7 mRNA]
Niclosamide results in decreased expression of MMP7 mRNA

PMID:27338550 PMID:28318631

NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902

G

matrix metallopeptidase 9

decreases expression
multiple interactions

Niclosamide results in decreased expression of MMP9 mRNA; Niclosamide results in decreased expression of MMP9 protein
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of MMP9 mRNA]

PMID:28824321 PMID:29480568 PMID:30143678

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mannose receptor, C type 2

increases expression

Niclosamide results in increased expression of MRC2 mRNA

NCBI chr10:90,261,986...90,323,187
Ensembl chr10:90,261,394...90,322,856

G

mitochondrial rRNA methyltransferase 2

decreases expression

Niclosamide results in decreased expression of MRM2 mRNA

NCBI chr12:14,309,556...14,314,759
Ensembl chr12:14,251,941...14,314,118

G

mitochondrial ribosomal protein L30

decreases expression

Niclosamide results in decreased expression of MRPL30 mRNA

NCBI chr 9:40,125,352...40,136,189
Ensembl chr 9:40,125,430...40,137,257

G

Myb/SANT DNA binding domain containing 7

decreases expression

Niclosamide results in decreased expression of MSANTD7 mRNA

NCBI chr17:74,728,927...74,735,527
Ensembl chr17:74,728,811...74,736,094

G

metallothionein 1, pseudogene 3

increases expression

Niclosamide results in increased expression of MT1E mRNA

NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2A

increases expression

Niclosamide results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions
increases expression

Niclosamide analog results in decreased phosphorylation of MTOR protein; Niclosamide results in decreased phosphorylation of MTOR protein
Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of MTOR protein]; Niclosamide inhibits the reaction [MTOR protein results in increased phosphorylation of EIF4EBP1 protein]
Niclosamide results in increased expression of MTOR mRNA

PMID:19771169 PMID:26643609 PMID:26703449 PMID:28284560 PMID:29843133 More...

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

major vault protein

increases expression

Niclosamide results in increased expression of MVP mRNA

NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380

G

MAX interactor 1, dimerization protein

increases expression

Niclosamide results in increased expression of MXI1 mRNA

NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases expression

Niclosamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]
Niclosamide results in decreased expression of MYC mRNA; Niclosamide results in decreased expression of MYC protein
[Niclosamide binds to Polyethyleneimine] which results in increased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC mRNA; [Niclosamide co-treated with bicalutamide] results in decreased expression of MYC protein; enzalutamide promotes the reaction [Niclosamide results in decreased expression of MYC protein]; Niclosamide inhibits the reaction [bicalutamide results in increased expression of MYC protein]; Niclosamide inhibits the reaction [IL6 protein results in increased expression of MYC protein]; Niclosamide inhibits the reaction [TNF protein results in increased expression of MYC mRNA]

PMID:19160421 PMID:20215516 PMID:22576131 PMID:25970160 PMID:25988281 More...

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYCL proto-oncogene, bHLH transcription factor

increases expression

Niclosamide results in increased expression of MYCL mRNA

NCBI chr 5:135,274,713...135,281,584
Ensembl chr 5:135,274,748...135,281,582

G

MYCN proto-oncogene, bHLH transcription factor

decreases expression

Niclosamide results in decreased expression of MYCN mRNA; Niclosamide results in decreased expression of MYCN protein

