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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:quercetagetin
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Accession:CHEBI:8695 term browser browse the term
Definition:A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.
Synonyms:exact_synonym: 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-chromen-4-one
 related_synonym: 2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4-benzopyrone;   2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-1-benzopyran-4-one;   3,3',4',5,6,7-hexahydroxyflavone;   6-Hydroxyquercetin;   Formula=C15H10O8;   InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H;   InChIKey=ZVOLCUVKHLEPEV-UHFFFAOYSA-N;   SMILES=OC1=CC=C(C=C1O)C1=C(O)C(=O)C2=C(O1)C=C(O)C(O)=C2O
 xref: CAS:90-18-6;   FooDB:FDB011897;   KEGG:C10122;   KNApSAcK:C00004677;   LIPID_MAPS_instance:LMPK12112983
 xref_mesh: MESH:C079163
 xref: PDBeChem:MYU;   PMID:20685402;   PMID:22223143;   PMID:23000494;   PMID:23142567;   Patent:KR20120035741;   Reaxys:332041;   Wikipedia:Quercetagetin


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quercetagetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein] CTD PMID:20685402 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Ar androgen receptor multiple interactions EXP quercetagetin inhibits the reaction [decamethrin results in increased phosphorylation of AR protein] CTD PMID:25299849 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP quercetagetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B] CTD PMID:20685402 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] CTD PMID:20685402 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] CTD PMID:20685402 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Pla2g2a phospholipase A2 group IIA affects activity ISO quercetagetin affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:156,359,725...156,362,297 		JBrowse link
casticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO casticin results in increased expression of ABCC5 mRNA CTD PMID:28444820 NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655 		JBrowse link
G Acan aggrecan multiple interactions EXP casticin inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]; casticin inhibits the reaction [IL1B protein results in decreased expression of ACAN protein] CTD PMID:38309612 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression ISO casticin results in increased expression of ADAM10 mRNA CTD PMID:28444820 NCBI chr 8:80,226,862...80,358,728
Ensembl chr 8:80,226,674...80,361,600 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 multiple interactions EXP casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS4 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS4 protein] CTD PMID:38309612 NCBI chr13:86,203,011...86,212,500
Ensembl chr13:86,202,642...86,212,514 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 multiple interactions EXP casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein] CTD PMID:38309612 NCBI chr11:38,486,945...38,533,516
Ensembl chr11:38,486,955...38,533,516 		JBrowse link
G Aftph aftiphilin decreases expression ISO casticin results in decreased expression of AFTPH mRNA CTD PMID:28444820 NCBI chr14:99,072,761...99,127,006
Ensembl chr14:99,072,761...99,126,727 		JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 decreases expression ISO casticin results in decreased expression of AGAP1 mRNA CTD PMID:28444820 NCBI chr 9:97,487,382...97,922,870
Ensembl chr 9:97,487,406...97,922,870 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression
multiple interactions 		ISO casticin results in increased expression of AIFM1 protein
[Fluorouracil co-treated with casticin] results in increased expression of AIFM1 protein 		CTD PMID:29098808 PMID:32270916 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:132,528,107...132,567,237 		JBrowse link
G Akirin2 akirin 2 decreases expression ISO casticin results in decreased expression of AKIRIN2 mRNA CTD PMID:28444820 NCBI chr 5:53,897,792...53,918,873
Ensembl chr 5:53,904,285...53,918,934 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
multiple interactions 		ISO
EXP 		casticin results in decreased expression of AKT1 protein
casticin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein] 		CTD PMID:28444820 PMID:38309612 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases expression ISO casticin results in decreased expression of AKT3 mRNA CTD PMID:27862857 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO casticin results in increased expression of ALDH1A1 mRNA CTD PMID:27862857 NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500 		JBrowse link
G Alx1 ALX homeobox 1 decreases expression ISO casticin results in decreased expression of ALX1 mRNA CTD PMID:28444820 NCBI chr 7:40,044,185...40,063,778
Ensembl chr 7:40,033,676...40,063,778 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO casticin results in increased expression of APAF1 protein CTD PMID:27862857 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Arl6ip4 ARF like GTPase 6 interacting protein 4 decreases expression ISO casticin results in decreased expression of ARL6IP4 mRNA CTD PMID:28444820 NCBI chr12:38,140,566...38,142,711
Ensembl chr12:38,140,550...38,142,724 		JBrowse link
G Armc9 armadillo repeat containing 9 decreases expression ISO casticin results in decreased expression of ARMC9 mRNA CTD PMID:28444820 NCBI chr 9:94,250,492...94,376,589
Ensembl chr 9:94,250,859...94,376,589 		JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like decreases expression ISO casticin results in decreased expression of ARPC5L mRNA CTD PMID:28444820 NCBI chr 3:43,169,518...43,177,224
Ensembl chr 3:43,169,462...43,177,240
Ensembl chr 9:43,169,462...43,177,240 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO casticin results in decreased expression of ASNS mRNA CTD PMID:28444820 NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO casticin results in decreased expression of ATF5 mRNA CTD PMID:28444820 NCBI chr 1:104,432,094...104,437,611
Ensembl chr 1:104,432,094...104,436,183 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO casticin results in increased expression of ATF6 protein CTD PMID:27862857 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033 		JBrowse link
G Atm ATM serine/threonine kinase decreases expression ISO casticin results in decreased expression of ATM protein CTD PMID:29098808 NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629 		JBrowse link
G Atox1 antioxidant 1 copper chaperone increases expression ISO casticin results in increased expression of ATOX1 mRNA CTD PMID:28444820 NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585 		JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 decreases expression ISO casticin results in decreased expression of ATP6V1G1 mRNA CTD PMID:28444820 NCBI chr 5:81,976,959...81,983,139
Ensembl chr 5:81,977,015...81,985,930 		JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 increases expression ISO casticin results in increased expression of ATP8A1 mRNA CTD PMID:28444820 NCBI chr14:40,668,932...40,911,465
Ensembl chr14:40,731,846...40,911,463 		JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO casticin results in decreased expression of ATR protein CTD PMID:29098808 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718 		JBrowse link
G Atxn7l3b ataxin 7-like 3B decreases expression ISO casticin results in decreased expression of ATXN7L3B mRNA CTD PMID:28444820 NCBI chr 7:48,322,451...48,325,975
Ensembl chr 7:50,208,676...50,212,190 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO casticin results in decreased expression of AVPR1A mRNA CTD PMID:28444820 NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:59,999,738...60,003,837 		JBrowse link
G Axin2 axin 2 increases expression ISO casticin results in increased expression of AXIN2 mRNA CTD PMID:27862857 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO casticin results in increased expression of BAK1 protein CTD PMID:27862857 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO casticin results in increased expression of BAMBI mRNA CTD PMID:27862857 NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247 		JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO casticin results in decreased expression of BASP1 mRNA CTD PMID:28444820 NCBI chr 2:77,546,628...77,594,297
