antibiotic antifungal drug - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	antibiotic antifungal drug	go back to main search page
Accession:	CHEBI:87113	browse the term
Definition:	Any antibiotic antifungal agent used to treat fungal infections in humans or animals.
Synonyms:	related_synonym:	antibiotic antifungal drugs

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Rat (915) Mouse (927) Human (963) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (32) Green Monkey (0) Naked Mole-rat (0) All
Genes (915)

amphotericin B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of ABCA1 mRNA

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily A member 12

decreases expression

Amphotericin B analog results in decreased expression of ABCA12 mRNA

NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049

G

ATP binding cassette subfamily B member 11

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCB1A mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCC2 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCC3 mRNA

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily G member 1

decreases expression

Amphotericin B analog results in decreased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCG2 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ATP binding cassette subfamily G member 5

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of ABCG5 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

acrosomal vesicle protein 1

increases expression

Amphotericin B analog results in increased expression of ACRV1 mRNA

NCBI chr 8:36,404,394...36,409,971
Ensembl chr 8:36,404,394...36,424,959

G

ADAM metallopeptidase with thrombospondin type 1 motif, 12

increases expression

Amphotericin B analog results in increased expression of ADAMTS12 mRNA

NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629

G

adenylate cyclase 2

increases expression

Amphotericin B analog results in increased expression of ADCY2 mRNA

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

adenosine A3 receptor

increases expression

Amphotericin B analog results in increased expression of ADORA3 mRNA

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

adrenoceptor alpha 2A

decreases expression

Amphotericin B analog results in decreased expression of ADRA2A mRNA

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

aldehyde dehydrogenase 8 family, member A1

decreases expression

Amphotericin B analog results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

ALK receptor tyrosine kinase

increases expression

Amphotericin B results in increased expression of ALK mRNA

NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034

G

arachidonate 5-lipoxygenase

decreases expression

Amphotericin B analog results in decreased expression of ALOX5 mRNA

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

alpha-methylacyl-CoA racemase

decreases expression

Amphotericin B analog results in decreased expression of AMACR mRNA

NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255

G

ankyrin 3

decreases expression

Amphotericin B analog results in decreased expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

annexin A9

decreases expression

Amphotericin B analog results in decreased expression of ANXA9 mRNA

NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374

G

adaptor related protein complex 3 subunit beta 2

increases expression

Amphotericin B analog results in increased expression of AP3B2 mRNA

NCBI chr 1:135,412,580...135,445,191
Ensembl chr 1:135,412,580...135,445,191

G

amyloid beta precursor protein binding family B member 2

increases expression

Amphotericin B analog results in increased expression of APBB2 mRNA

NCBI chr14:41,557,918...41,878,622
Ensembl chr14:41,557,972...41,877,495

G

apolipoprotein C2

increases expression

Amphotericin B analog results in increased expression of APOC2 mRNA

NCBI chr 1:79,329,429...79,334,397
Ensembl chr 1:79,329,428...79,334,476

G

aquaporin 3 (Gill blood group)

decreases expression

Amphotericin B analog results in decreased expression of AQP3 mRNA

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

aquaporin 5

increases expression

Amphotericin B analog results in increased expression of AQP5 mRNA

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

arginase 2

decreases expression

Amphotericin B analog results in decreased expression of ARG2 mRNA

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho guanine nucleotide exchange factor 26

increases expression

Amphotericin B results in increased expression of ARHGEF26 mRNA

NCBI chr 2:146,740,336...146,850,918
Ensembl chr 2:146,739,631...146,850,819

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

arrestin, beta 1

increases expression

Amphotericin B analog results in increased expression of ARRB1 mRNA

NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061

G

autophagy related 3

decreases expression

Amphotericin B results in decreased expression of ATG3 mRNA

NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224

G

ATPase phospholipid transporting 10B

increases expression

Amphotericin B analog results in increased expression of ATP10B mRNA

NCBI chr10:27,495,207...27,751,313
Ensembl chr10:27,408,747...27,749,637

G

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4

increases expression

Amphotericin B analog results in increased expression of B3GNT4 mRNA

NCBI chr12:33,070,221...33,073,904
Ensembl chr12:33,060,416...33,073,854

G

BAG cochaperone 4

decreases expression

Amphotericin B analog results in decreased expression of BAG4 mRNA

NCBI chr16:66,288,678...66,305,893
Ensembl chr16:66,288,678...66,308,663

G

BCL6, transcription repressor

decreases expression

Amphotericin B analog results in decreased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

BEN domain containing 5

decreases expression

Amphotericin B analog results in decreased expression of BEND5 mRNA

NCBI chr 5:126,290,648...126,336,662
Ensembl chr 5:125,254,956...126,534,367

G

bone morphogenetic protein 2

decreases expression

Amphotericin B analog results in decreased expression of BMP2 mRNA; Amphotericin B results in decreased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 7

increases expression

Amphotericin B analog results in increased expression of BMP7 mRNA

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

basonuclin zinc finger protein 1

increases expression

Amphotericin B analog results in increased expression of BNC1 mRNA

NCBI chr 1:135,917,676...135,943,333
Ensembl chr 1:135,917,687...135,943,333

G

bora, aurora kinase A activator

decreases expression

Amphotericin B analog results in decreased expression of BORA mRNA

NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322

G

calcium/calmodulin-dependent protein kinase II gamma

increases expression

Amphotericin B analog results in increased expression of CAMK2G mRNA

NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050

G

calpain 6

decreases expression

Amphotericin B analog results in decreased expression of CAPN6 mRNA

NCBI chr X:107,380,774...107,405,489
Ensembl chr X:107,380,774...107,405,489

G

carbonic anhydrase 12

decreases expression

Amphotericin B analog results in decreased expression of CA12 mRNA

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 14

increases expression

Amphotericin B analog results in increased expression of CA14 mRNA

NCBI chr 2:183,442,263...183,449,231
Ensembl chr 2:183,441,667...183,449,693

G

carbonic anhydrase 4

decreases expression

Amphotericin B analog results in decreased expression of CA4 mRNA

NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501

G

carbonic anhydrase 9

decreases expression

Amphotericin B analog results in decreased expression of CA9 mRNA

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

calcium responsive transcription factor

decreases expression

Amphotericin B analog results in decreased expression of CARF mRNA

NCBI chr 9:61,502,368...61,552,433
Ensembl chr 9:61,506,956...61,550,462

G

caspase 3

increases expression

Amphotericin B results in increased expression of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

calsequestrin 2

increases expression

Amphotericin B analog results in increased expression of CASQ2 mRNA

NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267

G

catalase

decreases expression

Amphotericin B results in decreased expression of CAT mRNA

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 20

increases expression

Amphotericin B analog results in increased expression of CCL20 mRNA; Amphotericin B results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

cyclin E2

decreases expression

Amphotericin B results in decreased expression of CCNE2 mRNA

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

G

C-C motif chemokine receptor 2

decreases expression

Amphotericin B results in decreased expression of CCR2 mRNA

NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100

G

CD14 molecule

decreases expression

Amphotericin B analog results in decreased expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD1d1 molecule

decreases expression

Amphotericin B analog results in decreased expression of CD1D mRNA

NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089

G

Cd2 molecule

increases expression

Amphotericin B analog results in increased expression of CD2 mRNA

NCBI chr 2:188,710,895...188,724,044
Ensembl chr 2:188,710,900...188,724,026

G

CD3 epsilon subunit of T-cell receptor complex

increases expression

Amphotericin B analog results in increased expression of CD3E mRNA

NCBI chr 8:45,303,848...45,315,005
Ensembl chr 8:45,303,852...45,315,022

G

CD84 molecule

increases expression

Amphotericin B analog results in increased expression of CD84 mRNA

NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076

G

cyclin-dependent kinase-like 5

increases expression

Amphotericin B analog results in increased expression of CDKL5 mRNA

NCBI chr X:33,757,605...33,988,075
Ensembl chr X:33,821,257...33,986,582

G

corneodesmosin

increases expression

Amphotericin B analog results in increased expression of CDSN mRNA

NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250

G

CEA cell adhesion molecule 15

increases expression

Amphotericin B analog results in increased expression of CEACAM21 mRNA

NCBI chr 1:77,368,376...77,373,343
Ensembl chr 1:77,368,966...77,372,663

G

centrosomal protein 76

decreases expression

Amphotericin B analog results in decreased expression of CEP76 mRNA

NCBI chr18:61,174,514...61,208,512
Ensembl chr18:61,178,310...61,208,504

G

glycoprotein hormones, alpha polypeptide

increases expression

Amphotericin B analog results in increased expression of CGA mRNA

NCBI chr 5:49,486,915...49,499,192
Ensembl chr 5:49,487,068...49,499,191

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

Amphotericin B analog results in increased expression of CHAC1 mRNA

NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526

G

chitinase 3 like 1

decreases expression

Amphotericin B analog results in decreased expression of CHI3L1 mRNA

NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787

G

cell adhesion molecule L1-like

decreases expression

Amphotericin B analog results in decreased expression of CHL1 mRNA

NCBI chr 4:136,291,504...136,505,830
Ensembl chr 4:136,291,463...136,503,265

G

calcineurin-like EF-hand protein 1

decreases expression

Amphotericin B analog results in decreased expression of CHP1 mRNA

NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251

G

cholinergic receptor nicotinic beta 3 subunit

increases expression

Amphotericin B analog results in increased expression of CHRNB3 mRNA

NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360

G

clusterin

affects expression
decreases expression

Amphotericin B affects the expression of CLU mRNA
Amphotericin B analog results in decreased expression of CLU mRNA

PMID:20623750 PMID:28534445

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cytidine monophospho-N-acetylneuraminic acid hydroxylase

decreases expression

Amphotericin B analog results in decreased expression of CMAHP mRNA

NCBI chr17:40,557,161...40,642,350
Ensembl chr17:40,583,667...40,642,275

G

cannabinoid receptor 2

increases expression

Amphotericin B analog results in increased expression of CNR2 mRNA

NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548

G

contactin 5

increases expression

Amphotericin B analog results in increased expression of CNTN5 mRNA

NCBI chr 8:6,735,715...7,967,727
Ensembl chr 8:6,738,239...7,967,957

G

collagen type V alpha 1 chain

increases expression

Amphotericin B analog results in increased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

catechol-O-methyltransferase

increases expression

Amphotericin B analog results in increased expression of COMT mRNA

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

carboxypeptidase D

decreases expression

Amphotericin B analog results in decreased expression of CPD mRNA

NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491

G

carnitine palmitoyltransferase 1B

decreases expression

Amphotericin B analog results in decreased expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

cysteine-rich secretory protein LCCL domain containing 2

increases expression

Amphotericin B analog results in increased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465

G

crystallin, beta B1

increases expression

Amphotericin B analog results in increased expression of CRYBB1 mRNA

NCBI chr12:44,369,734...44,383,344
Ensembl chr12:44,369,735...44,383,344

G

colony stimulating factor 2

increases expression

Amphotericin B analog results in increased expression of CSF2 mRNA; Amphotericin B results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

chondroitin sulfate N-acetylgalactosaminyltransferase 2

increases expression

Amphotericin B analog results in increased expression of CSGALNACT2 mRNA

NCBI chr 4:151,271,774...151,308,856
Ensembl chr 4:151,277,645...151,308,839

G

chondroitin sulfate proteoglycan 5

decreases expression

Amphotericin B analog results in decreased expression of CSPG5 mRNA

NCBI chr 8:110,220,506...110,234,766
Ensembl chr 8:110,220,653...110,234,758

G

C-X-C motif chemokine ligand 1

increases expression

Amphotericin B analog results in increased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

increases expression

Amphotericin B analog results in increased expression of CXCL2 mRNA; Amphotericin B results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

Amphotericin B analog results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

decreases expression

Amphotericin B analog results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 27, subfamily a, polypeptide 1

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP27A1 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

Amphotericin B analog results in increased expression of CYP2C19 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 4, subfamily b, polypeptide 1

decreases expression

Amphotericin B analog results in decreased expression of CYP4B1 mRNA

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450 family 7 subfamily A member 1

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP7A1 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

cytochrome P450 family 8 subfamily B member 1

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP8B1 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in decreased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

cytohesin 4

increases expression

Amphotericin B analog results in increased expression of CYTH4 mRNA

NCBI chr 7:110,152,232...110,176,726
Ensembl chr 7:110,152,272...110,176,741

G

doublecortin-like kinase 1

decreases expression

Amphotericin B analog results in decreased expression of DCLK1 mRNA

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

dendrocyte expressed seven transmembrane protein

increases expression

Amphotericin B analog results in increased expression of DCSTAMP mRNA

NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078

G

DNA-damage inducible transcript 3

increases expression

Amphotericin B results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DEAD/H-box helicase 11

increases expression

Amphotericin B results in increased expression of DDX11 mRNA

NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550

G

DEP domain containing MTOR-interacting protein

decreases expression

Amphotericin B analog results in decreased expression of DEPTOR mRNA

NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773

G

dehydrogenase/reductase 7

decreases expression

Amphotericin B analog results in decreased expression of DHRS7 mRNA

NCBI chr 6:91,332,259...91,347,856
Ensembl chr 6:91,251,323...91,347,892

G

dicer 1 ribonuclease III

decreases expression

Amphotericin B analog results in decreased expression of DICER1 mRNA

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

dickkopf WNT signaling pathway inhibitor 4

increases expression

Amphotericin B analog results in increased expression of DKK4 mRNA

NCBI chr16:69,403,215...69,406,580
Ensembl chr16:69,402,989...69,406,580

G

DLG associated protein 1

decreases expression
increases expression

Amphotericin B analog results in decreased expression of DLGAP1 mRNA
Amphotericin B analog results in increased expression of DLGAP1 mRNA