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

myosin heavy chain 3

increases expression

Niclosamide results in increased expression of MYH3 mRNA

NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992

G

myosin XVIIIb

increases expression

Niclosamide results in increased expression of MYO18B mRNA

NCBI chr12:43,747,003...43,953,694
Ensembl chr12:43,747,010...43,953,695

G

myogenic differentiation 1

increases expression

Niclosamide results in increased expression of MYOD1 mRNA

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

myogenin

increases expression

Niclosamide results in increased expression of MYOG protein

NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039

G

myomesin 3

increases expression

Niclosamide results in increased expression of MYOM3 mRNA

NCBI chr 5:147,992,737...148,043,282
Ensembl chr 5:147,992,737...148,043,274

G

myelin regulatory factor

increases expression

Niclosamide results in increased expression of MYRF mRNA

NCBI chr 1:206,854,175...206,886,276
Ensembl chr 1:206,854,175...206,886,157

G

NEDD4 binding protein 2-like 1

increases expression

Niclosamide results in increased expression of N4BP2L1 mRNA

NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257

G

N(alpha)-acetyltransferase 80, NatH catalytic subunit

increases expression

Niclosamide results in increased expression of NAA80 mRNA

NCBI chr 8:108,254,314...108,257,564
Ensembl chr 8:108,253,302...108,257,563

G

N-acetyltransferase 1

decreases expression

Niclosamide results in decreased expression of NAT1 mRNA

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

N-acetyltransferase domain containing 1

increases expression

Niclosamide results in increased expression of NATD1 mRNA

NCBI chr10:45,580,154...45,590,333

G

NBR1, autophagy cargo receptor

increases expression

Niclosamide results in increased expression of NBR1 mRNA

NCBI chr10:86,477,775...86,506,418
Ensembl chr10:86,478,290...86,506,412

G

nuclear receptor coactivator 5

decreases expression

Niclosamide results in decreased expression of NCOA5 mRNA

NCBI chr 3:153,736,420...153,769,838
Ensembl chr 3:153,736,420...153,769,553

G

NADPH dependent diflavin oxidoreductase 1

decreases expression

Niclosamide results in decreased expression of NDOR1 mRNA

NCBI chr 3:8,062,629...8,070,873
Ensembl chr 3:8,062,630...8,070,860

G

N-myc downstream regulated 1

increases expression

Niclosamide results in increased expression of NDRG1 mRNA

NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880

G

NADH:ubiquinone oxidoreductase subunit A10

decreases expression

Niclosamide results in decreased expression of NDUFA10 mRNA

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

G

NDUFA4, mitochondrial complex associated like 2

increases expression

Niclosamide results in increased expression of NDUFA4L2 mRNA

PMID:22576131 PMID:36318118

NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010

G

NADH:ubiquinone oxidoreductase subunit A7

decreases expression

Niclosamide results in decreased expression of NDUFA7 mRNA

NCBI chr 7:14,609,283...14,622,064
Ensembl chr 7:14,609,146...14,631,976

G

NADH:ubiquinone oxidoreductase subunit A8

decreases expression

Niclosamide results in decreased expression of NDUFA8 mRNA

NCBI chr 3:19,386,062...19,402,090
Ensembl chr 3:19,386,065...19,402,071

G

NADH:ubiquinone oxidoreductase subunit B10

decreases expression

Niclosamide results in decreased expression of NDUFB10 mRNA

NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442

G

NADH:ubiquinone oxidoreductase subunit B6

decreases expression

Niclosamide results in decreased expression of NDUFB6 mRNA

NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181

G

NADH:ubiquinone oxidoreductase subunit C1

increases expression

Niclosamide results in increased expression of NDUFC1 mRNA

NCBI chr 2:135,447,067...135,450,950
Ensembl chr 2:135,447,119...135,450,874

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

Niclosamide results in decreased expression of NDUFS2 mRNA

NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420

G

NADH:ubiquinone oxidoreductase core subunit S3

decreases expression

Niclosamide results in decreased expression of NDUFS3 mRNA

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

NADH:ubiquinone oxidoreductase core subunit S7

decreases expression

Niclosamide results in decreased expression of NDUFS7 mRNA

NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195

G

NADH:ubiquinone oxidoreductase core subunit S8

decreases expression

Niclosamide results in decreased expression of NDUFS8 mRNA

NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511

G

NADH:ubiquinone oxidoreductase subunit V3

increases expression

Niclosamide results in increased expression of NDUFV3 mRNA

NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074

G

nectin cell adhesion molecule 3

decreases expression

Niclosamide results in decreased expression of NECTIN3 mRNA

NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519

G

nuclear factor of activated T-cells 1

multiple interactions

Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]; Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]
Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of and affects the localization of NFATC1 protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of NFATC1 mRNA]

PMID:26792726 PMID:28824321

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

nuclear factor of activated T-cells 2 interacting protein

decreases expression

Niclosamide results in decreased expression of NFATC2IP mRNA

NCBI chr 1:180,954,834...180,971,847
Ensembl chr 1:180,955,043...180,971,747

G

nuclear factor I X

increases expression

Niclosamide results in increased expression of NFIX mRNA

NCBI chr19:23,355,388...23,450,360
Ensembl chr19:23,355,498...23,448,265

G

nuclear factor kappa B subunit 1

affects localization

Niclosamide affects the localization of NFKB1 protein

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

increases expression

Niclosamide results in increased expression of NFKB2 mRNA

NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor alpha

decreases phosphorylation
multiple interactions

Niclosamide results in decreased phosphorylation of NFKBIA protein
Niclosamide inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Niclosamide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of NFKBIA protein]; Niclosamide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]