Ensembl chr 2:77,546,092...77,597,178 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions 		ISO
EXP 		casticin results in increased expression of BAX protein
casticin inhibits the reaction [IL1B protein results in increased expression of BAX protein]
casticin inhibits the reaction [Fluorouracil results in increased expression of BAX protein] 		CTD PMID:27862857 PMID:29098808 PMID:32270916 PMID:38309612 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl11a BCL11 transcription factor A decreases expression ISO casticin results in decreased expression of BCL11A mRNA CTD PMID:28444820 NCBI chr14:102,230,147...102,325,289
Ensembl chr14:102,231,113...102,325,623 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions 		ISO
EXP 		casticin results in decreased expression of BCL2 protein
casticin inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]
[Fluorouracil co-treated with casticin] results in decreased expression of BCL2 protein 		CTD PMID:27862857 PMID:29098808 PMID:32270916 PMID:38309612 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions
increases expression 		ISO casticin results in decreased expression of BCL2L1 protein
casticin promotes the reaction [Fluorouracil results in decreased expression of BCL2L1 protein]; Fluorouracil promotes the reaction [casticin results in decreased expression of BCL2L1 protein]
casticin results in increased expression of BCL2L1 mRNA 		CTD PMID:27862857 PMID:29098808 PMID:32270916 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression
multiple interactions
decreases expression 		ISO casticin results in increased expression of BID protein
casticin inhibits the reaction [Fluorouracil results in increased expression of BID protein]
casticin results in decreased expression of BID protein 		CTD PMID:27862857 PMID:29098808 PMID:32270916 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 decreases expression ISO casticin results in decreased expression of BMAL1 mRNA CTD PMID:28444820 NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:176,829,305...176,864,739 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger multiple interactions
decreases expression 		ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA] CTD PMID:32268151 NCBI chr17:86,240,683...86,250,044
Ensembl chr17:86,243,491...86,250,024 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO casticin results in increased expression of BMP4 mRNA CTD PMID:27862857 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172 		JBrowse link
G Bnip2 BCL2 interacting protein 2 decreases expression ISO casticin results in decreased expression of BNIP2 mRNA CTD PMID:27862857 NCBI chr 8:79,521,375...79,539,148
Ensembl chr 8:79,521,363...79,547,368 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO casticin results in increased expression of BRCA1 protein CTD PMID:29098808 NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763 		JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO casticin results in decreased expression of BTF3 mRNA CTD PMID:28444820 NCBI chr 2:31,394,010...31,401,138
Ensembl chr 2:31,394,011...31,401,125
Ensembl chr13:31,394,011...31,401,125 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO casticin results in decreased expression of BTG1 mRNA CTD PMID:28444820 NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:33,227,833...33,230,406 		JBrowse link
G Cadm1 cell adhesion molecule 1 increases expression ISO casticin results in increased expression of CADM1 mRNA CTD PMID:28444820 NCBI chr 8:56,744,374...57,075,264
Ensembl chr 8:56,744,372...57,080,192 		JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 decreases expression ISO casticin results in decreased expression of CALCOCO1 mRNA CTD PMID:28444820 NCBI chr 7:135,713,208...135,728,044
Ensembl chr 7:135,713,208...135,727,928 		JBrowse link
G Calm1 calmodulin 1 decreases expression ISO casticin results in decreased expression of CALM1 mRNA CTD PMID:28444820 NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:125,217,246...125,225,381 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO casticin results in decreased expression of CAMK4 mRNA CTD PMID:27862857 NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,857,146...25,077,193 		JBrowse link
G Capn1 calpain 1 multiple interactions ISO casticin results in increased expression of and results in increased cleavage of CAPN1 protein CTD PMID:27862857 NCBI chr 1:212,705,219...212,736,134
Ensembl chr 1:212,705,222...212,729,445 		JBrowse link
G Capn2 calpain 2 increases expression ISO casticin results in increased expression of CAPN2 protein CTD PMID:27862857 NCBI chr13:96,681,902...96,732,625
Ensembl chr13:96,681,848...96,732,625 		JBrowse link
G Casp2 caspase 2 increases expression ISO casticin results in increased expression of CASP2 protein CTD PMID:27862857 NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity 		ISO
EXP 		casticin results in increased cleavage of and results in increased activity of CASP3 protein
casticin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]
casticin inhibits the reaction [Fluorouracil results in increased activity of CASP3 protein]
casticin results in increased activity of CASP3 protein 		CTD PMID:27862857 PMID:29098808 PMID:32270916 PMID:38309612 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp4 caspase 4 increases expression ISO casticin results in increased expression of CASP4 protein CTD PMID:27862857 NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:10,883,769...10,920,727 		JBrowse link
G Casp6 caspase 6 increases expression ISO casticin results in increased expression of CASP6 protein CTD PMID:27862857 NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:221,140,256...221,152,726 		JBrowse link
G Casp7 caspase 7 increases expression ISO casticin results in increased expression of CASP7 protein CTD PMID:27862857 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO
EXP 		casticin results in increased cleavage of and results in increased activity of CASP8 protein; casticin results in increased expression of and results in increased activity of CASP8 protein
casticin inhibits the reaction [IL1B protein results in increased cleavage of CASP8 protein] 		CTD PMID:27862857 PMID:29098808 PMID:38309612 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity 		ISO casticin results in increased cleavage of and results in increased activity of CASP9 protein
casticin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]
casticin results in increased activity of CASP9 protein 		CTD PMID:27862857 PMID:29098808 PMID:32270916 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase increases expression
multiple interactions 		ISO casticin results in increased expression of CAT protein
Fluorouracil inhibits the reaction [casticin results in increased expression of CAT protein] 		CTD PMID:32270916 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccdc122 coiled-coil domain containing 122 increases expression ISO casticin results in increased expression of CCDC122 mRNA CTD PMID:28444820 NCBI chr15:52,407,717...52,470,163
Ensembl chr15:58,816,873...58,879,592 		JBrowse link
G Ccdc174 coiled-coil domain containing 174 decreases expression ISO casticin results in decreased expression of CCDC174 mRNA CTD PMID:28444820 NCBI chr 4:125,949,203...125,976,179
Ensembl chr 4:125,949,420...125,976,178 		JBrowse link
G Ccdc90b coiled-coil domain containing 90B decreases expression ISO casticin results in decreased expression of CCDC90B mRNA CTD PMID:28444820 NCBI chr 1:156,045,192...156,058,750
Ensembl chr 1:156,045,138...156,061,403 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO casticin results in increased expression of CCN1 mRNA CTD PMID:28444820 NCBI chr 2:237,222,730...237,225,689
Ensembl chr 2:237,222,432...237,225,883 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO casticin results in decreased expression of CCNB1 protein CTD PMID:29098808 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 decreases expression ISO casticin results in decreased expression of CCT4 mRNA CTD PMID:28444820 NCBI chr14:101,193,057...101,205,935
Ensembl chr14:101,192,772...101,205,770 		JBrowse link
G Cd24 CD24 molecule increases expression ISO casticin results in increased expression of CD24 mRNA CTD PMID:27862857 NCBI chr20:48,655,549...48,661,786