NCBI chr 9:109,857,500...110,726,817
Ensembl chr 9:110,167,448...110,726,817

G

dynein, axonemal, heavy chain 3

increases expression

Amphotericin B analog results in increased expression of DNAH3 mRNA

NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474

G

DnaJ heat shock protein family (Hsp40) member A4

increases expression

Amphotericin B analog results in increased expression of DNAJA4 mRNA

NCBI chr 8:55,085,246...55,102,715
Ensembl chr 8:55,085,464...55,101,207

G

deltex E3 ubiquitin ligase 4

decreases expression

Amphotericin B analog results in decreased expression of DTX4 mRNA

NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818

G

dual oxidase 2

increases expression

Amphotericin B analog results in increased expression of DUOX2 mRNA

NCBI chr 3:109,223,809...109,247,023
Ensembl chr 3:109,226,924...109,245,902

G

DAZ interacting zinc finger protein 3

decreases expression

Amphotericin B analog results in decreased expression of DZIP3 mRNA

NCBI chr11:51,823,235...51,893,353
Ensembl chr11:51,823,231...51,893,353

G

E2F transcription factor 2

increases expression

Amphotericin B analog results in increased expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

endothelin receptor type B

increases expression

Amphotericin B results in increased expression of EDNRB mRNA

NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115

G

EFR3 homolog B

increases expression

Amphotericin B analog results in increased expression of EFR3B mRNA

NCBI chr 6:26,947,436...27,021,113
Ensembl chr 6:26,948,540...27,020,933

G

egl-9 family hypoxia-inducible factor 3

decreases expression

Amphotericin B analog results in decreased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

empty spiracles homeobox 2

decreases expression

Amphotericin B analog results in decreased expression of EMX2 mRNA

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

enolase 1

multiple interactions

Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of ENO1 mRNA]; Amphotericin B results in increased expression of and results in increased secretion of ENO1 protein

PMID:16189267 PMID:26259607

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

decreases expression

Amphotericin B analog results in decreased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

E1A binding protein p300

multiple interactions

Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]

NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

erythropoietin

multiple interactions
decreases expression

Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of EPO mRNA]
Amphotericin B results in decreased expression of EPO protein

PMID:697352 PMID:2299214 PMID:16189267

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

G

erythropoietin receptor

increases expression

Amphotericin B analog results in increased expression of EPOR mRNA; Amphotericin B results in increased expression of EPOR mRNA

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

epiregulin

increases expression

Amphotericin B analog results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

family with sequence similarity 13, member A

decreases expression

Amphotericin B analog results in decreased expression of FAM13A mRNA

NCBI chr 4:88,056,521...88,155,782
Ensembl chr 4:88,058,403...88,155,860

G

fatty acid synthase

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of FASN mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibulin 1

increases expression

Amphotericin B analog results in increased expression of FBLN1 mRNA

NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075

G

Fc gamma receptor 1A

increases expression

Amphotericin B analog results in increased expression of FCGR1A mRNA

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

G

fibrinogen beta chain

decreases expression

Amphotericin B analog results in decreased expression of FGB mRNA

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

fibroblast growth factor 4

increases expression

Amphotericin B analog results in increased expression of FGF4 mRNA

NCBI chr 1:200,023,937...200,027,793
Ensembl chr 1:200,024,056...200,025,466

G

FKBP prolyl isomerase 5

decreases expression

Amphotericin B analog results in decreased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

fibronectin leucine rich transmembrane protein 3

decreases expression

Amphotericin B analog results in decreased expression of FLRT3 mRNA; Amphotericin B results in decreased expression of FLRT3 mRNA

NCBI chr 3:127,994,491...128,008,137
Ensembl chr 3:127,994,226...128,007,841

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Amphotericin B analog results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FERM domain containing 4B

decreases expression

Amphotericin B analog results in decreased expression of FRMD4B mRNA

NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197

G

fibrinogen silencer binding protein

decreases expression

Amphotericin B analog results in decreased expression of FSBP mRNA

NCBI chr 5:25,058,003...25,064,276
Ensembl chr 5:25,032,066...25,104,616

G

far upstream element binding protein 1

decreases expression

Amphotericin B analog results in decreased expression of FUBP1 mRNA

NCBI chr 2:241,159,481...241,186,591
Ensembl chr 2:241,159,512...241,186,602

G

FMR1 autosomal homolog 1

decreases expression

Amphotericin B analog results in decreased expression of FXR1 mRNA

NCBI chr 2:116,884,167...116,937,590
Ensembl chr 2:116,884,248...116,937,590

G

FXYD domain-containing ion transport regulator 3

increases expression

Amphotericin B analog results in increased expression of FXYD3 mRNA

NCBI chr 1:86,305,531...86,312,455

G

galactose-3-O-sulfotransferase 1

decreases expression

Amphotericin B analog results in decreased expression of GAL3ST1 mRNA

NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388

G

galanin receptor 3

increases expression

Amphotericin B analog results in increased expression of GALR3 mRNA

NCBI chr 7:110,603,525...110,608,429
Ensembl chr 7:110,605,226...110,607,685

G

growth differentiation factor 15

increases expression

Amphotericin B analog results in increased expression of GDF15 mRNA; Amphotericin B results in increased expression of GDF15 mRNA

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

GDNF family receptor alpha 3

increases expression

Amphotericin B analog results in increased expression of GFRA3 mRNA

NCBI chr18:26,297,828...26,326,105
Ensembl chr18:26,297,829...26,326,105

G

GDNF family receptor alpha 4

increases expression

Amphotericin B analog results in increased expression of GFRA4 mRNA

NCBI chr 3:118,254,937...118,262,252
Ensembl chr 3:118,255,402...118,258,329

G

glucuronic acid epimerase

decreases expression

Amphotericin B analog results in decreased expression of GLCE mRNA

NCBI chr 8:62,546,104...62,612,144
Ensembl chr 8:62,546,107...62,612,040

G

glyoxalase domain containing 4

decreases expression

Amphotericin B results in decreased expression of GLOD4 mRNA

NCBI chr10:61,077,535...61,095,876
Ensembl chr10:61,066,421...61,095,898

G

glutaminase

increases expression

Amphotericin B analog results in increased expression of GLS mRNA

NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900

G

glutamate-ammonia ligase

decreases expression

Amphotericin B analog results in decreased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glycoprotein Ib platelet subunit alpha

increases expression

Amphotericin B analog results in increased expression of GP1BA mRNA

NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774

G

G protein-coupled receptor 20

increases expression

Amphotericin B results in increased expression of GPR20 mRNA

NCBI chr 7:105,601,761...105,611,959
Ensembl chr 7:105,602,368...105,603,430

G

glutamic--pyruvic transaminase

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased activity of GPT protein]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutamate ionotropic receptor delta type subunit 2

increases expression

Amphotericin B analog results in increased expression of GRID2 mRNA

NCBI chr 4:92,415,019...93,892,472
Ensembl chr 4:92,415,230...93,889,355

G

glutamate metabotropic receptor 6

increases expression

Amphotericin B analog results in increased expression of GRM6 mRNA

NCBI chr10:35,167,985...35,182,717
Ensembl chr10:35,167,985...35,182,717

G

glutathione S-transferase pi 1

decreases expression
multiple interactions

Amphotericin B results in decreased expression of GSTP1 mRNA
Amphotericin B inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]

PMID:20623750 PMID:23769903

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase theta 1

decreases expression

Amphotericin B results in decreased expression of GSTT1 mRNA

NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585

G

H2A clustered histone 4

decreases expression

Amphotericin B analog results in decreased expression of HIST1H2AC mRNA

NCBI chr17:42,799,884...42,800,387
Ensembl chr17:42,799,652...42,800,381

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases activity

Amphotericin B inhibits the reaction [[HIF1A protein binds to ARNT protein] which binds to EPO enhancer]; Amphotericin B inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]
Amphotericin B results in decreased activity of HIF1A protein

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible factor 1 subunit alpha inhibitor

multiple interactions

Amphotericin B promotes the reaction [HIF1AN protein binds to and results in increased hydroxylation of and results in decreased activity of HIF1A protein]

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

G

hypoxia inducible lipid droplet-associated

decreases expression

Amphotericin B analog results in decreased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

homeodomain interacting protein kinase 1

decreases expression

Amphotericin B analog results in decreased expression of HIPK1 mRNA

NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

increases expression

Amphotericin B analog results in increased expression of HMOX1 mRNA; Amphotericin B results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hook microtubule-tethering protein 1

decreases expression

Amphotericin B analog results in decreased expression of HOOK1 mRNA

NCBI chr 5:110,824,501...110,887,791
Ensembl chr 5:110,824,501...110,887,787

G

homeo box D3

decreases expression

Amphotericin B analog results in decreased expression of HOXD3 mRNA

NCBI chr 3:59,638,708...59,650,282
Ensembl chr 3:59,638,708...59,650,282

G

homeo box D4

decreases expression

Amphotericin B analog results in decreased expression of HOXD4 mRNA

NCBI chr 3:59,614,464...59,634,042
Ensembl chr 3:59,614,464...59,631,528

G

hemopexin

increases expression

Amphotericin B analog results in increased expression of HPX mRNA

NCBI chr 1:159,932,819...159,940,327
Ensembl chr 1:159,932,755...159,940,328

G

heat shock protein family A (Hsp70) member 1A

decreases expression

Amphotericin B analog results in decreased expression of HSPA1A mRNA

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

decreases expression

Amphotericin B analog results in decreased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 2

decreases expression

Amphotericin B analog results in decreased expression of HSPA2 mRNA

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 8

multiple interactions

Amphotericin B results in increased expression of and results in increased secretion of HSPA8 protein

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 3

increases expression

Amphotericin B analog results in increased expression of HSPB3 mRNA

NCBI chr 2:45,295,285...45,295,999
Ensembl chr 2:45,295,053...45,296,145

G

5-hydroxytryptamine receptor 3A

increases expression

Amphotericin B analog results in increased expression of HTR3A mRNA

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

intercellular adhesion molecule 1

increases expression

Amphotericin B analog results in increased expression of ICAM1 mRNA; Amphotericin B results in increased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 2

decreases expression

Amphotericin B analog results in decreased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of DNA binding 4

decreases expression

Amphotericin B analog results in decreased expression of ID4 mRNA; Amphotericin B results in decreased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

interferon gamma

multiple interactions
increases expression

[Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; [Antimony Sodium Gluconate co-treated with Amphotericin B] results in increased expression of IFNG protein
Amphotericin B analog results in increased expression of IFNG mRNA

PMID:17911647 PMID:28534445 PMID:29594315

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interferon gamma receptor 1

increases expression

Amphotericin B results in increased expression of IFNGR1

NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785

G

insulin-like growth factor binding protein 5

decreases expression

Amphotericin B results in decreased expression of IGFBP5 mRNA

NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156

G

interleukin 10

multiple interactions

[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13 receptor subunit alpha 2

increases expression

Amphotericin B analog results in increased expression of IL13RA2 mRNA

NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381

G

interleukin 1 beta

increases expression

Amphotericin B results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 2

decreases expression

Amphotericin B analog results in decreased expression of IL1R2 mRNA

NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725

G

interleukin 1 receptor accessory protein-like 2

increases expression

Amphotericin B analog results in increased expression of IL1RAPL2 mRNA

NCBI chr X:100,961,509...102,271,753
Ensembl chr X:100,961,812...102,271,753

G

interleukin 2

multiple interactions

[Amphotericin B co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

increases expression

Amphotericin B analog results in increased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta A

increases expression

Amphotericin B analog results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

INO80 complex subunit B

decreases expression

Amphotericin B analog results in decreased expression of INO80B mRNA

NCBI chr 4:115,627,907...115,631,069
Ensembl chr 4:115,627,908...115,631,456

G

insulin induced gene 1

increases expression

Amphotericin B analog results in increased expression of INSIG1 mRNA; Amphotericin B results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

G

interferon regulatory factor 5

increases expression

Amphotericin B analog results in increased expression of IRF5 mRNA

NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267

G

jagged canonical Notch ligand 1

decreases expression

Amphotericin B results in decreased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

kazrin, periplakin interacting protein

increases expression

Amphotericin B analog results in increased expression of KAZN mRNA

NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074

G

potassium voltage-gated channel subfamily B member 1

decreases expression

Amphotericin B analog results in decreased expression of KCNB1 mRNA

NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194

G

potassium voltage-gated channel subfamily Q member 4

decreases expression

Amphotericin B results in decreased expression of KCNQ4 mRNA

NCBI chr 5:134,275,145...134,326,992
Ensembl chr 5:134,275,934...134,326,932

G

KLF transcription factor 12

increases expression

Amphotericin B analog results in increased expression of KLF12 mRNA

NCBI chr15:76,628,778...77,062,000
Ensembl chr15:76,637,654...77,062,056

G

KLF transcription factor 9

decreases expression

Amphotericin B analog results in decreased expression of KLF9 mRNA

NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037

G

kelch-like family member 24

decreases expression

Amphotericin B analog results in decreased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

G

killer cell lectin like receptor B1A

increases expression

Amphotericin B analog results in increased expression of KLRB1 mRNA

NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675

G

kynurenine 3-monooxygenase

decreases expression

Amphotericin B analog results in decreased expression of KMO mRNA

NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881

G

lactalbumin, alpha

increases expression

Amphotericin B analog results in increased expression of LALBA mRNA

NCBI chr 7:129,625,531...129,628,034
Ensembl chr 7:129,625,535...129,628,061

G

lipocalin 2

decreases expression

Amphotericin B analog results in decreased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

low density lipoprotein receptor

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of LDLR mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

low density lipoprotein receptor class A domain containing 4

increases expression

Amphotericin B analog results in increased expression of LDLRAD4 mRNA

NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238

G

galectin 4

increases expression

Amphotericin B analog results in increased expression of LGALS4 mRNA

NCBI chr 1:84,124,766...84,132,481
Ensembl chr 1:84,124,764...84,132,481

G

LIM domain kinase 1

increases expression

Amphotericin B analog results in increased expression of LIMK1 mRNA

NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606

G

lipin 1

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of LPIN1 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of LPIN1 mRNA

NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097

G

large 60S subunit nuclear export GTPase 1

decreases expression

Amphotericin B results in decreased expression of LSG1 mRNA

NCBI chr11:70,132,919...70,168,526
Ensembl chr11:70,143,847...70,168,518

G

lysosomal trafficking regulator

increases expression

Amphotericin B analog results in increased expression of LYST mRNA

NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480

G

mucosal vascular addressin cell adhesion molecule 1

increases expression

Amphotericin B analog results in increased expression of MADCAM1 mRNA

NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703

G

MAF bZIP transcription factor

decreases expression

Amphotericin B analog results in decreased expression of MAF mRNA

NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365

G

monoamine oxidase A

decreases expression

Amphotericin B analog results in decreased expression of MAOA mRNA

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

microtubule-associated protein 1 light chain 3 beta

increases expression

Amphotericin B results in increased expression of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen-activated protein kinase kinase kinase 19

increases expression

Amphotericin B analog results in increased expression of MAP3K19 mRNA

NCBI chr13:39,300,150...39,343,502
Ensembl chr13:39,300,163...39,343,767

G

minichromosome maintenance complex component 3 associated protein

increases expression

Amphotericin B analog results in increased expression of MCM3AP mRNA

NCBI chr20:12,127,570...12,165,165
Ensembl chr20:12,127,570...12,165,165

G

MTOR associated protein, eak-7 homolog

increases expression

Amphotericin B analog results in increased expression of TLDC1 mRNA

NCBI chr19:47,813,899...47,836,830
Ensembl chr19:47,811,416...47,841,278

G

myocyte enhancer factor 2C

decreases expression

Amphotericin B analog results in decreased expression of MEF2C mRNA

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

G

microRNA 106b

increases expression

Amphotericin B analog results in increased expression of MIR106B

NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425

G

microRNA 138-1

increases expression

Amphotericin B results in increased expression of MIR138

NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064

G

microRNA 17

increases expression

Amphotericin B analog results in increased expression of MIR17

NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712

G

microRNA 181c

increases expression

Amphotericin B analog results in increased expression of MIR181C

NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628

G

microRNA 181d

decreases expression

Amphotericin B analog results in decreased expression of MIR181D

NCBI chr19:23,983,706...23,983,788
Ensembl chr19:23,983,706...23,983,788

G

microRNA 423

increases expression

Amphotericin B analog results in increased expression of MIR423; Amphotericin B results in increased expression of MIR423

NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226

G

microRNA 494

decreases expression

Amphotericin B analog results in decreased expression of MIR494; Amphotericin B results in decreased expression of MIR494

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

G

microRNA 99b

increases expression

Amphotericin B analog results in increased expression of MIR99B

NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090

G

microRNA let-7g

decreases expression

Amphotericin B analog results in decreased expression of MIRLET7G

NCBI chr 8:106,822,293...106,822,380
Ensembl chr 8:106,822,280...106,822,388

G

matrix metallopeptidase 28

decreases expression

Amphotericin B analog results in decreased expression of MMP28 mRNA

NCBI chr10:68,241,138...68,264,866
Ensembl chr10:68,241,138...68,264,866

G

M-phase phosphoprotein 8

decreases expression

Amphotericin B analog results in decreased expression of MPHOSPH8 mRNA

NCBI chr15:30,800,546...30,828,415
Ensembl chr15:30,686,613...30,828,810

G

metal response element binding transcription factor 2

decreases expression

Amphotericin B analog results in decreased expression of MTF2 mRNA

NCBI chr14:1,639,256...1,683,513
Ensembl chr14:1,640,746...1,683,524

G

mucin 2, oligomeric mucus/gel-forming

increases expression

Amphotericin B analog results in increased expression of MUC2 mRNA

NCBI chr 1:196,799,494...196,831,740
Ensembl chr 1:196,799,517...196,831,756

G

MX dynamin like GTPase 2

increases expression

Amphotericin B analog results in increased expression of MX2 mRNA

NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342

G

myosin XVB

increases expression

Amphotericin B analog results in increased expression of MYO15B mRNA

NCBI chr10:101,088,734...101,126,159
Ensembl chr10:101,104,209...101,125,693

G

myosin VIIA

increases expression

Amphotericin B analog results in increased expression of MYO7A mRNA

NCBI chr 1:152,342,611...152,414,171
Ensembl chr 1:152,344,448...152,414,157

G

N-acetyltransferase 8

decreases expression

Amphotericin B analog results in decreased expression of NAT8 mRNA

NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763

G

neural precursor cell expressed, developmentally down-regulated 9

decreases expression

Amphotericin B analog results in decreased expression of NEDD9 mRNA

NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019

G

neurofilament light chain

decreases expression

Amphotericin B analog results in decreased expression of NEFL mRNA

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

neurofilament medium chain

decreases expression

Amphotericin B analog results in decreased expression of NEFM mRNA

NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755

G

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

decreases expression

Amphotericin B analog results in decreased expression of NF2 mRNA

NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667

G

nucleolar protein 3

decreases expression

Amphotericin B analog results in decreased expression of NOL3 mRNA

NCBI chr19:33,154,061...33,158,250
Ensembl chr19:33,154,062...33,158,250

G

NPR2-like, GATOR1 complex subunit

decreases expression

Amphotericin B results in decreased expression of NPRL2 mRNA

NCBI chr 8:108,215,823...108,218,996
Ensembl chr 8:108,215,814...108,218,996

G

nuclear receptor subfamily 2, group E, member 1

increases expression

Amphotericin B analog results in increased expression of NR2E1 mRNA

NCBI chr20:46,050,134...46,071,257
Ensembl chr20:46,050,414...46,073,949

G

nuclear receptor subfamily 2, group F, member 1

decreases expression

Amphotericin B analog results in decreased expression of NR2F1 mRNA

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

5'-nucleotidase, cytosolic II

increases expression

Amphotericin B results in increased expression of NT5C2 mRNA

NCBI chr 1:245,770,993...245,896,925
Ensembl chr 1:245,772,277...245,897,913

G

neurotrophic receptor tyrosine kinase 2

decreases expression
increases expression

Amphotericin B analog results in decreased expression of NTRK2 mRNA
Amphotericin B analog results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

olfactory receptor family 10 subfamily J member 2

increases expression

Amphotericin B analog results in increased expression of OR10J1 mRNA

NCBI chr13:85,723,300...85,724,290
Ensembl chr13:85,719,234...85,724,767

G

olfactory receptor family 2 subfamily H member 2C

increases expression

Amphotericin B analog results in increased expression of OR2H2 mRNA

NCBI chr20:1,398,964...1,399,902
Ensembl chr20:1,395,108...1,400,441

G

ovo-like zinc finger 2

increases expression

Amphotericin B analog results in increased expression of OVOL2 mRNA

NCBI chr 3:131,677,391...131,707,123
Ensembl chr 3:131,677,391...131,708,359

G

poly(A) binding protein interacting protein 1

decreases expression

Amphotericin B results in decreased expression of PAIP1 mRNA

NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241

G

par-3 family cell polarity regulator

decreases expression

Amphotericin B results in decreased expression of PARD3 mRNA

NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778

G

par-6 family cell polarity regulator beta

increases expression

Amphotericin B analog results in increased expression of PARD6B mRNA

NCBI chr 3:156,790,540...156,811,620
Ensembl chr 3:156,790,540...156,811,622

G

phosphodiesterase 1A

decreases expression

Amphotericin B analog results in decreased expression of PDE1A mRNA

NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874

G

phosphodiesterase 4D

decreases expression

Amphotericin B analog results in decreased expression of PDE4D mRNA

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

phosphodiesterase 4D interacting protein

decreases expression

Amphotericin B analog results in decreased expression of PDE4DIP mRNA

NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379

G

PDZ and LIM domain 7

decreases expression

Amphotericin B analog results in decreased expression of PDLIM7 mRNA

NCBI chr17:9,124,565...9,139,814
Ensembl chr17:9,124,649...9,139,811

G

platelet and endothelial cell adhesion molecule 1

increases expression

Amphotericin B analog results in increased expression of PECAM1 mRNA

NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116

G

phosphoglycerate kinase 1

multiple interactions

Amphotericin B inhibits the reaction [Oxygen deficiency results in increased expression of PGK1 mRNA]

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

Amphotericin B analog results in decreased expression of PIK3R1 mRNA

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

paired-like homeodomain 2

decreases expression

Amphotericin B analog results in decreased expression of PITX2 mRNA; Amphotericin B results in decreased expression of PITX2 mRNA

NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293

G

pyruvate kinase L/R

increases expression

Amphotericin B analog results in increased expression of PKLR mRNA

NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870

G

plakophilin 1

increases expression

Amphotericin B analog results in increased expression of PKP1 mRNA

NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465

G

phospholipase A2 group IIA

increases expression

Amphotericin B analog results in increased expression of PLA2G2A mRNA

NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014

G

phospholipase C beta 1

increases expression

Amphotericin B analog results in increased expression of PLCB1 mRNA

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Amphotericin B analog results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

DNA polymerase gamma, catalytic subunit

increases expression

Amphotericin B analog results in increased expression of POLG mRNA; Amphotericin B results in increased expression of POLG mRNA

NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567

G

DNA polymerase mu

increases expression

Amphotericin B results in increased expression of POLM mRNA

NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086

G

periplakin

decreases expression

Amphotericin B analog results in decreased expression of PPL mRNA

NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575

G

protein phosphatase 1, regulatory subunit 3C

decreases expression

Amphotericin B analog results in decreased expression of PPP1R3C mRNA

NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961

G

phosphoserine aminotransferase 1

decreases expression

Amphotericin B analog results in decreased expression of PSAT1 mRNA

NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682

G

protein tyrosine phosphatase, non-receptor type 22

decreases expression

Amphotericin B analog results in decreased expression of PTPN22 mRNA

NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779

G

protein tyrosine phosphatase, receptor type, T

increases expression

Amphotericin B analog results in increased expression of PTPRT mRNA

NCBI chr 3:150,189,343...151,288,145
Ensembl chr 3:150,194,859...151,288,124

G

RAD54 homolog B

increases expression

Amphotericin B analog results in increased expression of RAD54B mRNA

NCBI chr 5:25,032,112...25,104,630
Ensembl chr 5:25,032,066...25,104,616

G

receptor activity modifying protein 3

increases expression

Amphotericin B analog results in increased expression of RAMP3 mRNA

NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902

G

retinoic acid receptor responder 1

decreases expression

Amphotericin B analog results in decreased expression of RARRES1 mRNA

NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978

G

RAS guanyl releasing protein 1

decreases expression

Amphotericin B analog results in decreased expression of RASGRP1 mRNA

NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056

G

RB binding protein 5, histone lysine methyltransferase complex subunit

decreases expression

Amphotericin B analog results in decreased expression of RBBP5 mRNA; Amphotericin B results in decreased expression of RBBP5 mRNA

NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107

G

RNA binding motif protein 47

decreases expression

Amphotericin B analog results in decreased expression of RBM47 mRNA

NCBI chr14:42,053,290...42,191,572
Ensembl chr14:42,154,142...42,189,431

G

regulator of calcineurin 2

decreases expression

Amphotericin B analog results in decreased expression of RCAN2 mRNA

NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856

G

REL proto-oncogene, NF-kB subunit

decreases expression

Amphotericin B analog results in decreased expression of REL mRNA

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RALBP1 associated Eps domain containing 2

decreases expression

Amphotericin B analog results in decreased expression of REPS2 mRNA

NCBI chr X:32,049,455...32,322,317
Ensembl chr X:32,049,399...32,317,414

G

regulator of G-protein signaling 2

decreases expression

Amphotericin B analog results in decreased expression of RGS2 mRNA; Amphotericin B results in decreased expression of RGS2 mRNA

NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385

G

Rh blood group, D antigen

increases expression

Amphotericin B analog results in increased expression of RHD mRNA

NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715

G

RHO family interacting cell polarization regulator 2

decreases expression

Amphotericin B analog results in decreased expression of FAM65B mRNA; Amphotericin B results in decreased expression of FAM65B mRNA

NCBI chr17:40,323,748...40,547,482
Ensembl chr17:40,323,867...40,548,092

G

required for meiotic nuclear division 5 homolog A

decreases expression

Amphotericin B analog results in decreased expression of RMND5A mRNA

NCBI chr 4:103,375,846...103,432,890
Ensembl chr 4:103,379,908...103,433,051

G

ribonuclease A family member 4

decreases expression

Amphotericin B analog results in decreased expression of RNASE4 mRNA

NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117

G

Rho family GTPase 3

increases expression

Amphotericin B results in increased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

RAR-related orphan receptor A

decreases expression

Amphotericin B analog results in decreased expression of RORA mRNA

NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931

G

ribosomal protein S8

increases expression

Amphotericin B analog results in increased expression of RPS8 mRNA

NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

decreases expression

Amphotericin B analog results in decreased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

ribosomal L1 domain containing 1

decreases expression

Amphotericin B analog results in decreased expression of RSL1D1 mRNA

NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593

G

RT1 class I, locus CE5

increases expression

Amphotericin B results in increased expression of HLA-F mRNA

NCBI chr20:3,403,418...3,479,476

G

reticulon 1

decreases expression

Amphotericin B analog results in decreased expression of RTN1 mRNA

NCBI chr 6:90,763,212...90,983,436
Ensembl chr 6:90,763,216...90,983,436

G

RUNX family transcription factor 3

decreases expression

Amphotericin B results in decreased expression of RUNX3 mRNA

NCBI chr 5:147,360,587...147,419,161
Ensembl chr 5:147,360,994...147,419,156

G

Sin3A associated protein 30

increases expression

Amphotericin B analog results in increased expression of SAP30 mRNA

NCBI chr16:32,747,777...32,753,114
Ensembl chr16:32,747,734...32,753,112

G

sodium channel epithelial 1 subunit alpha

decreases expression

Amphotericin B analog results in decreased expression of SCNN1A mRNA

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

serpin family A member 5

decreases expression

Amphotericin B analog results in decreased expression of SERPINA5 mRNA

NCBI chr 6:123,009,224...123,028,412
Ensembl chr 6:123,023,306...123,028,407

G

serpin family B member 3A

decreases expression

Amphotericin B analog results in decreased expression of SERPINB4 mRNA

NCBI chr13:23,241,303...23,246,328
Ensembl chr13:23,236,972...23,246,985

G

serum/glucocorticoid regulated kinase family, member 3

decreases expression

Amphotericin B results in decreased expression of SGK3 mRNA

NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476

G

sialic acid binding Ig like lectin 1

increases expression

Amphotericin B analog results in increased expression of SIGLEC1 mRNA

NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850

G

salt-inducible kinase 1

increases expression

Amphotericin B analog results in increased expression of SIK1 mRNA; Amphotericin B results in increased expression of SIK1 mRNA

NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991

G

solute carrier family 16, member 6

increases expression

Amphotericin B analog results in increased expression of SLC16A6 mRNA

NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 22, member 14

increases expression

Amphotericin B analog results in increased expression of SLC22A14 mRNA

NCBI chr 8:118,894,537...118,916,416
Ensembl chr 8:118,895,259...118,908,255

G

solute carrier family 22 member 7

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of SLC22A7 mRNA

NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921

G

solute carrier family 27 member 2

decreases expression

Amphotericin B analog results in decreased expression of SLC27A2 mRNA

NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208

G

solute carrier family 2 member 5

decreases expression

Amphotericin B analog results in decreased expression of SLC2A5 mRNA

NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106

G

solute carrier family 39 member 7

decreases expression

Amphotericin B analog results in decreased expression of SLC39A7 mRNA

NCBI chr20:4,823,166...4,826,538
Ensembl chr20:4,822,012...4,826,537

G

solute carrier family 5 member 1

increases expression

Amphotericin B analog results in increased expression of SLC5A1 mRNA

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

solute carrier family 6 member 6

decreases expression

Amphotericin B analog results in decreased expression of SLC6A6 mRNA

NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875

G

slit guidance ligand 1

decreases expression

Amphotericin B results in decreased expression of SLIT1 mRNA

NCBI chr 1:240,409,559...240,558,127
Ensembl chr 1:240,409,561...240,558,127

G

sorbin and SH3 domain containing 1

decreases expression

Amphotericin B analog results in decreased expression of SORBS1 mRNA

NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169

G

sortilin related receptor 1

decreases expression

Amphotericin B analog results in decreased expression of SORL1 mRNA

NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513

G

sperm associated antigen 8

decreases expression

Amphotericin B analog results in decreased expression of SPAG8 mRNA

NCBI chr 5:57,901,681...57,903,894
Ensembl chr 5:57,901,682...57,903,894

G

secreted phosphoprotein 1

affects expression

Amphotericin B affects the expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sprouty RTK signaling antagonist 1

decreases expression

Amphotericin B analog results in decreased expression of SPRY1 mRNA

NCBI chr 2:120,557,256...120,561,917
Ensembl chr 2:120,556,706...120,566,189

G

spectrin, beta, non-erythrocytic 5

increases expression

Amphotericin B analog results in increased expression of SPTBN5 mRNA

NCBI chr 3:107,013,783...107,054,878
Ensembl chr 3:107,013,265...107,054,324

G

squalene epoxidase

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Sodium Selenite results in increased abundance of Selenium] inhibits the reaction [[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of SREBF1 mRNA]; [Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

sterol regulatory element binding transcription factor 2

multiple interactions

[Vancomycin co-treated with Neomycin co-treated with Ampicillin co-treated with Metronidazole co-treated with Amphotericin B] results in increased expression of SREBF2 mRNA

NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848

G

stanniocalcin 1

decreases expression

Amphotericin B analog results in decreased expression of STC1 mRNA

NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264

G

stathmin 4

increases expression

Amphotericin B analog results in increased expression of STMN4 mRNA

NCBI chr15:40,541,305...40,559,253
Ensembl chr15:40,541,357...40,559,253

G

tachykinin precursor 3

increases expression

Amphotericin B analog results in increased expression of TAC3 mRNA

NCBI chr 7:63,562,552...63,569,170
Ensembl chr 7:63,562,552...63,569,170

G

tumor-associated calcium signal transducer 2

decreases expression

Amphotericin B analog results in decreased expression of TACSTD2 mRNA

NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650

G

TATA-box binding protein associated factor 13

decreases expression

Amphotericin B analog results in decreased expression of TAF13 mRNA

NCBI chr 2:196,205,219...196,215,882
Ensembl chr 2:196,205,243...196,215,878

G

TAL bHLH transcription factor 1, erythroid differentiation factor

increases expression

Amphotericin B analog results in increased expression of TAL1 mRNA

NCBI chr 5:128,586,776...128,600,976
Ensembl chr 5:128,587,701...128,600,976

G

transcription factor 20

increases expression

Amphotericin B analog results in increased expression of TCF20 mRNA

NCBI chr 7:113,953,449...114,104,166
Ensembl chr 7:113,954,089...114,051,839

G

teneurin transmembrane protein 1

decreases expression

Amphotericin B analog results in decreased expression of TENM1 mRNA

NCBI chr X:121,400,466...122,289,877
Ensembl chr X:121,403,649...122,290,207

G

terminal nucleotidyltransferase 5A

decreases expression

Amphotericin B analog results in decreased expression of FAM46A mRNA

NCBI chr 8:86,222,294...86,229,045
Ensembl chr 8:86,225,357...86,229,045

G

transcription factor Dp-2

decreases expression

Amphotericin B analog results in decreased expression of TFDP2 mRNA; Amphotericin B results in decreased expression of TFDP2 mRNA

NCBI chr 8:96,760,459...96,901,466
Ensembl chr 8:96,760,504...96,896,682

G

transcription factor EC

decreases expression

Amphotericin B analog results in decreased expression of TFEC mRNA

NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236

G

trefoil factor 1

increases expression

Amphotericin B analog results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

transforming growth factor, beta 1

multiple interactions

[Antimony Sodium Gluconate co-treated with Amphotericin B] results in decreased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

thymocyte selection associated family member 2

decreases expression

Amphotericin B analog results in decreased expression of THEMIS2 mRNA

NCBI chr 5:144,991,110...145,006,362
Ensembl chr 5:144,991,112...145,006,400

G

transmembrane and coiled-coil domain family 1

decreases expression

Amphotericin B analog results in decreased expression of TMCC1 mRNA

NCBI chr 4:149,069,252...149,239,585
Ensembl chr 4:149,069,260...149,239,620

G

transmembrane protein 140

decreases expression

Amphotericin B analog results in decreased expression of TMEM140 mRNA

NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455

G

transmembrane protein 151B

increases expression

Amphotericin B results in increased expression of TMEM151B mRNA

NCBI chr 9:15,456,446...15,464,289
Ensembl chr 9:15,455,801...15,464,302

G

transmembrane protein 176B

decreases expression

Amphotericin B analog results in decreased expression of TMEM176B mRNA

NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384

G

transmembrane protein 255A

decreases expression

Amphotericin B analog results in decreased expression of TMEM255A mRNA

NCBI chr X:116,970,793...117,035,008
Ensembl chr X:116,970,695...117,035,008

G

transmembrane protein 45A

decreases expression

Amphotericin B analog results in decreased expression of TMEM45A mRNA

NCBI chr11:43,713,309...43,799,526
Ensembl chr11:43,713,782...43,799,526

G

tumor necrosis factor

increases expression

Amphotericin B results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

increases expression

Amphotericin B analog results in increased expression of TNFAIP3 mRNA

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF superfamily member 4

decreases expression

Amphotericin B analog results in decreased expression of TNFSF4 mRNA

NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788

G

TOX high mobility group box family member 3

decreases expression

Amphotericin B analog results in decreased expression of TOX3 mRNA

NCBI chr19:16,648,338...16,757,151
Ensembl chr19:16,648,342...16,757,148

G

tumor protein p63

increases expression

Amphotericin B analog results in increased expression of TP63 mRNA

NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398

G

triggering receptor expressed on myeloid cells 1

decreases expression

Amphotericin B analog results in decreased expression of TREM1 mRNA

NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203

G

transient receptor potential cation channel, subfamily M, member 3

decreases expression

Amphotericin B analog results in decreased expression of TRPM3 mRNA

NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717

G

transient receptor potential cation channel, subfamily M, member 6

increases expression

Amphotericin B analog results in increased expression of TRPM6 mRNA

NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520

G

transcriptional repressor GATA binding 1

decreases expression

Amphotericin B analog results in decreased expression of TRPS1 mRNA

NCBI chr 7:81,916,668...82,142,733
Ensembl chr 7:81,921,601...82,141,905

G

testis-specific serine kinase 2

increases expression

Amphotericin B analog results in increased expression of TSSK2 mRNA

NCBI chr11:83,086,578...83,087,933

G

thioredoxin interacting protein

decreases expression

Amphotericin B analog results in decreased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

ubiquitin-conjugating enzyme E2D 2B

increases expression

Amphotericin B analog results in increased expression of UBE2D4 mRNA

NCBI chr14:1,915,999...1,917,473
Ensembl chr14:1,916,845...1,917,416

G

UDP glucuronosyltransferase family 1 member A9

affects expression

Amphotericin B affects the expression of UGT1A9 mRNA

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

ubiquitin specific peptidase 2

increases expression

Amphotericin B analog results in increased expression of USP2 mRNA

NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331

G

ubiquitin specific peptidase 36

increases expression

Amphotericin B results in increased expression of USP36 mRNA

NCBI chr10:103,497,349...103,528,877
Ensembl chr10:103,497,349...103,528,877

G

vav guanine nucleotide exchange factor 3

decreases expression

Amphotericin B analog results in decreased expression of VAV3 mRNA; Amphotericin B results in decreased expression of VAV3 mRNA

NCBI chr 2:197,011,901...197,354,321
Ensembl chr 2:197,011,831...197,354,321

G

vestigial-like family member 1

increases expression

Amphotericin B analog results in increased expression of VGLL1 mRNA

NCBI chr X:134,979,657...134,996,007

G

vanin 1

decreases expression

Amphotericin B analog results in decreased expression of VNN1 mRNA

NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395

G

X-prolyl aminopeptidase 2

increases expression

Amphotericin B analog results in increased expression of XPNPEP2 mRNA

NCBI chr X:127,287,765...127,317,036
Ensembl chr X:127,287,979...127,317,223

G

zinc finger and BTB domain containing 16

decreases expression

Amphotericin B analog results in decreased expression of ZBTB16 mRNA

NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011

G

zinc finger protein 236

increases expression

Amphotericin B analog results in increased expression of ZNF236 mRNA

NCBI chr18:75,976,478...76,072,428
Ensembl chr18:75,978,231...76,073,737

G

zinc finger protein 36, C3H type-like 2

decreases expression

Amphotericin B analog results in decreased expression of ZFP36L2 mRNA

NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064

G

zinc finger protein 652

decreases expression

Amphotericin B results in decreased expression of ZNF652 mRNA

NCBI chr10:80,626,555...80,706,397
Ensembl chr10:80,649,400...80,698,674

G

zinc finger protein X-linked

decreases expression

Amphotericin B results in decreased expression of ZFX mRNA

NCBI chr X:58,804,690...58,853,155
Ensembl chr X:58,804,691...58,853,265

G

zinc finger, matrin type 4

increases expression

Amphotericin B analog results in increased expression of ZMAT4 mRNA

NCBI chr16:67,969,410...68,361,377
Ensembl chr16:67,969,416...68,361,202

amphotericin B methyl ester

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hepatitis A virus cellular receptor 1

increases expression

methylamphotericin B results in increased expression of HAVCR1 mRNA

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

lipocalin 2

increases expression

methylamphotericin B results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

secreted phosphoprotein 1

increases expression

methylamphotericin B results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

TIMP metallopeptidase inhibitor 1

increases expression

methylamphotericin B results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

caspofungin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

histamine N-methyltransferase

decreases activity

caspofungin results in decreased activity of HNMT protein

NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012

everolimus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases activity

Everolimus results in decreased activity of ABCB11 protein

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects stability
affects response to substance
multiple interactions

ABCB1A protein affects the stability of Everolimus
ABCB1 polymorphism affects the susceptibility to Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1A protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCB1A protein affects the metabolism of irinotecan]

PMID:24727322 PMID:27169792

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects stability
multiple interactions

ABCB1B protein affects the stability of Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCB1B protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCB1B protein affects the metabolism of irinotecan]

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily G member 2

affects stability
multiple interactions

ABCG2 protein affects the stability of Everolimus
bis(4-nitrophenyl)phosphate inhibits the reaction [ABCG2 protein affects the stability of Everolimus]; Everolimus inhibits the reaction [ABCG2 protein affects the metabolism of irinotecan]

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions
decreases phosphorylation

Everolimus results in increased phosphorylation of AKT1 protein
Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; MK 2206 inhibits the reaction [Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]]
Everolimus results in decreased phosphorylation of AKT1 protein

PMID:16033851 PMID:22885370 PMID:23300809 PMID:28711525 PMID:37739323

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

increases phosphorylation
multiple interactions

Everolimus results in increased phosphorylation of AKT2 protein
Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT2 protein]; MK 2206 inhibits the reaction [Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT2 protein]]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

AKT serine/threonine kinase 3

multiple interactions
increases phosphorylation

Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT3 protein]; MK 2206 inhibits the reaction [Everolimus inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT3 protein]]
Everolimus results in increased phosphorylation of AKT3 protein

NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708

G

BCL2 associated X, apoptosis regulator

multiple interactions

Everolimus inhibits the reaction [Doxorubicin results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

Everolimus inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

baculoviral IAP repeat-containing 5

decreases expression
multiple interactions

Everolimus results in decreased expression of BIRC5 protein
Everolimus promotes the reaction [platycodin D results in decreased expression of BIRC5 protein]; navitoclax promotes the reaction [Everolimus results in decreased expression of BIRC5 protein]; platycodin D promotes the reaction [Everolimus results in decreased expression of BIRC5 protein]

PMID:21601561 PMID:28711525 PMID:28947240

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

bromodomain containing 4

multiple interactions

[MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene]

NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539

G

caspase 3

increases cleavage

Everolimus results in increased cleavage of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin A2

decreases expression

Everolimus results in decreased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin D1

decreases expression
multiple interactions

Everolimus results in decreased expression of CCND1 protein
[letrozole co-treated with Everolimus] results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

multiple interactions
decreases expression

[letrozole co-treated with Everolimus] results in decreased expression of CCND2 protein
Everolimus results in decreased expression of CCND2 protein

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

decreases expression

Everolimus results in decreased expression of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cadherin 1

increases expression

Everolimus results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

carboxylesterase 1D

decreases activity

Everolimus results in decreased activity of CES1 protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

decreases activity

Everolimus results in decreased activity of CES2 protein

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cytochrome c, somatic

multiple interactions

Everolimus inhibits the reaction [Doxorubicin results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

epidermal growth factor receptor

increases expression
multiple interactions

Everolimus results in increased expression of EGFR mRNA; Everolimus results in increased expression of EGFR protein
platycodin D inhibits the reaction [Everolimus results in increased expression of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

eukaryotic translation initiation factor 4E

increases phosphorylation
multiple interactions

Everolimus results in increased phosphorylation of EIF4E protein
Everolimus inhibits the reaction [Estradiol results in decreased phosphorylation of EIF4E protein]

NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 1

multiple interactions
decreases phosphorylation

[letrozole co-treated with Everolimus] results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein]; Everolimus promotes the reaction [platycodin D results in decreased phosphorylation of EIF4EBP1 protein]; Everolimus results in increased phosphorylation of and results in decreased activity of EIF4EBP1 protein; platycodin D promotes the reaction [Everolimus results in decreased phosphorylation of EIF4EBP1 protein]

PMID:16033851 PMID:16856892 PMID:16951235 PMID:21372221 PMID:28711525

NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984

G

eukaryotic translation initiation factor 4 gamma 1

multiple interactions

Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of EIF4G1 protein]

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

coagulation factor III, tissue factor

multiple interactions

Everolimus promotes the reaction [TNF protein results in increased expression of F3 protein]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

insulin-like growth factor 1 receptor

multiple interactions
increases expression

platycodin D inhibits the reaction [Everolimus results in increased expression of IGF1R protein]
Everolimus results in increased expression of IGF1R mRNA; Everolimus results in increased expression of IGF1R protein

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

integrin subunit alpha M

multiple interactions

Everolimus promotes the reaction [Tretinoin results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

microtubule-associated protein 1 light chain 3 alpha

increases lipidation

Everolimus results in increased lipidation of MAP1LC3A protein

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Everolimus promotes the reaction [N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in increased expression of and results in increased lipidation of MAP1LC3B protein]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

matrix metallopeptidase 9

multiple interactions

Everolimus inhibits the reaction [4-cresol results in increased expression of MMP9 protein]

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation
decreases activity

[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; [Letrozole co-treated with Everolimus] inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [4-cresol results in increased phosphorylation of MTOR protein]; Everolimus inhibits the reaction [Androstenedione affects the activity of MTOR protein]; Everolimus inhibits the reaction [Estradiol affects the activity of MTOR protein]; Everolimus inhibits the reaction [MTOR results in decreased susceptibility to Trabectedin]
Everolimus results in decreased phosphorylation of MTOR protein
Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]
Everolimus results in decreased activity of MTOR; Everolimus results in decreased activity of MTOR protein

PMID:16033851 PMID:20890178 PMID:21622721 PMID:24989011 PMID:30910523 More...

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
decreases response to substance
increases expression

[MYC protein results in decreased susceptibility to Everolimus] promotes the reaction [BRD4 protein binds to MYC gene]
Everolimus results in increased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

nerve growth factor

multiple interactions

Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of MTOR protein]]; Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 3

multiple interactions
decreases expression

Aspirin inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; cilostazol inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

nuclear receptor subfamily 1, group I, member 3

decreases activity

Everolimus results in decreased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

poly (ADP-ribose) polymerase 1

multiple interactions

[navitoclax co-treated with Everolimus] results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prostaglandin-endoperoxide synthase 2

increases expression

Everolimus results in increased expression of PTGS2 mRNA; Everolimus results in increased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases expression

Everolimus results in decreased expression of PTK2 protein modified form

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RB transcriptional corepressor 1

multiple interactions
decreases phosphorylation

[letrozole co-treated with Everolimus] results in decreased phosphorylation of and affects the activity of RB1 protein; Everolimus results in decreased phosphorylation of and affects the activity of RB1 protein
Everolimus results in decreased phosphorylation of RB1 protein

PMID:16033851 PMID:16856892

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

ras homolog family member A

decreases expression
multiple interactions

Everolimus results in decreased expression of RHOA protein
[Everolimus co-treated with Y 27632] inhibits the reaction [4-cresol results in increased expression of RHOA protein]

PMID:28258630 PMID:30910523

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

ribosomal protein S6

multiple interactions
decreases phosphorylation

[letrozole co-treated with Everolimus] results in decreased phosphorylation of RPS6 protein; Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6 protein]
Everolimus results in decreased phosphorylation of RPS6 protein

PMID:16033851 PMID:21372221 PMID:22885370 PMID:23151917 PMID:23300809 More...

NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602

G

ribosomal protein S6 kinase B1

multiple interactions

Everolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]]
Everolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]; Everolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]

PMID:16033851 PMID:19567381 PMID:24989011

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

sirtuin 1

multiple interactions
decreases expression

Aspirin inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]; cilostazol inhibits the reaction [Everolimus results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases expression

Everolimus results in decreased expression of SRC protein modified form

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

tumor necrosis factor

multiple interactions

Everolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; Everolimus promotes the reaction [TNF protein results in increased expression of F3 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vimentin

decreases expression

Everolimus results in decreased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

fumagillin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

multiple interactions

fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2 mRNA]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

methionyl aminopeptidase 1

decreases activity
multiple interactions

fumagillin results in decreased activity of METAP1 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

NCBI chr 2:226,991,305...227,024,360
Ensembl chr 2:226,991,301...227,024,434

G

methionyl aminopeptidase 2

multiple interactions
decreases activity

fumagillin promotes the reaction [Diethylnitrosamine results in increased expression of METAP2 mRNA]
fumagillin results in decreased activity of METAP2 protein
[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

PMID:14534293 PMID:15516829 PMID:15682466

NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434

G

telomerase reverse transcriptase

multiple interactions

fumagillin inhibits the reaction [Diethylnitrosamine results in increased activity of TERT protein]; fumagillin inhibits the reaction [Diethylnitrosamine results in increased expression of TERT mRNA]

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

multiple interactions

[fumagillin results in decreased activity of [METAP1 protein co-treated with METAP2 protein]] which results in decreased metabolism of YWHAG protein

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

griseofulvin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression

Griseofulvin results in increased expression of ABCB1A mRNA

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

increases expression

Griseofulvin results in increased expression of ABCB4 mRNA

NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202

G

angiotensin converting enzyme 2

decreases expression

Griseofulvin results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

adrenoceptor beta 3

decreases expression

Griseofulvin results in decreased expression of ADRB3 mRNA

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

5'-aminolevulinate synthase 1

affects expression
multiple interactions
increases activity
increases expression

Griseofulvin affects the expression of ALAS1 mRNA
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; [Ascorbic Acid co-treated with 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid] inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; Ascorbic Acid inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]; Melatonin inhibits the reaction [Griseofulvin results in increased activity of ALAS1 protein]
Griseofulvin results in increased expression of ALAS1 mRNA

PMID:10215191 PMID:12735108 PMID:15793285 PMID:24523661

NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917

G

annexin A2

increases expression

Griseofulvin results in increased expression of ANXA2 mRNA

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

annexin A3

affects expression

Griseofulvin affects the expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A5

increases expression

Griseofulvin results in increased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A6

increases expression

Griseofulvin results in increased expression of ANXA6 mRNA

NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433

G

amphiregulin

increases expression

Griseofulvin results in increased expression of AREG protein

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

betacellulin

increases expression

Griseofulvin results in increased expression of BTC protein

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

G

caspase 3

increases activity
increases cleavage

Griseofulvin results in increased activity of CASP3 protein
Griseofulvin results in increased cleavage of CASP3 protein

PMID:23329179 PMID:25412316

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

Griseofulvin results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

carbonyl reductase 1

affects expression

Griseofulvin affects the expression of CBR1 mRNA

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

CD14 molecule

affects expression

Griseofulvin affects the expression of CD14 mRNA

NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261

G

CD24 molecule

affects expression

Griseofulvin affects the expression of CD24A mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

collagen type I alpha 1 chain

increases expression

Griseofulvin results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type III alpha 1 chain

increases expression

Griseofulvin results in increased expression of COL3A1 mRNA

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

collagen type IV alpha 1 chain

affects expression

Griseofulvin affects the expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

cystatin B

increases expression

Griseofulvin results in increased expression of CSTB mRNA

NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526

G

cytochrome P450, family 1, subfamily a, polypeptide 2

affects expression
multiple interactions

Griseofulvin affects the expression of CYP1A2 mRNA
Griseofulvin promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]

PMID:9029748 PMID:12735108

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily a, polypeptide 3

affects expression

Griseofulvin affects the expression of CYP2A4 mRNA

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 2

affects expression

Griseofulvin affects the expression of CYP2B13 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

affects expression

Griseofulvin affects the expression of CYP2B10 mRNA

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily C, polypeptide 6

affects expression

Griseofulvin affects the expression of CYP2C29 mRNA

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

Griseofulvin results in increased expression of CYP3A4 mRNA; Griseofulvin results in increased expression of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily B member 1

decreases expression

Griseofulvin results in decreased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

elastin

affects expression

Griseofulvin affects the expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

epiregulin

increases expression

Griseofulvin results in increased expression of EREG protein

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

G

fatty acid binding protein 1

decreases expression

Griseofulvin results in decreased expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

ferrochelatase

decreases activity
increases expression
multiple interactions

Griseofulvin results in decreased activity of FECH protein
Griseofulvin results in increased expression of FECH mRNA
[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron; heme arginate inhibits the reaction [[Griseofulvin results in decreased activity of FECH protein] which results in decreased uptake of Iron]

PMID:10215191 PMID:15078340

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

follistatin-like 1

affects expression

Griseofulvin affects the expression of FSTL1 mRNA

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

G0/G1switch 2

decreases expression

Griseofulvin results in decreased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

growth arrest and DNA-damage-inducible, beta

affects expression

Griseofulvin affects the expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

gap junction protein, alpha 1

multiple interactions
increases expression

Griseofulvin results in increased expression of and results in increased localization of GJA1 protein
Griseofulvin results in increased expression of GJA1 mRNA

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutathione S-transferase mu 2

affects expression

Griseofulvin affects the expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

heme oxygenase 1

increases activity
increases expression

Griseofulvin results in increased activity of HMOX1 protein
Griseofulvin results in increased expression of HMOX1 mRNA; Griseofulvin results in increased expression of HMOX1 protein

PMID:10215191 PMID:15793285 PMID:16309571

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

immediate early response 3

affects expression

Griseofulvin affects the expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

insulin-like growth factor 1

decreases expression

Griseofulvin results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein, acid labile subunit

decreases expression

Griseofulvin results in decreased expression of IGFALS mRNA

NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677

G

insulin-like growth factor binding protein 2

affects expression

Griseofulvin affects the expression of IGFBP2 mRNA

NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937

G

interleukin 1 alpha

multiple interactions

Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

inhibin subunit beta C

decreases expression

Griseofulvin results in decreased expression of INHBC mRNA

NCBI chr 7:63,184,141...63,197,630
Ensembl chr 7:63,184,142...63,197,630

G

IQ motif containing GTPase activating protein 1

affects expression

Griseofulvin affects the expression of IQGAP1 mRNA

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

G

integrin subunit beta 2

affects expression

Griseofulvin affects the expression of ITGB2 mRNA

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

keratin 18

multiple interactions
increases expression
decreases response to substance

Griseofulvin promotes the reaction [KRT18 protein binds to KRT18 protein]
Griseofulvin results in increased expression of KRT18 mRNA; Griseofulvin results in increased expression of KRT18 protein
KRT18 protein results in decreased susceptibility to Griseofulvin

PMID:7504119 PMID:8770877 PMID:10952237 PMID:12388748

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

keratin 8

increases expression
increases phosphorylation

Griseofulvin results in increased expression of KRT8 mRNA; Griseofulvin results in increased expression of KRT8 protein
Griseofulvin results in increased phosphorylation of KRT8 protein

PMID:7504119 PMID:10952237 PMID:12735108 PMID:20643122

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

laminin subunit beta 1

decreases expression

Griseofulvin results in decreased expression of LAMB1 protein

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

G

laminin subunit beta 2

decreases expression
increases expression

Griseofulvin results in decreased expression of LAMB2 protein
Griseofulvin results in increased expression of LAMB2 mRNA