PMID:20215516 PMID:26116531 PMID:27492973 PMID:28824321 PMID:33524445

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor like 1

increases expression

Niclosamide results in increased expression of NFKBIL1 mRNA

NCBI chr20:3,589,974...3,608,348
Ensembl chr20:3,590,642...3,605,616

G

NKD inhibitor of WNT signaling pathway 1

multiple interactions
increases expression

Niclosamide inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA]
Niclosamide results in increased expression of NKD1 mRNA

PMID:22576131 PMID:24534281

NCBI chr19:18,476,344...18,549,380
Ensembl chr19:18,476,344...18,549,380

G

NK3 homeobox 1

multiple interactions
decreases expression

[Niclosamide co-treated with bicalutamide] results in decreased expression of NKX3-1 mRNA
Niclosamide results in decreased expression of NKX3-1 mRNA

NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441

G

NLR family, pyrin domain containing 3

multiple interactions

Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nicotinamide riboside kinase 1

increases expression

Niclosamide results in increased expression of NMRK1 mRNA

NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791

G

neuronatin

decreases expression

Niclosamide results in decreased expression of NNAT mRNA

NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834

G

nitric oxide synthase trafficking

decreases expression

Niclosamide results in decreased expression of NOSTRIN mRNA

NCBI chr 3:53,904,746...53,970,995
Ensembl chr 3:53,904,827...53,970,988

G

notch receptor 1

decreases activity
multiple interactions

Niclosamide results in decreased activity of NOTCH1 protein
Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]; Poloxamer promotes the reaction [Niclosamide inhibits the reaction [Thioacetamide results in increased expression of NOTCH1 mRNA]]

PMID:19160421 PMID:32961231

NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531

G

NOTUM, palmitoleoyl-protein carboxylesterase

increases expression

Niclosamide results in increased expression of NOTUM mRNA

NCBI chr10:105,933,245...105,940,327
Ensembl chr10:105,933,249...105,940,315

G

NOVA alternative splicing regulator 2

increases expression

Niclosamide results in increased expression of NOVA2 mRNA

NCBI chr 1:78,572,253...78,613,703
Ensembl chr 1:78,572,279...78,608,021

G

NADPH oxidase 1

decreases expression

Niclosamide results in decreased expression of NOX1 mRNA

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

neuronal PAS domain protein 4

increases expression

Niclosamide results in increased expression of NPAS4 mRNA

NCBI chr 1:202,281,260...202,298,681
Ensembl chr 1:202,281,958...202,286,724

G

natriuretic peptide receptor 1

increases expression

Niclosamide results in increased expression of NPR1 mRNA

NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505

G

nuclear receptor subfamily 1, group D, member 1

increases expression

Niclosamide results in increased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 1, group D, member 2

increases expression

Niclosamide results in increased expression of NR1D2 mRNA

NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

Niclosamide binds to and results in increased activity of NR1I3 protein alternative form

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 4, group A, member 1

increases expression

Niclosamide results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

neurexin 2

increases expression

Niclosamide results in increased expression of NRXN2 mRNA

NCBI chr 1:203,726,420...203,842,301
Ensembl chr 1:203,735,753...203,842,297

G

5',3'-nucleotidase, mitochondrial

increases expression

Niclosamide results in increased expression of NT5M mRNA

NCBI chr10:44,652,845...44,680,549
Ensembl chr10:44,652,975...44,679,150

G

netrin G2

increases expression

Niclosamide results in increased expression of NTNG2 mRNA

NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890

G

nudix hydrolase 18

increases expression

Niclosamide results in increased expression of NUDT18 mRNA

NCBI chr15:45,650,597...45,653,985
Ensembl chr15:45,650,664...45,653,963

G

nuclear protein 2, transcriptional regulator

increases expression

Niclosamide results in increased expression of NUPR2 mRNA

NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304

G

neurexophilin 1

decreases expression

Niclosamide results in decreased expression of NXPH1 mRNA

NCBI chr 4:36,998,068...37,311,135
Ensembl chr 4:36,997,669...37,311,132

G

neurexophilin 2

decreases expression

Niclosamide results in decreased expression of NXPH2 mRNA

NCBI chr 3:5,986,175...5,988,525
Ensembl chr 3:5,756,621...5,987,008

G

neurexophilin 4

increases expression

Niclosamide results in increased expression of NXPH4 mRNA

NCBI chr 7:63,367,758...63,376,579
Ensembl chr 7:63,367,761...63,376,579

G

neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1

increases expression

Niclosamide results in increased expression of NYAP1 mRNA

NCBI chr12:18,956,192...18,967,624
Ensembl chr12:18,956,268...18,967,543

G

2'-5' oligoadenylate synthetase 1A

decreases expression

Niclosamide results in decreased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