Ensembl chr20:48,655,805...48,661,785 		JBrowse link
G Cd44 CD44 molecule decreases expression
multiple interactions 		ISO casticin results in decreased expression of CD44 mRNA; casticin results in decreased expression of CD44 protein
casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein] 		CTD PMID:32268151 NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:109,612,054...109,699,424 		JBrowse link
G Cd83 CD83 molecule decreases expression ISO casticin results in decreased expression of CD83 mRNA CTD PMID:27862857 NCBI chr17:21,093,281...21,113,223
Ensembl chr17:21,093,281...21,113,047 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO casticin results in decreased expression of CDC25C protein CTD PMID:29098808 NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO casticin results in decreased expression of CDC42 mRNA CTD PMID:28444820 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:154,839,631...154,876,627 		JBrowse link
G Cdh17 cadherin 17 increases expression ISO casticin results in increased expression of CDH17 mRNA CTD PMID:27862857 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:30,060,090...30,112,226 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO casticin results in increased expression of CDK2 protein CTD PMID:29098808 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO casticin results in decreased expression of CDKN1A mRNA; casticin results in decreased expression of CDKN1A protein CTD PMID:27862857 PMID:29098808 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO casticin results in increased expression of CDKN1B mRNA CTD PMID:27862857 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO casticin results in increased expression of CDKN2A protein CTD PMID:29098808 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO casticin results in increased expression of CHEK2 protein CTD PMID:29098808 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G Chic2 cysteine-rich hydrophobic domain 2 decreases expression ISO casticin results in decreased expression of CHIC2 mRNA CTD PMID:28444820 NCBI chr14:33,511,839...33,546,181
Ensembl chr14:33,511,535...33,548,558 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO casticin results in decreased expression of CLDN1 mRNA CTD PMID:27862857 NCBI chr11:87,926,376...87,941,533
Ensembl chr11:87,926,337...87,941,529 		JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein decreases expression ISO casticin results in decreased expression of CNBP mRNA CTD PMID:28444820 NCBI chr 4:121,860,102...121,868,976
Ensembl chr 4:121,860,105...121,869,010 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO casticin results in decreased expression of COL1A1 mRNA CTD PMID:27862857 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP casticin inhibits the reaction [IL1B protein results in decreased expression of COL2A1 mRNA]; casticin inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein] CTD PMID:38309612 NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627 		JBrowse link
G Cpe carboxypeptidase E increases expression ISO casticin results in increased expression of CPE mRNA CTD PMID:28444820 NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO casticin results in increased expression of CREB1 mRNA CTD PMID:27862857 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression ISO casticin results in decreased expression of CRHBP mRNA CTD PMID:28444820 NCBI chr 2:28,427,139...28,439,446
Ensembl chr 2:28,427,139...28,439,446 		JBrowse link
G Crls1 cardiolipin synthase 1 decreases expression ISO casticin results in decreased expression of CRLS1 mRNA CTD PMID:28444820 NCBI chr 3:140,572,680...140,591,543
Ensembl chr 3:140,572,716...140,591,599 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO casticin results in increased expression of CRYAB mRNA CTD PMID:28444820 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases expression ISO casticin results in decreased expression of CSNK1A1 mRNA CTD PMID:28444820 NCBI chr18:57,285,156...57,320,540
Ensembl chr18:57,287,412...57,320,538 		JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 decreases expression ISO casticin results in decreased expression of CYB5R1 mRNA CTD PMID:28444820 NCBI chr13:48,401,061...48,407,466
Ensembl chr13:48,399,106...48,407,465 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO casticin results in increased expression of CYCS protein CTD PMID:27862857 PMID:29098808 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression ISO casticin results in decreased expression of DDIT3 mRNA CTD PMID:28444820 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Ddx27 DEAD-box helicase 27 decreases expression ISO casticin results in decreased expression of DDX27 mRNA CTD PMID:28444820 NCBI chr 3:176,163,220...176,182,418
Ensembl chr 3:176,163,203...176,182,410 		JBrowse link
G Dip2c disco-interacting protein 2 homolog C decreases expression ISO casticin results in decreased expression of DIP2C mRNA CTD PMID:28444820 NCBI chr17:65,338,711...65,724,111
Ensembl chr17:65,338,711...65,723,344 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO casticin results in decreased expression of DKK3 mRNA CTD PMID:27862857 NCBI chr 1:175,672,834...175,715,867
Ensembl chr 1:175,672,834...175,715,186 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases activity
decreases expression 		ISO casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin results in decreased expression of and results in decreased activity of DNMT1 protein; DNMT1 protein inhibits the reaction [casticin results in decreased activity of DNMT1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein] CTD PMID:32268151 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO casticin results in decreased expression of DUSP6 mRNA CTD PMID:28444820 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression ISO casticin results in decreased expression of DYRK1A mRNA CTD PMID:28444820 NCBI chr11:47,360,824...47,479,033
Ensembl chr11:47,360,850...47,479,033 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO casticin results in decreased expression of EGFR protein CTD PMID:28444820 NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta decreases expression ISO casticin results in decreased expression of EIF2S2 mRNA CTD PMID:28444820 NCBI chr 3:163,834,846...163,855,733
Ensembl chr 3:163,834,851...163,855,570 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO casticin results in decreased expression of EIF5 mRNA CTD PMID:28444820 NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:136,407,440...136,418,821 		JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO casticin results in increased expression of ENC1 mRNA CTD PMID:27862857 NCBI chr 2:30,285,274...30,297,194
Ensembl chr 2:30,283,736...30,315,721 		JBrowse link
G Endog endonuclease G decreases expression
increases expression
multiple interactions 		ISO casticin results in decreased expression of ENDOG protein
casticin results in increased expression of ENDOG protein
casticin inhibits the reaction [Fluorouracil results in increased expression of ENDOG protein] 		CTD PMID:29098808 PMID:32270916 NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573 		JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO casticin results in decreased expression of EP300 mRNA CTD PMID:27862857 NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:114,946,982...115,058,574 		JBrowse link
G Epb41l4b erythrocyte membrane protein band 4.1 like 4B decreases expression ISO casticin results in decreased expression of EPB41L4B mRNA CTD PMID:28444820 NCBI chr 5:76,486,886...76,647,752
Ensembl chr 5:76,486,902...76,647,752 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
decreases expression 		ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA] CTD PMID:32268151 NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:12,631,611...12,649,702 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases expression ISO casticin results in increased expression of ERBB3 mRNA CTD PMID:27862857 NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:1,579,816...1,601,120 		JBrowse link
G Esf1 ESF1 nucleolar pre-rRNA processing protein homolog decreases expression ISO casticin results in decreased expression of ESF1 mRNA CTD PMID:28444820 NCBI chr 3:147,908,405...147,961,567
Ensembl chr 3:147,908,405...147,961,485 		JBrowse link