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

leukocyte immunoglobulin like receptor B4

affects expression

Griseofulvin affects the expression of LILRB4 mRNA

NCBI chr 1:69,805,020...69,810,628
Ensembl chr 1:69,805,250...69,810,660

G

lipoprotein lipase

affects expression

Griseofulvin affects the expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

lymphocyte antigen 6 family member D

increases expression

Griseofulvin results in increased expression of LY6D mRNA

NCBI chr 7:106,643,225...106,644,733
Ensembl chr 7:106,643,232...106,644,733

G

microtubule-associated protein tau

increases expression

Griseofulvin results in increased expression of MAPT mRNA; Griseofulvin results in increased expression of MAPT mRNA alternative form; Griseofulvin results in increased expression of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

metallothionein 1

increases expression

Griseofulvin results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

neural proliferation, differentiation and control, 1

affects expression

Griseofulvin affects the expression of NPDC1 mRNA

NCBI chr 3:8,220,446...8,226,446
Ensembl chr 3:8,213,663...8,226,866

G

NAD(P)H quinone dehydrogenase 1

increases expression

Griseofulvin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

Griseofulvin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

3'-phosphoadenosine 5'-phosphosulfate synthase 2

affects expression

Griseofulvin affects the expression of PAPSS2 mRNA

NCBI chr 1:230,454,314...230,539,332
Ensembl chr 1:230,454,426...230,539,331

G

platelet factor 4

affects expression

Griseofulvin affects the expression of PF4 mRNA

NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365

G

cytochrome p450 oxidoreductase

affects expression

Griseofulvin affects the expression of POR mRNA

NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245

G

peroxisome proliferator activated receptor alpha

decreases expression

Griseofulvin results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

increases expression

Griseofulvin results in increased expression of PPARD mRNA

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

increases expression

Griseofulvin results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

periplakin

affects expression

Griseofulvin affects the expression of PPL mRNA

NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575

G

retinoic acid receptor, alpha

increases expression

Griseofulvin results in increased expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

retinoic acid receptor, beta

increases expression

Griseofulvin results in increased expression of RARB mRNA

NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288

G

retinoic acid receptor, gamma

increases expression

Griseofulvin results in increased expression of RARG mRNA

NCBI chr 7:133,367,833...133,390,301
Ensembl chr 7:133,367,833...133,390,177

G

retinoid X receptor alpha

decreases expression

Griseofulvin results in decreased expression of RXRA mRNA

NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712

G

retinoid X receptor gamma

decreases expression

Griseofulvin results in decreased expression of RXRG mRNA

NCBI chr13:79,743,430...79,785,173
Ensembl chr13:79,743,563...79,785,167

G

S100 calcium binding protein A6

increases expression

Griseofulvin results in increased expression of S100A6 mRNA

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

stearoyl-Coenzyme A desaturase 2

affects expression

Griseofulvin affects the expression of SCD2 mRNA

NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232

G

selectin E

multiple interactions

Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

selectin L

decreases expression

Griseofulvin results in decreased expression of SELL protein

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

sterol O-acyltransferase 1

affects expression

Griseofulvin affects the expression of SOAT1 mRNA

NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494

G

secreted phosphoprotein 1

affects expression

Griseofulvin affects the expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

transglutaminase 2

affects expression

Griseofulvin affects the expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

transmembrane 4 L six family member 4

affects expression

Griseofulvin affects the expression of TM4SF4 mRNA

NCBI chr 2:141,570,321...141,621,263
Ensembl chr 2:141,481,902...141,621,200

G

thymosin, beta 10

affects expression

Griseofulvin affects the expression of TMSB10 mRNA

NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028

G

thymosin beta 4, X-linked

affects expression

Griseofulvin affects the expression of TMSB4X mRNA

NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667
Ensembl chr10:27,128,610...27,146,667

G

tumor necrosis factor

multiple interactions

Griseofulvin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]

PMID:11154858 PMID:11367519

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP-glucose 6-dehydrogenase

affects expression

Griseofulvin affects the expression of UGDH mRNA

NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354

G

UDP glucuronosyltransferase family 1 member A1

affects expression

Griseofulvin affects the expression of UGT1A1 mRNA

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular cell adhesion molecule 1

affects expression
multiple interactions

Griseofulvin affects the expression of VCAM1 mRNA
Griseofulvin inhibits the reaction [IL1A protein results in increased expression of VCAM1 protein]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; Paclitaxel inhibits the reaction [Griseofulvin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]]

PMID:11154858 PMID:11367519 PMID:12735108

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vinculin

affects localization

Griseofulvin affects the localization of VCL protein

NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606

G

Wnt family member 3A

affects expression

Griseofulvin affects the expression of WNT3A mRNA

NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324

G

Y box binding protein 3

affects expression

Griseofulvin affects the expression of YBX3 mRNA

NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161

micafungin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

Micafungin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

MALT1 paracaspase

multiple interactions
affects binding

MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in increased ubiquitination of NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin promotes the reaction [MALT1 protein binds to NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin results in increased expression of MALT1 protein]
Micafungin binds to MALT1 protein

NCBI chr18:58,942,282...58,996,318
Ensembl chr18:58,942,299...58,994,260

G

NFE2 like bZIP transcription factor 2

multiple interactions

MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; MALT1 protein inhibits the reaction [Micafungin inhibits the reaction [Doxorubicin results in increased ubiquitination of NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin promotes the reaction [MALT1 protein binds to NFE2L2 protein]]; Micafungin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; Micafungin inhibits the reaction [Doxorubicin results in increased ubiquitination of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

natamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

clusterin

increases expression

Natamycin results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

ceruloplasmin

increases expression

Natamycin results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

fibrinogen alpha chain

increases expression

Natamycin results in increased expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen gamma chain

increases expression

Natamycin results in increased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

hepatitis A virus cellular receptor 1

increases expression

Natamycin results in increased expression of HAVCR1 mRNA

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

keratin 19

increases expression

Natamycin results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

lipocalin 2

increases expression

Natamycin results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

secreted phosphoprotein 1

increases expression

Natamycin results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

TIMP metallopeptidase inhibitor 1

increases expression

Natamycin results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

nystatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Nystatin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

caspase 8

multiple interactions

Nystatin inhibits the reaction [resveratrol affects the localization of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caveolin 1

multiple interactions

Nystatin inhibits the reaction [Quercetin affects the localization of CAV1 protein]

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

CD40 molecule

increases expression

Nystatin results in increased expression of CD40 protein

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

Cd80 molecule

increases expression

Nystatin results in increased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

increases expression

Nystatin results in increased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

clusterin

increases expression

Nystatin results in increased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

ceruloplasmin

increases expression

Nystatin results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

Fas associated via death domain

multiple interactions

Nystatin inhibits the reaction [resveratrol affects the localization of FADD protein]

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas cell surface death receptor

multiple interactions

Nystatin inhibits the reaction [resveratrol affects the localization of FAS protein]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibrinogen alpha chain

increases expression

Nystatin results in increased expression of FGA mRNA

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibrinogen gamma chain

increases expression

Nystatin results in increased expression of FGG mRNA

NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322

G

hepatitis A virus cellular receptor 1

increases expression

Nystatin results in increased expression of HAVCR1 mRNA

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

intercellular adhesion molecule 1

increases expression

Nystatin results in increased expression of ICAM1 protein

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

increases expression

Nystatin results in increased expression of IL1B mRNA; Nystatin results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

Nystatin results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

keratin 18

increases expression

Nystatin results in increased expression of KRT18 mRNA

NCBI chr 7:133,157,486...133,161,162
Ensembl chr 7:133,157,475...133,161,166
Ensembl chr10:133,157,475...133,161,166

G

keratin 19

increases expression

Nystatin results in increased expression of KRT19 mRNA

NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799

G

keratin 8

increases expression

Nystatin results in increased expression of KRT8 mRNA

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

lipocalin 2

increases expression

Nystatin results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

mitogen activated protein kinase 1

multiple interactions

Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [4-propylphenol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Diethylstilbestrol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK1 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein]

PMID:15072920 PMID:22230296

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Nystatin inhibits the reaction [4-ethylphenol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [4-propylphenol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Diethylstilbestrol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Nystatin inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estriol results in increased phosphorylation of MAPK3 protein]; Nystatin inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein]

PMID:15072920 PMID:22230296

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

prion protein

multiple interactions

Nystatin inhibits the reaction [Copper Sulfate results in increased uptake of and affects the localization of PRNP protein]

NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937

G

REL proto-oncogene, NF-kB subunit

increases activity

Nystatin results in increased activity of REL protein

NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892

G

RELA proto-oncogene, NF-kB subunit

increases activity

Nystatin results in increased activity of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

secreted phosphoprotein 1

increases expression

Nystatin results in increased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

TIMP metallopeptidase inhibitor 1

increases expression

Nystatin results in increased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TNF receptor superfamily member 10b

multiple interactions

Nystatin inhibits the reaction [Quercetin affects the localization of TNFRSF10A protein]

NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467

G

vimentin

increases expression

Nystatin results in increased expression of VIM mRNA

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

OSU-03012

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation
decreases response to substance

OSU 03012 results in decreased phosphorylation of AKT1 protein
AKT1 protein modified form results in decreased susceptibility to OSU 03012

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

3-phosphoinositide dependent protein kinase-1

multiple interactions
decreases response to substance

OSU 03012 binds to and results in decreased activity of PDPK1 protein
PDPK1 protein modified form results in decreased susceptibility to OSU 03012

NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623

ridaforolimus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

ridaforolimus inhibits the reaction [Radon results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

cadherin 1

multiple interactions

ridaforolimus inhibits the reaction [Radon results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 2

multiple interactions

ridaforolimus inhibits the reaction [Radon results in increased expression of CDH2 protein]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

fibronectin 1

multiple interactions

ridaforolimus inhibits the reaction [Radon results in increased expression of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

mechanistic target of rapamycin kinase

multiple interactions
decreases activity

ridaforolimus inhibits the reaction [Radon results in increased expression of MTOR protein modified form]
ridaforolimus results in decreased activity of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

snail family transcriptional repressor 1

multiple interactions

ridaforolimus inhibits the reaction [Radon results in increased expression of SNAI1 protein]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

vimentin

multiple interactions

ridaforolimus inhibits the reaction [Radon results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

sirolimus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-2-macroglobulin

increases expression

Sirolimus results in increased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

ATP binding cassette subfamily A member 1

multiple interactions
increases expression

[Sirolimus co-treated with Cyclosporine] results in decreased expression of ABCA1 protein; [Sirolimus co-treated with Tacrolimus] results in increased expression of ABCA1 protein
Sirolimus results in increased expression of ABCA1 mRNA

PMID:17016853 PMID:21865292

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

affects metabolic processing
affects transport

ABCB1 protein affects the metabolism of Sirolimus
ABCB1 protein affects the transport of Sirolimus

PMID:15707415 PMID:15760093 PMID:15964407

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 2

decreases expression

Sirolimus results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 8

decreases expression

Sirolimus results in decreased expression of ABCC8 mRNA

NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510

G

ATP binding cassette subfamily D member 3

decreases expression

Sirolimus results in decreased expression of ABCD3 protein

NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020

G

ankyrin repeat and BTB domain containing 3

multiple interactions

Sirolimus inhibits the reaction [TP73 protein results in increased expression of ABTB3 mRNA]

NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834

G

acyl-CoA dehydrogenase, long chain

multiple interactions

Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADL mRNA]]

NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220

G

acyl-CoA dehydrogenase medium chain

multiple interactions

Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of ACADM mRNA]]

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

angiotensin converting enzyme 2

decreases expression

Sirolimus results in decreased expression of ACE2 mRNA

NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977

G

alkaline ceramidase 2

multiple interactions

Sirolimus inhibits the reaction [TP73 protein results in decreased expression of ACER2 mRNA]

NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614

G

actin alpha 2, smooth muscle

multiple interactions

[Sirolimus co-treated with IGF1 protein] results in increased expression of ACTA2 protein
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

PMID:17908691 PMID:35405287

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

actin, beta

increases expression
multiple interactions

Sirolimus results in increased expression of ACTB mRNA
[Sirolimus binds to FKBP1A protein] which results in increased expression of ACTB mRNA

NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877

G

angiotensinogen

multiple interactions

Sirolimus inhibits the reaction [AGT protein affects the localization of Calcium]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

apoptosis inducing factor, mitochondria associated 1

decreases expression
multiple interactions

Sirolimus results in decreased expression of AIFM1 protein
[7-hydroxystaurosporine co-treated with Sirolimus] affects the localization of AIFM1 protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] affects the localization of AIFM1 protein]

PMID:15767555 PMID:16497721

NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256

G

AKT serine/threonine kinase 1

multiple interactions
decreases phosphorylation
affects phosphorylation
increases phosphorylation

[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein; [Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [Sirolimus co-treated with Arsenic Trioxide] results in decreased phosphorylation of AKT1 protein; Arsenic Trioxide inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]; Cisplatin inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Sirolimus affects the reaction [SLC31A1 protein affects the phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]
[Sirolimus co-treated with Resveratrol] promotes the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [[Cadmium Chloride co-treated with TGFB1 protein] results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [AKT1 protein mutant form results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1 protein]
Sirolimus results in decreased phosphorylation of AKT1 protein
Sirolimus affects the phosphorylation of AKT1 protein
[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein; Sirolimus results in increased phosphorylation of AKT1 protein
resveratrol inhibits the reaction [Sirolimus results in increased phosphorylation of AKT1 protein]; Sirolimus inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]
Rapamycin decreases phosphorylation of Akt1 protein in the aorta

CTD
RGD

PMID:15806154 PMID:18495876 PMID:18622747 PMID:19176369 PMID:21092744 More...