ornithine decarboxylase antizyme 3

increases expression

Niclosamide results in increased expression of OAZ3 mRNA

NCBI chr 2:182,073,212...182,076,147
Ensembl chr 2:182,073,215...182,082,399

G

OCA2 melanosomal transmembrane protein

increases expression

Niclosamide results in increased expression of OCA2 mRNA

NCBI chr 1:107,116,278...107,446,093
Ensembl chr 1:107,116,278...107,446,074

G

osteoclast stimulatory transmembrane protein

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OCSTAMP mRNA]

NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991

G

olfactory receptor 765

decreases expression

Niclosamide results in decreased expression of OR4F17 mRNA

NCBI chr 3:98,118,744...98,121,011
Ensembl chr 3:98,097,957...98,101,421
Ensembl chr 3:98,097,957...98,101,421

G

opioid binding protein/cell adhesion molecule-like

increases expression

Niclosamide results in increased expression of OPCML mRNA

NCBI chr 8:26,788,988...27,304,551
Ensembl chr 8:26,192,841...27,300,620

G

opsin 3

increases expression

Niclosamide results in increased expression of OPN3 mRNA

NCBI chr13:87,589,333...87,619,847
Ensembl chr13:87,589,333...87,619,847

G

ORAI calcium release-activated calcium modulator 3

increases expression

Niclosamide results in increased expression of ORAI3 mRNA

NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052

G

origin recognition complex, subunit 1

decreases expression

Niclosamide results in decreased expression of ORC1 mRNA

PMID:28284560 PMID:36318118

NCBI chr 5:123,324,273...123,348,375
Ensembl chr 5:123,324,315...123,348,375

G

osteoclast associated Ig-like receptor

multiple interactions

Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased expression of OSCAR mRNA]
Niclosamide inhibits the reaction [TNFSF11 protein results in increased expression of OSCAR mRNA]

PMID:26792726 PMID:28824321

NCBI chr 1:65,607,214...65,615,395
Ensembl chr 1:65,607,410...65,613,758

G

OTU deubiquitinase 1

increases expression

Niclosamide results in increased expression of OTUD1 mRNA

NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995

G

OTU deubiquitinase with linear linkage specificity like

decreases expression

Niclosamide results in decreased expression of OTULINL mRNA

NCBI chr 2:78,405,994...78,433,860
Ensembl chr 2:78,408,593...78,433,838

G

pyrimidinergic receptor P2Y6

decreases expression

Niclosamide results in decreased expression of P2RY6 mRNA

NCBI chr 1:155,295,110...155,330,610
Ensembl chr 1:155,295,111...155,330,808

G

poly(A) binding protein interacting protein 2B

increases expression

Niclosamide results in increased expression of PAIP2B mRNA

NCBI chr 4:116,292,001...116,323,387
Ensembl chr 4:116,292,020...116,323,379

G

paralemmin

increases expression

Niclosamide results in increased expression of PALM mRNA

NCBI chr 7:9,886,634...9,912,389
Ensembl chr 7:9,886,643...9,912,555

G

par-3 family cell polarity regulator beta

increases expression

Niclosamide results in increased expression of PARD3B mRNA

NCBI chr 9:63,038,435...64,067,178
Ensembl chr 9:63,038,436...64,068,053

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage
increases expression
decreases expression

[TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased cleavage of PARP1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Niclosamide results in increased cleavage of PARP1 protein]; bicalutamide promotes the reaction [Niclosamide results in increased expression of PARP1 protein modified form]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]; TP53 gene mutant form promotes the reaction [Niclosamide results in increased cleavage of PARP1 protein]; WNT7A protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]
Niclosamide results in decreased expression of PARP1 protein

PMID:24750999 PMID:25174399 PMID:26917416 PMID:28500234 PMID:30258081 More...