G Exosc3 exosome component 3 decreases expression ISO casticin results in decreased expression of EXOSC3 mRNA CTD PMID:28444820 NCBI chr 5:64,369,495...64,374,711
Ensembl chr 5:64,369,495...64,374,902 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 increases expression ISO casticin results in increased expression of EXT1 mRNA CTD PMID:28444820 NCBI chr 7:86,265,651...86,544,488
Ensembl chr 7:86,259,900...86,544,567 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO casticin results in increased expression of FADD protein CTD PMID:27862857 PMID:29098808 NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976 		JBrowse link
G Fam227a family with sequence similarity 227, member A increases expression ISO casticin results in increased expression of FAM227A mRNA CTD PMID:28444820 NCBI chr 7:113,054,751...113,096,898
Ensembl chr 7:113,054,751...113,096,868 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO casticin results in increased expression of FAS protein CTD PMID:27862857 PMID:29098808 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Faslg Fas ligand increases expression
decreases expression 		ISO casticin results in increased expression of FASLG protein
casticin results in decreased expression of FASLG protein 		CTD PMID:27862857 PMID:29098808 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503 		JBrowse link
G Fbxo11 F-box protein 11 decreases expression ISO casticin results in decreased expression of FBXO11 mRNA CTD PMID:28444820 NCBI chr 6:12,240,348...12,316,223
Ensembl chr 6:12,239,801...12,316,221 		JBrowse link
G Fbxo44 F-box protein 44 decreases expression ISO casticin results in decreased expression of FBXO44 mRNA CTD PMID:28444820 NCBI chr 5:163,866,517...163,875,928
Ensembl chr 5:163,866,517...163,875,614 		JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 decreases expression ISO casticin results in decreased expression of FEZ1 mRNA CTD PMID:28444820 NCBI chr 8:44,733,288...44,778,519
Ensembl chr 8:44,733,300...44,784,097 		JBrowse link
G Foxo3 forkhead box O3 decreases expression ISO casticin results in decreased expression of FOXO3 mRNA CTD PMID:27862857 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845 		JBrowse link
G Foxp2 forkhead box P2 decreases expression ISO casticin results in decreased expression of FOXP2 mRNA CTD PMID:28444820 NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:44,099,959...44,677,696 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression ISO casticin results in decreased expression of GADD45A mRNA CTD PMID:28444820 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO casticin results in decreased expression of GLUD1 mRNA CTD PMID:28444820 NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,646,509...9,680,210 		JBrowse link
G Gphn gephyrin decreases expression ISO casticin results in decreased expression of GPHN mRNA CTD PMID:28444820 NCBI chr 6:102,687,405...103,216,679
Ensembl chr 6:102,687,423...103,216,674 		JBrowse link
G Gpr85 G protein-coupled receptor 85 decreases expression ISO casticin results in decreased expression of GPR85 mRNA CTD PMID:28444820 NCBI chr 4:43,070,194...43,075,662
Ensembl chr 4:43,060,777...43,075,794 		JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO casticin results in decreased expression of GRB2 protein CTD PMID:28444820 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:101,380,356...101,448,138 		JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 decreases expression ISO casticin results in decreased expression of GRID2 mRNA CTD PMID:27862857 NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:93,745,277...95,219,868 		JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 decreases expression ISO casticin results in decreased expression of GTF2H2 mRNA CTD PMID:28444820 NCBI chr 2:33,358,863...33,386,726
Ensembl chr 2:33,358,869...33,386,688 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases expression ISO casticin results in decreased expression of HCN2 mRNA CTD PMID:27862857 NCBI chr 7:10,620,422...10,639,457
Ensembl chr 7:10,620,422...10,639,457 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP casticin inhibits the reaction [IL1B protein results in increased expression of HIF1A protein] CTD PMID:38309612 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hoxb8 homeo box B8 decreases expression ISO casticin results in decreased expression of HOXB8 mRNA CTD PMID:28444820 NCBI chr10:81,745,430...81,747,181
Ensembl chr10:81,739,704...81,747,802 		JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO casticin results in decreased expression of HOXB9 mRNA CTD PMID:27862857 NCBI chr10:81,733,857...81,737,363
Ensembl chr10:81,733,658...81,738,872 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO casticin results in decreased expression of HSPA4 mRNA CTD PMID:28444820 NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,908,866...37,949,835 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO casticin results in increased expression of HSPA5 protein CTD PMID:27862857 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO casticin results in increased expression of HSPA8 mRNA CTD PMID:28444820 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO casticin results in decreased expression of HSPA9 mRNA CTD PMID:28444820 NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,804,774...26,828,398 		JBrowse link
G Il12a interleukin 12A decreases expression ISO casticin results in decreased expression of IL12A mRNA CTD PMID:27862857 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP casticin inhibits the reaction [IL1B protein results in decreased expression of ACAN mRNA]; casticin inhibits the reaction [IL1B protein results in decreased expression of ACAN protein]; casticin inhibits the reaction [IL1B protein results in decreased expression of BCL2 protein]; casticin inhibits the reaction [IL1B protein results in decreased expression of COL2A1 mRNA]; casticin inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]; casticin inhibits the reaction [IL1B protein results in increased cleavage of CASP3 protein]; casticin inhibits the reaction [IL1B protein results in increased cleavage of CASP8 protein]; casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS4 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS4 protein]; casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]; casticin inhibits the reaction [IL1B protein results in increased expression of BAX protein]; casticin inhibits the reaction [IL1B protein results in increased expression of HIF1A protein]; casticin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; casticin inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein]; casticin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; casticin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]; casticin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; casticin inhibits the reaction [IL1B protein results in increased secretion of IL1B protein]; casticin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; casticin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:38309612 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions 		ISO
EXP 		casticin results in decreased expression of IL6 mRNA
casticin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] 		CTD PMID:27862857 PMID:38309612 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Ints6 integrator complex subunit 6 decreases expression ISO casticin results in decreased expression of INTS6 mRNA CTD PMID:28444820 NCBI chr15:41,080,584...41,224,350
Ensembl chr15:41,109,125...41,197,519 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression ISO casticin results in increased expression of IRAK4 mRNA CTD PMID:27862857 NCBI chr 7:127,561,777...127,588,762
Ensembl chr 7:127,561,717...127,597,109 		JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 decreases expression ISO casticin results in decreased expression of IRF2BP2 mRNA CTD PMID:28444820 NCBI chr19:71,456,689...71,462,368
Ensembl chr19:71,456,689...71,462,368 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO casticin results in decreased expression of KCNH2 mRNA CTD PMID:28444820 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Kctd9 potassium channel tetramerization domain containing 9 decreases expression ISO casticin results in decreased expression of KCTD9 mRNA CTD PMID:28444820 NCBI chr15:46,117,211...46,145,258