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT1 substrate 1

multiple interactions

[Sirolimus co-treated with resveratrol] results in decreased phosphorylation of AKT1S1 protein; resveratrol inhibits the reaction [Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]]; Sirolimus inhibits the reaction [TSC2 gene mutant form results in decreased phosphorylation of AKT1S1 protein]
[resveratrol co-treated with Sirolimus] results in decreased phosphorylation of AKT1S1 protein

NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677

G

AKT serine/threonine kinase 2

multiple interactions

[Sirolimus results in increased activity of AKT2 protein] which results in increased expression of CALD1 protein; [Sirolimus results in increased activity of AKT2 protein] which results in increased expression of MYH11 protein; Sirolimus results in increased phosphorylation of and results in increased activity of AKT2 protein

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

alkaline phosphatase, biomineralization associated

multiple interactions

Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of ALPL mRNA]]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

angiopoietin-like 6

increases expression

Sirolimus results in increased expression of ANGPTL6 mRNA

NCBI chr 8:19,413,617...19,419,925
Ensembl chr 8:19,413,619...19,419,925

G

aminopeptidase O

multiple interactions

Sirolimus inhibits the reaction [TP73 protein results in increased expression of AOPEP mRNA]

NCBI chr17:1,811,281...2,127,316
Ensembl chr17:1,811,980...2,127,331

G

apolipoprotein D

affects localization

Sirolimus affects the localization of APOD protein

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

amyloid beta precursor protein

decreases expression
increases expression

Sirolimus results in decreased expression of APP protein modified form
Sirolimus results in increased expression of APP protein modified form

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

aquaporin 2

multiple interactions
decreases expression

rosiglitazone inhibits the reaction [Sirolimus results in decreased expression of AQP2 protein]

NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468

G

androgen receptor

multiple interactions
increases activity
increases expression

[Sirolimus results in decreased activity of [MTOR protein binds to RPTOR protein]] which results in increased activity of AR protein; bicalutamide inhibits the reaction [Sirolimus results in increased activity of AR protein]; RPTOR protein inhibits the reaction [Sirolimus results in increased activity of AR protein]; Sirolimus affects the reaction [Testosterone results in increased expression of AR protein]; Sirolimus promotes the reaction [Dihydrotestosterone affects the expression of AR protein]
Sirolimus results in increased expression of AR protein

PMID:18776922 PMID:21036700

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

asparagine synthetase (glutamine-hydrolyzing)

multiple interactions

Sirolimus inhibits the reaction [IL2 protein results in increased expression of ASNS mRNA]

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 3

multiple interactions

[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

multiple interactions

Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]
Sirolimus inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]

PMID:24057571 PMID:29870746

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

multiple interactions

[Sirolimus co-treated with hydroquinone] results in decreased expression of ATF6 protein

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

autophagy related 4A, cysteine peptidase

increases expression

Sirolimus results in increased expression of ATG4A mRNA

NCBI chr X:104,665,345...104,765,271
Ensembl chr X:104,665,345...104,765,268

G

autophagy related 4B, cysteine peptidase

increases expression
multiple interactions

Sirolimus results in increased expression of ATG4B mRNA
Sirolimus inhibits the reaction [ATG4B protein results in increased expression of HK2 protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of LDHA protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [ATG4B protein results in increased expression of SLC2A1 protein]

PMID:21681844 PMID:36336208

NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103

G

autophagy related 5

multiple interactions
increases expression

[Sirolimus co-treated with TNF protein] results in increased expression of ATG5 mRNA; ATG5 protein affects the reaction [Sirolimus inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [Particulate Matter results in increased expression of ATG5 protein]]
[Sirolimus co-treated with cadmium acetate] results in increased expression of ATG5 mRNA; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of ATG5 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of ATG5 protein]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]]; Sirolimus promotes the reaction [Lipopolysaccharides results in increased expression of ATG5 protein]; Sirolimus promotes the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]
Sirolimus results in increased expression of ATG5 mRNA; Sirolimus results in increased expression of ATG5 protein

PMID:19682553 PMID:29128638 PMID:29505745 PMID:29781141 PMID:29870746 More...

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

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autophagy related 7

multiple interactions

[Sirolimus co-treated with TNF protein] results in increased expression of ATG7 mRNA

NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593

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aurora kinase B

multiple interactions

[fulvestrant co-treated with Sirolimus] results in decreased expression of AURKB mRNA

NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837

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BCL2-associated agonist of cell death

multiple interactions

Sirolimus inhibits the reaction [IL2 protein results in increased expression of BAD mRNA]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

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BCL2 associated X, apoptosis regulator

affects localization
multiple interactions
increases expression

Sirolimus affects the localization of BAX protein
[Curcumin co-treated with Sirolimus] results in increased expression of BAX; Sirolimus affects the reaction [SLC31A1 protein affects the expression of BAX protein]; Sirolimus inhibits the reaction [rebamipide results in decreased expression of BAX protein]; Sirolimus promotes the reaction [hydroquinone results in increased expression of BAX protein]
Sirolimus results in increased expression of BAX protein
[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX mRNA; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BAX protein; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of BAX protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]]; Sirolimus inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
Sirolimus results in increased expression of BAX mRNA; Sirolimus results in increased expression of BAX protein

PMID:11602639 PMID:15782132 PMID:19373661 PMID:19922502 PMID:29054700 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

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Bcl-2 binding component 3

multiple interactions

[[Sirolimus co-treated with Cisplatin] results in increased expression of TP73 protein] which results in increased expression of BBC3 protein; Sirolimus promotes the reaction [TP53 protein results in increased expression of BBC3 protein]

PMID:19560264 PMID:20686837

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

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BCL2, apoptosis regulator

multiple interactions
decreases expression
affects expression

[Curcumin co-treated with Sirolimus] results in decreased expression of BCL2; Sirolimus affects the reaction [SLC31A1 protein affects the expression of BCL2 protein]; Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [Doxorubicin results in increased expression of BCL2 protein]; Sirolimus inhibits the reaction [rebamipide results in increased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Ethanol results in increased expression of BCL2 protein]
Sirolimus results in decreased expression of BCL2 mRNA; Sirolimus results in decreased expression of BCL2 protein
[Sirolimus co-treated with IL2 protein] results in increased expression of BCL2 mRNA; Sirolimus inhibits the reaction [Particulate Matter results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; Sirolimus inhibits the reaction [sophoricoside inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]
Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [lactacystin results in decreased expression of BCL2 protein]; Sirolimus inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
Sirolimus affects the expression of BCL2 protein

PMID:11355896 PMID:15571967 PMID:18640276 PMID:19373661 PMID:19764996 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

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Bcl2-like 1

multiple interactions
decreases expression
increases expression

[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of BCL2L1 protein; Sirolimus inhibits the reaction [Colistin results in decreased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; Sirolimus inhibits the reaction [rebamipide results in increased expression of BCL2L1 protein]
Sirolimus results in decreased expression of BCL2L1 protein
[Sirolimus co-treated with IL2 protein] results in increased expression of BCL2L1 mRNA; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]
Sirolimus results in decreased expression of BCL2L1 mRNA; Sirolimus results in decreased expression of BCL2L1 protein
Sirolimus results in increased expression of BCL2L1 mRNA; Sirolimus results in increased expression of BCL2L1 protein

PMID:11355896 PMID:15767555 PMID:15782132 PMID:18097008 PMID:18789402 More...

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

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Bcl2-like 11

multiple interactions
increases expression
decreases expression

[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of BCL2L11 protein; Sirolimus inhibits the reaction [rebamipide results in decreased expression of BCL2L11 protein]; Sirolimus promotes the reaction [Cisplatin results in increased expression of BCL2L11 mRNA]
Sirolimus results in increased expression of BCL2L11 protein
Sirolimus results in decreased expression of BCL2L11 protein

PMID:18097008 PMID:21092744 PMID:29054700

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

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brain-derived neurotrophic factor

multiple interactions

Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; Sirolimus inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]; Sirolimus inhibits the reaction [Creatine results in increased expression of BDNF protein]; Sirolimus inhibits the reaction [Ketamine results in increased expression of BDNF protein]

PMID:17209049 PMID:33022268

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

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beclin 1

multiple interactions
increases expression

[Sirolimus co-treated with TNF protein] results in increased expression of BECN1 protein; Sirolimus inhibits the reaction [Ethanol results in increased degradation of BECN1 protein]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of BECN1 protein]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [Caffeine results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]
Sirolimus results in increased expression of BECN1 protein
Sirolimus results in increased expression of BECN1 mRNA; Sirolimus results in increased expression of BECN1 protein
[Sirolimus co-treated with cadmium acetate] results in increased expression of BECN1 mRNA; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [Epirubicin results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus promotes the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; Sirolimus promotes the reaction [T-2 Toxin results in increased expression of BECN1 mRNA]
Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in decreased expression of BECN1 protein]; Sirolimus inhibits the reaction [phenanthrene results in decreased expression of BECN1 mRNA]; Sirolimus inhibits the reaction [SIRT4 protein inhibits the reaction [Doxorubicin results in increased expression of BECN1 protein]]; Sirolimus promotes the reaction [Trichloroethylene results in increased expression of BECN1 protein]

PMID:20358864 PMID:21410490 PMID:26648565 PMID:26825372 PMID:27107786 More...

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

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bone gamma-carboxyglutamate protein

multiple interactions

Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
Sirolimus inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP mRNA]]

PMID:23111315 PMID:33450223

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

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BH3 interacting domain death agonist

multiple interactions
decreases expression
increases expression

[7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of BID protein
[Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID mRNA; [Sirolimus results in decreased activity of RPS6KB1 protein] which results in increased expression of BID protein
Sirolimus results in decreased expression of BID protein
Sirolimus results in increased expression of BID mRNA; Sirolimus results in increased expression of BID protein

PMID:15767555 PMID:18097008 PMID:19922502

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

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baculoviral IAP repeat-containing 2

multiple interactions
affects localization
increases expression

Sirolimus inhibits the reaction [Doxorubicin results in increased expression of BIRC2 protein]
Sirolimus affects the localization of BIRC2 protein
Sirolimus results in increased expression of BIRC2 protein

PMID:15571967 PMID:21357504

NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732

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baculoviral IAP repeat-containing 5

multiple interactions
decreases expression

[fulvestrant co-treated with Sirolimus] results in decreased expression of BIRC5 mRNA; Sirolimus inhibits the reaction [N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide results in increased expression of and affects the localization of BIRC5 protein]; Sirolimus promotes the reaction [Tamoxifen results in decreased expression of BIRC5 protein]
Sirolimus results in decreased expression of BIRC5 protein

PMID:19016759 PMID:19931998 PMID:21601561 PMID:24444656

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

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bone morphogenetic protein 2

multiple interactions

Sirolimus inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BMP2 mRNA]

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

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BCL2 interacting protein 3

multiple interactions

Sirolimus inhibits the reaction [IL2 protein results in increased expression of BNIP3 mRNA]

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

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betacellulin

multiple interactions

Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1A protein]; Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1B protein]; Sirolimus inhibits the reaction [BTC protein results in increased expression of CCND1 protein]

NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049

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Bruton tyrosine kinase

multiple interactions

Sirolimus inhibits the reaction [IL2 protein results in increased expression of BTK mRNA]

NCBI chr X:97,722,796...97,762,315
Ensembl chr X:97,722,802...97,761,853

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BUB1 mitotic checkpoint serine/threonine kinase

multiple interactions

[fulvestrant co-treated with Sirolimus] results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

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BUB1 mitotic checkpoint serine/threonine kinase B

multiple interactions

[fulvestrant co-treated with Sirolimus] results in decreased expression of BUB1B mRNA

NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547

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complement C1q A chain

decreases expression

Sirolimus results in decreased expression of C1QA mRNA

NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534

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complement C1q C chain

decreases expression

Sirolimus results in decreased expression of C1QC mRNA

NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017

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complement C3

decreases expression

Sirolimus results in decreased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

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caldesmon 1

multiple interactions
increases expression

[Sirolimus co-treated with IGF1 protein] results in increased expression of CALD1 protein; [Sirolimus results in increased activity of AKT2 protein] which results in increased expression of CALD1 protein
Sirolimus results in increased expression of CALD1 protein

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calcium/calmodulin-dependent protein kinase II alpha

multiple interactions

Sirolimus inhibits the reaction [Cadmium Chloride results in increased phosphorylation of CAMK2A protein]

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

calpain 1

decreases activity

Sirolimus results in decreased activity of CAPN1 protein

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

G

caspase 1

multiple interactions

Sirolimus inhibits the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]
Sirolimus inhibits the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; Sirolimus inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased cleavage of CASP1 protein]; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of CASP1 protein]; Sirolimus inhibits the reaction [Trichloroethylene results in increased expression of CASP1 mRNA]

PMID:30205151 PMID:31586597 PMID:35405287 PMID:36849104 PMID:37654027 More...

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

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caspase 12

decreases cleavage
multiple interactions

Sirolimus results in decreased cleavage of CASP12 protein
Sirolimus inhibits the reaction [cadmium acetate results in increased expression of CASP12 protein]

PMID:20511674 PMID:29870746

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

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caspase 2

multiple interactions

[Boc-D-FMK co-treated with Sirolimus] results in increased cleavage of CASP2 protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP2 protein]

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

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caspase 3

multiple interactions
increases activity
increases cleavage
increases expression
decreases activity

[7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP3 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP3 protein; [S 1 (combination) co-treated with Sirolimus] results in increased expression of CASP3 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP3 protein; Boc-D-FMK inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; Fluorouracil promotes the reaction [Sirolimus results in increased expression of CASP3 mRNA]; MCL1 protein inhibits the reaction [Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Rotenone results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Doxorubicin results in increased activity of CASP3 protein]; Sirolimus promotes the reaction [Fluorouracil results in increased expression of CASP3 mRNA]
Sirolimus results in increased activity of CASP3 protein
Sirolimus results in increased cleavage of CASP3 protein
Sirolimus results in decreased activity of CASP3 protein
Sirolimus results in increased expression of CASP3 mRNA; Sirolimus results in increased expression of CASP3 protein
[Sirolimus co-treated with Resveratrol] results in increased cleavage of CASP3 protein; Sirolimus inhibits the reaction [[Particulate Matter co-treated with Rotenone] results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [decamethrin results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form]; Sirolimus promotes the reaction [decamethrin results in increased cleavage of CASP3 protein]; Sirolimus results in decreased cleavage of and results in decreased activity of CASP3 protein
Sirolimus inhibits the reaction [[Rotenone co-treated with Particulate Matter] results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Sirolimus inhibits the reaction [gelsenicine results in increased cleavage of CASP3 protein]; Sirolimus inhibits the reaction [Particulate Matter results in increased expression of CASP3 protein]; Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]]; Sirolimus inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Cadmium results in increased cleavage of CASP3 protein]
Sirolimus results in increased expression of CASP3 protein modified form

PMID:14502240 PMID:15571967 PMID:15753396 PMID:15767555 PMID:15782132 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

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caspase 7

multiple interactions
decreases activity

[Curcumin co-treated with Sirolimus] results in increased activity of CASP7 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP7 protein
Sirolimus results in decreased activity of CASP7 protein

PMID:15753396 PMID:19373661 PMID:20031680

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

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caspase 8

multiple interactions
increases cleavage

[7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP8 protein; [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP8 protein; pyrazolanthrone inhibits the reaction [[Sirolimus co-treated with 7-hydroxystaurosporine] results in increased cleavage of CASP8 protein]; Sirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP8 protein]
Sirolimus results in increased cleavage of CASP8 protein
Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]]

PMID:15767555 PMID:17121904 PMID:18058806 PMID:25307878 PMID:28342888

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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caspase 9

multiple interactions
decreases activity

[7-hydroxystaurosporine co-treated with Sirolimus] results in increased cleavage of CASP9 protein; [Curcumin co-treated with Sirolimus] results in increased activity of CASP9 protein; [Sirolimus co-treated with Cisplatin] results in increased activity of CASP9 protein; [Sirolimus co-treated with Paclitaxel] results in increased cleavage of CASP9 protein; [tanespimycin co-treated with Sirolimus] results in increased cleavage of CASP9 protein; Sirolimus inhibits the reaction [Colistin results in increased activity of CASP9 protein]; Sirolimus promotes the reaction [Cisplatin results in increased cleavage of CASP9 protein]
Sirolimus results in decreased activity of CASP9 protein
[Swainsonine co-treated with Sirolimus] results in increased cleavage of CASP9 protein; Sirolimus inhibits the reaction [Staurosporine results in increased cleavage of CASP9 protein]
Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]]

PMID:15753396 PMID:15767555 PMID:16497721 PMID:17121904 PMID:18058806 More...

