allylamine antifungal drug - Ontology Report

naftifine results in decreased activity of KCNH2 protein

PMID:28551711

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

terbinafine

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Ccl2

C-C motif chemokine ligand 2

multiple interactions

Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl27

C-C motif chemokine ligand 27

multiple interactions

Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]

NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506

Ccl5

C-C motif chemokine ligand 5

multiple interactions

Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]

PMID:16784723 PMID:23688403

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

Cxcl10

C-X-C motif chemokine ligand 10

multiple interactions

Terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Terbinafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]

PMID:24471457

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

Terbinafine results in decreased activity of CYP1A1 protein

PMID:33814510

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1b1

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Terbinafine results in decreased activity of CYP1B1 protein

PMID:33814510

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

Cyp2d4

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases activity

[terbinafine results in decreased activity of CYP2D6 protein] inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol]

PMID:24894748

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

increases response to substance
increases expression

CYP3A4 protein results in increased susceptibility to Terbinafine
Terbinafine results in increased expression of CYP3A4 mRNA

PMID:21540358 PMID:36356836

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

Gstp1

glutathione S-transferase pi 1

multiple interactions

terbinafine inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

PMID:23769903

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

Il4

interleukin 4

multiple interactions
decreases secretion
decreases expression

1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [terbinafine results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [terbinafine results in decreased secretion of IL4 protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]

PMID:11886533 PMID:15284827 PMID:23688403

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

Il5

interleukin 5

multiple interactions
decreases expression
decreases secretion

1-Methyl-3-isobutylxanthine inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Terbinafine results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Terbinafine results in decreased secretion of IL5 protein]
terbinafine results in decreased expression of IL5 mRNA
terbinafine results in decreased secretion of IL5 protein

PMID:11886533 PMID:15284827

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

Kcnh2

potassium voltage-gated channel subfamily H member 2

decreases activity

terbinafine results in decreased activity of KCNH2 protein

PMID:28551711

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

Mapk1

mitogen activated protein kinase 1

increases phosphorylation

terbinafine results in increased phosphorylation of MAPK1 protein

PMID:20816994

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk3

mitogen activated protein kinase 3

increases phosphorylation

terbinafine results in increased phosphorylation of MAPK3 protein

PMID:20816994

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mmp2

matrix metallopeptidase 2

decreases expression

terbinafine results in decreased expression of MMP2 mRNA

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

Mmp9

matrix metallopeptidase 9

decreases expression

terbinafine results in decreased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

Nfe2l2

NFE2 like bZIP transcription factor 2

affects response to substance

NFE2L2 protein affects the susceptibility to terbinafine

PMID:21540358

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

Nfkbia

NFKB inhibitor alpha

multiple interactions

terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]

PMID:23688403

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Ptger2

prostaglandin E receptor 2

multiple interactions
increases response to substance

PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER2 protein results in increased susceptibility to terbinafine

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

Ptger3

prostaglandin E receptor 3

multiple interactions
increases response to substance

PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]
PTGER3 protein results in increased susceptibility to terbinafine

NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434

Ptk2

protein tyrosine kinase 2

decreases phosphorylation

terbinafine results in decreased phosphorylation of PTK2 protein

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

Pxn

paxillin

decreases phosphorylation

terbinafine results in decreased phosphorylation of PXN protein

NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931

Rhoa

ras homolog family member A

increases localization

terbinafine results in increased localization of RHOA protein

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

Rhob

ras homolog family member B

decreases expression

terbinafine results in decreased expression of RHOB protein

NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108

Rhoc

ras homolog family member C

increases localization

terbinafine results in increased localization of RHOC protein

NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306

RT1-CE16

RT1 class I, locus CE16

affects response to substance

HLA-A gene polymorphism affects the susceptibility to Terbinafine

PMID:28043905

NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563

Stat1

signal transducer and activator of transcription 1

multiple interactions

terbinafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein]

PMID:24471457

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

Tnf

tumor necrosis factor

multiple interactions
increases expression

Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; Dinoprostone deficiency inhibits the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER2 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]]; PTGER3 protein promotes the reaction [Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL27 protein]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Terbinafine inhibits the reaction [TNF protein results in increased expression of CCL5 protein]; Terbinafine inhibits the reaction [TNF protein results in increased secretion of Thromboxane B2]; Terbinafine promotes the reaction [TNF protein results in increased secretion of Dinoprostone]; U 0126 inhibits the reaction [Terbinafine results in increased expression of TNF protein]
terbinafine results in increased expression of TNF protein

PMID:16784723 PMID:20816994

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tslp

thymic stromal lymphopoietin

multiple interactions

4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]