Ensembl chr15:46,117,874...46,145,266 		JBrowse link
G Kirrel3 kirre like nephrin family adhesion molecule 3 decreases expression ISO casticin results in decreased expression of KIRREL3 mRNA CTD PMID:28444820 NCBI chr 8:41,123,692...41,663,528
Ensembl chr 8:41,123,878...41,664,147 		JBrowse link
G Klf9 KLF transcription factor 9 decreases expression ISO casticin results in decreased expression of KLF9 mRNA CTD PMID:28444820 NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:230,126,646...230,151,641 		JBrowse link
G Krt16 keratin 16 increases expression ISO casticin results in increased expression of KRT16 mRNA CTD PMID:28444820 NCBI chr10:85,669,276...85,672,211
Ensembl chr10:85,669,276...85,672,211 		JBrowse link
G Ldhb lactate dehydrogenase B decreases expression ISO casticin results in decreased expression of LDHB mRNA CTD PMID:27862857 NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO casticin results in decreased expression of LEF1 mRNA CTD PMID:27862857 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Lhfpl6 LHFPL tetraspan subfamily member 6 increases expression ISO casticin results in increased expression of LHFPL6 mRNA CTD PMID:28444820 NCBI chr 2:139,276,810...139,474,740
Ensembl chr 2:139,276,789...139,474,737 		JBrowse link
G Limch1 LIM and calponin homology domains 1 increases expression ISO casticin results in increased expression of LIMCH1 mRNA CTD PMID:28444820 NCBI chr14:41,466,433...41,779,477
Ensembl chr14:41,466,433...41,778,837 		JBrowse link
G Lpl lipoprotein lipase decreases expression ISO casticin results in decreased expression of LPL mRNA CTD PMID:27862857 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107 		JBrowse link
G Lrp5 LDL receptor related protein 5 increases expression ISO casticin results in increased expression of LRP5 mRNA CTD PMID:27862857 NCBI chr 1:210,243,499...210,346,886
Ensembl chr 1:210,243,502...210,346,822 		JBrowse link
G Ltv1 LTV1 ribosome biogenesis factor decreases expression ISO casticin results in decreased expression of LTV1 mRNA CTD PMID:28444820 NCBI chr 1:9,385,834...9,398,557
Ensembl chr 1:9,385,830...9,398,677 		JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO casticin results in decreased expression of MAF mRNA CTD PMID:28444820 NCBI chr19:60,259,200...60,622,145
Ensembl chr19:60,269,541...60,621,378 		JBrowse link
G Magoh mago homolog, exon junction complex subunit decreases expression ISO casticin results in decreased expression of MAGOH mRNA CTD PMID:28444820 NCBI chr 5:127,868,044...127,875,423
Ensembl chr 5:127,868,055...127,875,384 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases expression ISO casticin results in increased expression of MAP3K7 mRNA CTD PMID:27862857 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:51,154,352...51,212,012 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 increases expression ISO casticin results in increased expression of MAPRE2 mRNA CTD PMID:28444820 NCBI chr18:15,303,502...15,444,306
Ensembl chr18:15,303,533...15,442,796 		JBrowse link
G Mark3 microtubule affinity regulating kinase 3 decreases expression ISO casticin results in decreased expression of MARK3 mRNA CTD PMID:28444820 NCBI chr 6:136,447,327...136,537,409
Ensembl chr 6:136,448,531...136,537,404 		JBrowse link
G Max MYC associated factor X decreases expression ISO casticin results in decreased expression of MAX mRNA CTD PMID:28444820 NCBI chr 6:101,369,989...101,395,333
Ensembl chr 6:101,369,988...101,395,549 		JBrowse link
G Mbp myelin basic protein increases expression ISO casticin results in increased expression of MBP mRNA CTD PMID:28444820 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO casticin results in decreased expression of MCL1 protein CTD PMID:27862857 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 increases expression ISO casticin results in increased expression of MDC1 protein CTD PMID:29098808 NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,900,308...2,914,960 		JBrowse link
G Mecom MDS1 and EVI1 complex locus decreases expression ISO casticin results in decreased expression of MECOM mRNA CTD PMID:28444820 NCBI chr 2:114,837,815...115,393,052
Ensembl chr 2:114,837,840...115,393,038 		JBrowse link
G Mest mesoderm specific transcript increases expression ISO casticin results in increased expression of MEST mRNA CTD PMID:28444820 NCBI chr 4:60,321,814...60,332,288
Ensembl chr 4:60,316,102...60,333,509 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit decreases expression ISO casticin results in decreased expression of METTL3 mRNA CTD PMID:28444820 NCBI chr15:27,476,659...27,491,134
Ensembl chr15:27,476,660...27,487,487 		JBrowse link
G Mir148a microRNA 148a increases expression
multiple interactions 		ISO casticin results in increased expression of MIR148A mRNA
casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin affects the reaction [MIR148A mRNA results in increased expression of MIR148A mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA affects the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA] 		CTD PMID:32268151 NCBI chr 4:81,664,431...81,664,527 JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP casticin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein] CTD PMID:38309612 NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:12,782,813...12,793,105 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO casticin results in decreased expression of MMP2 mRNA
casticin results in decreased expression of MMP2 protein 		CTD PMID:27862857 PMID:28444820 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions 		ISO
EXP 		casticin results in decreased expression of MMP9 protein
casticin inhibits the reaction [IL1B protein results in increased expression of MMP9 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of MMP9 protein] 		CTD PMID:28444820 PMID:38309612 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mplkip M-phase specific PLK1 interacting protein decreases expression ISO casticin results in decreased expression of MPLKIP mRNA CTD PMID:28444820 NCBI chr17:52,069,154...52,071,978
Ensembl chr17:52,069,154...52,071,720 		JBrowse link
G Mrpl9 mitochondrial ribosomal protein L9 increases expression ISO casticin results in increased expression of MRPL9 mRNA CTD PMID:28444820 NCBI chr 2:184,768,837...184,775,787
Ensembl chr 2:184,763,529...184,775,777 		JBrowse link
G Muc13 mucin 13, cell surface associated increases expression ISO casticin results in increased expression of MUC13 mRNA CTD PMID:27862857 NCBI chr11:80,462,350...80,489,773
Ensembl chr11:80,465,737...80,485,474 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO casticin results in increased expression of MYD88 mRNA CTD PMID:27862857 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230 		JBrowse link
G Myo7a myosin VIIA increases expression ISO casticin results in increased expression of MYO7A mRNA CTD PMID:28444820 NCBI chr 1:161,755,110...161,825,397
Ensembl chr 1:161,755,110...161,825,365 		JBrowse link
G Nanog Nanog homeobox multiple interactions
decreases expression 		ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA] CTD PMID:32268151 NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061 		JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO casticin results in decreased expression of NARS1 mRNA CTD PMID:28444820 NCBI chr18:60,259,506...60,275,782
Ensembl chr18:60,259,516...60,275,782 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression ISO casticin results in decreased expression of NDUFS4 mRNA CTD PMID:28444820 NCBI chr 2:47,684,420...47,794,914
Ensembl chr 2:47,684,406...47,794,931 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO casticin results in decreased expression of NFKB1 mRNA CTD PMID:27862857 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 decreases expression ISO casticin results in decreased expression of NFKB2 mRNA CTD PMID:27862857 NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:255,107,374...255,114,637 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO casticin results in decreased expression of NFKBIA mRNA CTD PMID:27862857 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression ISO casticin results in decreased expression of NFKBIB mRNA CTD PMID:27862857 NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:93,173,820...93,326,366 		JBrowse link