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

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catalase

increases expression

Sirolimus results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

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caveolin 3

multiple interactions

Sirolimus inhibits the reaction [TP73 protein results in increased expression of CAV3 mRNA]

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

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cellular communication network factor 2

increases expression

Sirolimus results in increased expression of CCN2 mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

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cyclin A2

multiple interactions
decreases expression

[fulvestrant co-treated with Sirolimus] results in decreased expression of CCNA2 mRNA
Sirolimus results in decreased expression of CCNA2; Sirolimus results in decreased expression of CCNA2 protein

PMID:7503980 PMID:8419408 PMID:19016759 PMID:19505958

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

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cyclin B2

multiple interactions

[fulvestrant co-treated with Sirolimus] results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

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cyclin D1

multiple interactions
increases degradation
increases expression
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; [2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine co-treated with Sirolimus] results in decreased expression of CCND1; [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CCND1 protein; [Lithium Chloride results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [SB 216763 results in decreased activity of GSK3B protein] inhibits the reaction [Sirolimus results in decreased expression of CCND1 protein]; [Sirolimus co-treated with Letrozole] results in decreased expression of CCND1 protein; [Sirolimus co-treated with tanespimycin] results in decreased expression of CCND1 protein; [Sirolimus results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased degradation of CCND1 protein; Curcumin inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]
Sirolimus results in increased degradation of CCND1 protein
Sirolimus inhibits the reaction [BTC protein results in increased expression of CCND1 protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]

PMID:7532117 PMID:15753396 PMID:15767555 PMID:17121904 PMID:19105244 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

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cyclin D2

multiple interactions
decreases expression

[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]
Sirolimus inhibits the reaction [FSHB protein results in increased expression of CCND2 mRNA]
Sirolimus results in decreased expression of CCND2 protein

PMID:15070696 PMID:15778701 PMID:17510244

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

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cyclin D3

multiple interactions
decreases stability
decreases expression

[Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; Sirolimus inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]
Sirolimus results in decreased stability of CCND3 mRNA
Sirolimus inhibits the reaction [KITL protein results in increased expression of CCND3 protein]
Sirolimus results in decreased expression of CCND3 mRNA; Sirolimus results in decreased expression of CCND3 protein

PMID:10849422 PMID:12393642 PMID:15070696 PMID:15778701 PMID:15882288

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

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cyclin E1

multiple interactions
increases expression

Curcumin inhibits the reaction [Sirolimus results in increased expression of CCNE1 protein]

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin E2

multiple interactions

[Fulvestrant co-treated with Sirolimus] results in decreased expression of CCNE2 mRNA; Sirolimus inhibits the reaction [PIK3CA protein modified form results in increased expression of CCNE2 mRNA]

PMID:19016759 PMID:27542212

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

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cyclin G2

multiple interactions
increases expression

[cotylenin A co-treated with Sirolimus] results in increased expression of CCNG2 mRNA; Sirolimus inhibits the reaction [PIK3CA protein modified form results in decreased expression of CCNG2 mRNA]; Sirolimus inhibits the reaction [TP73 protein results in increased expression of CCNG2 mRNA]
Sirolimus results in increased expression of CCNG2 mRNA

PMID:18754885 PMID:21245298 PMID:24356939 PMID:27542212

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

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cyclin I

multiple interactions

Sirolimus inhibits the reaction [IL2 protein results in decreased expression of CCNI mRNA]

NCBI chr14:14,879,698...14,902,510
Ensembl chr14:14,879,717...14,902,510

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CD36 molecule

affects expression
multiple interactions

Sirolimus affects the expression of CD36 protein
Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]

PMID:17016853 PMID:19640849

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

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CD38 molecule

multiple interactions

CD38 gene mutant form promotes the reaction [Sirolimus results in increased expression of MAP1LC3B protein]; CD38 mutant form inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]

PMID:24238063 PMID:24445604

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

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Cd68 molecule

decreases expression

Sirolimus results in decreased expression of CD68 mRNA

PMID:17016853 PMID:21865292

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

Cd80 molecule

decreases expression

Sirolimus results in decreased expression of CD80 protein

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD84 molecule

increases expression

Sirolimus results in increased expression of CD84 mRNA

NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076

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CD86 molecule

decreases expression

Sirolimus results in decreased expression of CD86 protein

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

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cell division cycle 20

multiple interactions

[fulvestrant co-treated with Sirolimus] results in decreased expression of CDC20 mRNA

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

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cadherin 1

increases expression
multiple interactions

Sirolimus results in increased expression of CDH1 protein
Sirolimus inhibits the reaction [sodium arsenite results in decreased expression of CDH1 protein]
NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 mRNA]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]; Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Sirolimus promotes the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]

PMID:28624451 PMID:28888487 PMID:30053495

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

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cadherin 2

multiple interactions

Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]; Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein]

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

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cyclin-dependent kinase 1

multiple interactions
decreases expression
decreases activity

[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 mRNA; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 protein; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of CDK1 protein; [fulvestrant co-treated with Sirolimus] results in decreased expression of CDK1 mRNA
Sirolimus results in decreased expression of CDK1
Sirolimus inhibits the reaction [IL2 protein results in increased expression of CDK1 mRNA]
Sirolimus results in decreased activity of CDK1 protein
Sirolimus results in decreased expression of CDK1 mRNA; Sirolimus results in decreased expression of CDK1 protein

PMID:7503980 PMID:7532117 PMID:8419408 PMID:11355896 PMID:15767555 More...

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

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cyclin dependent kinase 2

multiple interactions
decreases activity

[Sirolimus co-treated with TGFB1 protein] affects the localization of CDK2 protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1A protein binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL1 protein] which binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] inhibits the reaction [[E2F4 protein binds to RBL2 protein] which binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1A protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]; [TGFB1 protein co-treated with Sirolimus] results in decreased activity of CDK2 protein; [TGFB1 protein co-treated with Sirolimus] results in decreased phosphorylation of CDK2 protein
Sirolimus results in decreased activity of CDK2 protein
[Sirolimus co-treated with TGFB1 protein] affects the localization of CDK2 protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1B protein binds to CDK2 protein]; [Sirolimus co-treated with TGFB1 protein] results in decreased activity of CDK2 protein; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]

PMID:7532117 PMID:12393642 PMID:12417722 PMID:14979923 PMID:21528311

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

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cyclin-dependent kinase 4

decreases expression

Sirolimus results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases expression

[(+)-JQ1 compound co-treated with Sirolimus] results in increased expression of CDKN1A mRNA; [(+)-JQ1 compound co-treated with Sirolimus] results in increased expression of CDKN1A protein; [S 1 (combination) co-treated with Sirolimus] results in increased expression of CDKN1A protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1A protein binds to CDK2 protein]; [Sirolimus co-treated with TGFB1 protein] results in increased expression of CDKN1A protein; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1A protein]; [TGFB1 protein co-treated with Sirolimus] results in increased expression of CDKN1A protein; Fluorouracil promotes the reaction [Sirolimus results in increased expression of CDKN1A mRNA]; Sirolimus inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A mRNA]; Sirolimus promotes the reaction [(+)-JQ1 compound results in increased expression of CDKN1A protein]; Sirolimus promotes the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; Sirolimus promotes the reaction [Fluorouracil results in increased expression of CDKN1A mRNA]
Niacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]; Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1A protein]; Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]; Sirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1A protein]; Sirolimus inhibits the reaction [N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone results in increased expression of CDKN1A protein]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1A protein]]
Sirolimus results in increased expression of CDKN1A mRNA; Sirolimus results in increased expression of CDKN1A protein
Sirolimus results in decreased expression of CDKN1A protein
Sirolimus inhibits the reaction [arsenite results in increased expression of CDKN1A protein]

PMID:12417722 PMID:14979923 PMID:17700525 PMID:19105244 PMID:19764996 More...

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

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cyclin-dependent kinase inhibitor 1B

multiple interactions
decreases degradation
increases expression
decreases expression

[Cisplatin inhibits the reaction [[Sirolimus results in increased phosphorylation of AKT1 protein] which results in increased phosphorylation of FOXO3 protein]] which results in increased expression of CDKN1B protein; [Decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA; [Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]; Sirolimus promotes the reaction [Cisplatin results in increased expression of CDKN1B mRNA]
Sirolimus results in decreased degradation of CDKN1B protein
[Sirolimus co-treated with TGFB1 protein] affects the localization of CDKN1B protein; [Sirolimus co-treated with TGFB1 protein] promotes the reaction [CDKN1B protein binds to CDK2 protein]; [TGFB1 protein co-treated with Sirolimus] promotes the reaction [CDK2 protein binds to CDKN1B protein]
Niacinamide inhibits the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]; Sirolimus inhibits the reaction [BTC protein affects the localization of CDKN1B protein]; Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]; Sirolimus inhibits the reaction [IGF1 protein affects the localization of CDKN1B protein]; SIRT1 protein promotes the reaction [Sirolimus inhibits the reaction [Glucose results in increased expression of CDKN1B protein]]
Sirolimus results in increased expression of CDKN1B protein
Sirolimus results in decreased expression of CDKN1B protein

PMID:12417722 PMID:12565877 PMID:14979923 PMID:15070696 PMID:16455087 More...

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

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caudal type homeo box 2

increases expression

Sirolimus results in increased expression of CDX2 mRNA

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

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CCAAT/enhancer binding protein alpha

decreases expression

Sirolimus results in decreased expression of CEBPA mRNA

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

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CCAAT/enhancer binding protein delta

multiple interactions

Sirolimus inhibits the reaction [Endrin results in increased expression of CEBPD mRNA]

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

centromere protein X

increases expression

Sirolimus results in increased expression of CENPX mRNA

NCBI chr10:105,991,469...105,994,310

G

complement factor D

decreases expression

Sirolimus results in decreased expression of CFD mRNA

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

cholinergic receptor nicotinic beta 3 subunit

multiple interactions

Sirolimus inhibits the reaction [TP73 protein results in increased expression of CHRNB3 mRNA]

NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360

G

cell death-inducing DFFA-like effector c

multiple interactions

Sirolimus inhibits the reaction [[Ethylene Chlorohydrin co-treated with Lipopolysaccharides] results in increased expression of CIDEC mRNA]

NCBI chr 4:146,569,288...146,582,173
Ensembl chr 4:146,569,289...146,582,173

G

CDC28 protein kinase regulatory subunit 1B

decreases expression

Sirolimus results in decreased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

claudin 7

increases expression

Sirolimus results in increased expression of CLDN7 mRNA

NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171

G

C-type lectin domain family 4, member A3

decreases expression

Sirolimus results in decreased expression of CLEC4A mRNA

NCBI chr 4:156,214,030...156,224,818
Ensembl chr 4:156,214,718...156,224,817

G

clustered mitochondria homolog

increases expression

Sirolimus results in increased expression of CLUH protein

NCBI chr10:59,509,580...59,531,345
Ensembl chr10:59,509,726...59,531,345

G

collagen type I alpha 1 chain

decreases expression
multiple interactions

Sirolimus results in decreased expression of COL1A1 mRNA
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]

PMID:21865292 PMID:35405287

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

Sirolimus inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]
Sirolimus inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A2 mRNA]

PMID:10535884 PMID:11343241

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type II alpha 1 chain

decreases expression

Sirolimus results in decreased expression of COL2A1 protein

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

ceruloplasmin

increases expression

Sirolimus results in increased expression of CP mRNA

NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075

G

carnitine palmitoyltransferase 1B

multiple interactions

Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT1B mRNA]]

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

carnitine palmitoyltransferase 2

multiple interactions

Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]; TNF protein inhibits the reaction [Sirolimus inhibits the reaction [Isoproterenol results in decreased expression of CPT2 mRNA]]

NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095

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cAMP responsive element binding protein 1

multiple interactions

[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of CREB1 protein]]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

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CREB3 regulatory factor

multiple interactions

[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of CREBRF mRNA

NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999

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CREB regulated transcription coactivator 2

decreases activity

Sirolimus results in decreased activity of CRTC2 protein

NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763

G

citrate synthase

multiple interactions

Sirolimus affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein]

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

chromosome segregation 1 like

decreases expression

Sirolimus results in decreased expression of CSE1L mRNA

NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865

G

colony stimulating factor 1

multiple interactions

Sirolimus inhibits the reaction [CSF1 protein results in increased phosphorylation of EIF4EBP1 protein]; Sirolimus inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 2

multiple interactions

Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CSF2 protein]]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

catenin beta 1

multiple interactions

Sirolimus promotes the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

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cathepsin K

multiple interactions
decreases expression

PDCD4 mutant form inhibits the reaction [Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased activity of CTSK protein]; Sirolimus inhibits the reaction [Pasteurella multocida toxin results in increased expression of CTSK mRNA]
Sirolimus results in decreased expression of CTSK mRNA

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

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C-X-C motif chemokine ligand 10

decreases expression

Sirolimus results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

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C-X-C motif chemokine ligand 13

decreases expression

Sirolimus results in decreased expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

cytochrome b-245 alpha chain

multiple interactions

Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBA protein]

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome b-245 beta chain

multiple interactions

Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of CYBB protein]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586