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

paired box 7

increases expression

Niclosamide results in increased expression of PAX7 mRNA

NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979

G

PBX homeobox 1

increases expression

Niclosamide results in increased expression of PBX1 mRNA

NCBI chr13:80,278,766...80,588,563
Ensembl chr13:80,278,770...80,588,594

G

PBX homeobox 2

increases expression

Niclosamide results in increased expression of PBX2 mRNA

NCBI chr20:4,151,500...4,156,425
Ensembl chr20:4,151,500...4,156,425

G

PBX homeobox interacting protein 1

increases expression

Niclosamide results in increased expression of PBXIP1 mRNA

NCBI chr 2:174,856,339...174,868,922
Ensembl chr 2:174,856,397...174,868,919

G

pyruvate carboxylase

increases expression

Niclosamide results in increased expression of PC mRNA

NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380

G

protocadherin 19

decreases expression

Niclosamide results in decreased expression of PCDH19 mRNA

NCBI chr X:96,767,686...96,873,477
Ensembl chr X:96,771,947...96,873,524

G

protocadherin 20

decreases expression

Niclosamide results in decreased expression of PCDH20 mRNA

NCBI chr15:64,425,534...64,431,790
Ensembl chr15:64,425,534...64,431,790

G

polycomb group ring finger 1

increases expression

Niclosamide results in increased expression of PCGF1 mRNA

NCBI chr 4:115,576,165...115,587,019
Ensembl chr 4:115,583,867...115,587,008

G

proliferating cell nuclear antigen

decreases expression

Niclosamide results in decreased expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

programmed cell death 4

increases expression

Niclosamide results in increased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

phosphodiesterase 4B

increases expression

Niclosamide results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

platelet derived growth factor receptor beta

increases expression
decreases expression

Niclosamide results in increased expression of PDGFRB mRNA
Niclosamide results in decreased expression of PDGFRB protein

PMID:34118929 PMID:36318118

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

pyruvate dehydrogenase kinase 1

multiple interactions

Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of PDK1 mRNA]

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

pyruvate dehydrogenase kinase 3

decreases expression
multiple interactions

Niclosamide results in decreased expression of PDK3 mRNA
Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of PDK3 mRNA]

NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557

G

PDZ and LIM domain 4

increases expression

Niclosamide results in increased expression of PDLIM4 mRNA

NCBI chr10:38,198,686...38,212,935
Ensembl chr10:38,198,689...38,212,938

G

PDZ domain containing 7

increases expression

Niclosamide results in increased expression of PDZD7 mRNA

NCBI chr 1:243,888,295...243,907,778
Ensembl chr 1:243,888,281...243,906,839

G

proline and glutamate rich with coiled coil 1

increases expression

Niclosamide results in increased expression of PERCC1 mRNA

NCBI chr10:14,187,858...14,190,634
Ensembl chr10:14,188,216...14,189,040
Ensembl chr10:14,188,216...14,189,040

G

phosphofructokinase, muscle

decreases expression

Niclosamide results in decreased expression of PFKM mRNA

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

phosphoglycerate kinase 1

multiple interactions

Niclosamide inhibits the reaction [Oxygen deficiency results in increased expression of PGK1 mRNA]

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

progesterone receptor

decreases expression

Niclosamide results in decreased expression of PGR mRNA

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

PHD finger protein 24

increases expression

Niclosamide results in increased expression of PHF24 mRNA

NCBI chr 5:57,143,428...57,171,054
Ensembl chr 5:57,142,632...57,168,497

G

phosphorylase kinase regulatory subunit alpha 2

decreases expression

Niclosamide results in decreased expression of PHKA2 mRNA

NCBI chr X:34,170,959...34,293,498
Ensembl chr X:34,171,323...34,293,466

G

pleckstrin homology-like domain, family A, member 1

increases expression

Niclosamide results in increased expression of PHLDA1 mRNA

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

G

pleckstrin homology-like domain, family B, member 3

increases expression

Niclosamide results in increased expression of PHLDB3 mRNA

NCBI chr 1:80,201,083...80,219,541
Ensembl chr 1:80,201,578...80,219,534

G

phytanoyl-CoA 2-hydroxylase interacting protein

increases expression

Niclosamide results in increased expression of PHYHIP mRNA

NCBI chr15:45,533,974...45,545,223
Ensembl chr15:45,533,974...45,545,221

G

peptidase inhibitor 15

decreases expression

Niclosamide results in decreased expression of PI15 mRNA

NCBI chr 5:1,395,094...1,423,213
Ensembl chr 5:1,395,094...1,423,213

G

phosphatidylinositol glycan anchor biosynthesis, class W

decreases expression

Niclosamide results in decreased expression of PIGW mRNA

NCBI chr10:69,746,996...69,782,656
Ensembl chr10:69,748,789...69,790,475

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

increases expression
multiple interactions

Niclosamide results in increased expression of PIK3CA mRNA
Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CSGALNACT1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of CXCL8 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HBP1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in decreased expression of HEY1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of DSCC1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of ENDOD1 mRNA]; Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]