G Nfkbid NFKB inhibitor delta decreases expression ISO casticin results in decreased expression of NFKBID mRNA CTD PMID:27862857 NCBI chr 1:94,808,459...94,824,726
Ensembl chr 1:94,808,453...94,817,861 		JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO casticin results in decreased expression of NFKBIE mRNA CTD PMID:27862857 NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:22,941,040...22,947,872 		JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 increases expression ISO casticin results in increased expression of NFX1 mRNA CTD PMID:28444820 NCBI chr 5:60,900,140...60,958,889
Ensembl chr 5:60,901,217...60,958,889 		JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 increases expression ISO casticin results in increased expression of NKD1 mRNA CTD PMID:27862857 NCBI chr19:34,649,803...34,722,846 JBrowse link
G Nme9 NME/NM23 family member 9 increases expression ISO casticin results in increased expression of NME9 mRNA CTD PMID:28444820 NCBI chr 8:100,013,190...100,034,511 JBrowse link
G Nmt1 N-myristoyltransferase 1 decreases expression ISO casticin results in decreased expression of NMT1 mRNA CTD PMID:28444820 NCBI chr10:88,488,918...88,525,496
Ensembl chr10:88,488,990...88,522,729 		JBrowse link
G Nol4l nucleolar protein 4-like decreases expression ISO casticin results in decreased expression of NOL4L mRNA CTD PMID:28444820 NCBI chr 3:162,345,059...162,467,849
Ensembl chr 3:162,348,211...162,468,048 		JBrowse link
G Nop58 NOP58 ribonucleoprotein decreases expression ISO casticin results in decreased expression of NOP58 mRNA CTD PMID:28444820 NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:68,615,010...68,638,909 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP casticin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein] CTD PMID:38309612 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Npas3 neuronal PAS domain protein 3 decreases expression ISO casticin results in decreased expression of NPAS3 mRNA CTD PMID:28444820 NCBI chr 6:76,438,064...77,263,185
Ensembl chr 6:76,438,260...77,263,185 		JBrowse link
G Nrg3 neuregulin 3 decreases expression ISO casticin results in decreased expression of NRG3 mRNA CTD PMID:27862857 NCBI chr16:14,256,540...15,374,107
Ensembl chr16:14,257,148...15,374,147 		JBrowse link
G Nup205 nucleoporin 205 decreases expression ISO casticin results in decreased expression of NUP205 mRNA CTD PMID:28444820 NCBI chr 4:64,822,051...64,887,996
Ensembl chr 4:64,822,065...64,887,988 		JBrowse link
G Nup37 nucleoporin 37 decreases expression ISO casticin results in decreased expression of NUP37 mRNA CTD PMID:28444820 NCBI chr 7:24,443,998...24,497,088
Ensembl chr 7:24,463,301...24,508,741 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression ISO casticin results in decreased expression of OLIG2 mRNA CTD PMID:27862857 NCBI chr11:43,961,585...43,964,961
Ensembl chr11:43,958,940...43,968,634 		JBrowse link
G Orc5 origin recognition complex, subunit 5 decreases expression ISO casticin results in decreased expression of ORC5 mRNA CTD PMID:28444820 NCBI chr 4:13,440,264...13,504,888
Ensembl chr 4:13,440,300...13,504,886 		JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 decreases expression ISO casticin results in decreased expression of OTUB2 mRNA CTD PMID:28444820 NCBI chr 6:128,309,863...128,328,444
Ensembl chr 6:128,299,693...128,328,433 		JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO casticin results in increased expression of P2RX7 mRNA CTD PMID:28444820 NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193 		JBrowse link
G Paip1 poly(A) binding protein interacting protein 1 decreases expression ISO casticin results in decreased expression of PAIP1 mRNA CTD PMID:28444820 NCBI chr 2:53,255,916...53,282,965
Ensembl chr 2:53,237,924...53,282,966 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 decreases expression ISO casticin results in decreased expression of PAK3 mRNA CTD PMID:27862857 NCBI chr  X:111,912,967...112,171,037
Ensembl chr  X:111,913,059...112,165,035 		JBrowse link
G Papola poly (A) polymerase alpha decreases expression ISO casticin results in decreased expression of PAPOLA mRNA CTD PMID:28444820 NCBI chr 6:130,446,236...130,499,371
Ensembl chr 6:130,446,797...130,499,336 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO casticin results in increased expression of PARP1 protein CTD PMID:32270916 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Pcdha1 protocadherin alpha 1 increases expression ISO casticin results in increased expression of PCDHA1 mRNA CTD PMID:28444820 Ensembl chr18:28,855,256...29,120,227 JBrowse link
G Phf10 PHD finger protein 10 decreases expression ISO casticin results in decreased expression of PHF10 mRNA CTD PMID:28444820 NCBI chr 1:64,625,373...64,642,110
Ensembl chr 1:64,624,465...64,642,049 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein decreases expression ISO casticin results in decreased expression of PICALM mRNA CTD PMID:28444820 NCBI chr 1:153,468,982...153,550,086
Ensembl chr 1:153,469,202...153,550,237 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO casticin results in decreased expression of PLAU protein CTD PMID:28444820 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO casticin results in increased expression of PMP22 mRNA CTD PMID:28444820 NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression 		ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA] CTD PMID:32268151 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,227,837...3,232,598 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO casticin results in decreased expression of PPARD mRNA CTD PMID:27862857 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO casticin results in increased expression of PPARG mRNA CTD PMID:27862857 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO casticin results in decreased expression of PPARGC1A mRNA CTD PMID:28444820 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213 		JBrowse link
G Ppp1r11 protein phosphatase 1, regulatory (inhibitor) subunit 11 decreases expression ISO casticin results in decreased expression of PPP1R11 mRNA CTD PMID:28444820 NCBI chr20:1,606,583...1,610,090
Ensembl chr20:1,606,577...1,613,212 		JBrowse link
G Ppp6r3 protein phosphatase 6, regulatory subunit 3 decreases expression ISO casticin results in decreased expression of PPP6R3 mRNA CTD PMID:28444820 NCBI chr 1:210,122,394...210,236,839
Ensembl chr 1:210,122,394...210,236,809 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression ISO casticin results in decreased expression of PRKAR2B mRNA CTD PMID:27862857 NCBI chr 6:54,291,143...54,381,639
Ensembl chr 6:54,291,151...54,381,411 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO casticin results in decreased expression of PRKDC protein CTD PMID:29098808 NCBI chr11:98,544,952...98,762,499
Ensembl chr11:98,544,954...98,762,108 		JBrowse link
G Prss44 serine protease 44 increases expression ISO casticin results in increased expression of PRSS44 mRNA CTD PMID:28444820 NCBI chr 8:119,670,088...119,683,717
Ensembl chr 8:119,670,112...119,683,717 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP casticin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; casticin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:38309612 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO casticin results in decreased expression of PTK2 protein CTD PMID:28444820 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A increases expression ISO casticin results in increased expression of PTPRA mRNA CTD PMID:28444820 NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:138,098,110...138,213,126 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO casticin results in decreased expression of PTPRD mRNA CTD PMID:28444820 NCBI chr 5:95,093,221...97,415,498
Ensembl chr 5:95,095,858...96,178,903 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression ISO casticin results in decreased expression of PTPRF mRNA CTD PMID:28444820 NCBI chr 5:137,027,376...137,109,405
Ensembl chr 5:137,028,164...137,095,426 		JBrowse link
G Qki QKI, KH domain containing RNA binding decreases expression ISO casticin results in decreased expression of QKI mRNA CTD PMID:28444820 NCBI chr 1:52,935,357...53,047,338