PMID:27542212 PMID:29843133

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase interacting protein 1

increases expression

Niclosamide results in increased expression of PIK3IP1 mRNA

NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

Niclosamide results in increased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

pyruvate kinase M1/2

increases expression

Niclosamide results in increased expression of PKM mRNA

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

phospholipase A2 group IVC

increases expression

Niclosamide results in increased expression of PLA2G4C mRNA

NCBI chr 1:74,237,714...74,275,757
Ensembl chr 1:74,236,211...74,274,656

G

plectin

increases expression

Niclosamide results in increased expression of PLEC mRNA

NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467

G

pleckstrin homology domain containing A2

increases expression

Niclosamide results in increased expression of PLEKHA2 mRNA

NCBI chr16:66,938,684...67,000,661
Ensembl chr16:66,939,109...66,999,395

G

pleckstrin homology and RhoGEF domain containing G4

increases expression

Niclosamide results in increased expression of PLEKHG4 mRNA

NCBI chr19:33,251,788...33,266,490
Ensembl chr19:33,249,706...33,266,357

G

proline-rich nuclear receptor coactivator 1

increases expression

Niclosamide results in increased expression of PNRC1 mRNA

NCBI chr 5:47,647,070...47,657,832
Ensembl chr 5:47,647,071...47,650,161

G

DNA polymerase delta 4, accessory subunit

increases expression

Niclosamide results in increased expression of POLD4 mRNA

NCBI chr 1:201,526,591...201,528,406
Ensembl chr 1:201,526,665...201,528,401

G

POU class 3 homeobox 1

increases expression

Niclosamide results in increased expression of POU3F1 mRNA

NCBI chr 5:136,910,391...136,913,371
Ensembl chr 5:136,910,391...136,913,371

G

POU class 5 homeobox 1

decreases phosphorylation

Niclosamide results in decreased phosphorylation of POU5F1 protein

NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891

G

peroxisome proliferator-activated receptor delta

increases expression

Niclosamide results in increased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

increases expression

Niclosamide results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase with EF-hand domain 2

decreases expression

Niclosamide results in decreased expression of PPEF2 mRNA

NCBI chr14:15,797,414...15,831,620
Ensembl chr14:15,797,435...15,831,491

G

PTPRF interacting protein alpha 3

increases expression

Niclosamide results in increased expression of PPFIA3 mRNA

NCBI chr 1:95,817,110...95,845,950
Ensembl chr 1:95,817,110...95,845,798

G

peptidylprolyl isomerase like 6

increases expression

Niclosamide results in increased expression of PPIL6 mRNA

NCBI chr20:44,989,509...45,017,833
Ensembl chr20:44,988,943...45,018,340

G

protein phosphatase 1, regulatory subunit 12B

increases expression

Niclosamide results in increased expression of PPP1R12B mRNA

NCBI chr13:46,199,418...46,397,108
Ensembl chr13:46,201,251...46,397,108

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Niclosamide results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

protein phosphatase 1, regulatory subunit 3B

decreases expression

Niclosamide results in decreased expression of PPP1R3B mRNA

NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406

G

protein phosphatase 2 catalytic subunit beta

decreases expression

Niclosamide results in decreased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

protein phosphatase 2 scaffold subunit A alpha

increases expression

Niclosamide results in increased expression of PPP2R1A mRNA

NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 2 scaffold subunit A beta

multiple interactions

Niclosamide inhibits the reaction [PIK3CA protein modified form results in increased expression of PPP2R1B mRNA]

NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485

G

protein phosphatase 2, regulatory subunit B, beta

decreases expression

Niclosamide results in decreased expression of PPP2R2B mRNA

NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025

G

protein phosphatase 2, regulatory subunit B, gamma

decreases expression

Niclosamide results in decreased expression of PPP2R2C mRNA

NCBI chr14:73,846,547...73,931,489
Ensembl chr14:73,846,547...73,931,864

G

PR/SET domain 1

multiple interactions

Niclosamide affects the reaction [FAS protein mutant form affects the expression of PRDM1 mRNA]