Ensembl chr 1:52,935,382...53,047,337 		JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO casticin results in decreased expression of RAPGEF4 mRNA CTD PMID:28444820 NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:77,217,039...77,509,978 		JBrowse link
G Rars1 arginyl-tRNA synthetase 1 decreases expression ISO casticin results in decreased expression of RARS1 mRNA CTD PMID:28444820 NCBI chr10:20,774,804...20,799,251
Ensembl chr10:20,774,805...20,799,251 		JBrowse link
G Rbmx2 RNA binding motif protein, X-linked 2 decreases expression ISO casticin results in decreased expression of RBMX2 mRNA CTD PMID:28444820 NCBI chr  X:127,888,514...127,896,239
Ensembl chr  X:132,757,012...132,774,750 		JBrowse link
G Rcor3 REST corepressor 3 decreases expression ISO casticin results in decreased expression of RCOR3 mRNA CTD PMID:28444820 NCBI chr13:106,156,166...106,196,542
Ensembl chr13:106,157,232...106,196,575 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO casticin results in decreased expression of RELA protein CTD PMID:28444820 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rexo2 RNA exonuclease 2 decreases expression ISO casticin results in decreased expression of REXO2 mRNA CTD PMID:28444820 NCBI chr 8:57,708,420...57,720,142
Ensembl chr 8:57,707,558...57,720,142 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO casticin results in decreased expression of RHOA protein CTD PMID:28444820 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression ISO casticin results in decreased expression of RPL22L1 mRNA CTD PMID:28444820 NCBI chr 2:113,683,196...113,685,132
Ensembl chr 2:113,683,196...113,685,132 		JBrowse link
G S100a13 S100 calcium binding protein A13 increases expression ISO casticin results in increased expression of S100A13 mRNA CTD PMID:28444820 NCBI chr 2:178,297,020...178,303,514
Ensembl chr 2:178,296,917...178,303,507 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 increases expression ISO casticin results in increased expression of SCN1B mRNA CTD PMID:28444820 NCBI chr 1:95,481,298...95,491,211
Ensembl chr 1:95,481,298...95,491,197 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 increases expression ISO casticin results in increased expression of SLC31A1 mRNA CTD PMID:28444820 NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO casticin results in decreased expression of SLC6A9 mRNA CTD PMID:28444820 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172 		JBrowse link
G Smad1 SMAD family member 1 increases expression ISO casticin results in increased expression of SMAD1 mRNA CTD PMID:27862857 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957 		JBrowse link
G Smad3 SMAD family member 3 increases expression ISO casticin results in increased expression of SMAD3 mRNA CTD PMID:27862857 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G decreases expression ISO casticin results in decreased expression of SNRPG mRNA CTD PMID:28444820 NCBI chr 4:120,369,676...120,377,263
Ensembl chr 4:120,369,685...120,377,261
Ensembl chr  X:120,369,685...120,377,261 		JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO casticin results in decreased expression of SNW1 mRNA CTD PMID:28444820 NCBI chr 6:112,826,374...112,850,459
Ensembl chr 6:112,826,381...112,858,180 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression 		ISO casticin promotes the reaction [Fluorouracil results in increased expression of SOD1 protein]; Fluorouracil promotes the reaction [casticin results in increased expression of SOD1 protein] CTD PMID:32270916 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO casticin results in decreased expression of SOS1 protein CTD PMID:28444820 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:20,286,117...20,363,350 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression
increases expression 		ISO casticin results in decreased expression of SPARC mRNA
casticin results in increased expression of SPARC mRNA 		CTD PMID:27862857 PMID:28444820 NCBI chr10:40,017,065...40,038,816
Ensembl chr10:40,017,075...40,039,268 		JBrowse link
G Sparcl1 SPARC like 1 increases expression ISO casticin results in increased expression of SPARCL1 mRNA CTD PMID:28444820 NCBI chr14:5,937,484...5,968,532
Ensembl chr14:5,914,535...5,969,120 		JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression ISO casticin results in increased expression of ST13 mRNA CTD PMID:28444820 NCBI chr 7:114,769,758...114,805,877
Ensembl chr 7:114,769,759...114,805,941 		JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 decreases expression ISO casticin results in decreased expression of ST3GAL3 mRNA CTD PMID:28444820 NCBI chr 5:136,755,780...136,958,081
Ensembl chr 5:136,755,678...136,955,987 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein decreases expression ISO casticin results in decreased expression of STRBP mRNA CTD PMID:28444820 NCBI chr 3:41,738,096...41,879,054
Ensembl chr 3:41,712,311...41,824,707 		JBrowse link
G Sugp1 SURP and G patch domain containing 1 decreases expression ISO casticin results in decreased expression of SUGP1 mRNA CTD PMID:28444820 NCBI chr16:19,386,588...19,417,460
Ensembl chr16:19,386,589...19,417,460 		JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO casticin results in decreased expression of SYNCRIP mRNA CTD PMID:28444820 NCBI chr 8:98,282,358...98,315,412
Ensembl chr 8:98,282,358...98,315,386 		JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO casticin results in decreased expression of SYT9 mRNA CTD PMID:28444820 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:170,687,606...170,881,375 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 decreases expression ISO casticin results in decreased expression of TAB2 mRNA CTD PMID:27862857 NCBI chr 1:4,195,400...4,245,485
Ensembl chr 1:4,195,400...4,245,485 		JBrowse link
G Tcf7 transcription factor 7 decreases expression ISO casticin results in decreased expression of TCF7 mRNA CTD PMID:28444820 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO casticin results in decreased expression of THRA mRNA CTD PMID:28444820 NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO casticin results in increased expression of TIMP2 mRNA CTD PMID:28444820 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Tlk2 tousled-like kinase 2 decreases expression ISO casticin results in decreased expression of TLK2 mRNA CTD PMID:28444820 NCBI chr10:90,648,623...90,748,427
Ensembl chr10:90,653,851...90,748,428 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO casticin results in decreased expression of TLR4 mRNA CTD PMID:27862857 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007 		JBrowse link
G Tmbim4 transmembrane BAX inhibitor motif containing 4 increases expression ISO casticin results in increased expression of TMBIM4 mRNA CTD PMID:27862857 NCBI chr 7:57,604,275...57,618,861
Ensembl chr 7:57,604,275...57,621,056 		JBrowse link
G Tmem45b transmembrane protein 45b increases expression ISO casticin results in increased expression of TMEM45B mRNA CTD PMID:27862857 NCBI chr 8:38,123,423...38,168,599
Ensembl chr 8:38,123,423...38,168,599 		JBrowse link
G Tmsb10 thymosin, beta 10 increases expression ISO casticin results in increased expression of TMSB10 mRNA CTD PMID:28444820 NCBI chr 4:106,568,080...106,569,210 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP casticin inhibits the reaction [IL1B protein results in increased secretion of TNF protein] CTD PMID:38309612 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO casticin results in increased expression of TNFSF10 protein CTD PMID:27862857 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tnpo1 transportin 1 decreases expression ISO casticin results in decreased expression of TNPO1 mRNA CTD PMID:28444820 NCBI chr 2:31,941,731...32,034,366
Ensembl chr 2:31,941,731...32,034,326 		JBrowse link
G Tor1aip2 torsin 1A interacting protein 2 decreases expression ISO casticin results in decreased expression of TOR1AIP2 mRNA CTD PMID:28444820 NCBI chr13:70,775,483...70,806,794
Ensembl chr13:70,780,275...70,806,789
Ensembl chr13:70,780,275...70,806,789 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression 		ISO casticin results in increased expression of TP53 protein modified form
casticin results in decreased expression of TP53 protein 		CTD PMID:29098808 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO casticin results in increased expression of TPI1 mRNA CTD PMID:28444820 NCBI chr 4:159,301,558...159,305,088
Ensembl chr 4:159,301,562...159,305,413 		JBrowse link
G Tpra1 transmembrane protein adipocyte associated 1 increases expression ISO casticin results in increased expression of TPRA1 mRNA CTD PMID:28444820 NCBI chr 4:121,364,093...121,375,275
Ensembl chr 4:122,921,323...122,932,517 		JBrowse link
G Tra2b transformer 2 beta decreases expression ISO casticin results in decreased expression of TRA2B mRNA CTD PMID:28444820 NCBI chr11:92,293,403...92,311,651
Ensembl chr11:92,293,410...92,311,781 		JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression ISO casticin results in increased expression of TRAP1 mRNA CTD PMID:27862857 NCBI chr10:11,971,259...12,005,306
Ensembl chr10:11,970,995...12,005,355 		JBrowse link
G Trio trio Rho guanine nucleotide exchange factor increases expression ISO casticin results in increased expression of TRIO mRNA CTD PMID:28444820 NCBI chr 2:80,235,485...80,531,824
Ensembl chr 2:80,235,485...80,531,612 		JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 decreases expression ISO casticin results in decreased expression of UBE2D3 mRNA CTD PMID:28444820 NCBI chr 2:226,543,194...226,571,001
Ensembl chr 2:226,540,531...226,573,144 		JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) decreases expression ISO casticin results in decreased expression of UBE2F mRNA CTD PMID:28444820 NCBI chr 9:99,293,506...99,328,690
Ensembl chr 9:99,293,515...99,330,479 		JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W decreases expression ISO casticin results in decreased expression of UBE2W mRNA CTD PMID:28444820 NCBI chr 5:7,474,039...7,531,526
Ensembl chr 5:7,474,003...7,598,245 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO casticin results in decreased expression of VEGFA mRNA CTD PMID:28444820 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vezf1 vascular endothelial zinc finger 1 decreases expression ISO casticin results in decreased expression of VEZF1 mRNA CTD PMID:28444820 NCBI chr10:73,341,666...73,373,320
Ensembl chr10:73,356,985...73,373,320 		JBrowse link
G Vim vimentin decreases expression
increases expression 		ISO casticin results in decreased expression of VIM mRNA
casticin results in increased expression of VIM mRNA 		CTD PMID:27862857 PMID:28444820 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO casticin results in decreased expression of VLDLR mRNA CTD PMID:28444820 NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:234,240,121...234,272,154 		JBrowse link
G Wac WW domain containing adaptor with coiled-coil decreases expression ISO casticin results in decreased expression of WAC mRNA CTD PMID:28444820 NCBI chr17:60,617,702...60,677,771
Ensembl chr17:60,617,544...60,679,267 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase decreases expression ISO casticin results in decreased expression of WEE1 protein CTD PMID:29098808 NCBI chr 1:173,605,609...173,632,450
Ensembl chr 1:173,608,949...173,632,449 		JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO casticin results in decreased expression of WNT5A mRNA CTD PMID:27862857 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,703,665...3,724,860 		JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 decreases expression ISO casticin results in decreased expression of WSB1 mRNA CTD PMID:28444820 NCBI chr10:64,700,752...64,717,038
Ensembl chr10:64,700,762...64,716,832 		JBrowse link
G Wtap WT1 associated protein decreases expression ISO casticin results in decreased expression of WTAP mRNA CTD PMID:28444820 NCBI chr 1:50,070,973...50,096,074
Ensembl chr 1:50,070,769...50,096,072 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO casticin results in increased expression of XBP1 mRNA CTD PMID:27862857 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO casticin results in decreased expression of XIAP protein CTD PMID:29098808 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression ISO casticin results in increased expression of YWHAB protein CTD PMID:29098808 NCBI chr 3:173,078,904...173,101,508
Ensembl chr 3:173,079,041...173,101,854 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma decreases expression ISO casticin results in decreased expression of YWHAG mRNA CTD PMID:28444820 NCBI chr12:26,381,106...26,409,466
Ensembl chr12:26,380,816...26,409,465 		JBrowse link
G Zbtb18 zinc finger and BTB domain containing 18 decreases expression ISO casticin results in decreased expression of ZBTB18 mRNA CTD PMID:28444820 NCBI chr13:91,971,602...91,980,058
Ensembl chr13:91,969,755...91,980,386 		JBrowse link
G Zfhx4 zinc finger homeobox 4 decreases expression ISO casticin results in decreased expression of ZFHX4 mRNA CTD PMID:28444820 NCBI chr 2:98,131,996...98,321,070
Ensembl chr 2:98,131,996...98,315,469 		JBrowse link
G Zfp384 zinc finger protein 384 decreases expression ISO casticin results in decreased expression of ZFP384 mRNA CTD PMID:28444820 NCBI chr 4:159,496,481...159,526,010
Ensembl chr 4:159,496,729...159,526,010 		JBrowse link
G Zfp711 zinc finger protein 711 decreases expression ISO casticin results in decreased expression of ZFP711 mRNA CTD PMID:28444820 NCBI chr  X:81,838,483...81,871,767
Ensembl chr  X:81,838,620...81,871,784 		JBrowse link
G Zfr zinc finger RNA binding protein decreases expression ISO casticin results in decreased expression of ZFR mRNA CTD PMID:28444820 NCBI chr 2:62,864,333...62,927,377
Ensembl chr 2:62,864,338...62,929,133 		JBrowse link
G Zkscan1 zinc finger with KRAB and SCAN domains 1 increases expression ISO casticin results in increased expression of ZKSCAN1 mRNA CTD PMID:28444820 NCBI chr12:22,080,319...22,101,389
Ensembl chr12:22,080,324...22,101,387 		JBrowse link
G Zscan2 zinc finger and SCAN domain containing 2 increases expression ISO casticin results in increased expression of ZSCAN2 mRNA CTD PMID:28444820 NCBI chr 1:144,243,082...144,258,192
Ensembl chr 1:144,242,595...144,258,188 		JBrowse link
G Zswim6 zinc finger, SWIM-type containing 6 increases expression ISO casticin results in increased expression of ZSWIM6 mRNA CTD PMID:28444820 NCBI chr 2:40,944,617...41,112,340
Ensembl chr 2:40,946,435...41,112,519 		JBrowse link
chrysosplenetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases activity ISO chrysosplenetin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects activity ISO chrysosplenetin affects the activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      chemical role 20396
        antioxidant 16464
          quercetagetin 292
            3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 0
            3',4',5-trihydroxy-3,6,7-trimethoxyflavone 0
            axillarin 0
            casticin 286
            chrysosplenetin 2
            chrysosplenol C 0
            eupatin 0
            patuletin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            organic molecule 20654
                              organic cyclic compound 20404
                                organic heterocyclic compound 19388
                                  oxacycle 18300
                                    benzopyran 12186
                                      1-benzopyran 11917
                                        flavonoid 7550
                                          anthoxanthin 4621
                                            flavones 4621
                                              hydroxyflavone 4598
                                                flavonols 4464
                                                  7-hydroxyflavonol 4430
                                                    quercetin 4367
                                                      quercetagetin 292
                                                        3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 0
                                                        3',4',5-trihydroxy-3,6,7-trimethoxyflavone 0
                                                        axillarin 0
                                                        casticin 286
                                                        chrysosplenetin 2
                                                        chrysosplenol C 0
                                                        eupatin 0
                                                        patuletin 0
paths to the root