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

protein kinase C, delta

increases expression

Niclosamide results in increased expression of PRKCD mRNA

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, theta

increases expression

Niclosamide results in increased expression of PRKCQ mRNA

NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704

G

pre-mRNA processing factor 8

decreases expression

Niclosamide results in decreased expression of PRPF8 mRNA

NCBI chr10:60,331,494...60,354,606
Ensembl chr10:60,331,494...60,354,606

G

proline rich 29

decreases expression

Niclosamide results in decreased expression of PRR29 mRNA

NCBI chr10:91,305,820...91,320,661
Ensembl chr10:91,305,723...91,310,439

G

proline rich 36

increases expression

Niclosamide results in increased expression of PRR36 mRNA

NCBI chr12:2,560,533...2,567,766
Ensembl chr12:2,560,536...2,567,742

G

presenilin 2

decreases expression

Niclosamide results in decreased expression of PSEN2 mRNA

NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174

G

PSMC3 interacting protein

decreases expression

Niclosamide results in decreased expression of PSMC3IP mRNA

NCBI chr10:86,024,281...86,027,928
Ensembl chr10:86,023,950...86,027,423

G

phosphatase and tensin homolog

increases expression

Niclosamide results in increased expression of PTEN mRNA

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin E receptor 4

decreases expression

Niclosamide results in decreased expression of PTGER4 mRNA

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

increases expression

Niclosamide results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

protein tyrosine kinase 2 beta

increases expression

Niclosamide results in increased expression of PTK2B mRNA

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

G

protein tyrosine phosphatase, receptor type, G

decreases expression

Niclosamide results in decreased expression of PTPRG mRNA

NCBI chr15:12,871,706...13,552,186
Ensembl chr15:12,871,721...13,554,094

G

protein tyrosine phosphatase, receptor type, H

increases expression

Niclosamide results in increased expression of PTPRH mRNA

NCBI chr 1:69,243,704...69,276,294
Ensembl chr 1:69,242,321...69,285,077

G

protein tyrosine phosphatase, receptor type, T

decreases expression

Niclosamide results in decreased expression of PTPRT mRNA

NCBI chr 3:150,189,343...151,288,145
Ensembl chr 3:150,194,859...151,288,124

G

R3H domain containing 2

increases expression

Niclosamide results in increased expression of R3HDM2 mRNA

NCBI chr 7:63,212,519...63,340,574
Ensembl chr 7:63,232,346...63,340,540

G

RAB26, member RAS oncogene family

increases expression

Niclosamide results in increased expression of RAB26 mRNA

NCBI chr10:13,553,395...13,558,063
Ensembl chr10:13,553,395...13,558,030

G

RAB3A, member RAS oncogene family

increases expression

Niclosamide results in increased expression of RAB3A mRNA

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

RAB3A interacting protein-like 1

increases expression

Niclosamide results in increased expression of RAB3IL1 mRNA

NCBI chr 1:206,646,168...206,682,718
Ensembl chr 1:206,646,155...206,679,972

G

Rab7b, member RAS oncogene family

increases expression

Niclosamide results in increased expression of RAB7B mRNA

NCBI chr13:43,121,168...43,147,581
Ensembl chr13:43,121,226...43,147,581

G

Rac family small GTPase 2

increases expression

Niclosamide results in increased expression of RAC2 mRNA

NCBI chr 7:110,101,344...110,128,718
Ensembl chr 7:110,116,260...110,128,720

G

RAD54 like

increases expression

Niclosamide results in increased expression of RAD54L mRNA

NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070

G

Raf-1 proto-oncogene, serine/threonine kinase

decreases phosphorylation
decreases expression

Niclosamide analog results in decreased phosphorylation of RAF1 protein
Niclosamide analog results in decreased expression of RAF1 protein; Niclosamide results in decreased expression of RAF1 protein

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RAS p21 protein activator 4

increases expression

Niclosamide results in increased expression of RASA4B mRNA

NCBI chr12:20,552,805...20,580,177
Ensembl chr12:20,552,806...20,580,147

G

Ras association domain family member 10

decreases expression

Niclosamide results in decreased expression of RASSF10 mRNA

NCBI chr 1:167,058,277...167,063,591
Ensembl chr 1:167,058,099...167,063,572

G

RNA binding motif protein 45

decreases expression

Niclosamide results in decreased expression of RBM45 mRNA

NCBI chr 3:61,305,973...61,320,950
Ensembl chr 3:61,305,924...61,320,952

G

reticulocalbin 3

increases expression

Niclosamide results in increased expression of RCN3 mRNA

NCBI chr 1:95,564,503...95,573,762
Ensembl chr 1:95,564,380...95,573,725

G

REST corepressor 2

increases expression

Niclosamide results in increased expression of RCOR2 mRNA

NCBI chr 1:204,453,403...204,461,403
Ensembl chr 1:204,454,360...204,460,838

G

receptor accessory protein 6

increases expression

Niclosamide results in increased expression of REEP6 mRNA

NCBI chr 7:9,373,927...9,380,845
Ensembl chr 7:9,373,927...9,380,597

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression

Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form]
Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form]
Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein

PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 PMID:28318631 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RELB proto-oncogene, NF-kB subunit

increases expression

Niclosamide results in increased expression of RELB mRNA

NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507

G

RAB15 effector protein

decreases expression

Niclosamide results in decreased expression of REP15 mRNA

NCBI chr 4:179,951,935...179,953,008
Ensembl chr 4:179,951,935...179,953,008

G

repulsive guidance molecule BMP co-receptor a

decreases expression

Niclosamide results in decreased expression of RGMA mRNA

NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918

G

regulator of G-protein signaling 10

increases expression

Niclosamide results in increased expression of RGS10 mRNA

NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697

G

regulator of G-protein signaling 13

decreases expression

Niclosamide results in decreased expression of RGS13 mRNA

NCBI chr13:55,922,290...55,955,753
Ensembl chr13:55,922,395...55,955,648

G

regulator of G-protein signaling 14

increases expression

Niclosamide results in increased expression of RGS14 mRNA

NCBI chr17:9,248,982...9,263,104
Ensembl chr17:9,249,019...9,263,104

G

regulator of G-protein signaling 8

decreases expression

Niclosamide results in decreased expression of RGS8 mRNA

NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807

G

Rho-related BTB domain containing 1

increases expression

Niclosamide results in increased expression of RHOBTB1 mRNA

NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012

G

ras homolog family member F, filopodia associated

multiple interactions

Niclosamide inhibits the reaction [Adenosine Triphosphate results in increased expression of RHOF mRNA]

NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703

G

Rab interacting lysosomal protein-like 1

increases expression

Niclosamide results in increased expression of RILPL1 mRNA

NCBI chr12:32,071,870...32,109,687
Ensembl chr12:32,071,693...32,109,938

G

Ras and Rab interactor 1

increases expression

Niclosamide results in increased expression of RIN1 mRNA

NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729

G

RIPOR family member 3

increases expression

Niclosamide results in increased expression of FAM65C mRNA

NCBI chr 3:156,687,253...156,760,524
Ensembl chr 3:156,687,517...156,715,061

G

ring finger protein 122

increases expression

Niclosamide results in increased expression of RNF122 mRNA

NCBI chr16:61,009,879...61,027,429
Ensembl chr16:61,009,879...61,027,448

G

ring finger protein 215

increases expression

Niclosamide results in increased expression of RNF215 mRNA

NCBI chr14:79,006,659...79,013,091
Ensembl chr14:79,006,688...79,013,091

G

ring finger protein 227

increases expression

Niclosamide results in increased expression of RNF227 mRNA

NCBI chr10:54,061,054...54,063,015
Ensembl chr10:54,059,947...54,063,010

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

Niclosamide results in decreased expression of ROCK1 mRNA; Niclosamide results in decreased expression of ROCK1 protein

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

ribosomal protein S6

affects phosphorylation

Niclosamide affects the phosphorylation of RPS6 protein

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase A5

increases expression

Niclosamide results in increased expression of RPS6KA5 mRNA

NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224

G

ribosomal protein S6 kinase B1

decreases phosphorylation

Niclosamide results in decreased phosphorylation of RPS6KB1 protein

PMID:27542212 PMID:30258081

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

ribonucleotide reductase regulatory subunit M2

decreases expression

Niclosamide results in decreased expression of RRM2 mRNA

NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773

G

regulator of sex limited protein 1

decreases expression

Niclosamide results in decreased expression of ZNF66 mRNA

NCBI chr 2:84,739,694...84,763,617
Ensembl chr 2:84,718,530...84,762,596

G

radial spoke head component 4A

decreases expression

Niclosamide results in decreased expression of RSPH4A mRNA

NCBI chr20:30,764,409...30,780,574
Ensembl chr20:30,764,409...30,780,574

G

reticulon 4 receptor

increases expression

Niclosamide results in increased expression of RTN4R mRNA

NCBI chr11:82,844,309...82,869,251
Ensembl chr11:82,844,309...82,869,466

G

reticulon 4 receptor-like 1

increases expression

Niclosamide results in increased expression of RTN4RL1 mRNA

NCBI chr10:60,043,246...60,116,977
Ensembl chr10:60,043,002...60,116,978

G

RUNX family transcription factor 2

decreases expression